Inula spp.

  • Weici Tang
  • Gerhard Eisenbrand

Abstract

The following entries representing Inula species are listed in the Chinese Pharmacopoeia:
  • Tumuxiang, Radix Inulae, is the dry roots of Inula helenium L. or I. racemosa Hook f. (Asteraceae) collected in the fall. It is used as a stomachic and analgesic and is recommended for the treatment of emesis, diarrhea, and prevention of miscarriage.

  • Jinfocao, Herba Inulae, is the dry aboveground part of I. linariifolia Turcz. and I. japonica Thunb., collected in the summer and fall. It is used as a diuretic and mucolytic for the treatment of cough and asthma.

  • Xuanfuhua, Flos Inulae, is the dry inflorescence of I. japonica and I. britannica L., collected in the summer and fall when the flowers come into bloom. It is used as a diuretic, antiemetic, and mucolytic.

Keywords

Quercetin Lactone Palmitate Inulin Terpene 

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References

  1. 1.
    Gerhardt C (1840) Chemische Untersuchungen über das Helenin. Liebigs Ann Chem 34:192–204CrossRefGoogle Scholar
  2. 2.
    Ruzicka L, Pieth P, Reichstein T, Ehmann T (1933) Polyterpene und Polyterpenoide LXXX, Zur Kenntnis der Alantolactone. Synthese des l,4-Dimethyl-6-isopropyl und des 1,5-Dimethyl-7-isopropylnaphthalins. Helv Chim Acta 16:268–275CrossRefGoogle Scholar
  3. 3.
    Tsuda K, Tanabe K, Iwai I, Funakoshi K (1957) The structure of alantolactone. J Am Chem Soc 79:5721–5724CrossRefGoogle Scholar
  4. 4.
    Asselineau C, Bory S (1958) The separation and structure of alantolactone and isoalantolac-tone. Compt Rend 246:1874–1877Google Scholar
  5. 5.
    Marshall JA, Cohen N (1964) The structure of alantolactone. J Org Chem 29:3727–3729CrossRefGoogle Scholar
  6. 6.
    Marshall JA, Cohen N (1965) The stereoselective total synthesis of alantolactone. J Am Chem Soc 87:2773–2774CrossRefGoogle Scholar
  7. 7.
    Schmalle HW (1986) Structure of 4β,10β-dimethyleudesma 5, 11(13)-diene-7β-lactone (alantolactone). Acta Crystallogr [C] C42:705–708Google Scholar
  8. 8.
    Wunderlich W (1959) Isolierung von reinem Isoalantolacton aus Inula helenium. J Pr Chem 9:107CrossRefGoogle Scholar
  9. 9.
    Ruzicka L, Meisen JA van (1931) Höhere Terpenverbindungen XLV. Zur Kenntnis des Alanto-lactons und des Isoalantolactons. Helv Chim Acta 14:397–410CrossRefGoogle Scholar
  10. 10.
    Hansen KFW (1931) Über Bitterstoffe aus der Alantwurzel (vorläufige Mitteilung). Chem Ber 64:67–71Google Scholar
  11. 11.
    Hansen KFW (1931) Über Bitterstoffe aus der Alantwurzel (IL Mitteilung über Bitterstoffe). Chem Ber 64:943–947Google Scholar
  12. 12.
    Ukita C, Nakazawa S (1960) Santonin analogs. IV. Structure of “iso”-tetrahydroalantolactone. J Am Chem Soc 82:2224–2228CrossRefGoogle Scholar
  13. 13.
    Rosik GG, Zinchenko AA, Reznichenko AA, Kovalev IP (1987) Quantitative determination of sesquiterpene lactones of Inula helenium L. by gas-liquid chromatography. Khim-Farm Zh 21:632–634Google Scholar
  14. 14.
    Bohlmann F, Mahanta PK, Jakupovic J, Rastogi C, Natu AA (1978) New sesquiterpene lactones from Inula species. Phytochemistry 17:1165–1172CrossRefGoogle Scholar
  15. 15.
    Yoshioka I, Yamada Y (1963) Isolation of dammaradienyl acetate from Inula helenium. Yaku-gaku Zasshi 83:801–802Google Scholar
  16. 16.
    Kowalewska K, Lutomski J (1978) Flavonoids in the inflorescences of Inula helenium L. Herba Pol 24:107–113 (CA 90:183169n)Google Scholar
  17. 17.
    Khvorost PP, Komissarenko NF (1976) Lactones of Inula helenium. Khim Prir Soedin 820–821Google Scholar
  18. 18.
    Karrer W (1976) Konstitution und Vorkommen der organischen Pflanzenstoffe, 2nd edn. Birkhäuser, BaselGoogle Scholar
  19. 19.
    Beyer H, Walter W (1984) Lehrbuch der organischen Chemie, 20th edn. Hirzel, Stuttgart, p 429Google Scholar
  20. 20.
    Bell DJ, Palmer A (1952) Structural studies on inulin from Inula helenium and on levans from Dactylis glomerata and Lolium italicum. J Chem Soc 3763–3770Google Scholar
  21. 21.
    St. Pyrek J (1977) Terpenes of Compositae plants. IV. Isolation of gaillardin from flowers of Inula britannica L. Rocz Chem 51:1277–1279 (CA 87:197230a)Google Scholar
  22. 22.
    Rybalko KS, Sheichenko VI, Maslova G A, Kiseleva EY, Gubanov IA (1968) Britanin, a lactone from Inula britannica. Khim Prir Soedin 4:251–252Google Scholar
  23. 23.
    Chugunov PV, Sheichenko VI, Bankovskii AI, Rybalko KS (1971) Structure of britanin, a sesquiterpenoid lactone from Inula britannica. Khim Prir Soedin 7:276–280Google Scholar
  24. 24.
    Krolikowska M, Wolbis M (1981) Polyphenols compounds in Inula britannica. Acta Pol Pharm 38:107–114 (CA 95:183890u)Google Scholar
  25. 25.
    Krolikowska M, Wolbis M (1979) Polyphenolic compounds in Inula britannica. Acta Pol Pharm 36:395 (CA 92:160563p)Google Scholar
  26. 26.
    Bohlmann F, Zdero C (1977) Naturally occurring terpene derivatives, part 104. New sesquiterpene lactones and thymol derivatives from Inula species. Phytochemistry 16:1243–1245CrossRefGoogle Scholar
  27. 27.
    Ito K, Lida T (1981) Seven sesquiterpene lactones from Inula britannica var. chinensis. Phytochemistry 20:271–273CrossRefGoogle Scholar
  28. 28.
    Chien MK, Chen ZN, Qin GW, Han J, Wang BD, Xu RS (1983) Studies on the chemical constituents of Inula linariaefolia Turcz. Acta Chim Sin 41:254–261Google Scholar
  29. 29.
    Bokadia MM, MacLeod AJ, Mehta SC, Mehta BK, Patel H (1986) The essential oil of Inula racemosa. Phytochemistry 25:2887–2888CrossRefGoogle Scholar
  30. 30.
    Raghavan R, Ravindranath KR, Trivedi GK, Paknikar SK, Bhattacharyya SC (1969) Inuno-lide. A sesquiterpene lactone from Inula racemosa root. Indian J Chem 7:310Google Scholar
  31. 31.
    Bhandari P, Rastogi RP (1983) Alloalantolactone, a sesquiterpene lactone from Inula racemosa. Indian J Chem [B] 22B:286–287Google Scholar
  32. 32.
    Kaur B, Kalsi PS (1985) Stereostructures of inunal and isoalloalantolactone, two biologically active sesquiterpene lactones from Inula racemosa. Phytochemistry 24:2007–2010CrossRefGoogle Scholar
  33. 33.
    Paknikar SK, Naik US, Raghavan R (1982) Occurrence of (-)-dammara-20,24-dien-3β-yl acetate in Inula racemosa. Indian J Chem [B] 21B:894Google Scholar
  34. 34.
    Goswami AC, Baruah RN, Sharma RP, Baruah JN, Kulanthaivel P, Herz W (1984) Germacra-nolides from Inula cappa. Phytochemistry 23:367–372CrossRefGoogle Scholar
  35. 35.
    Bohlmann F, Ahmed M, Jakupovic J (1982) Inositol angelates from Inula cappa. Phytochemistry 21:780–782CrossRefGoogle Scholar
  36. 36.
    Pieman AK (1983) Antifungal activity of helenin and isohelenin. Biochem Syst Ecol 11:183–186CrossRefGoogle Scholar
  37. 37.
    Azoulay P, Reynier JP, Balansard G, Gasquet M, Timon-David P (1986) Biogalenic and pharmacological study on three sesquiterpenes with antiparasitic actions: helenin, santonin and 12-carboxy-3,ll(13)-endesma-diene. Pharm Acta Helv 61:345–352PubMedGoogle Scholar
  38. 38.
    Mansurov MM (1973) Helenin action on blood coagulation. Farmakol Toksikol (Moscow) 36:335–338Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Weici Tang
    • 1
  • Gerhard Eisenbrand
    • 1
  1. 1.Lebensmittelchemie und UmwelttoxikologieUniversität KaiserslauternKaiserslauternGermany

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