Skip to main content
SpringerLink
Log in

Medikamentöse Therapie des ARDS

  • Conference paper
Book cover ZAK München 1987

  • 19 Accesses

Zusammenfassung

Die Vielzahl der Faktoren, die ein akutes Atemnotsyndrom des Erwachsenen auslösen können, und die Komplexität der beteiligten Pathomechanismen erschweren die Suche nach einem medikamentösen Therapieansatz, der über die supportive Therapie hinausgreift. An 1. Stelle muß daher die Behandlung der Grunderkrankung, z.B. die Behebung eines Schockzustandes, stehen. Ist dies nicht möglich, so kann potentiell ein Eingriff in den Ablauf der zellulären und humoralen Pathomechanismen ein weiteres Fortschreiten der Erkrankung verhindern. Die Manifestationen des Syndroms, wie pulmonale Hypertension und Lungenödem, sind ebenfalls einer Pharmakotherapie zugänglich. Über die Beeinflußbarkeit der Reparaturphase der Erkrankung im Sinne einer Vorbeugung und Vorbereitung der Wiederherstellung des geschädigten Organs ist bisher wenig bekannt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Appel PL, Shoemaker WC (1984) Hemodynamic and oxygen transport effects of prostaglandin El in patients with adult respiratory distress syndrome. Crit Care Med 12:528

    Article  PubMed  CAS  Google Scholar 

  2. Baumgartner J-D, Glauser MP, McCutchan JA, et al (1985) Prevention of gram-negative shock and death in surgical patients by antibody to endotoxin for glycolipid. Lancet ii: 59

    Article  Google Scholar 

  3. Bone RC, Fisher CJ Jr, Clemmer TP, Slotman GJ, Metz CA (1987) Early methylpredniso- lone treatment for septic syndrome and the adult respiratory distress syndrome. Chest 92:1032

    Article  PubMed  CAS  Google Scholar 

  4. Brigham K, Bowers R, McKeen C (1981) Endotoxin-induced lung injury in anesthetized sheep. Effect of methylprednisolone. Circ Shock 8:351

    Google Scholar 

  5. Brockmann DC, Stevens JH, O’Hanley P, et al (1986) The effects of prostaglandin El on the adult respiratory distress syndrome in septic primates. Am Rev Respir Dis 134:885

    PubMed  CAS  Google Scholar 

  6. Cooper JD, McDonald WD, Ali M, Menkes E, Masterson J, Klement P (1980) Prostaglandin production associated with the pulmonary vascular response to complement activation. Surgery 88:215

    PubMed  CAS  Google Scholar 

  7. Demling R, Smith M, Gunther R, et al (1981) Methylprednisolone prevention of increased lung vascular permeability following endotoxemia in sheep. J Clin Invest 67:1103

    Article  Google Scholar 

  8. Duchateau J, Haas M, Schreyen H, et al (1984) Complement activation in patients at risk of developing the adult respiratory distress syndrome. Am Rev Respir Dis 130:1058

    PubMed  CAS  Google Scholar 

  9. Esposito AL, Quinn LA, Lucey EC, Snider GL (1987) Effect of the elastase inhibitor, Eglin-c, on antibacterial mechanisms in experimental pneumonia. Am Rev Respir Dis 135:676

    PubMed  CAS  Google Scholar 

  10. Fantone JC, Kunkel SL, Ward PA, Zurier RB (1980) Suppression by prostaglandin El of vascular permeability induced by vasoactive inflammatory mediators. J Immunol 125:2591

    PubMed  CAS  Google Scholar 

  11. Feeley TW, Minty BD, Scudder CM, Jones JG, Royston D, Teng NNH (1987) The effect of human antiendotoxin monoclonal antibodies on endotoxin-induced lung injury in the rat. Am Rev Respir Dis 135:650

    Google Scholar 

  12. Fletcher JR, Ramwell PW (1980) Prostaglandins in shock: to give or to block? Adv Shock Res 3:57

    PubMed  CAS  Google Scholar 

  13. Groutas WC (1987) Inhibitors of leukocyte elastase and leukocyte cathepsin G. Agents for the treatment of emphysema and related ailments. Med Res Rev 7:227

    Article  PubMed  CAS  Google Scholar 

  14. Hammerschmidt DE, Weaver LJ, Hudson LD, Craddock PhR, Jacob HS (1980) Association of complement activation and elevated plasma-C5a with adult respiratory distress syndrome. Lancet i:947

    Article  Google Scholar 

  15. Higgs GA, Eakins KE, Mugridge KG, et al (1980) The effects of nonsteroidal antiinflammatory drugs on leukozyte migration in carrageenin induced inflammation. Eur J Pharmacol 66:81

    Article  PubMed  CAS  Google Scholar 

  16. Hinshaw LB, Archer LT, Beller-Todd BK, et al (1980) Survival of primates in LD100 septic shock following steroid/antibiotic therapy. J Surg Res 28:151

    Article  PubMed  CAS  Google Scholar 

  17. Holcroft JW, Vassar MJ, Weber CJ (1986) Prostaglandin El and survival in patients with the adult respiratory distress syndrome. A prospective trial. Ann Surg 203:371

    Article  PubMed  CAS  Google Scholar 

  18. Hosea S, Brown E, Hammer C, Frank M (1980) Role of complement activation in a model of adult respiratory distress syndrome. J Clin Invest 66:375

    Article  PubMed  CAS  Google Scholar 

  19. Johnson KJ, Ward PA (1982) Acute and progressive lung injury after contact with phorbol myristate acetate. Am J Pathol 107:29

    PubMed  CAS  Google Scholar 

  20. Lachmann B, Robertson B, Vogel J (1980) In vivo lung lavage as an experimental model of the respiratory distress syndrome. Acta Anaesth Scand 24:231

    Article  PubMed  CAS  Google Scholar 

  21. Martin WJ, Gadek JE, Hunninghake GW, Crystal RG (1981) Oxidant injury of lung parenchymal cells. J Clin Invest 68:1277

    Article  PubMed  CAS  Google Scholar 

  22. Metzger Z, Hoffeld J, Oppenheim J (1981) Regulation by PGE2 of the production of oxygen intermediates of LPS-activated macrophages. J Immunol 127:1109

    PubMed  CAS  Google Scholar 

  23. Montgomery AB, Stager MA, Carrico CJ, Hudson LD (1985) Causes of mortality in patients with the adult respiratory distress syndrome. Am Rev Respir Dis 132:485

    PubMed  CAS  Google Scholar 

  24. Neuhof H (1987) Pers. Mittig

    Google Scholar 

  25. Ogletree M, Brighamm KL (1982) Effects of cyclo-oxygenase inhibitors on pulmonary vascular responses to endotoxin in unanesthetized sheep. Prostaglandins, Leukotrienes Med 8:489

    CAS  Google Scholar 

  26. Ogletree ML, Brigham KL (1979) PGE1 reduces lung transvascular filtration during endotoxin induced high permeability in sheep. Clin Res 27:402A

    Google Scholar 

  27. Parrish DA, Mitchell BC, Henson PM, Larsen GL (1984) Pulmonary response of fifth component of complement-sufficient and -deficient mice to hyperoxia. J Clin Invest 74:956

    Article  PubMed  CAS  Google Scholar 

  28. Richman PS, Spragg RG, Merritt TA, Robertson B, Curstedt T (1987) Administration of porcine-lung surfactant to humans with ARDS: Initial experience. Am Rev Res Dis 135(Suppl):A5

    Google Scholar 

  29. Rinaldo JE (1986) Mediation of ARDS by leukocytes - Clinical evidence and implications for therapy. Chest 89:590

    Article  PubMed  CAS  Google Scholar 

  30. Rivkin I, Rosenblatt J, Becker EL (1975) The role of cyclic AMP in the chemotactic responsiveness and spontaneous motility of rabbit peritoneal neutrophils. The inhibition of neutrophil movement and the elevation of cyclic AMP levels by catecholamines, prostaglandins, theophylline, and cholera toxin. J Immunol 115:1126

    PubMed  CAS  Google Scholar 

  31. Schein RMH, Bergman R, Marcial EH, Schultz D, Duncan RC, Arnold PI, Sprung Ch L (1987) Complement activation and corticosteroid therapy in the development of the adult respiratory distress syndrome. Chest 91:850

    Article  PubMed  CAS  Google Scholar 

  32. Schnebli HP, Seemüller U, Fritz H, et al (1985) Eglin C, a pharmacologically active elastase inhibitor. Eur J Respir Dis 139 (Suppl):66

    CAS  Google Scholar 

  33. Schumer W (1976) Steroids in the treatment of clinical septic shock. Ann Surg 184:333

    Article  PubMed  CAS  Google Scholar 

  34. Seeger W, Ziegler A, Wolf HR (1987) Serum alpha-tocopherol levels after high-dose enteral vitamin E administration in patients with acute respiratory failure. Intensive Care Med 13:395

    Article  PubMed  CAS  Google Scholar 

  35. Shoemaker WC, Appel PL (1986) Effects of prostaglandin El in adult respiratory distress syndrome. Surgery 99:275

    PubMed  CAS  Google Scholar 

  36. Short B, Miller M, Fletcher J (1982) Improved survival in the suckling rat model of group B streptococcal sepsis after treatment with non-steroidal antiinflammatory durgs. Pediatrics 70:343

    PubMed  CAS  Google Scholar 

  37. Sibbald WJ, Anderson RR, Reid B, Holliday RL, Driedger AA (1981) Alveolo-capillary permeability in human septic ARDS. Chest 79 :133

    Article  PubMed  CAS  Google Scholar 

  38. Simon LM, Suttorp N (1985) Lung cell oxidant injury: Decrease in oxidant mediated cytotoxicity by N-acetylcysteine. Eur J Respir Dis 66 (Suppl 139): 132

    Google Scholar 

  39. Smith ME, Holcroft JW, Demling RH (1982) Prostaglandin El and prostacyclin infusion decrease thromboxane production in endotoxin-induced lung injury. J Surg Res 32:283

    Article  PubMed  CAS  Google Scholar 

  40. Snapper JR, Hutchison AA, Ogletree ML, Brigham KL (1983) Effects of cyclooxygenase inhibitors on the alterations in lung mechanics caused by endotoxemia in the unanesthetized sheep. J Clin Invest 72:63

    Article  PubMed  CAS  Google Scholar 

  41. Sprung CL, Caralis PV, Marcial EH, et al (1984) The effects of high-dose corticosteroids in patients with septic shock. New Engl J Med 311:1137

    Article  PubMed  CAS  Google Scholar 

  42. Staub NC, Ohkuda K (1978) PGE1 reverses increased lung microvascular permeability during air emboli. Microvase Res 15:271

    Article  Google Scholar 

  43. Stevens JH, O’Hanley P, Shapiro J, et al (1985) Effects of anti-C5a antibodies in the adult respiratory distress syndrome in septic primates. Clin Research 33:473A

    Google Scholar 

  44. Stevens JH, O’Hanley P, Shapiro JM, Mihm FG, Satoh PS, Collins JA, Raffin ThA (1986) Effects of anti-C5a antibodies on the adult respiratory distress syndrome in septic primates. J Clin Invest 77:1812

    Article  PubMed  CAS  Google Scholar 

  45. Tate RM, Morris HG, Schroeder WR, Repine JE (1984) Oxygen metabolites stimulate thromboxane production and vasoconstriction in isolated saline-perfused rabbit lungs. J Clin Invest 74:608

    Article  PubMed  CAS  Google Scholar 

  46. Tate RM, Repine JE (1983) Neutrophils and the adult respiratory distress syndrome. Am Rev Respir Dis 125:552

    Google Scholar 

  47. Teng NH, Kaplan HS, Herbert JM, et al (1985) Protection against gram-negative bacteremia and endotoxemia with human monoclonal IgM antibodies. Proc Natl Acad Sci USA 82:1790

    Article  PubMed  CAS  Google Scholar 

  48. The Veterans Administration Systemic Sepsis Cooperative Study Group (1987) Effect of high-dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. New Engl J Med 317:659

    Article  Google Scholar 

  49. Turrens JF, Crapo JD, Freeman BA (1984) Protection against oxygen toxicity by intravenous injection of liposome-entrapped catalase and superoxide dismutase. J Clin Invest 73:87

    Article  PubMed  CAS  Google Scholar 

  50. Tuxen DV, Cade JF (1986) Effect of aprotinin in adult respiratory distress syndrome. Anaesth Intensive Care 14:390

    PubMed  CAS  Google Scholar 

  51. Weigelt JA, Norcross JF, Borman KR, Snyder WH (1985) Early steroid therapy for respiratory failure. Arch Surg 120:536

    Article  PubMed  CAS  Google Scholar 

  52. Weissman G, Goldstein I, Hoffstein S (1976) Prostaglandines and the modulation by cyclic nucleotides of lysosomal enzyme release. Adv Prostaglandin Thromboxane Res 2:803

    Google Scholar 

  53. Ziegler EJ, McCutchan JA, Fierer J, Glauser MP, Sadoff JC, Douglas H, Braude AI (1982) Treatment of gram-negative bacteremia and shock with human antiserum to a mutant escherichia coli. New Engl J Med 307:1225

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. W. Kellermann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Anaesthesiologie, Klinikum Großhadern, Ludwig-Maximilians-Universität München, Marchioninistraße 15, D-8000, München 70, Deutschland

    Klaus Peter  & Joachim Groh  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1988 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Kellermann, W. (1988). Medikamentöse Therapie des ARDS. In: Peter, K., Groh, J. (eds) ZAK München 1987. Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine, vol 206. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73786-2_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73786-2_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-19387-6

  • Online ISBN: 978-3-642-73786-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation