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Die Bedeutung der Prostaglandine in der Pathophysiologie der Sepsis

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ZAK München 1987

Zusammenfassung

Die Prostaglandine gehören zu einem der vielen biologischen Mediatorsysteme, die in der Pathogenese des sepsisbedingten Multiorganversagens eine mutmaßliche Rolle spielen. Der Begriff Mediator bezieht sich auf ihre Funktion als Vermittler jener Effekte, die der Generalauslöser der gram-negativen chirurgischen Sepsis, das Endotoxin, auf eine Reihe von Organen und Organellen ausübt (vgl. Abb. 1).

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Literatur

  1. Bihari D, Smithies M, Gimson A, Tinker J (1987) The effects of vasodilatation with prostacyclin on oxygen delivery and uptake in critically ill patients. N Engl J Med 317:397–402

    Article  PubMed  CAS  Google Scholar 

  2. Blackwell GJ, Flower RJ, Hermann AG (1976) Effect of endotoxin on 15-hydroxyprosta- glandin-dehydrogenase in the rabbit jejunum and lung. Arch Int Pharmacodyn Ther 220:325

    PubMed  CAS  Google Scholar 

  3. Frölich JL, Ogletree M, Peskar BA, Brigham KL (1980) Pulmonary hypertension correlated to pulmonary thromboxane synthesis. In: Samuellson B, Ramwell PW, Paoletti R (eds) Advances in prostaglandins and thromboxane research. Raven Press 7, New York, pp 745–750

    Google Scholar 

  4. Messmer K (1987) Microcirculatory changes in endotoxinemia and septic shock. In: Vincent JL, Thijs LG (eds) Septic shock. (Update in intensive care and emergency medicine) Springer, Berlin Heidelberg New York London Paris Tokyo, pp 35–42

    Chapter  Google Scholar 

  5. Nakano J, Pracan AV (1973) Metabolic degradation of prostaglandin E1 in the lung and kidney of rats in endotoxin shock. Proc Soc Exp Biol Med 144:506

    PubMed  CAS  Google Scholar 

  6. Ogletree ML, Brigham KL (1979) Indomethacin augments endotoxin induced increased lung vascular permeability in sheep. Am Rev Respir Dis 119:383–389

    Google Scholar 

  7. Oettinger WKE, Walter GO, Jensen UM, Beyer A, Peskar BA (1983) Endogenous prostaglandin F in the hyperdynamic state of severe sepsis in man. Br J Surg 70 :237–239

    Article  PubMed  CAS  Google Scholar 

  8. Oettinger W (1987) Role of Prostaglandins and thromboxane. In: Vincent JL, Thijs LG (eds) Septic shock. (Update in intensive care and emergency medicine) Springer, Berlin Heidelberg New York London Paris Tokyo, pp 89–107

    Chapter  Google Scholar 

  9. Piper P, Vane J, Wyllie J (1970) Inactivation of prostaglandins by the lung. Nature 255:600–604

    Article  Google Scholar 

  10. Peskar BM, Weiler H, Kröner EE, Peskar BA (1981) Release of prostaglandins by small intestinal tissue of man and rat in vitro and the effect of endotoxin in the rat in vivo. Prostaglandins 21, 9

    Article  PubMed  CAS  Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Oettinger, W. (1988). Die Bedeutung der Prostaglandine in der Pathophysiologie der Sepsis. In: Peter, K., Groh, J. (eds) ZAK München 1987. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73786-2_4

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  • DOI: https://doi.org/10.1007/978-3-642-73786-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19387-6

  • Online ISBN: 978-3-642-73786-2

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