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Mechanisms of O3 and NO2 Toxicity in Lung Cells in Vitro

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Abstract

Ozone and nitrogen dioxide are major toxic components of photochemical smog. The morphological, physiological and biochemical effects on the respiratory system of man and experimental animals have been investigated over the last decades.

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References

  1. Alink, G.M., J.C.M. van der Hoeven, F.M.H. Debets, W.S.M. van de Ven, J.S.M. Boley and J.H. Koeman (1979) A new exposure model for in vitro testing of effects of gaseous pollutants on mammalian cells by means of gas diffusion through plastic films, Chemosphere, 2, 63–73.

    Article  Google Scholar 

  2. Evans, M.J., L.V. Johnson, R.J. Stephans and G. Freeman (1976) Renewal of the terminal bronchiolar epithelium in the rat following exposure to N02 or 03, Lab. Invest., 35, 246–257.

    PubMed  CAS  Google Scholar 

  3. Mason, R.J., M.C. Williams, R.C. Greenleaf and J.A. Clements (1977) Isolation and properties of type II alveolar cells from rat lung, Am. Rev. Resp. Dis., 115, 1015–1026.

    PubMed  CAS  Google Scholar 

  4. Rietjens, I.M.C.M., G.M. Alink and R.M.E. Vos (1985) The role of glutathione and changes in thiol homeostasis in cultured lung cells exposed to ozone, Toxicology, 35, 207–217.

    Article  PubMed  CAS  Google Scholar 

  5. Rietjens, I.M.C.M., M.C.M. Poelen, R.A. Hempenius, M.J.J. Gijbels and G.M. Alink (1986) Toxicity of ozone and nitrogen dioxide to alveolar macrophages: comparative study revealing differences in their mechanism of toxic action, J. Toxicol. Environ. Health, 19, 555–568.

    Article  PubMed  CAS  Google Scholar 

  6. Rietjens, I.M.C.M., H.H. Lemmink, G.M. Alink and P.J. van Bladeren (1987) The role of glutathione and glutathione S-transferases in fatty acid ozonide detoxification, Chem.-Biol. Interactions, 62, 3–14.

    Article  CAS  Google Scholar 

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© 1988 Springer-Verlag Berlin Heidelberg

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Alink, G.M., Rietjens, I.M.C.M. (1988). Mechanisms of O3 and NO2 Toxicity in Lung Cells in Vitro. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73766-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-73766-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73768-8

  • Online ISBN: 978-3-642-73766-4

  • eBook Packages: Springer Book Archive

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