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Lymphocytes

  • J. Morley
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 1)

Abstract

Classically, the involvement of lymphocytes in inflammatory skin lesions has been associated with immunological responses, whereby the host expresses, or develops, enhanced reactivity to an inciting allergen. Yet it is also known that lymphocytes can contribute to inflammatory responses induced by non-allergic stimuli. These observations may be reconciled by considering the allergic response to be an enhanced version of a non-selective inflammatory response involving lymphocyte activation.

Keywords

Migration Inhibition Factor Cellular Immunity Lymphocyte Activation Macrophage Migration Inhibition Factor Eicosatetraenoic Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Bloom BR, Bennett B (1966) Mechanisms of a reaction in vitro associated with delayed type hypersensitivity. Science 153:80–82PubMedCrossRefGoogle Scholar
  2. David JR (1966) Delayed hypersensitivity in vitro:its mediation by cell-free substances formed by lymphoid cell antigen interaction. Proc Natl Acad Sci USA 56:72–77PubMedCrossRefGoogle Scholar
  3. David JR, Lawrence HS, Thomas L (1964) Delayed hypersensitivity in vitro. II. Effect of sensitive cells on normal cells in the presence of antigen. J Immunol 93:274–278PubMedGoogle Scholar
  4. George M, Vaughan JH (1962) In vitro cell migration as a model for delayed hypersensitivity. Proc Soc Exp Biol Med 111:514–521PubMedGoogle Scholar
  5. Hanson JM, Rumjanek VM, Morley J (1982) Mediators of cellular immune reactions. Pharmacology and therapeutics 17:165–198PubMedCrossRefGoogle Scholar
  6. Morley J (1974) Prostaglandins and lymphokines in arthritis. Prostaglandins 8:315–326PubMedCrossRefGoogle Scholar
  7. Oppenheim JJ, Mizel SB, Meltzer MS (1979) Biological effects of lymphocyte and macrophage-derived mitogenic “amplication” factors. In:Cohen S, Pick E, Oppenheim JJ (eds) Biology of the lymphokines. Academic, New York, pp 291–323Google Scholar
  8. Szamel M, Resch K (1981) Modulation of enzyme activities in isolated lymphocyte plasma membranes by enzymatic modification of phospholipid fatty acids. J Biol Chem 256:11618–11623PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. Morley

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