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Histamine, Histamine Antagonists and Cromones

  • Chapter
Book cover Pharmacology of the Skin I

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 1))

Abstract

Histamine was discovered independently from two sources in the first decade of this century by KUTSCHER (1910) and by WINDAUS and VOGT (1907). WINDAUS and VOGT prepared histamine synthetically by the decarboxylation of histidine whereas Kutscher identified histamine as a base in ergot. Histamine is so called because the Greek word HISTOS means tissue and BARGER and DALE (1910) isolated the amine from guinea-pig intestinal tissue. Following the discovery of histamine in mammalian tissue, there was an extensive study of its biological effects by DALE and LAIDLAW (1910,1911), who noted the parallel between the actions of histamine in animals and the response of an animal to a foreign protein, normally inert, but to which the animal had been sensitised by prior injection. DALE and LAIDLAW (1919) also demonstrated that it was possible to produce shock in animals by the injection of histamine. DALE (1913) and SCHULTZ (1910) both independently demonstrated an anaphylactic reaction in isolated smooth muscle, following the original description in whole animals of the anaphylactic reaction to foreign protein by PORTIER and RICHET (1902).

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Authors
  1. J. C. Foreman
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Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Foreman, J.C. (1989). Histamine, Histamine Antagonists and Cromones. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin I. Handbook of Experimental Pharmacology, vol 87 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73797-8_18

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  • DOI: https://doi.org/10.1007/978-3-642-73797-8_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73799-2

  • Online ISBN: 978-3-642-73797-8

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