Sequence Directed Design of Recognition Peptides

  • Giorgio Fassina
  • Snorri S. Thorgeirsson
  • James G. Omichinski

Abstract

The intriguing properties of peptides coded by the non coding DNA strand (anti-sense peptides) have stimulated a number of investigations in the past few years aimed at elucidation of their biological significance and evaluation of their potential use. In several systems tested, anti-sense peptides were able to bind with relatively high affinity and specificity to the corresponding sense peptide, with rather profound implications for use in biotechnology. In an attempt to gain a better understanding of the phenomena, our attention has been focused on the possibility of re-creating peptides with anti-sense properties starting from amino acid sequence informations.

Keywords

HPLC Urea Codon Polypeptide Arginine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Giorgio Fassina
    • 1
  • Snorri S. Thorgeirsson
    • 1
  • James G. Omichinski
    • 1
  1. 1.Laboratory of Experimental Carcinogenesis, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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