Metabolism of Sex Steroids

  • F. Wright
  • P. Mauvais-Jarvis
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 87 / 1)

Abstract

In recent years, human skin has been recognised as a target organ for several steroid hormones, among them sex steroids, i.e. androgens, oestrogens and progesterone. Human skin participates not only in the catabolism of these steroids but also in the synthesis of active hormones from steroid precursors supplied by the blood vessels.

Keywords

Testosterone Progesterone NADPH Androgen Acne 

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References

  1. Adachi K (1973) The metabolism and control mechanism of human hair follicles. Curr Probl Dermatol 5:37–78PubMedGoogle Scholar
  2. Baulieu EE, Jung I (1970) A prostatic cytosol receptor. Biochem Biophys Res Commun 38:599–606PubMedCrossRefGoogle Scholar
  3. Bruchovsky N, Lieskovsky G (1979) Increased ratio of 5α-reductase:3 α (β) hydroxysteroid dehydrogenase activities in the hyperplastic human prostate. J Endocrinol 80:289–301PubMedCrossRefGoogle Scholar
  4. Bruchovsky N, Wilson JD (1968a) The conversion of testosterone to 5 α-androstane-17β-ol-3-one by rat prostate in vivo and in vitro. J Biol Chem 243:2012–2021Google Scholar
  5. Bruchovsky N, Wilson JD (1968 b) The intranuclear binding of testosterone and 5 α-an-drostane-17β-ol-3-one by rat prostate. J Biol Chem 243:5953–5960Google Scholar
  6. Chakraborty J, Thomson J, Mac Swenn MP, Muir AV, Caiman KC, Grant JK, Milne JA (1970) The in vitro metabolism of 7α-3H-dehydroepiandrosterone by human skin. Br J Dermatol 83:477–82Google Scholar
  7. Cherif-Cheikh JL, de Lignieres B (1974) Traitement de la séborrhée du cuir chevelu par la progestérone percutanée. Sem Hôp Ther 50:489–506Google Scholar
  8. Ebling FJ (1963) Hormonal control of the sebaceous gland in experimental animals. In:Montagna W, Ellis RA, Silver AF (eds) Sebaceous glands, vol IV. Pergamon, Oxford, pp 200–211Google Scholar
  9. Feldman RJ, Maibach HI (1969) Percutaneous penetration of steroids in man. J Invest Dermatol 52:89–94Google Scholar
  10. Flamigni C, Collins WP, Koullapis EN, Craft I, Dewhurst CJ, Sommerville IF (1971) Androgen metabolism in human skin. J Clin Endocrinol Metab 32:737–743PubMedCrossRefGoogle Scholar
  11. Frost P, Weinstein GD, Hsia SL (1966) Metabolism of estradiol-17β and estrone in human skin. J Invest Dermatol 46:584–585Google Scholar
  12. Frost P, Gomez EC, Weinstein GD, Lamas J, Hsia SL (1969) Metabolism of progesterone-4-14C in vitro in human skin and vaginal mucosa. Biochemistry 8:948–952CrossRefGoogle Scholar
  13. Giacomini M, Wright F (1980) The effects of progesterone and pregnanedione on the reductive metabolism of dihydrotestosterone in human skin. J Steroid Biochem 13:645–651PubMedCrossRefGoogle Scholar
  14. Gomez EC, Hsia SL (1968) In vitro metabolism of testosterone-4-14C and Δ4-androstene-3,17-dione-4-14C in human skin. Biochemistry 7:24–32PubMedCrossRefGoogle Scholar
  15. Imperato McGinley J, Guerrero L, Gautier T, Peterson RE (1974) Steroid 5α-reductase deficiency in man:an inherited form of male pseudohermaphrodism. Science 186:1213–1215CrossRefGoogle Scholar
  16. Keenan BS, Meyer WJ, Hadjian AJ, Migeon CJ (1975) Androgen receptor in human skin fibroblasts. Characterization of a specific 17β-hydroxy-5α-androstan-3-one-protein complex in cell sonicates and nuclei. Steroids 25:535–552PubMedCrossRefGoogle Scholar
  17. Kuttenn F, Mauvais-Jarvis P (1975) Testosterone 5 α-reduction in the skin of normal subjects and of patients with abnormal sex development. Acta Endocrinol 79:164–176PubMedGoogle Scholar
  18. Kuttenn F, Mowszowicz I, Wright F, Baudot N, Jaffiol C, Robin M, Mauvais-Jarvis P (1979) Male pseudohermaphroditism:a comparative study of one patient with 5 α-reductase deficiency and three patients with the complete form of testicular feminization. J Clin Endocrinol Metab 49:861–865PubMedCrossRefGoogle Scholar
  19. Kuttenn F, Mowszowicz I, Mauvais-Jarvis P (1980) Androgen metabolism in human skin. In:Mauvais-Jarvis P, Vickers CFH, Wepierre J (eds) Percutaneous absorption of steroids. Academic, London, pp 99–121Google Scholar
  20. Mahoudeau J A, Bardin CW, Lipsett MB (1971) The metabolic clearance rate and origin of plasma dihydro testosterone in man and its conversion to the 5 α-androstanediols. J Clin Invest 50:1338–1344PubMedCrossRefGoogle Scholar
  21. Mainwaring WIP (1975) Steroid hormone receptors:a survey. Vitam Horm 33:223–246PubMedCrossRefGoogle Scholar
  22. Mauvais-Jarvis P (1977) Androgen metabolism in human skin:mechanisms of control. In:Martini L, Motta M (eds) Androgens and antiandrogens. Raven, New York, pp 229–245Google Scholar
  23. Mauvais-Jarvis P, Bercovici JP, Gauthier F (1969a) In vivo studies on testosterone metabolism by skin of normal males and patients with the syndrome of testicular feminization. J Clin Endocrinol Metab 29:417–419CrossRefGoogle Scholar
  24. Mauvais-Jarvis P, Baudot N, Bercovici JP (1969b) In vitro studies on progesterone metabolism by human skin. J Clin Endocrinol Metab 29:1580–1585CrossRefGoogle Scholar
  25. Mauvais-Jarvis P, Bercovici JP, Crepy O, Gauthier F (1970) Studies on testosterone metabolism in subjects with testicular feminization syndrome. J Clin Invest 49:31–40PubMedCrossRefGoogle Scholar
  26. Mauvais-Jarvis P, Kuttenn F, Baudot N (1974) Inhibition of testosterone conversion to di- hydrotestosterone in men treated percutaneously by progesterone. J Clin Endocrinol Metab 38:142–147PubMedCrossRefGoogle Scholar
  27. Mauvais-Jarvis P, Kuttenn F, Wright F (1975) La progesterone administree par voie percutanée. Un antiandrogene a action locale. Ann Endocrinol 36:55–62Google Scholar
  28. Mauvais-Jarvis P, Kuttenn F, Gauthier-Wright F (1976) Testosterone 5α-reduction in human skin as an index of androgenicity. In:James VHT, Serio M, Giusti G (eds) The endocrine function of the human ovary. Academic, New York, pp 481–494Google Scholar
  29. Mowszowicz I, Wright F (1979) A simple and reliable technique for separating the androgen receptor from testosterone binding globulin in human tissues. Anal Biochem 92:164–169PubMedCrossRefGoogle Scholar
  30. Mowszowicz I, Kirchhoffer MO, Kuttenn F, Mauvais-Jarvis P (1980) Testosterone 5a-reductase activity of skin fibroblasts increase with serial subcultures. Mol Cell Endocrinol 17:41–50PubMedCrossRefGoogle Scholar
  31. Mowszowicz I, Riahi M, Wright F, Bouchard P, Kuttenn F, Mauvais-Jarvis P (1981 a) Androgen receptor in human skin cytosol. J Clin Endocrinol Metab 52:338–344CrossRefGoogle Scholar
  32. Mowszowicz I, Kopp F, Martin PM ( 1981 b) Multiple steroid binding sites in human skin cytosol. Und CIRD international symposium, Sophia Antipolis France, October 1981Google Scholar
  33. Robel P, Lasnitzki I, Baulieu EE (1971) Hormone metabolism and action:testosterone and metabolites in prostate organ culture. Biochimie 53:81–96CrossRefGoogle Scholar
  34. Rongone EL (1966) Testosterone metabolism by human male mammary skin. Steroids 7:489–504PubMedCrossRefGoogle Scholar
  35. Siiteri PK, Wilson JD (1974) Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab 38:113–125PubMedCrossRefGoogle Scholar
  36. Stewart ME, Pochi PE, Strauss JS, Wotiz HH, Clark SJ (1977) In vitro metabolism of 3H-testosterone by scalp and back skin:conversion of testosterone to 5α-androstane-3β,17β-diol. J Endocrinol 72:385–390PubMedCrossRefGoogle Scholar
  37. Voigt W, Hsia SL (1973) Further studies on testosterone -reductase of human skin. Structural features of steroid inhibitors. J Biol Chem 248:4280–4285PubMedGoogle Scholar
  38. Voigt W, Fernandez EP, Hsia SL (1970) Transformation of testosterone into 17β-hydroxy-5α-androstane-3-one by microsomal preparation of human skin. J Biol Chem 245:5594–5599PubMedGoogle Scholar
  39. Wilson JD, Walker JD (1969) The conversion of testosterone to 5α-androstan-17β-ol-3-one (dihydrotestosterone) by skin slices of man. J Clin Invest 48:371–378PubMedCrossRefGoogle Scholar
  40. Wright F, Giacomini M (1980) Reduction of dihydrotestosterone to androstanediols by human female skin in vitro. J Steroid Biochem 13:639–643PubMedCrossRefGoogle Scholar
  41. Wright F, Mowszowicz I, Mauvais-Jarvis P (1978) Urinary 5a-androstane-3α,17β-diol radioimmunoassay:a new clinical evaluation. J Clin Endocrinol Metab 47:850–854PubMedCrossRefGoogle Scholar
  42. Wright F, Kirchhoffer MO, Giacomini M (1980) Anti-androgen activity of progesterone in human skin. In:Mauvais-Jarvis P, Vickers CFH, Wepierre J (eds) Percutaneous absorption of steroids. Academic, London, pp 123–137Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. Wright
  • P. Mauvais-Jarvis

There are no affiliations available

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