Regulation of Axonal Growth

  • S. Rotshenker
Conference paper


A major manifestation of neural plasticity is the ability of adult nerve cells to regulate the growth of their axons. For example, peripheral nerve injury can be followed by the regeneration of the severed axons and the sprouting of intact axons. These two modes of growth may result in new synapse formation and therefore bear functional significance. Normally, severed axons regenerate into denervated tissues. Intact axons, on the other hand, can sprout into either deneravted or innervated target tissues. For example, after cutting some of the axons innervating a muscle, the remaining intact axons grow new processes that innervate denervated muscle fibers (Edds 1953; Brown et al. 1981). Sprouting and synapse formation in normally innervated muscles may take place after denervating muscles on the contralateral side of the body (e.g., Rotshenker 1979; Rotshenker and Tal 1985).


Axonal Growth Synapse Formation Motor Axon Peripheral Mechanism Sartorius Muscle 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • S. Rotshenker
    • 1
  1. 1.Department of Anatomy and EmbryologyHebrew University-Hadassah Medical SchoolJerusalemIsrael

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