Neutrophil and Eosinophil Chemotaxis and Cutaneous Inflammatory Reactions

  • A. J. Wardlaw
  • A. B. Kay
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 1)


Neutrophil and eosinophil leucocytes are derived principally from the bone marrow although colony forming cells circulate in the peripheral blood. Together with basophils they form the granulocyte series of white cells. Mature granulocytes are incapable of division (“end cells”) and have a life span of days once they have entered the circulation. Granulocytes exhibit random and directional locomotion (chemokinesis and chemotaxis), possess varying degrees of phagocytic activity, and actively secrete lysosomal enzymes and other biological agents following contact with an appropriate stimulus. Many of these properties are shared by mononuclear phagocytes but the neutrophil, and to a lesser degree the eosinophil, is more rapidly mobilised to the sites of inflammation.


Allergy Clin Immunol Chemotactic Factor Chemotactic Activity Glyceryl Ether Cold Urticaria 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. J. Wardlaw
  • A. B. Kay

There are no affiliations available

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