Desensitization of Pituitary Cells by Gonadotropin-Releasing Hormone in Vitro
Gonadotropin-releasing hormone (GnRH) stimulates the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The decapeptide is secreted from the hypothalamus in a pulsatile manner in humans and animals. This secretory pattern results in a pulsatile release of gonadotropins in women (Kiesel et al. 1986 a). Continuous administration of high doses of GnRH or its potent analogues induces desensitization of the pituitary to physiological pulses of GnRH, thus leading to medical castration. This method of pituitary desensitization has already gained importance in the treatment of sex-hormone-dependent diseases, such as endometriosis, uterine leiomyoma, precocious puberty, prostrate and breast cancer, as well as in contraception (see review by Sandow 1986). The mechanism of this effect, however, has not yet been fully clarified.
KeywordsLuteinizing Hormone Pituitary Cell GnRH Receptor Luteinizing Hormone Release Preincubation Period
Unable to display preview. Download preview PDF.
- Helm KJ, Kiesel L, Rabe T, Runnebaum B (1987) Kinetics of gonadotropin-releasing hormone induced desensitization of rat pituitary cells. Acta Endocrinol [Suppl 283] 114:184Google Scholar
- Kiesel L, Rabe T, Schleef J, Schweizer M, Klinga K, Runnebaum B (1986 a) Pulsatile secretory pattern of gonadotropins and steroids during the follicular and luteal phase of the menstrual cycle in women. In: Pulsatile GnRH 1985. Proceedings of the 3rd Ferring symposium on pulsatile GnRH, Noordwijk, 11–13 September 1985, Ferring, Haarlem, pp 43–49Google Scholar
- Kiesel L, Przylipiak A, Rabe T, Runnebaum B (1986 c) The role of novel arachidonic acid metabolites in GnRH action on gonadotropin release in vitro. Human Reprod 1:349–352Google Scholar
- Sandow J (1986) Pharmacology of LHRH agonists. In: Furr, Vakeling (eds) Pharmacology and clinical uses of hormone secretion and action. Holt-Saunders, Eastbourne, pp 365–384Google Scholar