Application of New Concepts in Cell-Mediated Immunity to the Development of Effective Antifertility Vaccines

  • D. J. Anderson
  • J. A. Hill
  • F. Haimovici
  • C. Xu


A successful antifertility vaccine, based on β-HCG (human chorionic gonadotropin), sperm, or other reproductive-tissue-specific antigens, must elicit an immune response which effectively achieves an antifertility effect. A major problem facing antifertility-vaccine development is the fact that reproductive-tissue antigens are weak immunogens; most vaccine studies to date, in both animal models and human phase I clinical trials, have failed to produce a sustained antibody response and/or the desired antifertility effect.


Female Reproductive Tract Human Endometrium Sperm Function Male Reproductive Tract Sperm Antigen 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • D. J. Anderson
    • 1
  • J. A. Hill
    • 1
  • F. Haimovici
    • 1
  • C. Xu
    • 1
  1. 1.Fearing Research Laboratory, Department of Obstetrics, Gynecology and Reproductive BiologyHarvard Medical SchoolBostonUSA

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