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Characterization of Gonadotropin Hormone-Releasing Hormone Analogs

  • J. Rivier
  • S. Koerber
  • J. Porter
  • C. Rivier
  • C. Hoeger
  • S. Struthers
  • M. Perrin
  • A. Corrigan
  • G. Tanaka
  • W. Vale
  • A. Hagler

Abstract

Characterization, a word often used in the chemical/biochemical and biological sciences, refers in each of these disciplines to distinct but certainly complementary analytical approaches to defining intrinsic properties of a particular compound or activity (including bio-, immuno-, radio- etc. activities). Here we describe some aspects of our research efforts at characterizing the decapeptide GnRH (gonadotropin hormone releasing hormone) using analogs as probes for the study of receptor binding and activation.

Keywords

Luteinizing Hormone GnRH Antagonist GnRH Analog GnRH Receptor Decapeptide GnRH 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Rivier
    • 1
  • S. Koerber
    • 2
  • J. Porter
    • 1
  • C. Rivier
    • 1
  • C. Hoeger
    • 1
  • S. Struthers
    • 1
  • M. Perrin
    • 1
  • A. Corrigan
    • 1
  • G. Tanaka
    • 2
  • W. Vale
    • 1
  • A. Hagler
    • 2
  1. 1.The Clayton Foundation Laboratories for Peptide Biology, The Salk InstituteLa JollaUSA
  2. 2.The Agouron InstituteLa JollaUSA

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