Neurophysiology of Electroacupuncture Analgesia

  • Richard S. S. Cheng

Abstract

In recent years, electroacupuncture (EA) analgesia has been the focus of intense multidisciplinary research. This research has been very productive, leading to the publication of numerous studies that have added to our understanding of the neurophysiology of pain perception and pain modulation. This article will review the results of some of these studies, from which the central roles in pain modulation played by the endorphins and various monoamines (serotonin, in particular) will become apparent. In conclusion, an integrated neurophysiological model of EA analgesia will be proposed.

Keywords

Morphine Serotonin Enzymatic Degradation Haloperidol Monoamine 

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References

  1. 1.
    Cheng RSS (1977) Electroacupuncture effect on cat spinal cord neurons and conscious mice: A new hypothesis is proposed. M. Sc. Thesis, Zoology, University of TorontoGoogle Scholar
  2. 2.
    Cheng RSS, Pomeranz B (1979 a) Electroacupuncture analgesia could be mediated by at least two pain-relieving mechanisms; endorphin and non-endorphin systems. Life Sci 25, 1957–1962PubMedCrossRefGoogle Scholar
  3. 3.
    Cheng RSS, Pomeranz B (1979b) Correlation of genetic difference in endorphin systems with analgesic effects of d-amino acids in mice. Brain Res 177: 583–587PubMedCrossRefGoogle Scholar
  4. 4.
    Cheng RSS, Pomeranz B (1980 a) Electroacupuncture analgesia is mediated by stereospecific opiate receptors and is reversed by antagonists of type I receptors. Life Sci 26: 631–639PubMedCrossRefGoogle Scholar
  5. 5.
    Cheng RSS, Pomeranz B (1980 b) Monoaminergic mechanisms of electroacupuncture analgesia. Brain Res 215: 77–93CrossRefGoogle Scholar
  6. 6.
    Cheng RSS, Pomeranz B (1980 c) A combined treatment with D-amino acids and electroacupuncture produces a greater analgesia than either treatment alone: naloxone reverses these effects, Pain 8, 231–236PubMedCrossRefGoogle Scholar
  7. 7.
    Cheng RSS, Pomeranz B, Yu G ( 1979 a) Dexamethasone partially reduces and 2% saline treatment abolished electroacupuncture analgesia: These findings implicate pituitary endorphins. Life Sci 24: 1481–1486PubMedCrossRefGoogle Scholar
  8. 8.
    Cheng RSS, McKibbin L, Buddha R, Pomeranz B (1980 c) Electroacupuncture elevates blood Cortisol levels in naive horse; sham treatment has no effect. Intern J Neurosci 10: 95–97CrossRefGoogle Scholar
  9. 9.
    Chiang CY, Tu HX, Chao YF, PAI YH, Ku HK, Cheng JK, Shang HY, Yang FY (1979) Effect of electrolytic or intracerebral injections of 5,6-dihydroxtrytamine in raphe nuclei on acupuncture analgesia in rats. Chin Med J 92: 129–136Google Scholar
  10. 10.
    Du HJ, Chao YF (1976) Localization of central structure involved in descending inhibitory effect of acupuncture on viscero-somatic reflex discharges. Scientia Sinica 19: 137–148PubMedGoogle Scholar
  11. 11.
    Ehrenpreis S, Balagot RC, Comathy J, Myles S (1978) Naloxone reversible analgesia in mice, produced by inhibitors of enkephalin. In second world congress on pain, vol 1, Montreal, p 260Google Scholar
  12. 12.
    Goldstein A, Tachibana S, Lowney LI, Hunkapiller M, Hood L (1979) Dynorphin-(l-13) An extra-ordinarily potent opioid peptide. Proc Natl Acad Sci, USA, 76: 6666–6670PubMedCrossRefGoogle Scholar
  13. 13.
    Greenberg J, Kubota K, Ehrenpreis S (1980) Bioassay of brain enkephalinases: Inhibition by d-phenylalanine ( DPA) and other substances producing analgesia in mice. Fed Proc 39: 606Google Scholar
  14. 14.
    Grevert P, Baizman ER, Goldstein A (1978) Naloxone effects on a nociceptive response of hypophysectomized and adrenalectomized mice. Life Sci 23: 723–728PubMedCrossRefGoogle Scholar
  15. 15.
    Guillemin R, Vargo T, Rossier J, Minick S, Ling H, Rivier C, Vale W, Bloom R (1977) Bendorphin and adrenocorticotropin are secreted concomitantly by the pituitary gland. Science 197: 1367–1369PubMedCrossRefGoogle Scholar
  16. 16.
    Han CS, Chou PH, Lu CC, Lu LH, Yang TH, Jen MF (1979) The role of central 5-hydroxytryptamine in acupuncture analgesia. Scientia Sinica 22: 91–104PubMedGoogle Scholar
  17. 17.
    Han JS, Xie GX (1984) Dynorphin: Important mediator for electroacupuncture analgesia in the spinal cord of the rabbit. Pain 18: 367–377Google Scholar
  18. 18.
    Katz RJ (1979) Hypophysectomy reduces Behavioral activation to morphine in the rat. Behavioral physiologyGoogle Scholar
  19. 19.
    Kim KC, Han YF, Yu LP, Feng J, Wang FS, Zhang ZD, Change AZ, Shen MP, Lu YY (1979) Role of brain serotonergic and catecholaminergic systems in acupuncture analgesia. Acta Physiol Sinica 31: 121–131Google Scholar
  20. 20.
    McLennen H, Gilfillan K, Heap Y (1977) Some pharmacological observations on the analgesia induced by acupuncture in rabbits. Pain 3: 229–238CrossRefGoogle Scholar
  21. 21.
    Okafor C, Mosnaim AD, Ehrenpreis S (1980) Uptake of D-phenylalanine (DPA) by mouse brain: Correlation with analgesic activity. Fed Proc 39: 386Google Scholar
  22. 22.
    Peets J, Pomeranz B (1978) CXBK mice dificient in opiate receptors show poor electroacupuncture analgesia. Nature 273: 675–676PubMedCrossRefGoogle Scholar
  23. 23.
    Pomeranz B, Cheng R (1979) Suppression of noxious responses in single neurons of cat spinal cord by electroacupuncture and its reversal by the opiate antagonist naloxone. Exp Neurol 64: 327–341PubMedCrossRefGoogle Scholar
  24. 24.
    Pomeranz BH, Cheng R, Law P (1977) Acupuncture Reduces electrophysiological and behavioral responses to noxious stimuli: pituitary is implicated. Exp Neurol 54: 172–178PubMedCrossRefGoogle Scholar
  25. 25.
    Pomeranz BH, Chiu D (1976) Naloxone blocks acupuncture analgesia and causes hyperalgesia: Endorphin is implicated. Life Sci 19: 1757–1762PubMedCrossRefGoogle Scholar
  26. 26.
    Pomeranz B, Paley D (1979) Electroacupuncture hypalgesia is mediated by afferent nerve impulses: an electrophysiological study in mice. Exp Neurol 66: 398–402PubMedCrossRefGoogle Scholar
  27. 27.
    Shen E, Ma WH, Lau C (1978) Involvement of descending on the splanchnically evoked potential in the orbital cortex of cat. Scientia Sinica 21: 677–685PubMedGoogle Scholar
  28. 28.
    Shen E, Tsai T, Lau C (1975) Supraspinal participation in the inhibitory effect of acupuncture on viscerosomatic reflex discharges. Chin Med J 1: 431–440PubMedGoogle Scholar
  29. 29.
    Sjolund B, Terenius L, Eriksson M (1977) Increased cerebrospinal fluid levels of endorphins after electroacupuncture. Acta Physiol Scand 100: 382–384PubMedCrossRefGoogle Scholar
  30. 30.
    Takeshige C, Kamada T, Oka K, Hisamitsu M (1978) The relationship between midbrain neurons (periaqueduct centrol gray and midbrain reticular formation) and acupuncture analgesia. Animal hypnosis. Second world congress on pain (abstract) voll, Montreal, p156Google Scholar
  31. 31.
    Tsou K, Wu SH, Wan FS, Ji XQ, Chang TS, Lo ES, Yi CC (1979) Increased levels of endorphins in the cisternal cerebrospinal fluid of rabbits in acupuncture analgesia. Acta Physiologiea Sinica 31: 371–376Google Scholar
  32. 32.
    Tung HW, Chiang CH, Fu LW (1978) Changes in monoamine fluorescence intensity in the rats midbrain raphe nuclei and locus coerulus in the process of acupuncture analgesia. Acta Biochem at Biophysica Sinica 10: 119–125Google Scholar
  33. 33.
    Yaksh TL, Wilson PR (1979) Spinal serotonin terminal system mediates antinociception. J of Pharmacol and Exp Therap 208: 446–453Google Scholar
  34. 34.
    Yi CC, Lu TH, Wu SH, Tsou K (1977) A study of the release of H(3)-5-hydroxytrytamine from brain during acupuncture and morphin analgesia. Scientia Sinica 20: 113–124Google Scholar
  35. 35.
    Zhang AZ, Pan X, Chen J, Mo W, Sun F (1979) Endorphins and acupuncture analgesia. In: National symposia of acupuncture and moxibustion and acupuncture anaesthesia. Beijing, China, p 32Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • Richard S. S. Cheng
    • 1
  1. 1.Pain Clinic St. Josephs Hospital and Bathurst Pain ClinicTorontoCanada

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