Sequence Directed Design of Recognition Peptides

  • Giorgio Fassina
  • Snorri S. Thorgeirsson
  • James G. Omichinski


The intriguing properties of peptides coded by the non coding DNA strand (anti-sense peptides) have stimulated a number of investigations in the past few years aimed at elucidation of their biological significance and evaluation of their potential use. In several systems tested, anti-sense peptides were able to bind with relatively high affinity and specificity to the corresponding sense peptide, with rather profound implications for use in biotechnology. In an attempt to gain a better understanding of the phenomena, our attention has been focused on the possibility of re-creating peptides with anti-sense properties starting from amino acid sequence informations.


Target Peptide Complementary Peptide Amino Acid Sequence Information Analytical High Performance Sense Peptide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Giorgio Fassina
    • 1
  • Snorri S. Thorgeirsson
    • 1
  • James G. Omichinski
    • 1
  1. 1.Laboratory of Experimental Carcinogenesis, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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