Skip to main content
SpringerLink
Log in

Prostaglandins, Leukotrienes, Related Compounds and Their Inhibitors

  • Chapter
Pharmacology of the Skin I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 1))

  • 286 Accesses

Abstract

KURZROK and LIEB (1930) found that fresh human semen induced either strong relaxation or strong contraction of the human uterus. Several years later, two independent workers, GOLDBLATT (1935) and VON EULER (1936), reported that seminal fluid contained smooth muscle-contracting and vasodepressor activity. VON EULER named the activity, which appeared to be lipid in nature, “prostaglandin”. He discovered that it could be extracted from seminal fluid of several species and from ram vesicular gland (VON EULER 1936). The isolation of pure crystalline prostaglandins, from vesicular glands, was achieved in 1957 (BERGSTRÖM and SJÖVALL) and was followed by the first structure elucidations (BERSTRÖM et al. 1962). It is now known that the prostaglandins constitute a family of compounds of unique structure. These compounds are widely distributed in nature and have potent biological activities.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Allen BR, Littlewood SM (1982) Benoxaprofen:effect on cutaneous lesions in psoriasis. Br Med J Clin Res 285:1241

    CAS  Google Scholar 

  • Amelang E, Prasad CM, Raymond RM, Grega GJ (1981) Interactions among inflammatory mediators on edema formation in the canine forelimb. Circ Res 49:298–306

    CAS  PubMed  Google Scholar 

  • Angaard E, Jonsson CE (1971) Effect of prostaglandins in lymph from scalded tissue. Acta Physiol Scand 81:440–447

    Google Scholar 

  • Angaard E, Samuelsson B (1964) Prostaglandins and related factors 28. Metabolism of prostaglandin E1 in guinea pig lung:the structures of two metabolites. J Biol Chem 239:4087–4102

    Google Scholar 

  • Archer CB, Juhlin L, MacDonald DM, Morley J, Page CP (1984) Synergistic interaction between leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) in human skin:a delayed- onset phenomenon. Br J Clin Pharmacol 17:610

    Google Scholar 

  • Barnett AH, Spiliopoulos AJ, Keen H (1980) Blockade of chlorpropamide-alcohol flushing by indomethacin suggests an association between prostaglandins and diabetic vascular complications. Lancet 11:164–166

    Google Scholar 

  • Barr RM, Brain SD, Camp RDR, Cilliers J, Greaves MW, Mallett AL, Misch K (1984) Levels of arachidonic acid and its metabolites in the skin in human allergic and irritant contact dermatitis. Br J Dermatol 111:23–28

    CAS  PubMed  Google Scholar 

  • Basran GS, Morley J, Paul W, Turner-Warwick M (1982) Evidence in man of synergistic interaction between putative mediators of acute inflammation and asthma. Lancet 1:935–937

    CAS  PubMed  Google Scholar 

  • Bergström S, Sjövall J (1957) The isolation of prostaglandin. Acta Chem Scand 11:1086

    Google Scholar 

  • Bergstrom S, Duner H, von Euler US, Pernow B, Sjovall J (1959) Observations on the effects of infusion of prostaglandin E in man. Acta Physiol Scand 45:145–151

    CAS  Google Scholar 

  • Bergström S, Ryhage R, Samuelsson B, Sjövall J (1962) The structure of prostaglandin E, F1, and F2. Acta Chem Scand 16:501–502

    Google Scholar 

  • Bergström S, Danielsson H, Samuelsson B (1964) The enzymatic conversion of essential fatty acids into prostaglandins. J Biol Chem 239:4006–4008

    Google Scholar 

  • Bisgaard H, Kristensen J, Sondergaard J (1982) The effect of leukotriene C4 and D4 on cutaneous blood flow in humans. Prostaglandins 23:797–801

    CAS  Google Scholar 

  • Black AK, Greaves MW, Hensby CN, Plummer NA, Warin AP (1978) The effects of indomethacin on arachidonic acid and prostaglandins E2 and F2 levels in human skin 24 h after u.v.B. and u.v.C. irradiation. Br J Clin Pharmacol 6:261–266

    CAS  PubMed  Google Scholar 

  • Black AK, Fincham N, Greaves MW, Hensby CN (1980) Time course changes in levels of arachidonic acid and prostaglandins D2, E2, F2 in human skin following ultraviolet B irradiation. Br J Clin Pharmacol 10:453–157

    CAS  PubMed  Google Scholar 

  • Blackwell GJ, Flower RJ, Nijkamp FP, Vane JR (1978) Phospholipase A2 activity of guinea-pig isolated perfused lungs:stimulation, and inhibition by anti-inflammatory steroids. Br J Pharmacol 62:79–89

    CAS  PubMed  Google Scholar 

  • Blackwell GJ, Carnuccio R, Di Rosa M, Flower RJ, Parente L, Persico P (1980) Macrocortin:a polypeptide causing the anti-phospholipase effect of glucocorticoids. Nature 287:147–149

    CAS  PubMed  Google Scholar 

  • Boot JR, Dawson W, Kitchen EA (1976) The chemotactic activity of thromboxane B2:a possible role in inflammation. J Physiol (Lond) 257:47

    Google Scholar 

  • Borgeat P, Samuelsson B (1979 a) Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. J Biol Chem 254:2643–2646

    CAS  Google Scholar 

  • Borgeat P, Samuelsson B (1979 b) Metabolism of arachidonic acid in polymorphonuclear leukoeytes. J Biol Chem 254:7865–7869

    CAS  Google Scholar 

  • Borgeat P, Samuelsson B (1979 c) Arachidonic acid metabolism in polymorphonuclear leukocytes: effect of calcium ionophore A23187. Proc Natl Acad Sci USA 76:2148–2152

    CAS  Google Scholar 

  • Brain SD, Camp RDR, Dowd PM, Black AK, Woollard PM, Mallet Al, Greaves MW (1982 a) Psoriasis and leukotriene B. Lancet 11:762–763

    Google Scholar 

  • Brain SD, Camp RDR, Leigh IM, Fort-Hutchinson AW (1982 b) The synthesis of leukotriene B4-like material by cultured human keratinocytes. J Invest Dermatol 78:328

    Google Scholar 

  • Brain SD, Camp RDR, Charleson S, Dowd PM, Ford-Hutchinson AW, Greaves MW, Kobza Black A (1984) The release of LTC4-like material from the involved lesional skin in psoriasis. Br J Clin Pharmacol 17:650

    Google Scholar 

  • Bray MA (1983) The pharmacology and pathophysiology of leukotriene B4. Br Med Bull 39:249–254

    CAS  PubMed  Google Scholar 

  • Bray MA, Cunningham FM, Ford-Hutchinson AW, Smith MJH (1981 a) Leukotriene B4: a mediator of vascular permeability. Br J Pharmacol 72:483–486

    CAS  Google Scholar 

  • Bray MA, Ford-Hutchinson AW, Smith MJH (1981b) Leukotriene B4:biosynthesis an biological activities. In:Piper PJ (ed) SRS-A and leukotrienes. Wiley, London

    Google Scholar 

  • Bray MA, Ford-Hutchinson AW, Smith MJH (1981 c) Leukotriene B4: an inflammatory mediator in vivo. Prostaglandins 22:213–222

    CAS  Google Scholar 

  • Brocklehurst WE (1967) The probable role of known mediators in hypersensibility reactions. In:Schild HO (ed) Proceedings of the 3rd International Pharmacological Meeting, vol II. Pergamon, Oxford, pp 67–75

    Google Scholar 

  • Camp RDR, Coutts AA, Greaves MW, Kay AB, Walport MJ (1983a) Responses of human skin to intradermal injection of leukotrienes C4, D4, and B4. Br J Pharmacol 80:497–502

    Google Scholar 

  • Camp RDR, Mallet Al, Woollard PM, Brain SD, Kobza Black A, Greaves MW (1983 b) The identification of hydroxy fatty acids in psoriatic skin. Prostaglandins 26:431–448

    CAS  Google Scholar 

  • Camp RDR, Russell Jones R, Brain S, Woollard P, Greaves MW (1984) Production of in- traepidermal microabscesses by topical application of leukotriene B4. J Invest Dermatol 82:202–204

    CAS  PubMed  Google Scholar 

  • Cashin CH, Dawson W, Kitchen EA (1977) The pharmacology of benoxaprofen (2-[4-chlorophenyl]-α-methyl-5-benzoxazole acetic acid), LRCL 3794, a new compound with anti-inflammatory activity apparently unrelated to inhibition of prostaglandin synthesis. J Pharm Pharmacol 29:330–336

    CAS  PubMed  Google Scholar 

  • Crawford JP, Movat HZ, Ranadive NS, Hay JB (1982) Pathways to inflammation induced by immune complexes:development of the Arthus reaction. Fed Proc 41:2583–2587

    CAS  PubMed  Google Scholar 

  • Crunkhorn P, Willis AL (1969) Actions and interactions of prostaglandins administered intradermally in rat and man. Br J Pharmacol 36:216

    Google Scholar 

  • Crunkhorn P, Willis AL (1971) Interaction between prostaglandins E and F given intradermally in the rat. Br J Pharmacol 41:507–512

    CAS  Google Scholar 

  • Cunningham FM, Carter HR, Smith MJH, Ford-Hutchinson AW, Bray MA (1981) Aggregation of polymorphonuclear leucocytes (PMNs) by leukotriene B4:effects of cyclooxygenase products and metabolic inhibitors. Agents Actions 11:583–584

    CAS  PubMed  Google Scholar 

  • Danon A, Assonline G (1978) Inhibition of prostaglandin biosynthesis by corticosteroids requires RNA and protein synthesis. Nature 273:552–554

    CAS  PubMed  Google Scholar 

  • Dawson W, Boot JR, Harvey J et al. (1982) The pharmacology of benoxaprofen with particular reference to effects on lipoxygenase product formation. Eur J Rheumatol Inflamm 5:61–68

    CAS  PubMed  Google Scholar 

  • Dowd PM, Kobza Black A, Woollard P, Camp RDR, Greaves MW (1984) The in vivo properties of 12-hydroxyeicosatetraenoic acid (12-HETE) in normal skin. J Invest Dermatol 82:413–414 (abstract)

    Google Scholar 

  • Drazen JM, Austen KP, Lewis RA, Clark DA, Goto G, Marfat A, Corey EJ (1980) Comparative airway and vascular activities of leukotrienes C-l and D in vivo and in vitro. Proc Natl Acad Sci USA 77:4354–4358

    CAS  PubMed  Google Scholar 

  • Dusting GJ, Moncada S, Vane JR (1978) Vascular actions of arachidonic acid and its metabolites in the perfused mesenteric and femoral beds of the dog. Eur J Pharmacol 49:65–72

    CAS  PubMed  Google Scholar 

  • Fantone JC, Marasco WA, Eglas LJ, Ward PA (1983) Anti-inflammatory effects of prostaglandin Ex:in vivo modulation of the formyl peptide chemotactic receptor on the rat neutrophil. J Immunol 130:1495–1497

    CAS  PubMed  Google Scholar 

  • Ferreira SH (1972) Prostaglandins, aspirin-like drugs and analgesia. Nature New Biol 240:200–203

    CAS  PubMed  Google Scholar 

  • Ferreira SH, Moncada S, Vane JR (1971) Indomethacin and aspirin abolish prostaglandin release from the spleen. Nature New Biol 231:237–239

    CAS  PubMed  Google Scholar 

  • Ferreira SH, Nakamura M, Abreu Castro MS (1978) The hyperalgesic effects of prostacyclin and PGE2. Prostaglandins 16:31–37

    CAS  PubMed  Google Scholar 

  • Flower RJ (1974) Drugs which inhibit prostaglandin biosynthesis. Pharmacol Rev 26:33–67

    CAS  PubMed  Google Scholar 

  • Flower RJ (1978) Steroidal anti-inflammatory drugs as inhibitors of phospholipase A2. Adv Prostaglandin and Thromboxane Leukotriene Res 3:105–112

    CAS  Google Scholar 

  • Flower RJ, Blackwell GJ (1979) Anti-inflammatory steroids induce biosynthesis of a phospholipase A2 inhibitor which prevents prostaglandin generation. Nature 278:456–459

    CAS  PubMed  Google Scholar 

  • Flower RJ, Harvey EA, Kingston WP (1976) Inflammatory effects of prostaglandin D2 in rat and human skin. Br J Pharmacol 56:229–233

    CAS  PubMed  Google Scholar 

  • Ford-Hutchinson AW, Smith AW, Walker JR (1976) Chemotactic activity of solutions of prostaglandin E1. Br J Pharmacol 56:345

    Google Scholar 

  • Ford-Hutchinson AW, Bray MA, Doig MV, Shipley ME, Smith MJH (1980) Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286:264–265

    CAS  PubMed  Google Scholar 

  • Ford-Hutchinson AW, Bray MA, Cunningham FM, Davidson EM, Smith MJH (1981) Isomers of LTB4 possess different biological potencies. Prostaglandins 21:143

    CAS  PubMed  Google Scholar 

  • Goetzl EJ, Pickett WC (1980) The human PMN leukocyte chemotactic activity of complex hydroxy-eicosatetraenoic acids (HETEs). J Immunol 125:1789–1791

    CAS  PubMed  Google Scholar 

  • Goetzl EJ, Sun FF (1979) Generation of unique monohydroxy-eicosatetraenoic acids from arachidonic acid by neutrophils. J Exp Med 150:406–411

    CAS  PubMed  Google Scholar 

  • Goetzl EJ, Woods JMW, Gorman RR (1977) Stimulation of human eosinophil and neutrophil PMN chemotaxis and random migration by 12-HETE. J Clin Invest 59:179–183

    CAS  PubMed  Google Scholar 

  • Goetzl EJ, Weller PE, Sun FF (1980) The regulation of human eosinophil function by endogenous mono-hydroxy-eicosatetraenoic acids (HETEs). J Immunol 124:926–933

    CAS  PubMed  Google Scholar 

  • Goldblatt MW (1935) Properties of humans seminal fluid. J Physiol (Lond) 84:208–218

    CAS  Google Scholar 

  • Grabbe J, Czarnetzki BM, Mardin M (1982) Chemotactic leukotrienes in psoriasis. Lancet 11:1464

    Google Scholar 

  • Greaves MW, Sondergaard J, McDonald-Gibson W (1971) Recovery of prostaglandins in human cutaneous inflammation. Br Med J [Clin Res] 2:258–260

    CAS  Google Scholar 

  • Gryglewski RJ, Panczenko B, Korbut R, Grodzinska L, Ocetkiewicz A (1975) Corticosteroids inhibit prostaglandin release from perfused mesenteric blood vessels of rabbit and from perfused lungs of sensitised guinea-pig. Prostaglandins 5:531–542

    Google Scholar 

  • Hamberg M, Samuelsson B (1974) Prostaglandin endoperoxides. Novel transformation of arachidonic acid in human platelets. Proc Natl Acad Sci USA 71:3400–3404

    CAS  PubMed  Google Scholar 

  • Hamberg M, Svensson J, Samuelsson B (1975) Thromboxane:a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci USA 72:2994–2998

    CAS  PubMed  Google Scholar 

  • Hammerström S, Hamberg M, Samuelsson B, Duell EA, Stawiski M, Voorhees JJ (1975) Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2 in epidermis of psoriasis. Proc Natl Acad Sci USA 72:5130–5134

    Google Scholar 

  • Hammerström S, Hamberg M, Duell EA et al. (1977) Glucocorticoid in inflammatory proliferative skin disease reduces arachidonic and hydroxyeicosatetraenoic acids. Science 197:994–995

    Google Scholar 

  • Hammerström S, Lindgren JA, Marcelo C, Duell EA, Anderson TF, Voorhees JJ (1979) Arachidonic acid transformation in normal and psoriatic skin. J Invest Dermatol 73:180–183

    Google Scholar 

  • Higgs EA, Moncada S, Vane JR (1978a) Inflammatory effects of prostacyclin (PGI2) and 6-oxo PGF1α in the rat paw. Prostaglandins 16:153–162

    CAS  Google Scholar 

  • Higgs EA, O’Grady J, Thrower PA, Moncada S (1979) Prostacyclin: inflammatory effects in human skin. Fourth international prostaglandin conference, May 1979, Washington DC, meeting abstracts, p 48

    Google Scholar 

  • Higgs GA, McCall E, Youlten LJF (1975) A chemotactic role for prostaglandins released from polymorphonuclear leucocytes during phagocytosis. Br J Pharmacol 53:539–546

    CAS  PubMed  Google Scholar 

  • Higgs GA, Moncada S, Vane JR (1978 b) Prostacyclin (PGI2) as a potent dilator of arterioles in the hamster cheek pouch. J Physiol (Lond) 526:43

    Google Scholar 

  • Higgs GA, Salmon JA, Spayne JA (1981) The inflammatory effects of hydroperoxy and hydroxy acid products of arachidonate lipoxygenase in rabbit skin. Br J Pharmacol 74:429–433

    CAS  PubMed  Google Scholar 

  • Hirata F, Schiffmann E, Venkatasubramanian K, Salomon D, Axelrod J (1980) A phospholipase A2 inhibitory protein in rabbit neutrophils induced by glucocorticoids. Proc Natl Acad Sci USA 77:2533–2536

    CAS  PubMed  Google Scholar 

  • Horton EW (1963) Action of prostaglandin E1 on tissues which respond to bradykinin. Nature 200:892–893

    CAS  PubMed  Google Scholar 

  • Johnson RA, Morton DR, Kinner JH, Corman RR, McGuire JR, Sun FF, Whittaker N, Bunting S, Salmon J, Moncada S, Vane JR (1976) The chemical characterization of prostaglandin X (prostacyclin). Prostaglandins 12:915–928

    CAS  PubMed  Google Scholar 

  • Jonsson DC, Angaard E (1972) Biosynthesis and metabolism of prostaglandin E2 in human skin. Scand J Clin Lab Invest 29:289–296

    CAS  PubMed  Google Scholar 

  • Jose PJ, Forrest MJ, Williams TJ (1981) Human C5a des Arg increases vascular permeability. J Immunol 127:2376–2380

    CAS  PubMed  Google Scholar 

  • Juhlin S, Michaelsson G (1969) Cutaneous vascular reactions to prostaglandins in healthy subjects and in patients with urticaria and atopic dermatitis. Acta Derm Venereol (Stockh) 49:251–261

    CAS  Google Scholar 

  • Kaley G, Weiner R (1968) Microcirculatory studies with prostaglandin E1 In:Ramwell PW, Shaw JE (eds) Prostaglandin symposium of the Worcester foundation for experimental biology. Interscience, New York, pp 321–328

    Google Scholar 

  • Katayama H, Kawada A (1981) Exacerbation of psoriasis induced by indomethacin. J Dermatol 8:323–337

    CAS  PubMed  Google Scholar 

  • Kingston T, Marks R (1982) Benoxaprofen:effect on cutaneous lesions in psoriasis. Br Med J [Clin Res] 285:1741

    Google Scholar 

  • Kligman AM, Kaidbey KH (1982) Phototoxicity to benoxaprofen. Eur J Rheumatol Inflamm 5:124–137

    CAS  PubMed  Google Scholar 

  • Kobza Black A, Greaves MW, Hensby CN, Plummer NA (1978) Increased prostaglandins E2 and F2 in human skin 6 and 24 h after ultraviolet B irradiation (290–320 nm). Br J Clin Pharmacol 5:431–436

    Google Scholar 

  • Kobza Black A, Greaves MW, Hensby CN (1982) The effect of systemic prednisolone on arachidonic acid, and prostaglandin E2 and F2 levels in human cutaneous inflammation. Br J Clin Pharmacol 14:391–394

    Google Scholar 

  • Komoriya K, Ohmori H, Azuma A, Kurozumi S, Hashimoto Y, Nicolaou KC, Barnette WF, Mangolda RL (1978) Prostaglandins 15:557–564

    CAS  PubMed  Google Scholar 

  • Kopaniak MM, Hay JB, Movat HZ (1978) The effect of hyperemia on vascular permeability. Microvasc Res 15:77–82

    CAS  PubMed  Google Scholar 

  • Kragballe K, Herlin T (1983) Benoxaprofen improves psoriasis:a double blind study. Arch Dermatol 119:548–552

    CAS  PubMed  Google Scholar 

  • Kurzrok R, Lieb CC (1930) Biochemical studies of human semen. II. The action of semen on the human uterus. Proc Soc Exp Biol Med 28:268–272

    Google Scholar 

  • Lewis AJ, Nelson DJ, Sugrue MF (1975) On the ability of prostaglandin and arachidonic acid to modulate experimentally induced oedema in rat paw. Br J Pharmacol 55:51–56

    CAS  PubMed  Google Scholar 

  • Lewis GP, Westwick J, Williams TJ (1977) Microvascular responses produced by the prostaglandin endoperoxide PGG2 in vivo. Br J Pharmacol 59:442

    Google Scholar 

  • Malik KU, McGiff JC (1976) Cardiovascular actions of prostaglandins. In:Karim SMM (ed) Prostaglandins:physiological, pharmacological and pathological aspects. MTP Press, Lancaster, pp 103–200

    Google Scholar 

  • Moncada S, Ferreira SH, Vane JR (1973) Prostaglandins, aspirin-like drugs and the oedema of inflammation. Nature 246:217–219

    CAS  PubMed  Google Scholar 

  • Moncada S, Gryglewski R, Bunting S, Vane JR (1976) An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature 263:663–665

    CAS  PubMed  Google Scholar 

  • Needleman P, Moncada S, Bunting S, Vane JR, Hamberg M, Samuelsson B (1976) Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature 261:558–560

    CAS  PubMed  Google Scholar 

  • Nugteren DH (1975) Arachidonate lipoxygenase in blood platelets. Biochim Biophys Acta 380:299–307

    CAS  PubMed  Google Scholar 

  • O’Flaherty JT, Kreutzer DL, Ward PA (1979) Effect of prostaglandins E1, E2, and F2 on neutrophil aggregation. Prostaglandins 17 (2):201–210

    PubMed  Google Scholar 

  • O’Flaherty JT, Thomas MH, Less CJ, McCall CE (1981) Neutrophil aggregating activity of monohydroxy-eicosatetraenoic acids. Am J Pathol 104:55–62

    PubMed  Google Scholar 

  • Palmer RMJ, Stepney RJ, Higgs GA, Eakins K (1980) Chemokinetic activity of arachidonic acid lipoxygenase products on leucocytes of different species. Prostaglandins 20:411–418

    CAS  PubMed  Google Scholar 

  • Peck MJ, Williams TJ (1978) Prostacyclin (PGI2) potentiates bradykinin-induced plasma exudation in rabbit skin. Br J Pharmacol 62:464–465 P

    Google Scholar 

  • Peck MJ, Piper PJ, Williams TJ (1981) The effect of leukotrienes C4 and D4 on the micro-vasculature of guinea-pig skin. Prostaglandins 21:315–321

    CAS  PubMed  Google Scholar 

  • Phillips WS, Lightman SL (1981) Is cutaneous flushing prostaglandin mediated? Lancet 1:754–756

    CAS  PubMed  Google Scholar 

  • Piper PJ (1983) Pharmacology of leukotrienes. Br Med Bull 39:255–259

    CAS  PubMed  Google Scholar 

  • Piper PJ, Vane JR (1969) Release of additional factors in anaphylaxis and its antagonism by anti-inflammatory drugs. Nature 223:29–35

    CAS  PubMed  Google Scholar 

  • Rome LH, Lands WFM (1975) Structural requirements for time-dependent inhibition of prostaglandin biosynthesis by anti-inflammatory drugs. Proc Natl Acad Sci USA 72:4863–4865

    CAS  PubMed  Google Scholar 

  • Ruzicka T, Printz MP (1982) Arachidonic acid metabolism in guinea-pig skin. Biochim Biophys Acta 711:391–397

    CAS  PubMed  Google Scholar 

  • Ruzicka T, Simmer T, Peskar BA, Braun Falco O (1984) Leukotrienes in skin of atopic dermatitis. Lancet I:222

    Google Scholar 

  • Shen TY (1979) Prostaglandin synthetase inhibitors I. Handb Exp Pharmacol 50/11:305–347

    CAS  Google Scholar 

  • Sirois P, Roy S, Borgeat P, Picard S, Corey EJ (1981) Structural requirement for the action of leukotriene B4 on the guinea-pig lung:importance of double bond geometry in the 6,8,10-triene unit. Biochem Biophys Res Commun 99:385–390

    CAS  PubMed  Google Scholar 

  • Smith JB, Willis AL (1971) Aspirin selectively inhibits prostaglandin production in human platelets. Nature New Biol 321:235–237

    Google Scholar 

  • Solomon LM, Juhlin L, Kirschbaum MM (1968) Prostaglandins on cutaneous vasculature. J Invest Dermatol 51:280–282

    CAS  PubMed  Google Scholar 

  • Sondergaard J, Greaves MW (1970) Pharmacological studies in inflammation due to ultraviolet radiation. J Pathol 101:93–97

    CAS  PubMed  Google Scholar 

  • Sondergaard J, Greaves MW (1971) Prostaglandin E1:effect on human cutaneous vasculature and skin histamine. Br J Dermatol 84:424

    CAS  PubMed  Google Scholar 

  • Sondergaard J, Greaves MW, Jorgenson HP (1974) Recovery of prostaglandins in human primary irritant dermatitis. Arch Dermatol 110:556–558

    CAS  PubMed  Google Scholar 

  • Soter NA, Lewis RA, Corey EJ, Austen KF (1983) Local effects of synthetic leukotrienes (LTC4, LTD4, LTE4 and LTB4) in human skin. J Invest Dermatol 80:115–119

    CAS  PubMed  Google Scholar 

  • Strakosch CR, Jefferys DB, Keen H (1980) Blockade of chlorpropamide alcohol flush by aspirin. Lancet 1:394–396

    CAS  PubMed  Google Scholar 

  • Thomas G, West GB (1973) Prostaglandins as modulators of bradykinin responses. J Pharm Pharmacol 25:747–748

    CAS  PubMed  Google Scholar 

  • Turner SR, Campbell JA, Lynn WS (1975a) Polymorphonuclear leukocyte chemotaxis toward oxidized lipid components of cell membranes. J Exp Med 141:1437–1441

    CAS  PubMed  Google Scholar 

  • Turner SR, Tainer JA, Lynn WS (1975 b) Biogenesis of chemotactic molecules by the arachidonate lipoxygenase system of platelets. Nature 257:680–681

    CAS  Google Scholar 

  • Vadas P, Hay JB (1982) The appearance and significance of phospholipase A2 in lymph draining tuberculin reactions. Am J Pathol 107:285–291

    CAS  PubMed  Google Scholar 

  • Vadas P, Wasi S, Movat HZ, Hay JB (1981) Extracellular phospholipase A2 mediates inflammatory hyperaemia. Nature 293:583–585

    CAS  PubMed  Google Scholar 

  • Van Dorp DA, Beerthuis RK, Nugteren DH, Vonkeman H (1964) The biosynthesis of prostaglandins. Biochim Biophys Acta 90:204–207

    CAS  Google Scholar 

  • Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirinlike drugs. Nature 231:232–235

    CAS  Google Scholar 

  • Von Euler US (1936) On the specific vasodilating and plain muscle stimulating substance from accessory genital glands in man and certain animals (prostaglandin and vesiglandin). J Physiol (Lond) 88:213–234

    Google Scholar 

  • Wedmore CV, Williams TJ (1981) Control of vascular permeability by polymorphonuclear leucocytes in inflammation. Nature 289:646–650

    CAS  PubMed  Google Scholar 

  • Williams TJ (1979) Prostaglandin E2, prostaglandin I2 and the vascular changes of inflammation. Br J Pharmacol 65:517–524

    CAS  PubMed  Google Scholar 

  • Williams TJ (1982) Vasoactive intestinal polypeptide is more potent than prostaglandin E2 as a vasodilator and oedema potentiator in rabbit skin. Br J Pharmacol 77:505–509

    CAS  PubMed  Google Scholar 

  • Williams TJ (1983) Interactions between prostaglandins, leukotrienes and other mediators of inflammation. Br Med Bull 39:239–242

    CAS  PubMed  Google Scholar 

  • Williams TJ, Jose PJ (1981) Mediation of increased vascular permeability after complement activation:histamine-independent action of rabbit C5a. J Exp Med 153:136–153

    CAS  PubMed  Google Scholar 

  • Williams TJ, Morley J (1973) Prostaglandins as potentiators of increased vascular permeability in inflammation. Nature 246:215–217

    CAS  PubMed  Google Scholar 

  • Williams TJ, Peck MJ (1977) Role of prostaglandin-mediated vasodilatation in inflammation. Nature 270:530–532

    CAS  PubMed  Google Scholar 

  • Williams TJ, Piper PJ (1980) The action of chemically pure SRS-A on the microcirculation in vivo. Prostaglandins 19:779–789

    CAS  PubMed  Google Scholar 

  • Ziboh VA, Marcelo CL, Voorhees JJ (1981) Induced lipoxygenation of arachidonic acid in mouse epidermal keratinocytes by calcium ionophore A23187, abstracted. J Invest Dermatol 76:307

    Google Scholar 

  • Ziboh VA, Mallia C, Morhart E, Taylor JR (1982) Induced biosynthesis of cutaneous prostaglandins by ionizing irradiation (41362). Proc Soc Exp Biol Med 169:386–391

    CAS  PubMed  Google Scholar 

Download references

Authors
  1. S. D. Brain
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. J. Williams
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., F.R.C.P.

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Brain, S.D., Williams, T.J. (1989). Prostaglandins, Leukotrienes, Related Compounds and Their Inhibitors. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin I. Handbook of Experimental Pharmacology, vol 87 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73797-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73797-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73799-2

  • Online ISBN: 978-3-642-73797-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation