Abstract
Environmental pollutants do not influence or affect all tissues and cell types to the same extent. Organ specific reactions due to the particular metabolic capacities of each differentiated cell type are well known. This has to be considered when trying to define the hazardous potency of environmental chemicals. Since in vitro procedures today play an important role in toxicological research, type as well as origin of the cell cultures might be crucial points with respect to their possible applcation in risk assessment.
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References
McDowell, E.M. and B.F. Trump (1983) Histogenesis of preneoplastic and neoplastic lesions in traceobronchial epithelium, Surv. Synth. Path. Res. 2, 235–279.
Emura, M., H.-B. Richter-Reichhelm, W. Boning, R. Eichinger, C. Schoch, J. Althoff and U. Mohr (1982) A fetal respiratory epithelial cells line for studying some problems of transplacental carcinogenesis in Syrian golden hamsters, J. Cancer Res. Clin. Oncol. 104, 133–144
McKeehan, W.L., K. A. McKeehan, S.L. Hammond and R.G. Ham (1977) Improved medium for clonal growth of human diploid fibroblasts at low concentrations of serum protein, In Vitro 13, 399–416
Emura, M., U. Mohr, M. Riebe, M. Aufderheide and D.L. Dungworth (1987) Predisposition of cloned fetal hamster lung epithelial cells to transformation by a precarcinogen, benzo(a)pyrene, using growth hormone supplementation and collagen gel substratum, Cancer Res. 47, 1155–1160
Jacob, J. G. Grimmer, G. Raab, M. Emura, M. Riebe and U. Mohr (in press) Comparison of chrysene metabolism in epithelial human bronchial and Syrian hamster lung cells, Cancer Letters
Speit, G. (1984) Considerations on the mechanism of differential staining of BrdU-substituted chromosomes, Hum. Genet. 67, 264–269
Rothfels, K.H. and L. Siminovitch (1958) An air-drying technique for flattening chromosomes in mammalian cells grown in vitro, Stain Technol. 33, 73–77
Emura, M., M. Riebe, M. Aufderheide and U. Mohr (1986) A fetal Syrian hamster lung cell line as an in vitro model for respiratory carcinogenesis, Exp. Pathol. 29, 211–216
Trump, B.F., E.M. McDowell, F. Glavin, L.A. Barrett, P.J. Becci, W. Schürch, H.E. Kaiser and C.C. Harris (1978) The respiratory epithilium. III. Histogenesis of epidermoid metaplasia and carcinoma in situ in the human, J. Natl. Cancer Inst. 61, 563–575
Grimmer, G., J. Jacob, A. Schmoldt, G. Raab, U. Mohr and M. Emura (1983) Metabolism of benzo(a)anthracene in hamster lung cells in culture in comparison to rat liver microsomes, Proceedings of 7th International Symposium of PAH, Columbus, Ohio on 28.10.1983
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© 1988 Springer-Verlag Berlin Heidelberg
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Riebe, M., Emura, M., Aufderheide, M., Mohr, U. (1988). Target Organ Cells as in Vitro Test Systems for Toxicity, Mutagenicity, DNA-Repair and Transformation by Environmental Pollutants. In: Seemayer, N.H., Hadnagy, W. (eds) Environmental Hygiene. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73766-4_12
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DOI: https://doi.org/10.1007/978-3-642-73766-4_12
Publisher Name: Springer, Berlin, Heidelberg
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