Neurotoxicology of heavy metals: Synaptic transmission as influenced by mono- and divalent metalcations
Divalent, essential cations like magnesium-, zink- or calciumions play a pivotal role in many biological processes and are effective in relatively low concentrations. In many organs the action of heavy metals is manifested by an interaction with the physiological functions especially of calcium, i.e. in the nervous system the regulation of transmitter-release in synaptic transmission.
KeywordsSynaptic Transmission Neuromuscular Junction Presynaptic Nerve Terminal Endplate Potential Presynaptic Nerve Ending
Unable to display preview. Download preview PDF.
- (1).Katz, B. (1969): The release of neural trans mitter substances. Liverpool University Press, Liverpool, U.K.Google Scholar
- Wiegand, H., H. Lohmann, S. Uhlig (1986): The action of thallium, cadmium and cobalt on presynaptic Ca++-currents in mouse motor nerve terminals. Naunyn-Schmiedebergs Arch. Pharmacol. 334 (Suppl.), R16.Google Scholar
- (4).Copper, G.P. and R.S. Manalis (1983): Influence of heavy metals on synaptic transmission: A review. Neurotoxicology 4, 69–84.Google Scholar