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Acetylcholine, Atropine and Related Cholinergics and Anticholinergics

  • M. A. Zar
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 1)

Abstract

There are sound reasons for believing that of all the neurotransmitters, acetylcholine (Fig. 1) was the earliest to appear during evolution (MICHAELSON 1974). It must be attributed to fortuitous coincidence that acetylcholine was also the first neurotransmitter to be isolated and identified in that role (LOEWI 1921; LOEWI and NAVRATIL 1926). Brilliant though the first definite demonstration of neurohumoral transmission by Loewi was, it must be appreciated that firm theoretical background for his research had been laid down earlier by the meticulously accurate comparison of the response to acetylcholine and to stimulation of parasympathetic nerves (DALE 1914).

Keywords

Muscarinic Receptor Sweat Gland Anticholinergic Drug Anticholinergic Agent Eccrine Sweat Gland 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Abell E, Morgan K (1974) The treatment of idiopathic hyperhidrosis by glycopyrronium bromide and tap water iontophoresis. Br J Dermatol 91:87–91PubMedCrossRefGoogle Scholar
  2. Ariens EJ (1954) Affinity and intrinsic activity in the theory of competitive inhibition. Arch Int Pharmacodyn Ther 99:32–9PubMedGoogle Scholar
  3. Birks R, MacIntosh FC (1961) Acetylcholine metabolism of a sympathetic ganglion. Can J Biochem Physiol 39:787–827CrossRefGoogle Scholar
  4. Briscoe S, Burn JH (1954) The formation of an acetylcholine-like substance by the isolated rabbit heart. J Physiol (Lond) 126:181–190Google Scholar
  5. Brun R, Favre F (1954) Experiences sur la transpiration. 7. Examens par certaines substances. Dermatologia 108:257–270CrossRefGoogle Scholar
  6. Burn JH, Kottegoda SR (1953) Action of eserine on the auricles of the rabbit heart. J Physiol (Lond) 121:360–373Google Scholar
  7. Coon JM, Rothman S (1939) Nature of the sweat response to drugs with nicotine-like action. Proc Soc Exp Biol Med 42:231–233Google Scholar
  8. Coon JM, Rothman S (1941) The sweat response to drugs with nicotine-like action. J Pharmacol Exp Ther 73:1–11Google Scholar
  9. Cotton DWK, Van den Hurk JJMA, Mier PD (1973) Hydrolysis of acetylcholine by soluble and particulate preparations of skin from normal and atopic subjects. Br J Dermatol 88:579–582PubMedCrossRefGoogle Scholar
  10. Dale HH (1914) The action of certain esters and ethers of choline and their relationship to muscarine. J Pharmacol Exp Ther 6:147–190Google Scholar
  11. Dale HH, Feldberg W (1934) The chemical transmission of secretory impulses to the sweat glands of the cat. J Physiol (Lond) 82:121–128Google Scholar
  12. Evans CL (1957) Sweating and sympathetic innervation. Br Med Bull 13:197–201PubMedGoogle Scholar
  13. Feldberg W, Lin RCY (1950) Synthesis of acetylcholine in the wall of the digestive tract. J Physiol (Lond) 111:96–118Google Scholar
  14. Frankland JC, Seville RH (1971) The treatment of hyperhidrosis with topical propantheline — a new technique. Br J Dermatol 85:577–581PubMedCrossRefGoogle Scholar
  15. Gibson TE, Shelley WB (1948) Sexual and racial difference in the response of sweat glands to acetylcholine and pilocarpine. J Invest Dermatol 11:137–142PubMedGoogle Scholar
  16. Grice KA, Bettley FR (1966) Inhibition of sweating by poldine methosulphate (Nacton). Its use for measuring insensible perspiration. Br J Dermatol 78:458–464PubMedCrossRefGoogle Scholar
  17. Harbison RD, Olubadewo JO, Dwivedi C, Sastry BVR (1975) Proposed role of the placental cholinergic system in the regulation of fetal growth and development. In: Morselli PL, Garattini S, Sereni F (eds) Basic and therapeutic aspects of perinatal pharmacology. Raven, New York, pp 107–120Google Scholar
  18. Herxheimer A (1956) The nervous pathway mediating cholinergic urticaria. Clin Sci 15:195–205PubMedGoogle Scholar
  19. Hurley HJ, Shelley WB, Koelle GB (1953) The distribution of cholinesterases in human skin with special reference to eccrine and apocrine sweat glands. J Invest Dermatol 21:139–147PubMedGoogle Scholar
  20. Janowitz HD, Grossman MI (1950) The response of sweat glands to some locally acting agents in human subjects. J Invest Dermatol 13:453–458Google Scholar
  21. Johnson RH, Spalding JMK (1974) Disorders of autonomic nervous system. Blackwell, Oxford, pp 179–198Google Scholar
  22. Kahn D, Rothman S (1942) Sweat response to acetylcholine. J Invest Dermatol 5:431–444CrossRefGoogle Scholar
  23. Kuno Y, Kashiwabara K (1937) An effective method for suppression of local sweating. Chin J Physiol 11:41–45Google Scholar
  24. Lloyd DPC (1965) Cholinergy and adrenergy in the neural control of sweat glands. In: Curtis DR, McIntyre AK (eds) Studies in physiology. Springer, Berlin Heidelberg New York, pp 169–178Google Scholar
  25. Loewi O (1921) Über humorale Ubertragbarkeit der Herznervenwirkung. Pflügers Arch Ges Physiol 189:239–242CrossRefGoogle Scholar
  26. Loewi O, Navratil E (1926) Über humorale Übertragbarkeit der Herznervenwirkung. X. Mitteilung über das Schicksal des Vagusstoff. Pflügers Arch Ges Physiol 214:688Google Scholar
  27. Longmore J, Bradshaw CM, Szabadi E (1985) Effects of locally and systemically administered cholinoceptor antagonists on the secretory response of human eccrine sweat glands to carbachol. Br J Clin Pharmacol 20:1–8PubMedGoogle Scholar
  28. MacMillan FSK, Reller HH, Synder FH (1964) The antiperspirant action of topically applied anticholinergics. J Invest Dermatol 43:363–377PubMedGoogle Scholar
  29. Magnus I A, Thompson RHS (1954) Cholinesterase activity of human skin. Br J Dermatol 66:163–174PubMedCrossRefGoogle Scholar
  30. Maple S, Bradshaw CM, Szabadi E (1982) Pharmacological responsiveness of sweat glands in anxious patients and healthy volunteers. Br J Psychiatry 141:154–161PubMedCrossRefGoogle Scholar
  31. McMahan D (1972) Chemical messengers in development: a hypothesis. Science 185:1012–1021CrossRefGoogle Scholar
  32. Megay KV (1935) Versuche an biologischen Testobjekten über die Natur des im Schweiβ vorhandenen vagometischen Stoffes. Pflügers Arch Ges Physiol 236:159–165CrossRefGoogle Scholar
  33. Michaelson MJ (1974) Some aspects of evolutionary pharmacology. Biochem Pharmacol 23:2211–2224CrossRefGoogle Scholar
  34. Mier PD, Cotton DWK (1976) The molecular biology of skin, 1st edn. Blackwell, OxfordGoogle Scholar
  35. Ott I, Wood Field GBW (1878) Sweat centres: the effect of muscarin and atropin on them. J Physiol (Lond) 1:193–195Google Scholar
  36. Paton WDM, Zar MA (1968) The origin of acetylcholine released from guinea-pig intestine and longitudinal muscle strips. J Physiol (Lond) 194:13–33Google Scholar
  37. Randall WC, Kimura KK (1955) The pharmacology of sweating. Pharmacol Rev 7:365–397PubMedGoogle Scholar
  38. Rothman S, Coon JM (1940) Axon reflex response to acetylcholine in the skin. J Invest Dermatol 3:79–97CrossRefGoogle Scholar
  39. Ryan TJ (1973) Inflammation, fibrin and fibrinolysis. In: Jarret A (ed) The physiology and pathophysiology of the skin, vol 2. Academic, London, pp 745–777Google Scholar
  40. Sastry BVR, Sadavongvivad C (1978) Cholinergic systems in non-nervous tissues. Pharmacol Rev 30:65–132PubMedGoogle Scholar
  41. Sato K (1977) The physiology, pharmacology and biochemistry of the eccrine sweat glands. Rev Physiol Biochem Pharmacol 79:51–131PubMedCrossRefGoogle Scholar
  42. Scott A (1962) Acetylcholine in normal and diseased skin. Br J Dermatol 74:317–322PubMedCrossRefGoogle Scholar
  43. Shelley WB, Horvath PN (1951) Comparative study on the effect of anticholinergic compounds on sweating. J Invest Dermatol 16:267–274PubMedGoogle Scholar
  44. Silver A, Versau A, Montagna W (1963) Studies of sweating and sensory function in cases of peripheral nerve injuries of the hand. J Invest Dermatol 40:243–258PubMedGoogle Scholar
  45. Singer M (1959) The acetylcholine content of the normal forelimb regenerate of the adult newt, Triturus. Dev Biol 1:603–620CrossRefGoogle Scholar
  46. Singer M (1974) Neurotropic control of limb regeneration in the newt. Ann NY Acad Sci 228:308–321PubMedCrossRefGoogle Scholar
  47. Stephenson RP (1956) A modification of receptor theory. Br J Pharmacol Chemother 11:379–393PubMedGoogle Scholar
  48. Stoughton RB, Chiu F, Fritsch W, Nurse D (1964) Topical suppression of eccrine sweat delivery with a new anticholinergic. J Invest Dermatol 42:151–155PubMedGoogle Scholar
  49. Thayson JH, Schwartz IL, Dole VP (1952) Fatigue of sweat glands. Fed Proc 11:161–162Google Scholar
  50. Tweedy J, Ringer S (1880) On the mydriatic properties of homatropin or oxytoluyltropein. With an account of its general physiological action. Lancet 1:795–796CrossRefGoogle Scholar
  51. Van den Broek MD, Bradshaw CM, Szabadi E (1984) The effects of psychological “stressor” and raised ambient temperature on the pharmacological responsiveness of human eccrine sweat glands: implications for sweat gland hyper-responsiveness in anxiety states. Eur J Clin Pharmacol 26:209–213PubMedCrossRefGoogle Scholar
  52. Wada M, Arai T, Takagaki T, Nakagawa T (1952) Axon reflex mechanism in sweat responses to nicotine, acetylcholine and sodium chloride. J Appl Physiol 4:745–752PubMedGoogle Scholar
  53. Warndorff JA (1970) The response of the sweat gland to acetylcholine in atopic subjects. Br J Dermatol 83:306–311PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

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  • M. A. Zar

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