Abstract
Pergolide mesylate, a synthetic semiergoline, is a potent dopamine agonist which holds promise as a treatment for Parkinson’s disease. Its chemical name is (8 β)-8-[(methylthio)methyl]-6-propylergoline monomethanesulfonate; its empirical formula is C20H30N2O3S2 (Fig. 1), and its molecular weight is 410.6.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Calne DB, Teychenne PF, Claveria LE, Eastman R, Greenacre JK, Petrie A (1974) Bromocriptine in parkinsonism. Br Med J [Clin Res] 4: 442–444
Clemens JA, Smalstig EB (1979) Effects of some new dopamine agonists on turning behavior in 6-hydroxydopamine lesioned rats. IRCS Med Sci 6: 427
Diamond SG, Markham CH (1984) One-year trial of pergolide as an adjunct to Sinemet in treatment of Parkinson’s disease. In: Hassler RG, Christ JF (eds) Advances in neurology. Raven, New York, pp 537–539
Diamond SG, Markham CH, Treciokas LJ (1985) Double-blind trial of pergolide for Parkinson’s disease, Neurology 35: 291–295
Goetz CG, Tanner CM, Glantz RH, Klawans HL (1985) Chronic agonist therapy for Parkinson’s disease: a 5-year study of bromocriptine and pergolide. Neurology 35: 749–751
Goldstein M, Lieberman A, Lew JY, Asano T, Rosenfeld MR, Makman MH (1980) Interaction of pergolide with central dopaminergic receptors. Proc Natl Acad Sci USA 77: 3725–3728
Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology (Minneapolis) 17: 427–442
Hoehn MM, Schear MJ, Heaton A (1985) Comparison of pergolide, bromocriptine, and mesulergine in the management of complications of levodopa therapy. Neurology 35 (Suppl 1): 202
Horowski R (1978) Differences in the dopaminergic effects of the ergot derivatives bromocriptine, lisuride and D-LSD as compared with apomorphine. Eur J Pharmacol 51: 157–166
Hurtig HI, Saykin A, Stern MB, Melvin G, Cline S, Fuller J, Gur R (1985) Pergolide improves motor function in Parkinson’s disease without causing adverse mental effects: a neuropsychological study. Neurology 35 (Suppl 1): 202
Ilson J, Fahn S, Mayeux R, Cote LJ (1982) Pergolide treatment in parkinsonism. Neurology 32 (2): 181
Ilson J, Fahn S, Mayeux R, Cote LJ, Snider SR (1983) Pergolide treatment in parkinsonism. In: Fahn S, Calne DB, Shoulson I (eds) Experimental therapeutics of movement disorders, Vol 37. Raven, New York, pp 85–94
Jankovic J (1985) Long-term study of pergolide in Parkinson’s disease. Neurology 35: 296–299
Jiang DH, Reches A, Wagner HR, Fahn S (1984) Biochemical and behavioral evaluation of pergolide as a dopamine agonist in the rat brain. Neuropharmacology 23: 295–301
Kleinberg DL, Lieberman A, Todd J, Greising J, Neophytides A, Kupersmith M (1980) Pergolide mesylate: a potent day-long inhibitor of prolactin in rhesus monkeys, and patients with Parkinson’s disease. J Clin Endocrinol Metab 51: 152–154
Kurland R, Miller C, Levy R, Macik B, Hamill R, Shoulson I (1985) Long-term experience with pergolide therapy of advanced parkinsonism. Neurology 35: 738–742
Lang AE, Quinn N, Brincat S, Marsden CD, Parkes JD (1982) Pergolide in late-stage Parkinson disease. Ann Neurol 12: 243–247
Lees AJ, Stern GM (1981) Pergolide and lisuride for levodopa-induced oscillations. Lancet 2: 577
Leibowitz M, Lieberman A, Goldstein M, Neophytides A, Kupersmith M, Gopinathan G, Mehl S (1981) Cardiac effects of pergolide. Clin Pharmacol Ther 30: 718–723
Lemberger L, Crabtree RE (1979) Pharmacologic effects in man of a potent, long-acting dopamine receptor agonist. Science 205: 1151–1153
LeWitt PA, Ward CD, Larsen TA, Raphaelson MI, Newman RP, Foster N, Dambrosia JM, Calne DB (1983) Comparison of pergolide and bromocriptine therapy in parkinsonism. Neurology 33: 1009–1014
Lieberman AN, Goldstein M, Leibowitz M, Neophytides A, Kupersmith M, Pact V, Kleinberg D (1981) Treatment of advanced Parkinson disease with pergolide. Neurology 31: 675–682
Lieberman AN, Goldstein M, Gopinathan G, Leibowitz M, Neophytides A, Walker R, Hiesiger E, Nelson J (1982) Further studies with pergolide in Parkinson disease. Neurology 32: 1181–1184
Lieberman AN, Goldstein M, Leibowitz M, Gopinathan G, Neophytides A, Hiesiger E, Nelson J, Walker R (1984) Long-term treatment with pergolide: decreased efficacy with time. Neurology 34: 223–226
Lieberman AN, Leibowitz M, Gopinathan G, Walker R, Hiesiger E, Nelson J, Goldstein M (1985) Review: the use of pergolide and lisuride, two experimental dopamine agonists, in patients with advanced Parkinson disease. Am J Med Sci 290: 102–106
Lieberman AN, Gopinathan G, Neophytides A (1986) Efficacy of pergolide and mesulergine. Eur Neurol 25: 86–90
Markham CH, Diamond SG (1981) Evidence to support early levodopa therapy in Parkinson disease. Neurology 31: 125–131
Markham CH, Diamond SG (1986 a) Modification of Parkinson’s disease by long-term levodopa. Arch Neurol 43(4):405–407
Markham CH, Diamond SG (1986b) Long-term follow up of early dopa treatment in Parkinson’s disease. Ann Neurol 19: 365–372
Mear JY, Barroche G, de Smet Y, Weber M, Lhermitte F, Agid Y (1984) Pergolide in the treatment of Parkinson’s disease. Neurology 34: 983–986
Rabey JM, Passeltiner P, Markey K, Asano T, Goldstein M (1981) Stimulation of pre- and post-synaptic dopamine receptors by an ergoline and by a partial ergoline. Brain Res 225: 347–356
Reavill C, Jenner P, Marsden CD (1981) Puzzles of the mechanism of action of bromocriptine. In: Gessa EL, Corsini GU (eds) Basic pharmacology, vol 1. Apomorphine and other dopaminomimetics. Raven, New York, pp 229–239
Rinne UK (1981) Dopaminergic agonists in the treatment of Parkinson’s disease. Abstracts, 12th world congress of neurology, 20–25 September, Kyoto, Japan. Excerpta Medica, Amsterdam, p 133
Rinne UK (1986) Early combination of bromocriptine and levodopa in the treatment of Parkinson’s disease. In: Fahn S, Marsden CD, Jenner P, Teychenne P. (eds) Recent developments in Parkinson’s disease. Raven, New York, pp 267–271
Roth RH (1979) Dopamine autoreceptors: pharmacology, function and comparison with postsynaptic dopamine receptors. Community Psychopharmacol 3: 429–445
Sage JI, Duvoisin RC (1985 a) Long-term efficacy of pergolide in patients with Parkinson’s disease. Ann Neurol 18:137
Sage JI, Duvoisin RC (1985b) Pergolide therapy in Parkinson’s disease: a double-blind, placebo-controlled study. Clin Neuropharmacol 8(3):260–265
Shoulson I, Miller C, Kurlan R, Levy R, Macik B, Hamill R (1982) Parkinsonism and on-off fluctuations: long-term effects of pergolide therapy. Ann Neurol 12: 97
Stern Y, Mayeux R, Ilson J, Fahn S, Cote L (1984) Pergolide therapy for Parkinson’s disease: neurobehavioral changes. Neurology 34: 201–204
Tanner CM, Klawans HL (1982) Pergolide mesylate: new therapy for Parkinson disease. Ann Intern Med 96 (4): 522–523
Tanner CM, Goetz CG, Glantz RH, Glatt SL, Klawans HL (1982) Pergolide mesylate and idiopathic Parkinson disease. Neurology (NY) 32: 1175–1179
Tanner CM, Chhablani R, Goetz CG, Klawans HL (1985) Pergolide mesylate: lack of cardiac toxicity in patients with cardiac disease. Neurology 35: 918–921
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Markham, C.H., Diamond, S.G. (1989). Pergolide in the Treatment of Parkinson’s Disease. In: Calne, D.B. (eds) Drugs for the Treatment of Parkinson’s Disease. Handbook of Experimental Pharmacology, vol 88. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73899-9_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-73899-9_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-73901-9
Online ISBN: 978-3-642-73899-9
eBook Packages: Springer Book Archive