Modulation of Glial Cell Response to Injury and CNS Regeneration

  • M. Schwartz
  • A. Cohen
  • A. Harel
  • A. Solomon
  • M. Belkin


Axonal injury initiates a cellular response in the non-neuronal cells surrounding the axons. This response includes proliferation of certain non-neuronal cells and infiltration of scavenger cells such as macrophages. For years it was accepted that this cellular response impedes regeneration due to the mechanical barrier created by the proliferating cells which make up scar tissue. The experimental evidence in this direction is not conclusive and it is not clear whether the lack of growth evolves from a barrier or from a deficiency in supportive elements.


Optic Nerve Neural Cell Adhesion Molecule Nonneuronal Cell Fish Plasma Injured Sciatic Nerve 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. Schwartz
    • 1
  • A. Cohen
    • 1
  • A. Harel
    • 1
  • A. Solomon
    • 1
  • M. Belkin
    • 1
  1. 1.Department of NeurobiologyThe Weizmann Institute of ScienceRehovotIsrael

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