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Localization of Endogenous Phosphoserine Residues in the Primary Structure of Proteins

  • H. E. Meyer
  • C. C. Kuhn
  • G. F. Meyer
  • K. Swiderek
  • C. Weber
  • E. Hoffmann-Posorske
  • H. Korte
  • L. M. G. HeilmeyerJr.

Abstract

Localization of phosphorylated amino acids within the primary structure of phosphorylated proteins is a prerequisite for understanding their function. Of particular interest are those residues which are phosphorylated in vivo (endogenous phosphate), since these phospho-amino acids are physiologically relevant e.g. in the regulation of enzyme activities, ion channel mechanisms and other regulatory mechanisms.

Keywords

Cardiac Troponin Beta Subunit Cysteic Acid Performic Acid Phosphorylase Kinase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Dedner N, Meyer HE, Ashton C and Wildner GF (1988) The N-terminal sequence analysis of the 8 kDa protein in Chlamydomonas reinhardii. Localization of the phosphothreonine. FEBS Lett, in pressGoogle Scholar
  2. Meyer HE, Hoffmann-Posorske E, Korte H and Heilmeyer LMG (1986) Sequence analysis of phosphoserine-containing peptides. Modification for picomolar sensitivity. FEBS Lett 204: 61–66PubMedCrossRefGoogle Scholar
  3. Meyer HE, Hoffmann-Posorske E, Kuhn CC and Heilmeyer LMG (1988) microcharacterization of phosphoserine containing proteins. Localization of the autophosphorylation sites of skeletal muscle phosphorylase kinase. In: Tschesche H (ed) Modern Methods in Protein Chemistry, Vol.3 Walter de Gruyter & Co., Berlin New York, p 185–212Google Scholar
  4. Swiderek K, Jaquet K, Meyer HE and Heilmeyer LMG (1988) Cardiac troponin I, isolated from bovine heart, contains two adjacent phosphoserines. A first example of phosphoserine determination by derivatisation to S-ethylcysteine. Eur J Biochem, in pressGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. E. Meyer
    • 1
  • C. C. Kuhn
    • 1
  • G. F. Meyer
    • 1
  • K. Swiderek
    • 1
  • C. Weber
    • 1
  • E. Hoffmann-Posorske
    • 1
  • H. Korte
    • 1
  • L. M. G. HeilmeyerJr.
    • 1
  1. 1.Institut für Physiologische Chemie, Abteilung Biochemie Supramolekularer SystemeRuhr-Universität BochumBochumGermany

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