Optokinetic and Vestibular Oculomotor Responses and their Interaction Following Hemilabyrinthectomy in the Cat

  • C. Maioli
Conference paper

Abstract

One of the most striking examples of plasticity in the central nervous system is the compensation of the highly disabling deficits which result from unilateral peripheral vestibular lesions. In fact, many studies in different species (cf. Schaefer and Meyer 1974) have shown that the vestibular compensation processes are remarkable both in their speed and in the degree of functional recovery. In particular, ocular and postural imbalance subside almost completely within the first post-operative week, and behavioral tests in cats and monkeys have shown that 30–40 days after hemilabyrinthectomy (HL) the recovery of postural and locomotor abnormalities is so extensive that it is often difficult to distinguish between operated and non-operated animals (Lacour et al. 1976; Xerri and Lacour 1980).

Keywords

Vestibular Nucleus Lesion Side Spontaneous Nystagmus Velocity Storage Slow Phase Velocity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Baarsma EA, Collewijn H (1975) Changes in compensatory eye movements after unilateral labyrinthectomy in the rabbit. Arch Oto-Rhino-Laryngol 211: 219–230CrossRefGoogle Scholar
  2. Baker R, Berthoz A (1975) Is the prepositus hypoglossi nucleus the source of another vestibulo-ocular pathway? Brain Res 86: 121–127PubMedCrossRefGoogle Scholar
  3. Baker R, Berthoz A, Delgado-Garcia J (1977) Monosynaptic excitation of trochlear motoneurons following electrical stimulation of the prepositus hypoglossi nucleus. Brain Res 121: 157–161PubMedCrossRefGoogle Scholar
  4. Cazin L, Magnin M, Lannou J (1982) Non-cerebellar visual afferents to the vestibular nuclei involving the prepositus hypoglossi complex: an autoradiographic study in the rat. Exp Brain Res 48: 309–313PubMedCrossRefGoogle Scholar
  5. Cazin L, Lannou J, Precht W (1984) An electrophysiological study of pathways mediating optokinetic responses to the vestibular nucleus in the rat. Exp Brain Res 54: 337–348PubMedCrossRefGoogle Scholar
  6. Cheron G, Gillis P, Godaux E (1986) Lesions in the cat prepositus complex: effects on the op-tokinetic system. J Physiol (Lond) 372: 95–111Google Scholar
  7. Cohen B, Uemura T, Takemori S (1973) Effects of labyrinthectomy on optokinetic nystagmus and optokinetic afternystagmus. Equilibrium Res 3: 88–93Google Scholar
  8. Cohen B, Suzuki J, Raphan T (1983) Role of the otolith organs in generation of horizontal nystagmus: effects of selective labyrinthine lesions. Brain Res 276: 159–164PubMedCrossRefGoogle Scholar
  9. Collewijn H (1976) Impairment of optokinetic (after-)nystagmus by labyrinthectomy in the rabbit. Exp Neurol 52: 146–156PubMedCrossRefGoogle Scholar
  10. Dichgans J, Schmidt CL, Graf W (1973) Visual input improves the speedometer function of the vestibular nuclei in the goldfish. Exp Brain Res 18: 319–322PubMedGoogle Scholar
  11. Fuller JH (1981) Eye and head movements during vestibular stimulation in the alert rabbit. Brain Res 205: 363–381PubMedCrossRefGoogle Scholar
  12. Gauthier GM, Robinson DA (1975) Adaptation of the human vestibulo-ocular reflex to magnifying lenses. Brain Res 92: 331–335PubMedCrossRefGoogle Scholar
  13. Gernandt BE, Thulin CA (1952) Vestibular connections of the brain stem. Am J Physiol 171: 121–127PubMedGoogle Scholar
  14. Graybiel AM, Hartwieg EA (1974) Some afferent connections of the oculomotor complex in the cat: an experimental study with tracer techniques. Brain Res 81: 543–551PubMedCrossRefGoogle Scholar
  15. Hikosaka O, Igusa Y (1980) Axonal projection of prepositus hypoglossi and reticular neurons in the brainstem of the cat. Exp Brain Res 39: 441–451PubMedGoogle Scholar
  16. Lacour M, Roll JP, Appaix M (1976) Modifications and development of spinal reflexes in the alert baboon (Papio papio) following an unilateral vestibular neurotomy. Brain Res 113: 255–269PubMedCrossRefGoogle Scholar
  17. Lopez-Barneo J, Darlot C, Berthoz A, Baker R (1982) Neuronal activity in prepositus nucleus correlated with eye movement in the alert cat. J Neurophysiol 47: 329–352PubMedGoogle Scholar
  18. Maciewicz RJ, Eagen K, Kaneko CRS, Highstein SM (1977) Vestibular and medullary brain stem afferents to the abducens nucleus in the cat. Brain Res 123: 229–240PubMedCrossRefGoogle Scholar
  19. Magnin M, Courjon JH, Flandrin JM (1983) Possible visual pathways to the cat vestibular nuclei involving the nucleus prepositus hypoglossi. Exp Brain Res 51: 298–303PubMedCrossRefGoogle Scholar
  20. Maioli C, Precht W (1984) The horizontal optokinetic nystagmus in the cat. Exp Brain Res 55: 494–506PubMedCrossRefGoogle Scholar
  21. Maioli C, Precht W (1985) On the role of vestibulo-ocular reflex plasticity in recovery after unilateral peripheral vestibular lesions. Exp Brain Res 59: 267–272PubMedCrossRefGoogle Scholar
  22. Maioli C, Precht W, Ried S (1982) Vestibuloocular and optokinetic reflex compensation following hemilabyrinthectomy in the cat. In: Roucoux A, Crommelinck M (eds) Physiological and pathological aspects of eye movements. Junk, The Hague, pp 202–208Google Scholar
  23. Maioli C, Precht W, Ried S (1983) Short- and long-term modifications of vestibulo-ocular response dynamics following unilateral vestibular nerve lesions in the cat. Exp Brain Res 50: 259–274PubMedCrossRefGoogle Scholar
  24. Markham CH, Yagi T, Curthoys IS (1977) The contribution of the contralateral labyrinth to the second order vestibular neuronal activity in the cat. Brain Res 138: 99–109PubMedCrossRefGoogle Scholar
  25. McCrea R, Baker R, Delgado-Garcia J (1979) Afferent and efferent organization of the prepositus hypoglossi nucleus. In: Granit R, Pompeiano O (eds) Reflex control of posture and movements. Elsevier/North-Holland, Amsterdam, pp 653–665CrossRefGoogle Scholar
  26. Melvill-Jones G (1977) Plasticity in the adult vestibulo-ocular reflex arc. Phil Trans R Soc Lond J Biol Sci 278: 319–334CrossRefGoogle Scholar
  27. Miles FA, Lisberger SG (1981) Plasticity in the vestibulo-ocular reflex: a new hypothesis. Annu Rev Neurosci 4: 273–299PubMedCrossRefGoogle Scholar
  28. Precht W, Maioli C, Dieringer N, Cochran S (1981) Mechanisms of compensation of the vestibulo-ocular reflex after vestibular neurotomy. In: Flohr H, Precht W (eds) Lesion-induced neuronal plasticity in sensorimotor systems. Springer, Berlin Heidelberg New York, pp 221–230Google Scholar
  29. Precht W, Cazin L, Blanks R, Lannou J (1982) Anatomy and physiology of the optokinetic path-ways to the vestibular nuclei in the rat. In: Roucoux A, Crommelinck M (eds) Physiological and pathological aspects of eye movements. Junk, The Hague, pp 153–172CrossRefGoogle Scholar
  30. Ried S, Maioli C, Precht W (1984) Vestibular nuclear neuron activity in chronically hemilabyrinthectomized cats. Acta Oto-Laryngol 98: 1–13CrossRefGoogle Scholar
  31. Schaefer KP, Meyer DL (1974) Compensation of vestibular lesions. In: Kornhuber HH (ed) Handbook of sensory physiology, vol VI/2. Springer, Berlin Heidelberg New York, pp 463–490Google Scholar
  32. Shimazu H, Precht W (1966) Inhibition of central vestibular neurons from the contralateral labyrinth and its mediating pathway. J Neurophysiol 29: 467–492PubMedGoogle Scholar
  33. Steiger H J, Biittner-Ennever JA (1979) Oculomotor nucleus afferents in the monkey demonstrated with horseradish peroxidase. Brain Res 160: 1–15PubMedCrossRefGoogle Scholar
  34. Uemura T, Cohen B (1973) Effects of vestibular nuclei lesions on vestibulo-ocular reflexes and posture in monkeys. Acta Oto-Laryngol 315: 1–71Google Scholar
  35. Waespe W, Henn V (1977) Neuronal activity in the vestibular nuclei of the alert monkey during vestibular and optokinetic stimulation. Exp Brain Res 27: 523–538PubMedCrossRefGoogle Scholar
  36. Wolfe JW, Kos CM (1977) Nystagmic responses of the rhesus monkey to rotational stimulation following unilateral labyrinthectomy: final report. Trans Am Acad Ophthalmol Oto-Laryngol 84: 38–45Google Scholar
  37. Xerri C, Lacour M (1980) Compensation des déficits posturaux et cinétiques après neurectomie vestibulaire unilatérale chez le chat. Rôle de l’activité sensorimotrice. Acta Oto-Laryngol 90: 414–424CrossRefGoogle Scholar
  38. Zee DS, Yee RD, Robinson DA (1976) Optokinetic responses in labyrinthine-defective human beings. Brain Res 113: 423–428PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • C. Maioli
    • 1
  1. 1.Istituto di Fisiologia dei Centri Nervosi - CNRMilanoItaly

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