The Antigenic Structure of Lysozyme as Detected by T-cells
Both T cells and B cells are capable of recognizing antigens, however, their modes of recognition differ. B cells bind protein antigens by means of their surface immunoglobulins, whereas T cells recognize antigens on the surface of an antigen presenting cell (APC) and only in association with a cell surface molecule encoded by the major histocompatibility complex (MHC) (Rosenthal 1978; Unanue 1984). Experimental evidence has been provided which shows that B cells respond to both a native and a denatured antigen, eliciting antibodies specific for each of the two forms; T cells usually do not respond to antigens in the native form, only to antigens metabolically processed by the APC (Benjamin et al 1984; Ziegler and Unanue 1981).
KeywordsMajor Histocompatibility Complex Major Histocompatibility Complex Molecule Antigenic Structure Immunodominant Epitope Major Histocompatibility Complex Haplotype
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