Target Organ Cells as in Vitro Test Systems for Toxicity, Mutagenicity, DNA-Repair and Transformation by Environmental Pollutants

  • M. Riebe
  • M. Emura
  • M. Aufderheide
  • U. Mohr
Conference paper


Environmental pollutants do not influence or affect all tissues and cell types to the same extent. Organ specific reactions due to the particular metabolic capacities of each differentiated cell type are well known. This has to be considered when trying to define the hazardous potency of environmental chemicals. Since in vitro procedures today play an important role in toxicological research, type as well as origin of the cell cultures might be crucial points with respect to their possible applcation in risk assessment.


Polycyclic Aromatic Hydrocarbon Sister Chromatid Exchange Chemical Carcinogen Differentiate Cell Type Carcinogen Metabolism 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1988

Authors and Affiliations

  • M. Riebe
    • 1
  • M. Emura
    • 1
  • M. Aufderheide
    • 1
  • U. Mohr
    • 1
  1. 1.Institute for Experimental PathologyHannover Medical SchoolHannover 61Germany

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