ACTH (4–10) and ACTH (1–24) Influence Neurite Outgrowth and Neural Development of Fetal Rat Cerebral Cultures

  • C. Richter-Landsberg
  • I. Bruns
  • H. Flohr
Conference paper


The central and peripheral nervous systems are targets for a group of ACTH/MSH-like peptides, collectively termed melanocortins. These peptides and some of their (noncorticotrophic) fragments and analogs, such as ACTH (4–10) and ACTH (4–9), α-MSH and Org 2766, affect numerous neurophysiological functions, in particular, those underlying memory and learning (for reviews see Gispen and Zwiers 1985, De Wied and Jolles 1982). Recent evidence indicates that these peptides also influence lesion-induced plastic processes in both the central and peripheral nervous system.


Neurite Outgrowth AChE Activity Acetylcholinesterase Activity Neuritic Bundle ACTH Fragment 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • C. Richter-Landsberg
    • 1
  • I. Bruns
    • 1
  • H. Flohr
    • 1
  1. 1.Department of NeurobiologyUniversity of BremenBremenGermany

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