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Neonatal Versus Adult Hemicerebellectomy: A Behavioral and Anatomical Analysis

  • L. Petrosini
  • M. Molinari
  • T. Gremoli
  • A. Granato

Abstract

In spite of several reports on infant lesion effects, the degree to which brain damage occurring early in life results in sparing or greater recovery of motor function than that seen after comparable damage in adults is still uncertain (Schneider 1979). On one hand, following neonatal spinal transection (Bregman and Goldberger 1983) or cortical ablations (D’Amato and Hicks 1980), there is greater recovery of some postural reflexes when compared with the same lesions sustained in adulthood. On the other hand, coexistent with these examples of greater recovery, are examples of equivalent or even greater deficits or poorer motor performances (Finger et al. 1978). Namely, it has been reported that neonatally hemicerebellectomized rats exhibit a more impaired locomotion in comparison with rats hemicerebellectomized in adulthood (Gramsbergen and IJkema-Paassen 1984). These conflicting findings are complicated by the influence of normal development on motor behavior, by the stage of maturity of the pathways at the time of the lesion, and finally by the nature of the motor behaviors, since different aspects of the same behavior may respond differently to the same lesion. Considering these numerous variables, this study is focused on comparing various motor behaviors of rats hemicerebellectomized neonatally with those of rats hemicerebellectomized at weaning or in adulthood, to analyze the problem of whether cerebellar lesions made during different maturation stages provoke different effects. Particular care was taken to obtain adequate experimental conditions for comparisons of the three age-at-lesion groups; all cerebellar lesions were very similar, and repeated and extremely fine assessments of motor function using similar tests were performed at comparable long periods after lesion.

Keywords

Joint Angle Cerebellar Lesion Lesion Side Body Tilt Great Recovery 
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References

  1. Altman J (1982) Morphological development of the rat cerebellum and some of its mechanisms. In: Palay SL, Chan-Palay V (eds) The cerebellum. New vistas. Springer, Berlin Heidelberg New York, pp 8–49 (Experimental Brain Research, suppl 6 )Google Scholar
  2. Bovolenta P, Liem RKH, Mason CA (1984) Development of cerebellar astroglia: transitions in form and cytoskeletal content. Dev Biol 102: 248–259PubMedCrossRefGoogle Scholar
  3. Bregman BS, Goldberger ME (1982) Anatomical plasticity and sparing of function after spinal cord damage in neonatal cats. Science 217: 553–555PubMedCrossRefGoogle Scholar
  4. Bregman BS, Goldberger ME (1983) Infant lesion effect. II. Sparing and recovery of function after spinal cord damage in newborn and adult cats. Dev Brain Res 9: 119–135CrossRefGoogle Scholar
  5. Castro AJ (1978) Projections of the superior cerebellar peduncle in rats and the development of new connections in response to neonatal hemicerebellectomy. J Comp Neurol 178: 611–628PubMedCrossRefGoogle Scholar
  6. Castro AJ, Smith DE (1979) Plasticity of spinovestibular projections in response to hemicerebellectomy in newborn rats. Neurosci Lett 12: 69–74PubMedCrossRefGoogle Scholar
  7. D’Amato CJ, Hicks SP (1980) Development of the motor system: effects of radiation on developing corticospinal neurons and locomotor functions. Exp Neurol 70: 1–23PubMedCrossRefGoogle Scholar
  8. Finger S, Simmonds D, Posner R (1978) Anatomical, physiological and behavioural effects of neonatal sensorimotor cortex ablation in the rat. Exp Neurol 60: 364–373CrossRefGoogle Scholar
  9. Gramsbergen A, IJkema-Paassen J (1982) CNS plasticity after hemicerebellectomy in the young rat. Quantitative relations between aberrant and normal cerebello-rubral projections. Neurosci Lett 33: 129–134PubMedCrossRefGoogle Scholar
  10. Gramsbergen A, IJkema-Paassen J (1984) The effects of early cerebellar hemispherectomy in the rat: behavioural, neuroanatomical and electrophysiological sequelae. In: Finger S, Almli CR (eds) Early brain damage. Academic Press, London, pp 155–177 (Neurobiology and Behaviour, vol 2 )Google Scholar
  11. Leonard CT, Goldberger ME (1987) Consequences of damage to the sensorimotor cortex in neo-natal and adult cats. I. Sparing and recovery of function. Dev Brain Res 32: 1–14CrossRefGoogle Scholar
  12. Leong SK (1977) Plasticity of cerebellar efferent after neonatal lesions in albino rats. Neurosci Lett 52: 281–289Google Scholar
  13. Manni E, Dow RS (1963) Some observations of the effects of cerebellectomy in the rat. J Comp Neurol 121: 189–194PubMedCrossRefGoogle Scholar
  14. Molinari M, Bentivoglio M, Granato A, Minciacchi D (1986) Increased collateralization of the cerebellothalamic pathway following neonatal hemicerebellectomy. Brain Res 372: 1–10PubMedCrossRefGoogle Scholar
  15. Naus CG, Flumerfelt BA, Hrycyshyn AW (1984) Topographic specificity of aberrant cerebellorubral projections following neonatal hemicerebellectomy in the rat. Brain Res 309: 1–15PubMedCrossRefGoogle Scholar
  16. O’Donoghue DL, Kartje-Tillotson G, Castro AJ (1987) Forelimb motor cortical projections in normal rats and after neonatal hemicerebellectomy: an anatomical study based upon the axonal transport of WGA/HRP. J Comp Neurol 256: 274–283PubMedCrossRefGoogle Scholar
  17. Petrosini L (1984) Task-dependent rate of recovery from hemilabyrinthectomy: an analysis of swimming and locomotor performances. Physiol Behav 33: 799–804PubMedCrossRefGoogle Scholar
  18. Schneider GE (1979) Is it really better to have your brain lesion early? A revision of the Kennard Principle. Neuropsychologia 17: 557–583PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • L. Petrosini
    • 1
  • M. Molinari
    • 2
  • T. Gremoli
    • 1
  • A. Granato
    • 2
  1. 1.Institutes of Human PhysiologyCatholic UniversityRomeItaly
  2. 2.Institutes of NeurologyCatholic UniversityRomeItaly

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