7.5% NaCl/Dextran 70 Solution in the Prehospital Care of the Trauma Patient

  • M. J. Vassar
  • C. A. Perry
  • J. W. Holcroft
Conference paper
Part of the Anaesthesiologie und Intensivmedizin / Anaesthesiology and Intensive Care Medicine book series (A+I, volume 205)


Trauma ist the leading cause of mortality in young adults. Death occurs most often as a result of either brain injury or hemorrhage [1]. Hemorrhage remains a problem because it is impossible for medical personnel to infuse adequate volumes of fluid through the peripheral venous catheters that are mandated by the intensely vasoconstricted veins of the patient in traumatic shock [2, 3]. An intravenous fluid that could achieve resuscitation with small volumes would solve this problem.


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  1. 1.
    Trunkey DD (1983) Trauma. Sci Am 249: 28–33PubMedCrossRefGoogle Scholar
  2. 2.
    Trunkey DD (1984) Is ALS necessary for pre-hospital trauma care? J Trauma 24: 86–87PubMedCrossRefGoogle Scholar
  3. 3.
    Smith JP, Bodai BI, Hill AS, Frey CF (1985) Pre-hospital stabilization of critically injured patients: a failed concept. J Trauma 25: 65–70PubMedCrossRefGoogle Scholar
  4. 4.
    Smith GJ, Kramer GC, Perron P, Nakayama S, Gunther RA, Holcroft JW (1986) A comparison of several hypertonic solutions for resuscitation of bled sheep. J Surg ResGoogle Scholar
  5. 5.
    Kramer GC, Perron PR, Lindsey DC, et al (1986) Small-volume resuscitation with hypertonic saline dextran solution. Surgery 100: 239–246PubMedGoogle Scholar
  6. 6.
    Hands RD, Gunther RA, Perron PR, Mertens SS, Holcroft JW, Kramer GC (1986) Peripheral injection of hypertonic saline-dextran to resuscitate from hemorrhagic shock. Circ Shock 18: 377–378Google Scholar
  7. 7.
    Holcroft JW, Vassar MJ, Turner JE, Derlet RW, Kramer GC (1987) 3% Nacl and 7.5% dextran 70 in the resuscitation of severely injured patients. Ann Surg 206: 279–288PubMedCrossRefGoogle Scholar
  8. 8.
    Danowski TS, Winkler AW, Elkinton JR (1946) The treatment of shock due to salt depletion: comparison of the hemodynamic effects of isotonic saline, of hypertonic saline, and of isotonic glucose solutions. J Clin Invest 25: 130–138CrossRefGoogle Scholar
  9. 9.
    Nakayama S, Sibley L, Gunther RA, Holcroft JW, Kramer GC (1984) Small volume resuscitation with hypertonic saline (2,400 mOsm/liter) during hemorrhagic shock. Circ Shock 13: 149–159PubMedGoogle Scholar
  10. 10.
    Nakayama S, Kramer GC, Carlsen RC, et al (1985) Infusion of very hypertonic saline to bled rats: membrane potentials and fluid shifts. J Surg Res 38: 180–186PubMedCrossRefGoogle Scholar
  11. 11.
    Rowe GG, McKenna DH, Corliss RJ, Sialer S (1972) Hemodynamic effects of hypertonic sodium chloride. J Appl Physiol 32: 182–184PubMedGoogle Scholar
  12. 12.
    Kock-Weser J (1963) Influence of osmolarity of perfusate on contractility of mammalian myocardium. Am J Physiol 204: 957–962Google Scholar
  13. 13.
    Wildenthal K, Mierzwiak DS, Mitchell JH (1969) Acute effects of increased serum osmolality on left ventricular performance. Am J Physiol 216: 898–904PubMedGoogle Scholar
  14. 14.
    Wildenthal K, Skelton CL, Coleman HN (1969) Cardiac muscle mechanics in hyperosmotic solutions. Am J Physiol 217: 302–306PubMedGoogle Scholar
  15. 15.
    Templeton GH, Mitchel JH, Wildenthal K (1972) Influence of hyperosmolality on left ventricular stiffness. Am J Physiol 222: 1406–1411PubMedGoogle Scholar
  16. 16.
    Silbert S (1926) The treatment of thromboangiitis obliterans by intravenous injection of hypertonic salt solution: preliminary report. JAMA 86: 1759–1761CrossRefGoogle Scholar
  17. 17..
    Maningas PA, Volk K, DeGuzman L (In Press) Resuscitation during hemorrhagic shock in swine: effect on organ blood flow. Crit Care MedGoogle Scholar
  18. 18.
    Lopes OU, Pontieri V, Rocha e Silva M, Velasco IT (1981) Hyperosmotic NaCI and severe hemorrhagic shock: role of innervated lung. Am J Physiol 241: H883–90PubMedGoogle Scholar
  19. 19.
    Velasco IT, Pontieri V, Rocha e Silva M, Lopes O (1980) Hyperosmotic NaCI and severe hemorrhagic shock. Am J Physiol 239:H664–73PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. J. Vassar
  • C. A. Perry
  • J. W. Holcroft

There are no affiliations available

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