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Cytogenetic Findings in Styrene Workers in Relation to Exposure

  • A. Forni
  • E. Goggi
  • E. Ortisi
  • R. Cecchetti
  • G. Cortona
  • G. Sesana
  • L. Alessio

Abstract

Styrene is a volatile fluid which is increasingly used in the production of polyester resins due to its capacity to polymerize. Since styrene and especially styrene oxide, one of the styrene metabolites in humans, have resulted to be mutagenic and clastogenic in several short term tests, a possible carcinogenic effect of this solvent has been suggested (1,2). In the last decade, several cytogenetic studies have been performed in groups of workers exposed to styrene in different industrial settings with conflicting results (see reviews in 1,3).

Keywords

Chromosome Aberration Cumulative Exposure Polyester Resin Mandelic Acid Styrene Oxide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. (1).
    International Agency for Research on Cancer (1982) Chemicals, Industrial Processes and Industries associated with Cancer in Humans, IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Suppl. 4, IARC, Lyon, 229–233.Google Scholar
  2. (2).
    Lauwerys, R. (1984) Styrene, in L. Alessio, A. Berlin, M. Boni and R. Roi eds., Biological Indicators for the Assessment of Human Exposure to Industrial Chemicals, EUR 8903 EN, Commission of the European Communities, Luxembourg, 67–81.Google Scholar
  3. (3).
    Ashby, J. and C.R. Richardson (1985) Tabulation and assessment of 113 human surveillance cytogenetic studies conducted between 1965 and 1984, Mutat. Res., 154, 111–133.PubMedGoogle Scholar
  4. (4).
    Buckton, K.E. and H.J. Evans eds. (1973) Methods for the analysis of human chromosome aberrations, WHO, Geneva.Google Scholar
  5. (5).
    ISCN (1978) An International System for Human Cytogenetic Nomenclature, Cytogenet. Cell Genet., 21, 309–404.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • A. Forni
    • 1
  • E. Goggi
    • 2
  • E. Ortisi
    • 1
  • R. Cecchetti
    • 2
  • G. Cortona
    • 3
  • G. Sesana
    • 3
  • L. Alessio
    • 4
  1. 1.Institute of Occupational HealthUniversity of MilanMilanItaly
  2. 2.Unit of Occupational Health, USSL 61Carate Brianza (Milan)Italy
  3. 3.Service of Occupational Medicine,USSL 63Desio HospitalDesio (Milan)Italy
  4. 4.Institute of Occupational HealthUniversity of BresciaBresciaItaly

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