Skip to main content

Return of Function After Optic Tract Lesions in Adult Rats: Spontaneous Axonal Regeneration?

  • Conference paper

Abstract

It is unusual to see a spontaneous regeneration of severed axons suggested as one of the many possible mechanisms which may contribute to the often-observed improvement in functions which were compromised immediately after injury to the adult mammalian central nervous system (CNS). Severed axons in the CNS do not generally show the vigorous, albeit often randomly directed, regrowth of peripheral axons (Ramón y Cajal 1928), and it is rare to find that they have crossed a cut unless induced to do so by adjacent implanted tissue which they enter, but within which they tend to remain (Kromer et al. 1981; So and Aguayo 1985; Berry et al. 1986; Vidal-Sanz et al. 1987).

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Berry M, Rees L, Sievers J (1986) Regeneration of axons in the mammalian visual system. Exp Brain Res Suppl 13: 18–33

    Article  Google Scholar 

  • Bunt SM, Lund RD (1982) Optic fiber arrangements in the visual pathways of Long Evans hooded rats. Proc Soc Neurosci 8: 451

    Google Scholar 

  • Diamond J, Foerster A, Visheau B (1983) Optic tract regeneration in the adult rat: anatomy. Proc Soc Neurosci 9: 694

    Google Scholar 

  • Foerster AP (1982) Spontaneous regeneration of cut axons in the adult rat brain. J Comp Neurol 210: 335–356

    Article  PubMed  CAS  Google Scholar 

  • Foerster AP (1985 a) Return of function in rat superior colliculus after optic tract lesions. Can J Physiol Pharmacol 63: Axii

    Google Scholar 

  • Foerster AP (1985 b) Superior collicular correlates of partial optic tract lesions in rats. Proc Soc Neurosci 11: 1007

    Google Scholar 

  • Foerster AP, Holmes M, Diamond J (1983) Optic tract regeneration in the adult rat: physiology. Proc Soc Neurosci 9: 694

    Google Scholar 

  • Kromer LF, Bjorklund A, Stenevi U (1981) Regeneration of the septohippocampal pathways in adult rats is promoted by using embryonic hippocampal implants as bridges. Brain Res 210: 173–200

    Article  PubMed  CAS  Google Scholar 

  • Linden R, Perry VH (1983) Massive retinotectal projection in rats. Brain Res 272: 145–149

    Article  PubMed  CAS  Google Scholar 

  • Marks A (née Foerster AP) (1972) Regenerative reconstruction of a tract in a rat’s brain. Exp Neurol 34: 455–464

    Article  Google Scholar 

  • Mastronarde DN (1984) Organization of the cat’s tract as assessed by single-axon recordings. J Comp Neurol 227: 14–22

    Article  PubMed  CAS  Google Scholar 

  • Mesulam M-M, Mufson EJ (1980) The rapid anterograde transport of horseradish peroxidase. Neurosci 5: 1277–1286

    Article  CAS  Google Scholar 

  • Ramón y Cajal S (1928) Degeneration and regeneration in the nervous system, (May RM, Transi 1959 ). Hafner, New York

    Google Scholar 

  • Siminoff R, Schwassman HO, Kruger L (1966) An electrophysiological study of the visual projection to the superior colliculus of the rat. J Comp Neurol 127: 435–444

    Article  PubMed  CAS  Google Scholar 

  • So K-F, Aguayo AJ (1985) Lengthy regrowth of cut axons from ganglion cells after peripheral nerve transplantation into the retina of aculd rats. Brain Res 328: 349–354

    Article  PubMed  CAS  Google Scholar 

  • So K-F, Xiao Y-M, Diao Y-C (1986) Effects on the growth of damaged ganglion cell axons after peripheral nerve transplantation in adult hamsters. Brain Res 377: 168–172

    Article  PubMed  CAS  Google Scholar 

  • Torrealba F, Guillery RW, Eysel U, Polley EH, Mason CA (1982) Studies of retinal representation within the cat’s optic tract. J Comp Neurol 211: 377–396

    Article  PubMed  CAS  Google Scholar 

  • Vidal-Sanz M, Bray GM, Villega-Perez MP, Thanos S, Aguayo A J (1987) Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat. J Neurosci 7: 2894–2909

    PubMed  CAS  Google Scholar 

  • Yamadori T, Inamura Y, Minra M (1975) The termination and pattern of localized distribution of the nerve fields in rats. Hirosaki Med J 271: 48–71

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Foerster, A.P. (1988). Return of Function After Optic Tract Lesions in Adult Rats: Spontaneous Axonal Regeneration?. In: Flohr, H. (eds) Post-Lesion Neural Plasticity. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73849-4_41

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73849-4_41

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73851-7

  • Online ISBN: 978-3-642-73849-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics