Midazolam in Total Intravenous Anaesthesia. Pharmacodynamic and Pharmacokinetic Aspects
The history of intravenous anaesthesia goes back to 1665 when Sir Christopher Wren  published his experiments on the injection of opium into a ligated vein of a dog using a quill and a bladder as syringe. He reported “the success was that opium, being soon circulated into the brain, did within a short time stupify, though not kill the dog”. Intravenous anaesthesia had thus been described and a continuous search for agents with suitable pharmacodynamic and pharmacokinetic properties was initiated. The safe use of intravenous anaesthesia developed not only from research work but also from the many incidents that occurred during these early days. One of the most dramatic examples of this was the seemingly indiscriminate use of barbiturates in casualities following the Japanese raid on Pearl Harbour in 1941 . The drugs used, thiopentone and hexobarbitone, were described as “an ideal form of euthanasia”.
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