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Pharmacology of the Skin I pp 271–286Cite as

Cytokines in Relation to Inflammatory Skin Disease

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 87 / 1))

Abstract

Cytokines are soluble, non-antibody proteins that orchestrate many immunological reactions including cell-mediated immune responses; lymphocyte activation, proliferation and differentiation; and haemopoietic mechanisms. The term encompasses the mediators derived from activated T-lymphocytes, i.e. lymphokines (LKs) (DUMONDE et al. 1969); monocytes/macrophages, i.e. monokines (MKs) (WAKSMAN and NAMBA 1976); and those mediators whose cellular origin is known to be more diverse, e.g. interferons. All cytokines were originally described in terms of their biological activity(ies) with little knowledge of their chemical structure. From the application of more precise biological assays, immunoassays, and more sensitive biochemical techniques, it became apparent that different lymphokine or cytokine activities could actually be mediated by the same molecule(s). Consequently, at the 2nd International Workshop on Lymphokines in 1979, the generic term “interleukin” (“between leucocytes”) was introduced to bring together some of these mediators (AARDEN et al. 1979). Historically, the concept of special mediators of immunological regulation, rather than direct cellular or anti-body-mediated mechanisms, evolved from studies of delayed-type hypersensitivity and inflammation, and has been extensively documented (ADELMAN et al. 1979; ROCKLIN et al. 1980; WATSON 1981; HANSON et al. 1982; DUMONDE and HAMBLIN 1983).

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Authors
  1. K. A. Brown
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  2. B. A. Ellis
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  3. D. C. Dumonde
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Editor information

Editors and Affiliations

  1. The Institute of Dermatology, St. Thomas’s Hospital, Lambeth Palace Road, SE1 7EH, London, Great Britain

    Malcolm W. Greaves M.D., Ph.D., F.R.C.P.

  2. Department of Dermatology, The Royal Victoria Infirmary, The University of Newcastle upon Tyne, NE1 4LP, Newcastle upon Tyne, Great Britain

    Sam Shuster M.D., F.R.C.P.

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© 1989 Springer-Verlag Berlin Heidelberg

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Brown, K.A., Ellis, B.A., Dumonde, D.C. (1989). Cytokines in Relation to Inflammatory Skin Disease. In: Greaves, M.W., Shuster, S. (eds) Pharmacology of the Skin I. Handbook of Experimental Pharmacology, vol 87 / 1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73797-8_17

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  • DOI: https://doi.org/10.1007/978-3-642-73797-8_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73799-2

  • Online ISBN: 978-3-642-73797-8

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