Abstract
A successful antifertility vaccine, based on β-HCG (human chorionic gonadotropin), sperm, or other reproductive-tissue-specific antigens, must elicit an immune response which effectively achieves an antifertility effect. A major problem facing antifertility-vaccine development is the fact that reproductive-tissue antigens are weak immunogens; most vaccine studies to date, in both animal models and human phase I clinical trials, have failed to produce a sustained antibody response and/or the desired antifertility effect.
This research was supported by NIH grant CA 42738 and by the Fearing Laboratory Endowment.
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© 1988 Springer-Verlag Berlin Heidelberg
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Anderson, D.J., Hill, J.A., Haimovici, F., Xu, C. (1988). Application of New Concepts in Cell-Mediated Immunity to the Development of Effective Antifertility Vaccines. In: Runnebaum, B., Rabe, T., Kiesel, L. (eds) Female Contraception. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73790-9_34
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DOI: https://doi.org/10.1007/978-3-642-73790-9_34
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