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Blood Flow — Including Microcirculation

  • Chapter
Pharmacology of the Skin I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 1))

Abstract

Changes in blood flow occur continually in health and disease and measurement can provide valuable information on endogenous and exogenous substances involved in regulating flow, on the progress of a disease process and on the efficacy of therapeutic agents. This chapter is concerned with some of the many techniques available for measuring blood flow in skin.

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References

  • Anand P, Bloom SR, McGregor GP (1983) Topical capsaicin pretreatment inhibits axon reflex vasodilation caused by somatostatin and vasoactive intestinal polypeptide in human skin. Br J Pharmacol 78:665–669

    PubMed  CAS  Google Scholar 

  • Angelsen BAJ, Brubakk AO (1976) Transcutaneous measurement of blood flow velocity in the human aorta. Cardiovasc Res 10:368–379

    Article  PubMed  CAS  Google Scholar 

  • Anliker M, Casty M, Friedli P, Kubli R, Kreller H (1977) Non-invasive measurement of blood flow. In:Hwang NHC, Norman NA (eds) Cardiovascular flow dynamics and measurements. University Park Press, Baltimore, pp 43–88

    Google Scholar 

  • Baker DW, Johnson SL, Strandness DE (1974) Prospects for quantitation of transcutaneous pulsed Doppler techniques in cardiology and peripheral vascular diseases. In:Reneman RS (ed) Cardiovascular applications of ultrasound. Elsevier-North Holland, Amsterdam, p 108

    Google Scholar 

  • Buckberg GD, Luck JC, Payne DB, Joffman JIE, Archie JP, Fixler DE (1971) Some sources of error in measuring regional blood flow with radioactive microspheres. J Appl Physiol 31:598–604

    PubMed  CAS  Google Scholar 

  • Cappelen C, Hall KV (1967) Electromagnetic blood flowmetry in clinical surgery. Acta Chir Scand [Suppl] 368:3–27

    Google Scholar 

  • Challoner AVJ (1972) Measurement of cutaneous blood flow by isotope clearance and thermal conductance methods. In:Ryan TJ, Jolles B, Holti G (eds) Methods in microcirculation studies. Lewis, London, p 43

    Google Scholar 

  • Challoner AVJ (1975) Accurate measurement of skin blood flow by a thermal conductance method. Med Biol Eng 13:196–201

    Article  PubMed  CAS  Google Scholar 

  • Cohnheim J (1889) Lectures on general pathology. The New Sydenham Society, London

    Google Scholar 

  • Cook LJ, Shuster S (1981) The effect of placebo and “aggro” on the weal and flare response to histamine. Br J Dermatol 104:27–29

    Article  PubMed  CAS  Google Scholar 

  • Crunkhorn P, Willis AL (1971) Cutaneous reaction to intradermal prostaglandins. Br J Pharmacol 41:49–56

    PubMed  CAS  Google Scholar 

  • Einav S, Berman HS, Fuhro RC, DiGiovanni PR, Fine S, Fridman JD (1975) Measurement of velocity profiles of red blood cells in the microcirculation by laser Doppler anemometry. Biorheology 12:203–205

    PubMed  CAS  Google Scholar 

  • Engelhart M, Kristensen JK (1983) Evaluation of cutaneous blood flow responses by 133xenon washout and a laser-Doppler flowmeter. J Invest Dermatol 80:12–15

    Article  PubMed  CAS  Google Scholar 

  • Fagrell B, Fronek A, Intaglietta M (1977) A microscope-television system for studying flow velocity in human skin capillaries. Am J Physiol 283:H318–H321

    Google Scholar 

  • Foreman JC, Jordan CC, Piotrowski W (1982) Interaction of neurotensin with the substance P receptor mediating histamine release from rat mast cells and the flare in human skin. Br J Pharmacol 77:531–539

    PubMed  CAS  Google Scholar 

  • Franklin DL, Schlegel W, Rushmer RF (1961) Blood flow measured by Doppler frequency shift of back-scattered ultrasound. Science 134:564–565

    Article  PubMed  CAS  Google Scholar 

  • Gross PM, Marcus ML, Heistad DD (1981) Measurement of blood flow to bone and marrow in experimental animals by means of the microsphere technique. J Bone Joint Surg [Am] 63:1028–1031

    CAS  Google Scholar 

  • Hales JRS, Cliff WF (1977) Direct observations of the behaviour of microspheres in microvasculature. Bibl Anat 15:87–91

    PubMed  Google Scholar 

  • Harell GS, Dickhoner WA, Breiman RS (1977) The simultaneous visualization of microspheres and blood flow in the microvascular bed of the hamster cheek pouch. Microvasc Res 13:203–210

    Article  PubMed  CAS  Google Scholar 

  • Hatfield HS (1950) A heat flow meter. J Physiol (Lond) 111:10 P

    Google Scholar 

  • Hertzman AB (1938) The blood supply of various skin areas as estimated by the photoelectric plethysmograph. Am J Physiol 124:328–340

    Google Scholar 

  • Hertzman AB, Randall WC (1948) Regional differences in the basal and maximal rates of blood flow in the skin. J Appl Physiol 1:234–241

    PubMed  CAS  Google Scholar 

  • Heymann MA, Payne DB, Hoffman JIE, Rudolph AM (1977) Blood flow measurements with radionuclide labelled particles. Prog Cardiovasc Dis 20:55–79

    Article  PubMed  CAS  Google Scholar 

  • Holloway GA, Watkins DW (1977) Laser Doppler measurement of cutaneous blood flow. J Invest Dermatol 69:306–309

    Article  PubMed  Google Scholar 

  • Holti G (1955) The copper-tellurite-copper thermocouple adapted as a skin thermometer. Clin Sci 14:137–141

    PubMed  CAS  Google Scholar 

  • Holti G (1978) Experimentally controlled evaluation of vasoactive drugs in digital ischemia. Angiology 29:89–94

    Article  PubMed  CAS  Google Scholar 

  • Holti G, Mitchell KW (1978) Estimation of the nutrient skin blood flow using a segmented thermal clearance probe. Clin Exp Dermatol 3:189–198

    Article  PubMed  CAS  Google Scholar 

  • Intaglietta M, Silverman NR, Tompkins WR (1975) Capillary flow measurements in vivo and in situ by television methods. Micro vase Res 10:165–179

    Article  CAS  Google Scholar 

  • Juhlin L, Michaelsson G (1969) Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis. Acta Derm Venereol (Stockh) 49:251–261

    CAS  Google Scholar 

  • Kety SS (1949) Measurement of regional circulation by the local clearance of radioactive sodium. Am Heart J 38:321–328

    Article  PubMed  CAS  Google Scholar 

  • Le-Cong P, Zweifach BW (1979) In vivo and in vitro velocity measurements in micro vasculature with a laser. Microvasc Res 17:131–141

    Article  PubMed  CAS  Google Scholar 

  • Lee BY, Trainor FS, Thoden WR, Kauner D, Madden JL (1980) Use of non-invasive electromagnetic flowmetry in the assessment of peripheral arterial disease. Surg Gynecol Obstet 150:342–346

    PubMed  CAS  Google Scholar 

  • Lee BY, Trainor FS, Thoden WR, Kauner D, Madden JL (1980) Use of non-invasive electromagnetic flowmetry in the assessment of peripheral arterial disease. Surg Gynecol Obstet 150:342–346

    PubMed  CAS  Google Scholar 

  • Levenson J A, Peronneau PA, Simon A, Safar ME (1981) Pulsed Doppler:determination of diameter, blood flow velocity and volumic flow of brachial artery in man. Cardiovasc Res 15:164–170

    Article  PubMed  CAS  Google Scholar 

  • Lewis T (1927) The blood vessels of the human skin and their responses. Shaw, London

    Google Scholar 

  • Macey DJ, Oliver R (1972) Infrared thermography. In:Ryan TJ, Jolles B, Holti G (eds) Methods in microcirculation studies. Lewis, London, p 57

    Google Scholar 

  • McCleod FD (1967) Directional Doppler demodulation. Proc Annu Conf Eng Med Biol 9:27.1.

    Google Scholar 

  • McDonagh PF, Salel AF, Krohn KA, Rhode EA, Mason DT (1978) Analysis of myocardial and total body integral extraction ratios of rubidium-86. Am J Physiol 235:H794 — H802

    PubMed  CAS  Google Scholar 

  • Mills CJ, Shillingford JP (1967) A catheter tip electromagnetic velocity probe and its evaluation. Cardiovasc Res 1:263–273

    Article  Google Scholar 

  • Moore CD, Gewertz BL, Wheeler HT, Fry WJ (1981) An additional source of error in the microsphere measurement of regional blood flow. Microvasc Res 21:377–383

    Article  PubMed  CAS  Google Scholar 

  • Neutze JM, Wyler F, Rudolph AM (1968) Use of radioactive microspheres to assess distribution of cardiac output in rabbits. Am J Physiol 215:486–495

    PubMed  CAS  Google Scholar 

  • Nigra CAL, Andrews DF, McKee NH (1981) Quantitative assessment of low blood flow using an electromagnetic flowmeter. J Surg Res 31:201–209

    Article  PubMed  CAS  Google Scholar 

  • Nilsson GE, Tenland T, Oberg PA (1980a) Evaluation of a laser Doppler flow meter for measurement of tissue blood flow. IEEE Trans Biomed Eng 27:597–604

    Article  CAS  Google Scholar 

  • Nilsson GE, Tenland T, Oberg PA (1980b) A new instrument for continuous measurement of tissue blood flow by light beating spectroscopy. IEEE Trans Biomed Eng 27:12–19

    Article  CAS  Google Scholar 

  • Oberg PA, Nilsson GE, Tenland T, Holmstrom A, Lewis DH (1979) Use of a new laser Doppler flowmeter for measurement of capillary blood flow in skeletal muscle after bullet wounding. Acta Chir Scand [Suppl] 489–145–150

    CAS  Google Scholar 

  • Ofjord ES, Clausen G, Aukland K (1981) Skimming of microspheres in vitro: implications for measurement of intrarenal blood flow. Am J Physiol 241:H342–H347

    PubMed  CAS  Google Scholar 

  • Peronneau PP, Deloche A, Hung B-M, Hinglais J (1967) Debitmetrie ultrasonore — Developpementes et applications experimentales. Eur Surg Res 1:147–156

    Article  Google Scholar 

  • Powers EW, Frayer WW (1978) Laser Doppler measurement of blood flow in the microcirculation. Plast Reconstr Surg 61:250–255

    Article  PubMed  Google Scholar 

  • Ring EFJ, Josh J A (1968) Skin temperature measurement by radiometry. Br Med J 4:448

    Article  PubMed  CAS  Google Scholar 

  • Rolfe P (1979) Theoretic aspects of skin blood flow estimation using thermal, optical and electrical impedance techniques. Birth Defects 15:135–147

    PubMed  CAS  Google Scholar 

  • Rushmer RF, Baker DW, Stegall HF (1966) Transcutaneous Doppler flow detection as a nondestructive technique. J Appl Physiol 21:554–566

    PubMed  CAS  Google Scholar 

  • Sapirstein LA (1956) Fractionation of the cardiac output of rats with isotopic potassium. Circ Res 4:689–692

    PubMed  CAS  Google Scholar 

  • Sapirstein LA (1958) Regional blood flow by fractional distribution of indicators. Am J Physiol 193:161–168

    PubMed  CAS  Google Scholar 

  • Sejrsen P (1969) Blood flow in cutaneous tissue in man studied by washout of radioactive xenon. Circ Res 25:215–229

    PubMed  CAS  Google Scholar 

  • Smith RE, Morales (1944a) On the theory of blood-tissue exchanges. I. Fundamental equations. Bull Math Biophys 6:125–131

    Article  Google Scholar 

  • Smith RE, Morales MF (1944b) On the theory of blood-tissue exchanges. II. Applications. Bull Math Biophys 6:133–139

    Article  Google Scholar 

  • Stern MD (1975) In vivo evaluation of microcirculation by coherent light scattering. Nature 254:56–58

    Article  PubMed  CAS  Google Scholar 

  • Stern MD, Lappe DL, Bowen PD, Chimosky JE, Holloway GA, Keiser HR, Bowman RL (1977) Continuous measurement of tissue blood flow by laser-Doppler spectroscopy. Am J Physiol 232:H441–H448

    PubMed  CAS  Google Scholar 

  • Strandness DE, Kennedy JW, Judge TP, McLeod FD (1969) Transcutaneous directional flow detection:a preliminary report. Am Heart J 78:65–74

    Article  PubMed  Google Scholar 

  • Tanaka T, Riva C, Ben-Sira I (1974) Blood velocity measurements in human retinal vessels. Science 186:830–831

    Article  PubMed  CAS  Google Scholar 

  • Tyml K, Sherebrin MH (1980) A method for on-line measurements of red cell velocity in microvessels using computerized frame by frame analysis of television images. Microvasc Res 20:1–8

    Article  PubMed  CAS  Google Scholar 

  • Vatner SF, Franklin D, Van Citters RL (1970) Simultaneous comparison and calibration of the Doppler and electromagnetic flowmeters. J Appl Physiol 29:907–910

    PubMed  CAS  Google Scholar 

  • Watkins D, Holloway GA (1978) An instrument to measure cutaneous blood flow using the Doppler shift of laser light. IEEE Trans Biomed Eng 25:28–33

    Article  PubMed  CAS  Google Scholar 

  • Wayland H, Johnson PC (1967) Erythrocyte velocity measurement in microvessels by a two-slit photometric method. J Appl Physiol 22:333–337

    PubMed  CAS  Google Scholar 

  • Williams KL, Williams FL, Handley RS (1960) Infrared radiation thermometry in clinical practice. Lancet 11:958–959

    Google Scholar 

  • Williams TJ (1979) Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation. Br J Pharmacol 65:517–524

    PubMed  CAS  Google Scholar 

  • Young CMA, Hopewell JW (1980) The evaluation of an isotope clearance technique in the dermis of pig skin:a correlation of functional and morphological parameters. Microvasc Res 20:182–194

    Article  PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Forrest, M.J., Williams, T.J. (1989). Blood Flow — Including Microcirculation. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin I. Handbook of Experimental Pharmacology, vol 87 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73797-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-73797-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73799-2

  • Online ISBN: 978-3-642-73797-8

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