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PET pp 30–67Cite as

Modelle zur Quantifizierung von PET-Messungen

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Zusammenfassung

PET ermöglicht, quantitativ radioaktiv markierte Moleküle im lebenden Organismus von außen zu verfolgen. Um aus den gemessenen Aktivitätsverteilungen und ihrem zeitlichen Verlauf die interessierenden Größen wie z. B. regionale Durchblutung, Stoffwechselrate oder Rezeptordichte zu extrahieren, ist es im allgemeinen notwendig, die komplizierten physiologischen und biochemischen Vorgänge modellmäßig so zu vereinfachen, daß sie durch einfache, lösbare mathematische Gleichungen beschrieben werden können. Dabei darf das Modell nur so viele unbekannte Parameter haben, wie durch die Meßdaten und eventuell zusätzlich vorliegende Information eindeutig bestimmt werden können. Dies ist zwar trivial und selbstverständlich, hat jedoch die Konsequenz, daß es nur sehr wenige praktisch anwendbare Modelle in der PET gibt, die hinreichend validiert werden konnten.

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Authors and Affiliations

  1. MPI für neurologische Forschung, Ostmerheimer Str. 200, 5000, Köln 91, Deutschland

    Professor Dr. Klaus Wienhard, Dr. Rainer Wagner & Professor Dr. Wolf-Dieter Heiss

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  1. Professor Dr. Klaus Wienhard
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  2. Dr. Rainer Wagner
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  3. Professor Dr. Wolf-Dieter Heiss
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© 1989 Springer-Verlag Berlin Heidelberg

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Wienhard, K., Wagner, R., Heiss, WD. (1989). Modelle zur Quantifizierung von PET-Messungen. In: PET. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73843-2_2

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  • DOI: https://doi.org/10.1007/978-3-642-73843-2_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73844-9

  • Online ISBN: 978-3-642-73843-2

  • eBook Packages: Springer Book Archive

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