Advertisement

Path- and Homefinding of Regenerating Retinal Axons in Goldfish

  • C. A. O. Stuermer

Abstract

The reformation of the retinotopic map by regenerating goldfish retinal axons has been well documented with behavioral and electrophysiological techniques (reviews: by Jacobson 1978; Gaze 1978). To account for the reliability with which regenerating axons return to their retinotopic target sites in tectum, Sperry (1963) proposed that “cells and fibers must carry some kind of individual identification tags, presumably cytochemical in nature, by which they are distinguished one from another almost to the level of the single neuron”. In their classical anatomical paper, Attardi and Sperry (1963) conveyed the view that regenerating axons follow their old pathways and proceed directly to their prespecified loci on tectum by 4 weeks after nerve section.

Keywords

Growth Cone Retinal Axon Optic Nerve Section Retinotectal Projection Tectal Region 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Attardi DG, Sperry RW (1963) Preferential selection of central pathways by regenerating optic fibers. Exp Neurol 7: 46–64PubMedCrossRefGoogle Scholar
  2. Bonhoeffer F, Gierer A (1984) How do retinal axons find their targets on tectum? TINS, pp 378–381Google Scholar
  3. Busse U, Stuermer CAO (1987) Navigation and target recognition of regenerating retinal axons in long-term denervated tecta in goldfish. Neurosci Abstr 13Google Scholar
  4. Cook JE (1983) Tectal paths of regenerated optic axons in the goldfish: evidence from retrograde labelling with horseradish peroxidase. Exp Brain Res 51: 433–442CrossRefGoogle Scholar
  5. Cook JE, Horder TJ (1977) The multiple factors determining retinotopic order in the growth of optic fibres into the optic tectum. Philos Trans R Soc Lond B Biol Sci 278: 261–276PubMedCrossRefGoogle Scholar
  6. Cook JE, Rankin ECC (1986) Impaired refinement of the regenerated retinotectal projection of the goldfish in stroboscopic light: a quantitative study. Exp Brain Res 63: 421–430PubMedCrossRefGoogle Scholar
  7. Easter SS, Stuermer CAO (1984) An evaluation of the hypothesis of shifting terminals in goldfish optic tectum. J Neurosci 4: 1052–1063PubMedGoogle Scholar
  8. Fujisawa H, Tani N, Watanabe K, Ibata Y (1982) Branching of regenerating retinal axons and preferential selection of appropriate branches for specific neuronal connection in the newt. Dev Biol 90: 43–57PubMedCrossRefGoogle Scholar
  9. Gaze RM (1970) The formation of nerve connections. Academic Press, London Gierer A (1981) Development of projections between areas of the nervous system. Biol Cybern 42: 69–78Google Scholar
  10. Hartlieb E, Stuermer CAO (1987) Path and target finding of retinal axons under the influence of TTX in the retinotectal system of goldfish. New Frontiers in Brain Res. Thieme, Stuttgart New YorkGoogle Scholar
  11. Jacobson M (1978) Developmental neurobiology. Plenum, New YorkGoogle Scholar
  12. Meyer RL, Sakurai K, Schauwecker E (1985) Topography of regenerating optic fibers in goldfish traced with local wheat germ injections into retina: evidence for discontinious microtopography in the retinotectal projection. J Comp Neurol 239: 27–43PubMedCrossRefGoogle Scholar
  13. Murray M (1976) Regeneration of retinal axons in the goldfish optic tectum. J Comp Neurol 168: 175–196PubMedCrossRefGoogle Scholar
  14. Rankin ECC, Cook JE (1986) Topographic refinement of the regenerating retinotectal projection of the goldfish in standard laboratory conditions. A quantitative WGA-HRP study. Exp Brain Res 63: 409–420PubMedCrossRefGoogle Scholar
  15. Schmidt JT (1978) Retinal fibers alter tectal positional markers during the expansion of the half retinal projection in goldfish. J Comp Neurol 177: 279–300PubMedCrossRefGoogle Scholar
  16. Sperry RW (1963) Chemoaffinity in the orderly growth of nerve fiber patterns and connections. Proc Natl Acad Sci USA 50: 703–709PubMedCrossRefGoogle Scholar
  17. Stuermer CAO (1984) Rules for retinotectal terminal arborizations in the goldfish optic tectum. A whole-mount study. J Comp Neurol 229: 214–232PubMedCrossRefGoogle Scholar
  18. Stuermer CAO (1988) The trajectories of regenerating retinal axons in the goldfish tectum I. J Comp Neurol 267: 55–68PubMedCrossRefGoogle Scholar
  19. Stuermer CAO (1988) The trajectories of regenerating retinal axons in the goldfish tectum II. J Comp Neurol 267: 69–91PubMedCrossRefGoogle Scholar
  20. Stuermer CAO, Easter SS (1984 a) A comparison of the normal and regenerated retinotectal pathways of goldfish. J Comp Neurol 223: 57–76CrossRefGoogle Scholar
  21. Stuermer CAO, Easter SS (1984 b) Rules of order in the retinotectal fascicles of goldfish. J Neurosci 4: 1045–1051Google Scholar
  22. Walter J, Kern-Veits B, Huf J, Stolze B, Bonhoeffer F (1987) Recognition of position-specific properties of tectal cell membranes by retinal axons invitro. Development 101: 685–696PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • C. A. O. Stuermer
    • 1
  1. 1.Friedrich-Miescher-Laboratorium der Max-Planck-GesellschaftTübingenGermany

Personalised recommendations