Modulation of Glial Cell Response to Injury and CNS Regeneration
Axonal injury initiates a cellular response in the non-neuronal cells surrounding the axons. This response includes proliferation of certain non-neuronal cells and infiltration of scavenger cells such as macrophages. For years it was accepted that this cellular response impedes regeneration due to the mechanical barrier created by the proliferating cells which make up scar tissue. The experimental evidence in this direction is not conclusive and it is not clear whether the lack of growth evolves from a barrier or from a deficiency in supportive elements.
KeywordsOptic Nerve Neural Cell Adhesion Molecule Nonneuronal Cell Fish Plasma Injured Sciatic Nerve
Unable to display preview. Download preview PDF.
- Aguayo A, Samuel D, Richardson P, Bray G (1978b) Axonal elongation in peripheral and central nervous system transplantations. Adv Cell Neurobiol 3: 215–221Google Scholar
- Harel A, Fainaru M, Shafer Z, Schwartz M (1987 a) Optic nerve regeneration in adult fish is associated with accumulation of apolipoprotein-A-I manifested preferentially in one isoform. (submitted)Google Scholar
- Harel A, Rubinstein M, Solomon A, Belkin M, Schwartz M (1987 b) Isolation of a growth associated triggering factor from regenerating optic nerve. J Neurochem (Abst) (in press)Google Scholar
- Ignatius MJ, Gebicke-Harter PJ, Skene JHP, Schilling JW, Weisgraber KH, Mahley RW, Shooter EM (1986) Expression of apolipoprotein E during nerve degeneration and regeneration. Proc Natl Acad Sci USA 83: 1125–1129Google Scholar
- Liesi P, Kaakola S, Dahl D, Vaheri A (1984 b) Laminin is induced in astrocytes of adult brain by injury. EMBO J 3: 683–686Google Scholar
- Margolis RV, Margolis RK (1979) Complex carbohydrates of nervous tissue. Plenum, New YorkGoogle Scholar
- Ramon y Cajal S (1928) Degeneration and regeneration of the nervous system. English translation and reprint ( 1959 ) Hafner, New YorkGoogle Scholar
- Schachner M (1982) Glial antigens and the expression of neuroglial phenotypes. TINS, July 1982, pp 225–228Google Scholar
- Schwartz M, Harel A, Stein-Izsak C, Solomon A, Bawnik Y, Belkin M ( 1987 a) Growth associated triggering factors and central nervous system response to injury. In: Stein DG, Sabel B (eds) Pharmacological Approaches to the Treatment of Brain and Spinal Cord Injuries. Plenum, New YorkGoogle Scholar
- Schwartz M, Erlich M, Doron A, Benbasat S, Lavie V, Belkin M (1987 b) The effects of low energy laser irradiation of posttraumatic degeneration of adult rabbit optic nerve. Lasers Surg Med 7: 51Google Scholar