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Application of New Concepts in Cell-Mediated Immunity to the Development of Effective Antifertility Vaccines

  • D. J. Anderson
  • J. A. Hill
  • F. Haimovici
  • C. Xu

Abstract

A successful antifertility vaccine, based on β-HCG (human chorionic gonadotropin), sperm, or other reproductive-tissue-specific antigens, must elicit an immune response which effectively achieves an antifertility effect. A major problem facing antifertility-vaccine development is the fact that reproductive-tissue antigens are weak immunogens; most vaccine studies to date, in both animal models and human phase I clinical trials, have failed to produce a sustained antibody response and/or the desired antifertility effect.

Keywords

Female Reproductive Tract Human Endometrium Sperm Function Male Reproductive Tract Sperm Antigen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. J. Anderson
    • 1
  • J. A. Hill
    • 1
  • F. Haimovici
    • 1
  • C. Xu
    • 1
  1. 1.Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive BiologyHarvard Medical SchoolBostonUSA

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