Advertisement

Polyamines

  • J. C. Allen
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 1)

Abstract

It seems strange that the ubiquitous bio-organic cations the polyamines have, until recently, been consigned to the boxroom of biochemistry. Nevertheless, it is now apparent that they play a variety of subtle and sometimes essential roles. This chapter emphasises their participation in normal and abnormal epidermis; restrictions on space make it quite impossible to do justice to many general recent developments, and the reader is referred to more comprehensive treatments for further information (COHEN 1971; TABOR and TABOR 1976; JÄNNE et al. 1978; GAUGAS 1980).

Keywords

Ornithine Decarboxylase Polyamine Level Polyamine Biosynthesis Polyamine Oxidase Mouse Epidermis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Abdel-Monem MM, Ohno K (1977) Polyamine metabolism. II. N-(Monoaminoalkyl) and N-(polyaminoalkyl) acetamides in human urine. J Pharm Sci 66:1195–1197PubMedGoogle Scholar
  2. Aigner-Held R, Daves GD (1980) Polyamine metabolites and conjugates in man and higher animals: a review of the literature. Physiol Chem Phys Med NMR 12: 389–400Google Scholar
  3. Alarcon RA (1970) Acrolein. IV. Evidence for the formation of the cytotoxic aldehyde from enzymatically oxidised spermine or spermidine. Arch Biochem Biophys 137:365–375PubMedGoogle Scholar
  4. Alhonen-Hongisto L (1980) Regulation of S-adenosylmethionine decarboxylase in Ehrlich ascites-carcinoma cells grown in culture. Biochem J 190:747–754PubMedGoogle Scholar
  5. Allen JC, Smith CJ (1979) Chalones. A reappraisal. Biochem Soc Trans 7:584–592PubMedGoogle Scholar
  6. Allen JC, Smith CJ, Curry MC, Gaugas JM (1977) Identification of a thymic inhibitor (“chalone”) of lymphocyte transformation as a spermine complex. Nature 267: 623–625PubMedGoogle Scholar
  7. Allen JC, Smith CJ, Hussain JI, Thomas JM, Gaugas JM (1979) Inhibition of lymphocyte proliferation by polyamines requires ruminant plasma polyamine oxidase. Eur J Biochem 102:153–158PubMedGoogle Scholar
  8. Bachrach U (1970) Oxidised polyamines. Ann NY Acad Sci 171:939–956Google Scholar
  9. Bachrach U (1980) The induction of ornithine decarboxylase in normal and neoplastic cells. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 81–107Google Scholar
  10. Bachrach U, Seiler N (1981) Formation of acetylpolyamines and putrescine from sper-midine by normal and transformed chick embryo fibroblasts. Cancer Res 41:1205–1208PubMedGoogle Scholar
  11. Bachrach U, Katz A, Hochman J (1978) Polyamines and protein kinase I. Induction of ornithine decarboxylase and activation of protein kinase in rat glioma cells. Life Sci 22:817–822Google Scholar
  12. Ben-Hur E, Riklis E (1981) Inhibition of induced ornithine decarboxylase activity in Chinese hamster cells by gamma irradiation, far ultraviolet light and psoralen plus near ultraviolet light: a comparative study. Int J Radiat Biol 39:527–535Google Scholar
  13. Bloomfield VA, Wilson RW, Rau DC (1980) Polyeleetrolyte effects in DNA condensation by polyamines. Biophys Chem 11:339–343PubMedGoogle Scholar
  14. Böhlen P, Grove J, Beya MF, Koch-Weser J, Henry MH, Grosshans E (1978) Skin polyamine levels in psoriasis: the effect of dithranol therapy. Eur J Clin Invest 8:215–218PubMedGoogle Scholar
  15. Bolton PH, Kearns DR (1978) H-bonding interactions of polyamines with the 2′-OH of RNA. Nucleic Acids Res 5:1315–1324PubMedGoogle Scholar
  16. Boynton AL, Whitfield JF, Isaacs RJ (1976) A possible involvement of polyamines in the initiation of DNA synthesis by human WI-38 and mouse BALB/3T3 cells. J Cell Physiol 89:481–488PubMedGoogle Scholar
  17. Burton DR, Forsén S, Ramansson P (1981) The interaction of polyamines with DNA. A 23Na NMR study. Nucleic Acids Res 9:1219–1228PubMedGoogle Scholar
  18. Byrd WJ, Jacobs DM, Amoss MS (1977) Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature 267:621–623PubMedGoogle Scholar
  19. Calderara CM, Zappia V, Bachrach D (eds) (1981) Advances in polyamine research, vol 3. Raven, New YorkGoogle Scholar
  20. Cannellakis ES, Viceps-Madore D, Kyriakidis DA, Heller JS (1979) The regulation and function of ornithine decarboxylase and of the polyamines. In: Horecker BL, Stadtman ER (eds) Current topics in cellular regulation, vol 15. Academic, New York, pp 155–202Google Scholar
  21. Cannellakis ES, Heller JS, Kyriakidis DA (1981) The interaction of ornithine decarboxylase with its antizyme. In: Calderara CM, Zappia V, Bachrach U (eds) Advances in polyamine research, vol 3. Raven, New York, pp 1–13Google Scholar
  22. Clark-Lewis I, Murray AW (1978) Tumor promotion and the induction of ornithine decarboxylase activity in mechanically stimulated mouse skin. Cancer Res 38:494–497PubMedGoogle Scholar
  23. Cohen SS (1971) Introduction to the polyamines. Prentice-Hall, New JerseyGoogle Scholar
  24. Cohen SS (1977) Meeting report: conference on polyamines and cancer. Cancer Res 37:939–942Google Scholar
  25. Cooper KD, Shukla JB, Rennert OM (1978) Polyamine compartmentalization in various disease states. Clin Chim Acta 82:1–7PubMedGoogle Scholar
  26. Dewey DL (1978) The identification of a cell culture inhibitor in a tumour extract. Cancer Lett 4:77–84PubMedGoogle Scholar
  27. De Young LM, Helmes CT, Chao WR, Young JM, Miller Y (1981) Paradoxical effect of anthralin on 12-O-tetradecanoylphorbol-13-acetate-induced mouse epidermal orni-thine decarboxylase activity, proliferation, and tumour promotion. Cancer Res 41:204–208PubMedGoogle Scholar
  28. Di Pasquale A, White D, McGuire J (1978) Epidermal growth factor stimulates putrescine transport and ornithine decarboxylase activity in cultivated human fibroblasts. Exp Cell Res 116:317–323Google Scholar
  29. Duffy PE, Kremzner LT (1977) Ornithine decarboxylase activity and polyamines in relation to aging of fibroblasts. Exp Cell Res 108:435–440PubMedGoogle Scholar
  30. Folk JE, Park MH, Chung SI, Schrode J, Lester EP, Cooper HL (1980) Polyamines as physiological substrates for transglutaminases. J Biol Chem 225:3695–3700Google Scholar
  31. Fong WF, Heller JS, Cannellakis ES (1976) The appearance of an ornithine decarboxylase inhibitory protein upon the addition of putrescine to cell cultures. Biochim Biophys Acta 428:456–465PubMedGoogle Scholar
  32. Fujiki H Mori M, Sugimura T, Hirota M, Ohigashi H, Koshimizu K (1980) Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives. J Cancer Res Clin Oncol 98:9–13Google Scholar
  33. Gahl WA, Pitot HC (1978) Reversal by aminoguaijidine of the inhibition of proliferation of human fibroblasts by spermidine and spermine. Chem Biol Interact 22:91–98PubMedGoogle Scholar
  34. Gange RW (1981) Epidermal ornithine decarboxylase activity and thymidine incorpora-tion following treatments with ultraviolet A combined with topical 8-methoxypsoralen or anthracene in the hairless mouse. Br J Dermatol 105:247–255PubMedGoogle Scholar
  35. Gange RW, Dequoy PR (1980) Topical spermine and putrescine stimulated DNA synthesis in the hairless mouse epidermis. Br J Dermatol 103:27–32PubMedGoogle Scholar
  36. Gaugas JM (ed) (1980) Polyamines in biomedical research. Wiley, ChichesterGoogle Scholar
  37. Gaugas JM, Dewey DL (1979) Evidence for serum binding of oxidised spermine and its potent G1-phase inhibition of cell proliferation. Br J Cancer 39: 548–557PubMedGoogle Scholar
  38. Grimm W, Marks F (1974) Effect of tumor-promoting phorbol esters on the normal and isoproterenol-elevated level of adenosine-3′,5′-cyclic monophosphate in mouse epidermis in vivo. Cancer Res 34:3128–3134PubMedGoogle Scholar
  39. Grosshans E, Henry M, Bohlen P, Grove J, Beya MF, Koch-Weser J (1978) Skin polyamine levels in psoriasis — the effect of therapy. J Invest Dermatol 70:227Google Scholar
  40. Haddox MK, Russell DH (1981) Increased nuclear conjugated polyamines and transglutaminase during liver regeneration. Proc Natl Acad Sci USA 78:1712–1716PubMedGoogle Scholar
  41. Ham RG (1964) Putrescine and related amines as growth factors for a mammalian cell line. Biochem Biophys Res Commun 14:34–38PubMedGoogle Scholar
  42. Heby O, Andersson G (1978) Tumour cell death: the probable cause of increased polyamide levels in physiological fluids. Acta Pathol Microbiol Immunol Scand [A] 86:17–20Google Scholar
  43. Heby O, Andersson G (1980) Polyamines and the cell cycle. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 17–34Google Scholar
  44. Heby O, Gray JW, Lindl PA, Marton LJ, Wilson CB (1976) Changes in L-ornithine decarboxylase activity during the cell cycle. Biochem Biophys Res Commun 71:99–105PubMedGoogle Scholar
  45. Heby O, Andersson G, Gray JW (1978) Interference with S and G2 phase progression by polyamine synthesis inhibitors. Exp Cell Res 111:461–464PubMedGoogle Scholar
  46. Heller JS, Chen KY, Kyriakidis DA, Fong WF, Cannellakis ES (1978) The modulation of the induction of ornithine decarboxylase by spermine, spermidine and diamines. J Cell Physiol 96:225–234PubMedGoogle Scholar
  47. Higgins ML, Tillman MC, Rupp JP, Leach FL (1969) The effect of polyamines on cell culture cells. J Cell Physiol 74:149–154PubMedGoogle Scholar
  48. Hölltä E (1977) Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase. Biochemistry 61:91–100Google Scholar
  49. Huse Y, Mitsui Y, Iitaka Y, Miyaki K (1978) Preliminary X-ray studies on the interaction of salmon sperm DNA with spermine. J Mol Biol 122:43–53PubMedGoogle Scholar
  50. Igarashi K, Watanabe Y, Nakamura K, Kojima M, Fujiki Y, Hirose S (1978) Effect of spermidine on N-formylmethionyl-tRNA binding to 30S ribosomal subunits and on N-formylmethiony-tRNA-dependent polypeptide synthesis. Biochem Biophys Res Commun 83:806–813PubMedGoogle Scholar
  51. Igarashi K, Kojima M, Watanabe Y, Maeda K, Hirose S (1980) Stimulation of polypeptide synthesis by spermidine at the level of initiation in rabbit reticulocyte and wheat germ cell-free systems. Biochem Biophys Res Commun 97:480–486PubMedGoogle Scholar
  52. Illei G, Morgan DML (1979) The distribution of polyamine oxidase activity in the feto-maternal compartments. Br J Obstet Gynaecol 86:873–877PubMedGoogle Scholar
  53. Israel M, Zoll EC, Muhammed N, Modest EJ (1973) Synthesis and antitumor evaluation of the presumed cytotoxic metabolites of spermine and N,N′-bis(3-aminopropyl)nonane-1,9-diamirie. J Med Chem 16:1–5PubMedGoogle Scholar
  54. Iversen OH (1981) The chalones. In: Baserga R (ed) Handbook of experimental pharmacology, vol 57. Springer, Berlin Heidelberg New York, pp 491–550Google Scholar
  55. Jänne J, Pösö H, Raina A (1978) Polyamines in rapid growth and cancer. Biochim Biophys Acta 473:241–293PubMedGoogle Scholar
  56. Käpyaho K, Pösö H, Jänne J (1980) Role of propylamine transferases in hormone-induced stimulation of polyamine biosynthesis. Biochem J 192:59–63PubMedGoogle Scholar
  57. Kano I, Nebert DW (1981) Ornithine decarboxylase induction in liver and hepatoma-derived cell cultures. No detectable differences between control and 3-methylcholan-threne-treated cells. Mol Pharmacol 20:172–178PubMedGoogle Scholar
  58. Karpetsky TP, Hieter PA, Frank JJ, Lery CC (1977) Polyamines, ribonucleases and the stability of RNA. Mol Cell Biochem 17:89–99PubMedGoogle Scholar
  59. Kawamura M, Tanigawa Y, Kitamura A, Miyake Y, Shimoyama M (1981) Effect of polyamines on purified poly(ADP-ribose) synthetase from rat liver nuclei. Biochim Biophys Acta 652:121–128PubMedGoogle Scholar
  60. Kishore GS, Boutwell RK (1981) Induction of mouse hepatic ornithine decarboxylase by skin application of 12-O-tetradecanoylphorbol-13-acetate. Experientia 37:179–180PubMedGoogle Scholar
  61. Knutson JC, Morris DR (1978) Cellular polyamine depletion reduces DNA synthesis inisolated lymphocyte nuclei. Biochim Biophys Acta 520:291–301PubMedGoogle Scholar
  62. Lanz R, Brune K (1981) Dissociation of tumour-promoter-induced effects on prostaglandin release, polyamine synthesis and cell proliferation of 3T3 cells. Biochem J 194:975–982PubMedGoogle Scholar
  63. Lauharanta J, Kousa M, Kapyaho K, Linnamaa K, Mustakallio K (1981) Reduction of increased polyamine levels in psoriatic lesions by retinoid and PUVA treatments. Br J Dermatol 105:267–272PubMedGoogle Scholar
  64. Lesiewicz J, Morrison DM, Goldsmith LA (1980) Ornithine decarboxylase in rat skin. 2. Differential response to hair plucking and a tumor promoter. J Invest Dermatol 75:411–416PubMedGoogle Scholar
  65. Lichti U, Bowden GT, Patterson E, Ben T, Yuspa SH (1980) Germicidal ultraviolet light induces ornithine decarboxylase in mouse epidermal cells and modifies the induction caused by phorbol ester tumor promoters. Photochem Photobiol 32:177–182PubMedGoogle Scholar
  66. Lichti U, Patterson E, Hennings H, Yuspa SH (1981) The tumor promoter 12-O-tetrade-canoylphorbol-13-acetate induces ornithine decarboxylase in proliferating basal cells but not in differentiating cells from mouse epidermis. J Cell Physiol 107:261–270PubMedGoogle Scholar
  67. Lowe NJ (1980) Epidermal ornithine decarboxylase, polyamines, cell proliferation and tumor promotion. Arch Dermatol 116:822–825PubMedGoogle Scholar
  68. Lowe NJ, Verma AK, Boutwell RK (1978) Ultraviolet light induces epidermal ornithine decarboxylase. J Invest Dermatol 71:417–118PubMedGoogle Scholar
  69. Lutaya G, Griffiths JR (1981) Rapid formation of spermine in skeletal muscle during tetanic stimulation. FEBS Lett 123:186–188PubMedGoogle Scholar
  70. Mamont PS, Danzin C (1981) In vitro and in vivo regulation of S-adenosyl-L-methionine decarboxylase by polyamines. In: Calderara CM, Zappia V, Bachrach U (eds) Advances in poly amine research, vol 3. Raven, New York, pp 123–135Google Scholar
  71. Marcelo CL, Voorhees JJ (1980) Cyclic nucleotides, prostaglandins and polyamines in psoriasis. Pharmacol Ther 9:297–310PubMedGoogle Scholar
  72. Marks R (1978) Epidermal activity in the involved and uninvolved skin of patients with psoriasis. Br J Dermatol 98:399–404PubMedGoogle Scholar
  73. Maudsley DB (1979) Regulation of polyamine biosynthesis. Biochem Pharmacol 28:153–161PubMedGoogle Scholar
  74. Maurer HR, Maschler R (1979) The influence of spermine, spermidine and various sera on T-lymphocyte and granulocyte colony growth in vitro. Z Naturforsch [C] 34:452–459Google Scholar
  75. McCormick F (1977) Polyamine metabolism in enucleated mouse L-cells. J Cell Physiol 93:285–292PubMedGoogle Scholar
  76. Mizutani A, Inoue H, Takeda Y (1974) Changes in polyamine metabolism during wound healing in rat skin. Biochim Biophys Acta 338:183–190Google Scholar
  77. Morgan DML (1980) Polyamine oxidases. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 285–302Google Scholar
  78. Morgan DML, Illei G (1980) Polyamine — polyamine oxidase interaction: part of maternal protective mechanism against fetal rejection. Br Med J [Clin Res] 280:1295–1297Google Scholar
  79. Morrison DM, Goldsmith LA (1978) Ornithine decarboxylase in rat skin. J Invest Dermatol 70:309–313PubMedGoogle Scholar
  80. Mufson RA, Astrup EG, Simsiman RC, Boutwell RK (1977) Dissociation of increases in levels of 3′,5′-cyclic AMP and 3′,5′-cyclic GMP from induction of ornithine decarboxylase by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis in vivo. Proc Natl Acad Sci USA 74:657–661PubMedGoogle Scholar
  81. Murray AW, Solanki Y, Froscio M, Rogers A (1980) Effects of cholera toxin on ornithine decarboxylase activity in mouse skin. J Invest Dermatol 75:508–511PubMedGoogle Scholar
  82. Nebert DW, Jensen NM, Perry JW, Oka T (1980) Association between ornithine decarboxylase induction and the Ah locus in mice treated with polycyclic aromatic hydrocarbons. J Biol Chem 255:6836–6842PubMedGoogle Scholar
  83. Nishioka K, Ezaki K, Hart JS (1980) A preliminary study of polyamines in the bone marrow plasma of adult patients with leukaemia. Clin Chim Acta 107:59–66PubMedGoogle Scholar
  84. Nöthig-Laslo V, Weygand-Durasevic I, Zivkovic T, Kucan Z (1981) Binding of spermine to tRNA stabilizes the conformation of the anticodon loop and creates strong binding sites for divalent cations. Eur J Biochem 117:263–267PubMedGoogle Scholar
  85. Nordlie RC, Johnson WT, Comatzer WE, Twedell GW (1979) Stimulation by polyamines of carbamyl phosphate: glucose phosphotransferase and glucose-6-phosphate phosphohydrolase activities of multifunctional glucose-6-phosphatase. Biochim Biophys Acta 585:12–23PubMedGoogle Scholar
  86. O’Brien TG (1976) The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis. Cancer Res 36:2644–2653PubMedGoogle Scholar
  87. O’Brien TG, Diamond L (1978) Ornithine decarboxylase, polyamines and tumor promoters. In: Slaga TJ, Sivak A, Boutwell RK (eds) Carcinogenesis, vol 2. Raven, New York, pp 273–287Google Scholar
  88. Peterson AO, McCann V, Black HS (1980) Dietary modification of UV-induced epidermal ornithine decarboxylase. J Invest Dermatol 75:408–410PubMedGoogle Scholar
  89. Pleshkewych A, Kramer DL, Kelly E, Porter CW (1980) Independence of drug action on mitochondria and polyamines in L1210 leukemia cells treated with methylglyoxal-bis (guanylhydrazone). Cancer Res 40:4533–4540PubMedGoogle Scholar
  90. Pohjanpelto P (1973) Relationship between putrescine and the proliferation of human fibroblasts in vitro. Exp Cell Res 80:137–142PubMedGoogle Scholar
  91. Pohjanpelto P (1976) Putrescine transport is greatly increased in human fibroblasts initiated to proliferate. J Cell Biol 68:512–520PubMedGoogle Scholar
  92. Pohjanpelto P, Raina A (1972) Identification of a growth factor produced by human fibroblasts as putrescine. Nature 235:247–249Google Scholar
  93. Pohjanpelto P, Virtanen I, Hölltä E (1981) Polyamine starvation causes disappearance of actin filaments and microtubules in polyamine-auxotrophic CHO cells. Nature 293:475–477PubMedGoogle Scholar
  94. Probst E, Krebs A (1975) Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles. Biochim Biophys Acta 407:147–157PubMedGoogle Scholar
  95. Proctor MS, Fletcher HV, Shukla JB, Rennert OM (1975) Elevated spermidine and spermine levels in the blood of psoriasis patients. J Invest Dermatol 65:409–411PubMedGoogle Scholar
  96. Proctor MS, Wilkinson DI, Orenberg EK, Farber EM (1979) Lowered cutaneous and urinary levels of polyamines with clinical improvement in treated psoriasis. Arch Dermatol 115:945–949PubMedGoogle Scholar
  97. Proctor MS, Liu SCC, Wilkinson DI (1980) Effect of methylglyoxal bis-guanylhydrazone on polyamine biosynthesis, growth and differentiation of cultured keratinoeytes. Arch Dermatol Res 269:61–68PubMedGoogle Scholar
  98. Quash G, Keolouangkhot T, Gazzolo L, Ripoli H, Saez S (1979) Diamine oxidase and polyamine oxidase activities in normal and transformed cells. Biochem J 177:275–282PubMedGoogle Scholar
  99. Quigley GJ, Teeter MM, Rich A (1978) Structural analysis of spermine and magnesium ion binding to yeast Phe-tRNA. Proc Natl Acad Sci USA 75:64–68PubMedGoogle Scholar
  100. Rennert OM, Chan WY, Griesmann G (1980) Polyamine-peptide conjugates: proposed functions. Physiol Chem Phys Med NMR 12:441–150Google Scholar
  101. Romano M, Cecco L, Cerra M, Montuori R, De Rosa C (1980) Polyamines as biological markers of the effectiveness of therapy in acute leukemia. Tumori 66:677–687PubMedGoogle Scholar
  102. Rupniak HT, Paul D (1978 a) Lack of a correlation between polyamine synthesis and DNA synthesis by cultured rat liver cells and fibroblasts. J Cell Physiol 96:261–263Google Scholar
  103. Rupniak HT, Paul D (1978 b) Regulation of the cell cycle by polyamines in normal and transformed fibroblasts. In: Campbell RA, Morris DR, Bartos D, Daves GD, Bartos F (eds) Advances in polyamine research, vol 1. Raven, New York, pp 117–126Google Scholar
  104. Rupniak HT, Paul D (1980) Selective killing of transformed cells by exploitation of their defective cell cycle control by polyamines. Cancer Res 40:293–297PubMedGoogle Scholar
  105. Russell DH (1971) Increased polyamine concentrations in the urine of human cancer patients. Nature 233:144Google Scholar
  106. Russell DH (1977) Clinical relevance of polyamines as biochemical markers of tumor kinetics. Clin Chem 23:22–27PubMedGoogle Scholar
  107. Russell DH (1981) Posttranslational modification of ornithine decarboxylase by its product putrescine. Biochem Biophys Res Commun 99:1167–1172PubMedGoogle Scholar
  108. Russell DH, Combest WL, Duell EA, Stawiski MA, Anderson T, Voorhees JJ (1977) Increased ornithine decarboxylase and S-adenosylmethionine decarboxylase activities in involved and uninvolved skin samples from patients with psoriasis. Fed Proc 36:970Google Scholar
  109. Sakakibara S, Yoshikawa K (1979) Urinary polyamine levels in patients with psoriasis. Arch Dermatol 265:133–137Google Scholar
  110. Scalabrino G, Pigatto P, Ferioli ME, Modena D, Puevari M, Carú A (1980) Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas. J Invest Dermatol 74:122–124PubMedGoogle Scholar
  111. Seiler N (1980) Assay of polyamines in tissues and body fluids. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 435–461Google Scholar
  112. Seiler N, Knödgen B (1979) Effects of ultraviolet light on epidermal polyamine metabolism. Biochem Med 21:168–181PubMedGoogle Scholar
  113. Seiler N, Bolkenius FN, Knödgen B (1980 a) Acetylation of spermidine in polyamine catabolism. Biochim Biophys Acta 633:181–190Google Scholar
  114. Seiler N, Bolkenius FN, Knödgen B, Mamont P (1980 b) Polyamine oxidase in rat tissues. Biochim Biophys Acta 615:480–488Google Scholar
  115. Seiler N, Koch-Weser J, Knödgen B, Richards W, Tardif C, Bolkenius FN, Schecter P, Tell G, Mamont P, Fozard J, Bachrach U, Grosshans E ( 1981 a) The significance of acetylation in the urinary excretion of polyamines. In: Calderara CM, Zappia V, Bachrach U (eds) Advances in polyamine research, vol 3. Raven, New York, pp 197–211Google Scholar
  116. Seppänen P, Alhonen-Hongisto L, Jänne J (1981) Death of tumor cells in response to the use of a system of stimulated polyamine uptake for the transport of methyl-glyoxal bis-(guanylhydrazone). Eur J Biochem 118:571–576PubMedGoogle Scholar
  117. Stastny M, Cohen S (1970) Epidermal growth factor IV. The induction of ornithine decarboxylase. Biochim Biophys Acta 204:578–589PubMedGoogle Scholar
  118. Stüttgen G (1968) Basic low molecular weight amine content of the skin. Fette Seifen Anstrichsm 70:667–669Google Scholar
  119. Sukumar S, Nagarajan B (1978) Effect of various therapeutic treatments on polyamine contents in experimental fibrosarcoma. Indian J Biochem Biophys 15:169–172PubMedGoogle Scholar
  120. Sunkara PS, Pargac MB, Nishioka K, Rao PN (1979 a) Differential effects of inhibition of polyamine biosynthesis on cell cycle traverse and structure of the prematurely condensed chromosomes of normal and transformed cells. J Cell Physiol 98:451–457Google Scholar
  121. Sunkara PS, Rao PN, Nishioka K, Brinkley BR (1979 b) Role of polyamines in cytokinesis of mammalian cells. Exp Cell Res 119:63–68Google Scholar
  122. Sunkara PS, Ramakrishna S, Nishioka K, Rao PN (1981) The relationship between the levels and rates of synthesis of polyamines during mammalian cell cycle. Life Sci 28:1497–1506PubMedGoogle Scholar
  123. Tabor CW, Rosenthal SM (1956) Pharmacology of spermine and spermidine. Some effects on animals and bacteria. J Pharmacol Exp Ther 116:139–155PubMedGoogle Scholar
  124. Tabor CW, Tabor H, Bachrach U (1964) Identification of the aminoaldehydes produced by the oxidation of spermine and spermidine with purified plasma amine oxidase. J Biol Chem 239:2194–2203PubMedGoogle Scholar
  125. Takami H, Nishioka K (1980) Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. Br J Cancer 41:751–756PubMedGoogle Scholar
  126. Tanigawa Y, Kawasaki K, Imai Y, Shimoyama M (1980) Effect of polyamines on ADP-ribosylation by chick-embryo-liver nuclei. Biochim Biophys Acta 608:82–95PubMedGoogle Scholar
  127. Tashima Y, Hasegawa M, Lane LK, Schwartz A (1981) Specific effects of spermine onNa+, K+-adenosine triphosphatase. J Biochem (Tokyo) 89:249–255Google Scholar
  128. Townsend RM, Banda PW, Marton LJ (1976) Polyamines in malignant melanoma. Cancer 38:2088–2092PubMedGoogle Scholar
  129. Verma AK, Boutwell RK (1977) Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis. Cancer Res 37:2196–2201PubMedGoogle Scholar
  130. Verma AK, Rice HM, Boutwell RK (1977) Prostaglandins and tumor promotion: inhibition of tumor promoter-elicited ornithine decarboxylase activity in epidermis by inhibitors of prostaglandin synthesis. Biochem Biophys Res Commun 79:1160–1166PubMedGoogle Scholar
  131. Verma AK, Lowe NJ, Boutwell RK (1979) Induction of mouse epidermal ornithine decarboxylase activity and DNA synthesis by ultraviolet light. Cancer Res 39:1035–1040PubMedGoogle Scholar
  132. Wallace HM, Keir HM (1979) The effect of spermidine on RNA polymerase II activity in isolated nuclei from baby-hamster kidney cells (BHK-21/C13). Biochem Soc Trans 7:1086–1087PubMedGoogle Scholar
  133. Wallace HM, Keir HM (1981) Uptake and excretion of polyamines from baby hamster kidney cells (BHK-21/C13). The effect of serum on confluent cultures. Biochim Biophys Acta 676:25–30PubMedGoogle Scholar
  134. Wallace HM, Duff PM, Pearson CK, Keir HM (1981) The effect of polyamines on DNA synthesis in vitro. Biochim Biophys Acta 652:354–357PubMedGoogle Scholar
  135. Weekes RG, Verma AK, Boutwell RK (1980) Inhibition by putrescine of the induction of epidermal ornithine decarboxylase and tumor promotion caused by 12-O-tetradeca-noylphorbol-13-acetate. Cancer Res 40:4013–4018PubMedGoogle Scholar
  136. Williams-Ashman HG, Cannellakis ZN (1980) Transglutaminase-mediated covalent attachment of polyamines to proteins: mechanisms and potential physiological significance. Physiol Chem Phys Med NMR 12:457–472Google Scholar
  137. Wright RK, Buehler BA, Schott SN, Rennert OM (1978) Spermine and spermidine, modulators of the cell surface enzyme adenyl cyclase. Pediatr Res 12:830–833PubMedGoogle Scholar
  138. Yuspa SH, Lichti U, Ben T (1980) Local anaesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Proc Natl Acad Sci USA 77:5312–5316PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. C. Allen

There are no affiliations available

Personalised recommendations