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Polyamines

  • Chapter
Pharmacology of the Skin I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 1))

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Abstract

It seems strange that the ubiquitous bio-organic cations the polyamines have, until recently, been consigned to the boxroom of biochemistry. Nevertheless, it is now apparent that they play a variety of subtle and sometimes essential roles. This chapter emphasises their participation in normal and abnormal epidermis; restrictions on space make it quite impossible to do justice to many general recent developments, and the reader is referred to more comprehensive treatments for further information (COHEN 1971; TABOR and TABOR 1976; JÄNNE et al. 1978; GAUGAS 1980).

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References

  • Abdel-Monem MM, Ohno K (1977) Polyamine metabolism. II. N-(Monoaminoalkyl) and N-(polyaminoalkyl) acetamides in human urine. J Pharm Sci 66:1195–1197

    CAS  PubMed  Google Scholar 

  • Aigner-Held R, Daves GD (1980) Polyamine metabolites and conjugates in man and higher animals: a review of the literature. Physiol Chem Phys Med NMR 12: 389–400

    CAS  Google Scholar 

  • Alarcon RA (1970) Acrolein. IV. Evidence for the formation of the cytotoxic aldehyde from enzymatically oxidised spermine or spermidine. Arch Biochem Biophys 137:365–375

    CAS  PubMed  Google Scholar 

  • Alhonen-Hongisto L (1980) Regulation of S-adenosylmethionine decarboxylase in Ehrlich ascites-carcinoma cells grown in culture. Biochem J 190:747–754

    CAS  PubMed  Google Scholar 

  • Allen JC, Smith CJ (1979) Chalones. A reappraisal. Biochem Soc Trans 7:584–592

    CAS  PubMed  Google Scholar 

  • Allen JC, Smith CJ, Curry MC, Gaugas JM (1977) Identification of a thymic inhibitor (“chalone”) of lymphocyte transformation as a spermine complex. Nature 267: 623–625

    CAS  PubMed  Google Scholar 

  • Allen JC, Smith CJ, Hussain JI, Thomas JM, Gaugas JM (1979) Inhibition of lymphocyte proliferation by polyamines requires ruminant plasma polyamine oxidase. Eur J Biochem 102:153–158

    CAS  PubMed  Google Scholar 

  • Bachrach U (1970) Oxidised polyamines. Ann NY Acad Sci 171:939–956

    CAS  Google Scholar 

  • Bachrach U (1980) The induction of ornithine decarboxylase in normal and neoplastic cells. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 81–107

    Google Scholar 

  • Bachrach U, Seiler N (1981) Formation of acetylpolyamines and putrescine from sper-midine by normal and transformed chick embryo fibroblasts. Cancer Res 41:1205–1208

    CAS  PubMed  Google Scholar 

  • Bachrach U, Katz A, Hochman J (1978) Polyamines and protein kinase I. Induction of ornithine decarboxylase and activation of protein kinase in rat glioma cells. Life Sci 22:817–822

    CAS  Google Scholar 

  • Ben-Hur E, Riklis E (1981) Inhibition of induced ornithine decarboxylase activity in Chinese hamster cells by gamma irradiation, far ultraviolet light and psoralen plus near ultraviolet light: a comparative study. Int J Radiat Biol 39:527–535

    CAS  Google Scholar 

  • Bloomfield VA, Wilson RW, Rau DC (1980) Polyeleetrolyte effects in DNA condensation by polyamines. Biophys Chem 11:339–343

    CAS  PubMed  Google Scholar 

  • Böhlen P, Grove J, Beya MF, Koch-Weser J, Henry MH, Grosshans E (1978) Skin polyamine levels in psoriasis: the effect of dithranol therapy. Eur J Clin Invest 8:215–218

    PubMed  Google Scholar 

  • Bolton PH, Kearns DR (1978) H-bonding interactions of polyamines with the 2′-OH of RNA. Nucleic Acids Res 5:1315–1324

    CAS  PubMed  Google Scholar 

  • Boynton AL, Whitfield JF, Isaacs RJ (1976) A possible involvement of polyamines in the initiation of DNA synthesis by human WI-38 and mouse BALB/3T3 cells. J Cell Physiol 89:481–488

    CAS  PubMed  Google Scholar 

  • Burton DR, Forsén S, Ramansson P (1981) The interaction of polyamines with DNA. A 23Na NMR study. Nucleic Acids Res 9:1219–1228

    CAS  PubMed  Google Scholar 

  • Byrd WJ, Jacobs DM, Amoss MS (1977) Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunity. Nature 267:621–623

    CAS  PubMed  Google Scholar 

  • Calderara CM, Zappia V, Bachrach D (eds) (1981) Advances in polyamine research, vol 3. Raven, New York

    Google Scholar 

  • Cannellakis ES, Viceps-Madore D, Kyriakidis DA, Heller JS (1979) The regulation and function of ornithine decarboxylase and of the polyamines. In: Horecker BL, Stadtman ER (eds) Current topics in cellular regulation, vol 15. Academic, New York, pp 155–202

    Google Scholar 

  • Cannellakis ES, Heller JS, Kyriakidis DA (1981) The interaction of ornithine decarboxylase with its antizyme. In: Calderara CM, Zappia V, Bachrach U (eds) Advances in polyamine research, vol 3. Raven, New York, pp 1–13

    Google Scholar 

  • Clark-Lewis I, Murray AW (1978) Tumor promotion and the induction of ornithine decarboxylase activity in mechanically stimulated mouse skin. Cancer Res 38:494–497

    CAS  PubMed  Google Scholar 

  • Cohen SS (1971) Introduction to the polyamines. Prentice-Hall, New Jersey

    Google Scholar 

  • Cohen SS (1977) Meeting report: conference on polyamines and cancer. Cancer Res 37:939–942

    Google Scholar 

  • Cooper KD, Shukla JB, Rennert OM (1978) Polyamine compartmentalization in various disease states. Clin Chim Acta 82:1–7

    CAS  PubMed  Google Scholar 

  • Dewey DL (1978) The identification of a cell culture inhibitor in a tumour extract. Cancer Lett 4:77–84

    CAS  PubMed  Google Scholar 

  • De Young LM, Helmes CT, Chao WR, Young JM, Miller Y (1981) Paradoxical effect of anthralin on 12-O-tetradecanoylphorbol-13-acetate-induced mouse epidermal orni-thine decarboxylase activity, proliferation, and tumour promotion. Cancer Res 41:204–208

    PubMed  Google Scholar 

  • Di Pasquale A, White D, McGuire J (1978) Epidermal growth factor stimulates putrescine transport and ornithine decarboxylase activity in cultivated human fibroblasts. Exp Cell Res 116:317–323

    Google Scholar 

  • Duffy PE, Kremzner LT (1977) Ornithine decarboxylase activity and polyamines in relation to aging of fibroblasts. Exp Cell Res 108:435–440

    CAS  PubMed  Google Scholar 

  • Folk JE, Park MH, Chung SI, Schrode J, Lester EP, Cooper HL (1980) Polyamines as physiological substrates for transglutaminases. J Biol Chem 225:3695–3700

    Google Scholar 

  • Fong WF, Heller JS, Cannellakis ES (1976) The appearance of an ornithine decarboxylase inhibitory protein upon the addition of putrescine to cell cultures. Biochim Biophys Acta 428:456–465

    CAS  PubMed  Google Scholar 

  • Fujiki H Mori M, Sugimura T, Hirota M, Ohigashi H, Koshimizu K (1980) Relationship between ornithine decarboxylase-inducing activity and configuration at C-4 in phorbol ester derivatives. J Cancer Res Clin Oncol 98:9–13

    Google Scholar 

  • Gahl WA, Pitot HC (1978) Reversal by aminoguaijidine of the inhibition of proliferation of human fibroblasts by spermidine and spermine. Chem Biol Interact 22:91–98

    CAS  PubMed  Google Scholar 

  • Gange RW (1981) Epidermal ornithine decarboxylase activity and thymidine incorpora-tion following treatments with ultraviolet A combined with topical 8-methoxypsoralen or anthracene in the hairless mouse. Br J Dermatol 105:247–255

    CAS  PubMed  Google Scholar 

  • Gange RW, Dequoy PR (1980) Topical spermine and putrescine stimulated DNA synthesis in the hairless mouse epidermis. Br J Dermatol 103:27–32

    CAS  PubMed  Google Scholar 

  • Gaugas JM (ed) (1980) Polyamines in biomedical research. Wiley, Chichester

    Google Scholar 

  • Gaugas JM, Dewey DL (1979) Evidence for serum binding of oxidised spermine and its potent G1-phase inhibition of cell proliferation. Br J Cancer 39: 548–557

    CAS  PubMed  Google Scholar 

  • Grimm W, Marks F (1974) Effect of tumor-promoting phorbol esters on the normal and isoproterenol-elevated level of adenosine-3′,5′-cyclic monophosphate in mouse epidermis in vivo. Cancer Res 34:3128–3134

    CAS  PubMed  Google Scholar 

  • Grosshans E, Henry M, Bohlen P, Grove J, Beya MF, Koch-Weser J (1978) Skin polyamine levels in psoriasis — the effect of therapy. J Invest Dermatol 70:227

    Google Scholar 

  • Haddox MK, Russell DH (1981) Increased nuclear conjugated polyamines and transglutaminase during liver regeneration. Proc Natl Acad Sci USA 78:1712–1716

    CAS  PubMed  Google Scholar 

  • Ham RG (1964) Putrescine and related amines as growth factors for a mammalian cell line. Biochem Biophys Res Commun 14:34–38

    CAS  PubMed  Google Scholar 

  • Heby O, Andersson G (1978) Tumour cell death: the probable cause of increased polyamide levels in physiological fluids. Acta Pathol Microbiol Immunol Scand [A] 86:17–20

    CAS  Google Scholar 

  • Heby O, Andersson G (1980) Polyamines and the cell cycle. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 17–34

    Google Scholar 

  • Heby O, Gray JW, Lindl PA, Marton LJ, Wilson CB (1976) Changes in L-ornithine decarboxylase activity during the cell cycle. Biochem Biophys Res Commun 71:99–105

    CAS  PubMed  Google Scholar 

  • Heby O, Andersson G, Gray JW (1978) Interference with S and G2 phase progression by polyamine synthesis inhibitors. Exp Cell Res 111:461–464

    CAS  PubMed  Google Scholar 

  • Heller JS, Chen KY, Kyriakidis DA, Fong WF, Cannellakis ES (1978) The modulation of the induction of ornithine decarboxylase by spermine, spermidine and diamines. J Cell Physiol 96:225–234

    CAS  PubMed  Google Scholar 

  • Higgins ML, Tillman MC, Rupp JP, Leach FL (1969) The effect of polyamines on cell culture cells. J Cell Physiol 74:149–154

    CAS  PubMed  Google Scholar 

  • Hölltä E (1977) Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase. Biochemistry 61:91–100

    Google Scholar 

  • Huse Y, Mitsui Y, Iitaka Y, Miyaki K (1978) Preliminary X-ray studies on the interaction of salmon sperm DNA with spermine. J Mol Biol 122:43–53

    CAS  PubMed  Google Scholar 

  • Igarashi K, Watanabe Y, Nakamura K, Kojima M, Fujiki Y, Hirose S (1978) Effect of spermidine on N-formylmethionyl-tRNA binding to 30S ribosomal subunits and on N-formylmethiony-tRNA-dependent polypeptide synthesis. Biochem Biophys Res Commun 83:806–813

    CAS  PubMed  Google Scholar 

  • Igarashi K, Kojima M, Watanabe Y, Maeda K, Hirose S (1980) Stimulation of polypeptide synthesis by spermidine at the level of initiation in rabbit reticulocyte and wheat germ cell-free systems. Biochem Biophys Res Commun 97:480–486

    CAS  PubMed  Google Scholar 

  • Illei G, Morgan DML (1979) The distribution of polyamine oxidase activity in the feto-maternal compartments. Br J Obstet Gynaecol 86:873–877

    CAS  PubMed  Google Scholar 

  • Israel M, Zoll EC, Muhammed N, Modest EJ (1973) Synthesis and antitumor evaluation of the presumed cytotoxic metabolites of spermine and N,N′-bis(3-aminopropyl)nonane-1,9-diamirie. J Med Chem 16:1–5

    CAS  PubMed  Google Scholar 

  • Iversen OH (1981) The chalones. In: Baserga R (ed) Handbook of experimental pharmacology, vol 57. Springer, Berlin Heidelberg New York, pp 491–550

    Google Scholar 

  • Jänne J, Pösö H, Raina A (1978) Polyamines in rapid growth and cancer. Biochim Biophys Acta 473:241–293

    PubMed  Google Scholar 

  • Käpyaho K, Pösö H, Jänne J (1980) Role of propylamine transferases in hormone-induced stimulation of polyamine biosynthesis. Biochem J 192:59–63

    PubMed  Google Scholar 

  • Kano I, Nebert DW (1981) Ornithine decarboxylase induction in liver and hepatoma-derived cell cultures. No detectable differences between control and 3-methylcholan-threne-treated cells. Mol Pharmacol 20:172–178

    CAS  PubMed  Google Scholar 

  • Karpetsky TP, Hieter PA, Frank JJ, Lery CC (1977) Polyamines, ribonucleases and the stability of RNA. Mol Cell Biochem 17:89–99

    CAS  PubMed  Google Scholar 

  • Kawamura M, Tanigawa Y, Kitamura A, Miyake Y, Shimoyama M (1981) Effect of polyamines on purified poly(ADP-ribose) synthetase from rat liver nuclei. Biochim Biophys Acta 652:121–128

    CAS  PubMed  Google Scholar 

  • Kishore GS, Boutwell RK (1981) Induction of mouse hepatic ornithine decarboxylase by skin application of 12-O-tetradecanoylphorbol-13-acetate. Experientia 37:179–180

    CAS  PubMed  Google Scholar 

  • Knutson JC, Morris DR (1978) Cellular polyamine depletion reduces DNA synthesis inisolated lymphocyte nuclei. Biochim Biophys Acta 520:291–301

    CAS  PubMed  Google Scholar 

  • Lanz R, Brune K (1981) Dissociation of tumour-promoter-induced effects on prostaglandin release, polyamine synthesis and cell proliferation of 3T3 cells. Biochem J 194:975–982

    CAS  PubMed  Google Scholar 

  • Lauharanta J, Kousa M, Kapyaho K, Linnamaa K, Mustakallio K (1981) Reduction of increased polyamine levels in psoriatic lesions by retinoid and PUVA treatments. Br J Dermatol 105:267–272

    CAS  PubMed  Google Scholar 

  • Lesiewicz J, Morrison DM, Goldsmith LA (1980) Ornithine decarboxylase in rat skin. 2. Differential response to hair plucking and a tumor promoter. J Invest Dermatol 75:411–416

    CAS  PubMed  Google Scholar 

  • Lichti U, Bowden GT, Patterson E, Ben T, Yuspa SH (1980) Germicidal ultraviolet light induces ornithine decarboxylase in mouse epidermal cells and modifies the induction caused by phorbol ester tumor promoters. Photochem Photobiol 32:177–182

    CAS  PubMed  Google Scholar 

  • Lichti U, Patterson E, Hennings H, Yuspa SH (1981) The tumor promoter 12-O-tetrade-canoylphorbol-13-acetate induces ornithine decarboxylase in proliferating basal cells but not in differentiating cells from mouse epidermis. J Cell Physiol 107:261–270

    CAS  PubMed  Google Scholar 

  • Lowe NJ (1980) Epidermal ornithine decarboxylase, polyamines, cell proliferation and tumor promotion. Arch Dermatol 116:822–825

    CAS  PubMed  Google Scholar 

  • Lowe NJ, Verma AK, Boutwell RK (1978) Ultraviolet light induces epidermal ornithine decarboxylase. J Invest Dermatol 71:417–118

    CAS  PubMed  Google Scholar 

  • Lutaya G, Griffiths JR (1981) Rapid formation of spermine in skeletal muscle during tetanic stimulation. FEBS Lett 123:186–188

    CAS  PubMed  Google Scholar 

  • Mamont PS, Danzin C (1981) In vitro and in vivo regulation of S-adenosyl-L-methionine decarboxylase by polyamines. In: Calderara CM, Zappia V, Bachrach U (eds) Advances in poly amine research, vol 3. Raven, New York, pp 123–135

    Google Scholar 

  • Marcelo CL, Voorhees JJ (1980) Cyclic nucleotides, prostaglandins and polyamines in psoriasis. Pharmacol Ther 9:297–310

    CAS  PubMed  Google Scholar 

  • Marks R (1978) Epidermal activity in the involved and uninvolved skin of patients with psoriasis. Br J Dermatol 98:399–404

    CAS  PubMed  Google Scholar 

  • Maudsley DB (1979) Regulation of polyamine biosynthesis. Biochem Pharmacol 28:153–161

    CAS  PubMed  Google Scholar 

  • Maurer HR, Maschler R (1979) The influence of spermine, spermidine and various sera on T-lymphocyte and granulocyte colony growth in vitro. Z Naturforsch [C] 34:452–459

    Google Scholar 

  • McCormick F (1977) Polyamine metabolism in enucleated mouse L-cells. J Cell Physiol 93:285–292

    CAS  PubMed  Google Scholar 

  • Mizutani A, Inoue H, Takeda Y (1974) Changes in polyamine metabolism during wound healing in rat skin. Biochim Biophys Acta 338:183–190

    CAS  Google Scholar 

  • Morgan DML (1980) Polyamine oxidases. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 285–302

    Google Scholar 

  • Morgan DML, Illei G (1980) Polyamine — polyamine oxidase interaction: part of maternal protective mechanism against fetal rejection. Br Med J [Clin Res] 280:1295–1297

    CAS  Google Scholar 

  • Morrison DM, Goldsmith LA (1978) Ornithine decarboxylase in rat skin. J Invest Dermatol 70:309–313

    CAS  PubMed  Google Scholar 

  • Mufson RA, Astrup EG, Simsiman RC, Boutwell RK (1977) Dissociation of increases in levels of 3′,5′-cyclic AMP and 3′,5′-cyclic GMP from induction of ornithine decarboxylase by the tumour promoter 12-O-tetradecanoylphorbol-13-acetate in mouse epidermis in vivo. Proc Natl Acad Sci USA 74:657–661

    CAS  PubMed  Google Scholar 

  • Murray AW, Solanki Y, Froscio M, Rogers A (1980) Effects of cholera toxin on ornithine decarboxylase activity in mouse skin. J Invest Dermatol 75:508–511

    CAS  PubMed  Google Scholar 

  • Nebert DW, Jensen NM, Perry JW, Oka T (1980) Association between ornithine decarboxylase induction and the Ah locus in mice treated with polycyclic aromatic hydrocarbons. J Biol Chem 255:6836–6842

    CAS  PubMed  Google Scholar 

  • Nishioka K, Ezaki K, Hart JS (1980) A preliminary study of polyamines in the bone marrow plasma of adult patients with leukaemia. Clin Chim Acta 107:59–66

    CAS  PubMed  Google Scholar 

  • Nöthig-Laslo V, Weygand-Durasevic I, Zivkovic T, Kucan Z (1981) Binding of spermine to tRNA stabilizes the conformation of the anticodon loop and creates strong binding sites for divalent cations. Eur J Biochem 117:263–267

    PubMed  Google Scholar 

  • Nordlie RC, Johnson WT, Comatzer WE, Twedell GW (1979) Stimulation by polyamines of carbamyl phosphate: glucose phosphotransferase and glucose-6-phosphate phosphohydrolase activities of multifunctional glucose-6-phosphatase. Biochim Biophys Acta 585:12–23

    CAS  PubMed  Google Scholar 

  • O’Brien TG (1976) The induction of ornithine decarboxylase as an early, possibly obligatory, event in mouse skin carcinogenesis. Cancer Res 36:2644–2653

    PubMed  Google Scholar 

  • O’Brien TG, Diamond L (1978) Ornithine decarboxylase, polyamines and tumor promoters. In: Slaga TJ, Sivak A, Boutwell RK (eds) Carcinogenesis, vol 2. Raven, New York, pp 273–287

    Google Scholar 

  • Peterson AO, McCann V, Black HS (1980) Dietary modification of UV-induced epidermal ornithine decarboxylase. J Invest Dermatol 75:408–410

    CAS  PubMed  Google Scholar 

  • Pleshkewych A, Kramer DL, Kelly E, Porter CW (1980) Independence of drug action on mitochondria and polyamines in L1210 leukemia cells treated with methylglyoxal-bis (guanylhydrazone). Cancer Res 40:4533–4540

    CAS  PubMed  Google Scholar 

  • Pohjanpelto P (1973) Relationship between putrescine and the proliferation of human fibroblasts in vitro. Exp Cell Res 80:137–142

    CAS  PubMed  Google Scholar 

  • Pohjanpelto P (1976) Putrescine transport is greatly increased in human fibroblasts initiated to proliferate. J Cell Biol 68:512–520

    CAS  PubMed  Google Scholar 

  • Pohjanpelto P, Raina A (1972) Identification of a growth factor produced by human fibroblasts as putrescine. Nature 235:247–249

    CAS  Google Scholar 

  • Pohjanpelto P, Virtanen I, Hölltä E (1981) Polyamine starvation causes disappearance of actin filaments and microtubules in polyamine-auxotrophic CHO cells. Nature 293:475–477

    CAS  PubMed  Google Scholar 

  • Probst E, Krebs A (1975) Ornithine decarboxylase activity in relation to DNA synthesis in mouse interfollicular epidermis and hair follicles. Biochim Biophys Acta 407:147–157

    CAS  PubMed  Google Scholar 

  • Proctor MS, Fletcher HV, Shukla JB, Rennert OM (1975) Elevated spermidine and spermine levels in the blood of psoriasis patients. J Invest Dermatol 65:409–411

    CAS  PubMed  Google Scholar 

  • Proctor MS, Wilkinson DI, Orenberg EK, Farber EM (1979) Lowered cutaneous and urinary levels of polyamines with clinical improvement in treated psoriasis. Arch Dermatol 115:945–949

    CAS  PubMed  Google Scholar 

  • Proctor MS, Liu SCC, Wilkinson DI (1980) Effect of methylglyoxal bis-guanylhydrazone on polyamine biosynthesis, growth and differentiation of cultured keratinoeytes. Arch Dermatol Res 269:61–68

    CAS  PubMed  Google Scholar 

  • Quash G, Keolouangkhot T, Gazzolo L, Ripoli H, Saez S (1979) Diamine oxidase and polyamine oxidase activities in normal and transformed cells. Biochem J 177:275–282

    CAS  PubMed  Google Scholar 

  • Quigley GJ, Teeter MM, Rich A (1978) Structural analysis of spermine and magnesium ion binding to yeast Phe-tRNA. Proc Natl Acad Sci USA 75:64–68

    CAS  PubMed  Google Scholar 

  • Rennert OM, Chan WY, Griesmann G (1980) Polyamine-peptide conjugates: proposed functions. Physiol Chem Phys Med NMR 12:441–150

    CAS  Google Scholar 

  • Romano M, Cecco L, Cerra M, Montuori R, De Rosa C (1980) Polyamines as biological markers of the effectiveness of therapy in acute leukemia. Tumori 66:677–687

    CAS  PubMed  Google Scholar 

  • Rupniak HT, Paul D (1978 a) Lack of a correlation between polyamine synthesis and DNA synthesis by cultured rat liver cells and fibroblasts. J Cell Physiol 96:261–263

    CAS  Google Scholar 

  • Rupniak HT, Paul D (1978 b) Regulation of the cell cycle by polyamines in normal and transformed fibroblasts. In: Campbell RA, Morris DR, Bartos D, Daves GD, Bartos F (eds) Advances in polyamine research, vol 1. Raven, New York, pp 117–126

    Google Scholar 

  • Rupniak HT, Paul D (1980) Selective killing of transformed cells by exploitation of their defective cell cycle control by polyamines. Cancer Res 40:293–297

    CAS  PubMed  Google Scholar 

  • Russell DH (1971) Increased polyamine concentrations in the urine of human cancer patients. Nature 233:144

    CAS  Google Scholar 

  • Russell DH (1977) Clinical relevance of polyamines as biochemical markers of tumor kinetics. Clin Chem 23:22–27

    CAS  PubMed  Google Scholar 

  • Russell DH (1981) Posttranslational modification of ornithine decarboxylase by its product putrescine. Biochem Biophys Res Commun 99:1167–1172

    CAS  PubMed  Google Scholar 

  • Russell DH, Combest WL, Duell EA, Stawiski MA, Anderson T, Voorhees JJ (1977) Increased ornithine decarboxylase and S-adenosylmethionine decarboxylase activities in involved and uninvolved skin samples from patients with psoriasis. Fed Proc 36:970

    Google Scholar 

  • Sakakibara S, Yoshikawa K (1979) Urinary polyamine levels in patients with psoriasis. Arch Dermatol 265:133–137

    CAS  Google Scholar 

  • Scalabrino G, Pigatto P, Ferioli ME, Modena D, Puevari M, Carú A (1980) Levels of activity of the polyamine biosynthetic decarboxylases as indicators of degree of malignancy of human cutaneous epitheliomas. J Invest Dermatol 74:122–124

    CAS  PubMed  Google Scholar 

  • Seiler N (1980) Assay of polyamines in tissues and body fluids. In: Gaugas JM (ed) Polyamines in biomedical research. Wiley, Chichester, pp 435–461

    Google Scholar 

  • Seiler N, Knödgen B (1979) Effects of ultraviolet light on epidermal polyamine metabolism. Biochem Med 21:168–181

    CAS  PubMed  Google Scholar 

  • Seiler N, Bolkenius FN, Knödgen B (1980 a) Acetylation of spermidine in polyamine catabolism. Biochim Biophys Acta 633:181–190

    CAS  Google Scholar 

  • Seiler N, Bolkenius FN, Knödgen B, Mamont P (1980 b) Polyamine oxidase in rat tissues. Biochim Biophys Acta 615:480–488

    CAS  Google Scholar 

  • Seiler N, Koch-Weser J, Knödgen B, Richards W, Tardif C, Bolkenius FN, Schecter P, Tell G, Mamont P, Fozard J, Bachrach U, Grosshans E ( 1981 a) The significance of acetylation in the urinary excretion of polyamines. In: Calderara CM, Zappia V, Bachrach U (eds) Advances in polyamine research, vol 3. Raven, New York, pp 197–211

    Google Scholar 

  • Seppänen P, Alhonen-Hongisto L, Jänne J (1981) Death of tumor cells in response to the use of a system of stimulated polyamine uptake for the transport of methyl-glyoxal bis-(guanylhydrazone). Eur J Biochem 118:571–576

    PubMed  Google Scholar 

  • Stastny M, Cohen S (1970) Epidermal growth factor IV. The induction of ornithine decarboxylase. Biochim Biophys Acta 204:578–589

    CAS  PubMed  Google Scholar 

  • Stüttgen G (1968) Basic low molecular weight amine content of the skin. Fette Seifen Anstrichsm 70:667–669

    Google Scholar 

  • Sukumar S, Nagarajan B (1978) Effect of various therapeutic treatments on polyamine contents in experimental fibrosarcoma. Indian J Biochem Biophys 15:169–172

    CAS  PubMed  Google Scholar 

  • Sunkara PS, Pargac MB, Nishioka K, Rao PN (1979 a) Differential effects of inhibition of polyamine biosynthesis on cell cycle traverse and structure of the prematurely condensed chromosomes of normal and transformed cells. J Cell Physiol 98:451–457

    CAS  Google Scholar 

  • Sunkara PS, Rao PN, Nishioka K, Brinkley BR (1979 b) Role of polyamines in cytokinesis of mammalian cells. Exp Cell Res 119:63–68

    CAS  Google Scholar 

  • Sunkara PS, Ramakrishna S, Nishioka K, Rao PN (1981) The relationship between the levels and rates of synthesis of polyamines during mammalian cell cycle. Life Sci 28:1497–1506

    CAS  PubMed  Google Scholar 

  • Tabor CW, Rosenthal SM (1956) Pharmacology of spermine and spermidine. Some effects on animals and bacteria. J Pharmacol Exp Ther 116:139–155

    CAS  PubMed  Google Scholar 

  • Tabor CW, Tabor H, Bachrach U (1964) Identification of the aminoaldehydes produced by the oxidation of spermine and spermidine with purified plasma amine oxidase. J Biol Chem 239:2194–2203

    CAS  PubMed  Google Scholar 

  • Takami H, Nishioka K (1980) Raised polyamines in erythrocytes from melanoma-bearing mice and patients with solid tumours. Br J Cancer 41:751–756

    CAS  PubMed  Google Scholar 

  • Tanigawa Y, Kawasaki K, Imai Y, Shimoyama M (1980) Effect of polyamines on ADP-ribosylation by chick-embryo-liver nuclei. Biochim Biophys Acta 608:82–95

    CAS  PubMed  Google Scholar 

  • Tashima Y, Hasegawa M, Lane LK, Schwartz A (1981) Specific effects of spermine onNa+, K+-adenosine triphosphatase. J Biochem (Tokyo) 89:249–255

    CAS  Google Scholar 

  • Townsend RM, Banda PW, Marton LJ (1976) Polyamines in malignant melanoma. Cancer 38:2088–2092

    CAS  PubMed  Google Scholar 

  • Verma AK, Boutwell RK (1977) Vitamin A acid (retinoic acid), a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced ornithine decarboxylase activity in mouse epidermis. Cancer Res 37:2196–2201

    CAS  PubMed  Google Scholar 

  • Verma AK, Rice HM, Boutwell RK (1977) Prostaglandins and tumor promotion: inhibition of tumor promoter-elicited ornithine decarboxylase activity in epidermis by inhibitors of prostaglandin synthesis. Biochem Biophys Res Commun 79:1160–1166

    CAS  PubMed  Google Scholar 

  • Verma AK, Lowe NJ, Boutwell RK (1979) Induction of mouse epidermal ornithine decarboxylase activity and DNA synthesis by ultraviolet light. Cancer Res 39:1035–1040

    CAS  PubMed  Google Scholar 

  • Wallace HM, Keir HM (1979) The effect of spermidine on RNA polymerase II activity in isolated nuclei from baby-hamster kidney cells (BHK-21/C13). Biochem Soc Trans 7:1086–1087

    CAS  PubMed  Google Scholar 

  • Wallace HM, Keir HM (1981) Uptake and excretion of polyamines from baby hamster kidney cells (BHK-21/C13). The effect of serum on confluent cultures. Biochim Biophys Acta 676:25–30

    CAS  PubMed  Google Scholar 

  • Wallace HM, Duff PM, Pearson CK, Keir HM (1981) The effect of polyamines on DNA synthesis in vitro. Biochim Biophys Acta 652:354–357

    CAS  PubMed  Google Scholar 

  • Weekes RG, Verma AK, Boutwell RK (1980) Inhibition by putrescine of the induction of epidermal ornithine decarboxylase and tumor promotion caused by 12-O-tetradeca-noylphorbol-13-acetate. Cancer Res 40:4013–4018

    CAS  PubMed  Google Scholar 

  • Williams-Ashman HG, Cannellakis ZN (1980) Transglutaminase-mediated covalent attachment of polyamines to proteins: mechanisms and potential physiological significance. Physiol Chem Phys Med NMR 12:457–472

    CAS  Google Scholar 

  • Wright RK, Buehler BA, Schott SN, Rennert OM (1978) Spermine and spermidine, modulators of the cell surface enzyme adenyl cyclase. Pediatr Res 12:830–833

    CAS  PubMed  Google Scholar 

  • Yuspa SH, Lichti U, Ben T (1980) Local anaesthetics inhibit induction of ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate. Proc Natl Acad Sci USA 77:5312–5316

    CAS  PubMed  Google Scholar 

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Authors
  1. J. C. Allen
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Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Allen, J.C. (1989). Polyamines. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin I. Handbook of Experimental Pharmacology, vol 87 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73797-8_26

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  • DOI: https://doi.org/10.1007/978-3-642-73797-8_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73799-2

  • Online ISBN: 978-3-642-73797-8

  • eBook Packages: Springer Book Archive

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