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Neuronal Metabolic Basis of the Conditioning Lesion Effect

  • I. G. McQuarrie
Conference paper

Abstract

The cell body response to axonal interruption is a fundamental reaction of the neuron. This activates the “growth mode” of neuronal metabolism, a genomic induction that leads to the accelerated turnover of messenger ribonucleic acid (mRNA) in association with the production of new messenger RNA and additional nucleolar DNA (Torvik and Skjorten 1974; Watson 1974; Grafstein and McQuarrie 1978; Hoffman et al. 1987). The “growth mode” gives first priority to the synthesis and axonal transport of structural and regulatory proteins that are used to assemble microtubules and microfilaments: tubulin, actin, microtubule associated proteins (MAPs), and calmodulin (Grafstein and McQuarrie 1978; McQuarrie 1983, 1988; Tetzlaff et al. 1986; Hoffman et al. 1987). Increases in transport are also seen for a trace protein, GAP-43, that appears to catalyze membrane assembly (Skene and Willard 1981 a; Jacobson et al. 1986; Perry et al. 1987). There is a concurrent reduction in metabolic activities that support the production of neurotransmitter molecules and neurofilaments (Grafstein and McQuarrie 1978; Hoffman and Lasek 1980; Tetzlaff et al. 1986; Hoffman et al. 1987; Wong and Oblinger 1987). The reduction in neurofilament transport causes a thinning of parent axons; radial regrowth does not occur until reconnection of the daughter axon with a functionally matched target organ (Cragg and Thomas 1961; Zalewski 1970; Hoffman et al. 1985, 1987; Wong and Oblinger 1987).

Keywords

Axonal Transport Slow Component Axonal Regeneration Nerve Cell Body Motor Axon 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • I. G. McQuarrie
    • 1
    • 2
    • 3
  1. 1.Division of NeurosurgerySchool of Medicine, Case Western Reserve University ClevelandUSA
  2. 2.Department of Developmental Genetics and AnatomySchool of Medicine, Case Western Reserve University ClevelandUSA
  3. 3.Veterans Administration Medical CenterClevelandUSA

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