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Coptis spp.

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Book cover Chinese Drugs of Plant Origin

Abstract

Huanglian, Rhizoma Coptidis, is the dry rhizome of Coptis chinensis Franch., C. deltoidea C.Y. Cheng et Hsiao, or C. teetoides C.Y. Cheng (Ranunculaceae), which is collected in the fall. Coptis rhizome is one of the most well known and widely used herbs in traditional Chinese medicine. It is officially listed in the Chinese Pharmacopoeia and is used as a bacteriostatic, antipyretic, and antiphlogistic for the treatment of gastroenteritis, diarrhea, vomiting, icterus, fever, insomnia, hematemesis, nose bleeding, conjunctivitis, toothache, carbuncle, and abscess and as a bitter digestive for the treatment of indigestion. It is used for treatment of eczema by external application.

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References

  1. Schramm G, Tang W (1959) Pharmacognosy of Coptis, Chinese Pharmacopoeia 1953. Pharmazie 14:405–408

    PubMed  CAS  Google Scholar 

  2. Wang HK, Yang PC, Chen HM (1964) Alkaloids from roots of Coptis chinensis var. omeiensis. IV. Acta Pharm Sin 11:382–388

    CAS  Google Scholar 

  3. Wang HK, Yang PC, Chen HM (1964) Alkaloids from roots of Coptis chinensis var. shihchuen-sis. V. Acta Pharm Sin 11:389–392

    CAS  Google Scholar 

  4. Chatterjee A (1950) Constituents of Coptis teeta. Sci Cult 15:330

    CAS  Google Scholar 

  5. Yang TH, Chen KT (1969) Alkaloids of Formosan Coptis quinquefolia. Taiwan Ko Hsueh 23:30–36 (CA 73:106340h)

    CAS  Google Scholar 

  6. Yang MK, Liao RH, Huang ZM (1983) Study on the alkaloids of Ya Lian (Coptis deltoidea) Chin Trad Herb Drugs 14:151–153

    CAS  Google Scholar 

  7. Zhang XC, Yuan XL, Sun YQ (1985) Identification of species of Coptis and Phellodendron by TLC-DM. J Shenyang Coll Pharm 2:280–283

    CAS  Google Scholar 

  8. Qin XX, Wu CY, Chen BL (1986) Analysis of berberine-type alkaloids in Rhizoma coptidis and Chinese patent medicines by micellar chromatography. Acta Pharm Sin 21:458–465

    Google Scholar 

  9. Wang MZ, Zhu M (1984) Determination of alkaloids in Coptis by high performance thin-layer chromatography. Chin J Pharm Anal 4:12–15

    Google Scholar 

  10. Fang XP, Wang TZ, Zhang H, Shuai H, Li D, Xie CK (1989) Quantitative determination of five alkaloids in plants of Coptis from China. J Chin Mat Med 14:97–99

    CAS  Google Scholar 

  11. Li XJ, Tian XH, Chen YX, Li F, Duan MS, Zhou YY (1986) Separation and identification of epiberberine in coptis (Coptis chinensis. Chin Trad Herb Drugs 17:2–3

    CAS  Google Scholar 

  12. Ikuta A, Itokawa H (1983) Estimation of Coptis rhizomes on TLC. Shoyakugaku Zasshi 37:195–197

    CAS  Google Scholar 

  13. Ikuta A, Kobayashi A, Itokawa H (1984) Studies on the quantitative analysis of protoberberine alkaloids in Japanese, Chinese and other countries Coptis rhizomes by thin layer chro-matograph-densitometry. Shoyakugaku Zasshi 38:279–282

    CAS  Google Scholar 

  14. Chang NC (1948) In vitro antibacterial action of extracts from Coptis roots. Proc Soc Exp Biol Med 69:141–143

    PubMed  CAS  Google Scholar 

  15. Ukita T, Mizuno D, Tamura T (1949) The antibacterial properties of berberinium chloride. Jpn J Exp Med 20:103–108 (CA 44:3087e)

    PubMed  CAS  Google Scholar 

  16. Chang NC (1948) In vitro antibacterial action of extracts from Coptis roots. Proc Soc Exp Biol Med 69:141–143

    PubMed  CAS  Google Scholar 

  17. Ukita T, Mizuno D, Tamura T (1949) The antibacterial properties of berberinium chloride. Jpn J Exp Med 20:103–108 (CA 44:3087e)

    PubMed  CAS  Google Scholar 

  18. Sado S (1947) Pharmacological study of berberine and its derivatives. II. J Pharm Soc Jpn 67:166–170

    CAS  Google Scholar 

  19. Amin AH, Subbaiah TV, Abbasi KM (1969) Berberine sulfate: antimicrobial activity, bioassay and mode of action. Can J Microbiol 15:1067–1076

    Article  PubMed  Google Scholar 

  20. Kowalewski Z, Kedzia W, Mirska I (1972) Effect of berberine sulfate on Staphylococci. Arch Immunol Ther Exp 20:353–360

    CAS  Google Scholar 

  21. Modak S, Modak MJ, Venkataraman A (1970) Mechanism of action of berberine on Vibrio cholerae and V. cholerae biotype eltor. Indian J Med Res 58:1510–1522

    PubMed  CAS  Google Scholar 

  22. Modak MJ, Modak S, Venkataraman A (1970) Effect on berberine on the fatty acid composition of Vibrio cholerae and V cholerae biotype eltor. Indian J Med Res 58:1523–1527

    PubMed  CAS  Google Scholar 

  23. Dutta NK, Marker PH, Rao NR (1972) Berberine in toxin-induced experimental cholera. Appendix on berberine in toxin-induced experimental cholera. Br J Pharmacol 44:153–159

    PubMed  CAS  Google Scholar 

  24. Sack RB, Froehlich JL (1982) Berberine inhibits intestinal secretory response of Vibrio cholerae and Escherichia coli enterotoxins. Infect Immun 35:471–475

    PubMed  CAS  Google Scholar 

  25. Zhu BL, Ahrens FA (1982) Effect of berberine on intestinal secretion mediated by Escherichia coli heat-stable enterotoxin in jejunum of pigs. Am J Vet Res 43:1594–1598

    PubMed  CAS  Google Scholar 

  26. Swabb EA, Tai YH, Jordan L (1981) Reversal of cholera toxin-induced secretion in rat ileum by luminal berberine. Am J Physiol 241:G248-G252

    PubMed  CAS  Google Scholar 

  27. Tai YH, Feser JF, Marnane WG, Desjeux JF (1981) Antisecretory effects of berberine in rat ileum. Am J Physiol 241:G253-G258

    PubMed  CAS  Google Scholar 

  28. Jezowa L, Kaczmarek F, Rafinski T (1966) The synergic action of berberine hydrochloride and tuberculostatic preparations upon the growth of Mycobacterium tuberculosis in vitro. Herba Pol 12:266–272 (CA 67:88503h)

    CAS  Google Scholar 

  29. Sabir M, Mahajan VM, Mohapatra LN, Bhide NK (1976) Experimental study of the antitra-choma action of berberine. Indian J Med Res 64:1160–1167

    PubMed  CAS  Google Scholar 

  30. Yamahara J, Kawakita J, Kuraba K, Sawada T (1972) Biological studies of Coptis japonica and berberine type alkaloids. 3. Influence of berberine, coptisine and the extract of Coptis rhizoma on the fecal flora. Shoyakugaku Zasshi 26:84–89

    CAS  Google Scholar 

  31. Pitea M, Margineanu C (1972) Correlations between chemical structure and antibacterial activity of berberine. Clujul Med 45:465–469 (CA 80:78706f)

    CAS  Google Scholar 

  32. Mahajan VM, Sharma A, Rattan A (1982) Antimycotic activity of berberine sulfate: an alkaloid from an Indian medicinal herb. Sabouraudia 20:79–81 (CA 98:2666u)

    Article  PubMed  CAS  Google Scholar 

  33. Mirska I, Kedzia H, Kowalewski Z, Kedzia W (1972) Effect of berberine sulfate on healthy mice infected with Candida albicans. Arch Immunol Ther Exp 20:921–929

    CAS  Google Scholar 

  34. Sawada T, Yamahara J, Goto K, Yamamura M (1971) Evaluation of crude drugs by bioassay. IV. Antibacterial activities of the components of Coptidis rhizoma. Shoyakugaku Zasshi 25: 74–78

    CAS  Google Scholar 

  35. Kulkarni SK, Dandiya PC, Varandani NL (1972) Pharmacological investigations of berberine sulfate. Jpn J Pharmacol 22:11–16

    Article  PubMed  CAS  Google Scholar 

  36. Sabbaiah TV, Amin AH (1967) Effect of berberine sulfate on Entamoeba histolytica. Nature 215:527–528

    Article  Google Scholar 

  37. Otsuka H, Tsukui M, Matsuoka T, Goto M, Fujimura H, Hiramatsu Y, Sawada T (1974) Antiinflammatory agents. Antiinflammatory screening by a fertile egg method. Yakugaku Zasshi 94:796–801

    PubMed  CAS  Google Scholar 

  38. Otsuka H, Fujimura H, Sawada T, Goto M (1981) Studies on antiinflammatory agents. II. Antiinflammatory constituents from rhizome of Coptis japonica Makino. Yakugaku Zasshi 101:883–890

    PubMed  CAS  Google Scholar 

  39. Akhter MH, Sabir M, Bhide NK (1977) Antiinflammatory effect of berberine in rats injected locally with cholera toxin. Indian J Med Res 65:133–141

    PubMed  CAS  Google Scholar 

  40. Shvarev LF, Tsetlin AL (1972) Antiblastic properties of berberine and its derivatives. Farmakol Toksikol 35:73–75 (CA 76:148880b)

    PubMed  CAS  Google Scholar 

  41. Schmitz H (1951) Storage of berberine in the granules of tumor cells. Naturwissenschaften 38:405

    Article  CAS  Google Scholar 

  42. Honda F, Oka M, Akashi A, Nishino Y (1960) Pharmacological studies on the metabolism of cancer tissues. XXX. Influence of berberine and related compounds on the oxidation of DL-ala-nine in rat ascites hepatoma. Yakugaku Kenkyu 32:830–835 (CA 55:10695e)

    CAS  Google Scholar 

  43. Mollov NM, Duchevska KB, Silyanovska K, Stoichev S (1968) Cytotoxic effect of alkaloids from Thalictrum minus elatum and their derivatives. CR Acad Bulg Sci 21:605–608 (CA 69:58087z)

    CAS  Google Scholar 

  44. Hladon B, Kowalewski Z, Bobkiewicz T, Gronostaj K (1978) Cytotoxic activity of some Chelidonium maius alkaloids on human and animal tumor cell cultures in vitro. Ann Pharm (Poznan) 13:61–68 (CA 92:15307d)

    CAS  Google Scholar 

  45. Hoshi A, Ikekawa T, Ikeda Y, Shirakawa S, Iigo M, Kuretani K (1976) Antitumor activity of berberrubine derivatives. Gann 67:321–325

    PubMed  CAS  Google Scholar 

  46. Creasey WA (1979) Biochemical effects of berberine. Biochem Pharmacol 28:1081–1084

    Article  PubMed  CAS  Google Scholar 

  47. Kumazawa Y, Itagaki A, Fukumoto M, Fujisawa H, Nishimura C, Nomoto K (1984) Activation of peritoneal macrophages by berberine-type alkaloids in terms of induction of cytostatic activity. Int J Immunopharmacol 6:587–592

    Article  PubMed  CAS  Google Scholar 

  48. Chun YT, Yip TT, Lau KL, Kong YC, Sankawa U (1979) A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmacol 10:177–182

    Article  PubMed  CAS  Google Scholar 

  49. Ko ST, Lim DY (1980) Influence of berberine on the blood pressure of rabbits. Arch Pharmacol Res 3:23–30 (CA 95:35556z)

    Article  CAS  Google Scholar 

  50. Fukuda H, Watanabe K, Kudo Y (1970) Cardiovascular effect of 9-substituted berberines. Chem Pharm Bull (Tokyo) 18:1299–1304

    CAS  Google Scholar 

  51. Hou DH, Li L, Wang QJ, Chen GF (1983) Studies on the antihypoxic and antiarrhythmic effect of five protoberberine compounds. J Nanjing Pharm Coll 30–33

    Google Scholar 

  52. Tang QY, Li GH, Li JL, Xu Y (1985) Effects of intravenous infusion of berberine hydrochloride on cardiovascular function. Pharm Ind 16:130–133

    CAS  Google Scholar 

  53. Greco RJ, Lefer AM, Maroko PR (1983) Actions of a new inotropic agent, berberine, on vascular smooth muscle. IRCS Med Sci Libr Compend 11:570–571

    CAS  Google Scholar 

  54. Shaffer JE (1985) Inotropic and chronotropic activity of berberine on isolated guinea pig atria. J Cardiovasc Pharmacol 7:307–315

    Article  PubMed  CAS  Google Scholar 

  55. Hobara N, Watanabe A (1984) Berberine-induced bile bilirubin secretion in the rat. Curr Ther Res 35:663–667

    CAS  Google Scholar 

  56. Chan MY (1977) The effect of berberine on bilirubin excretion in the rat. Comp Med East West 5:161–168

    Article  PubMed  Google Scholar 

  57. Oshiba S, Ueno H, Mihara H, Okamoto S (1974) Effect of berberine on bile secretion. Nihon Univ J Med 16:69–79 (CA 81:114662v)

    CAS  Google Scholar 

  58. Skursky L, Kovar J (1970) Inhibition of LADH (Ever alcohol dehydrogenase) by berberine and some related alkaloids. Wenner-Gren Cent Int Symp Ser 18:653–662 (CA 80:142267t)

    CAS  Google Scholar 

  59. Pavelka S, Kovar J (1975) Interaction of liver alcohol dehydrogenase with protoberberine alkaloids. Collect Czech Chem Commun 40:753–768

    CAS  Google Scholar 

  60. Kovar J, Duerrova E, Skursky L (1979) Differences in the interactions of liver alcohol dehydrogenase with probes binding into the substrate pocket. Eur J Biochem 101:507–514

    Article  PubMed  CAS  Google Scholar 

  61. Mikes V, Yaguzhinskij LS (1985) Interaction of fluorescent berberine alkyl derivatives with respiratory chain of rat liver mitochondria. J Bioenerg Biomembr 17:23–32

    Article  PubMed  CAS  Google Scholar 

  62. Schewe T, Müller W (1976) Inhibition of the respiratory chain by the alkaloids berberine sulfate, alpinigenine and tetrahydropalmatine. Acta Biol Med Ger 35:1010–1021

    Google Scholar 

  63. Berezhinskaya W, Aleshinskaya EE, Trutneva (1968) Anticholinesterase activity of some iso-quinoline alkaloids. Farmakol Toksikol 31:296–299

    CAS  Google Scholar 

  64. Ulrichova J, Kovar J, Simanek V (1985) Interaction of quaternary aromatic isoquinoline alkaloids with acetylcholinesterase from Electrophorus electricus. Collect Czech Chem Commun 50:978–983

    Article  CAS  Google Scholar 

  65. Ulrichova J, Walterova D, Preininger V, Simanek V (1983) Inhibition of butyrylcholinesterase activity by some isoquinoline alkaloids. Planta Med 48:174–177

    Article  CAS  Google Scholar 

  66. Shimamoto K, Uchizumi S, Inoue K (1957) The anticurare action of berberine. Nippon Yakuri-gaku Zasshi 53:75–80 (CA 52:7520a)

    Article  CAS  Google Scholar 

  67. Meyerson LR, McMurtrey KD, Davis VE (1978) Isoquinoline alkaloids. Inhibitory actions on cation-dependent ATP-phosphohydrolases. Neurochem Res 3:239–357

    Article  PubMed  CAS  Google Scholar 

  68. Sethi ML (1983) Enzyme inhibition. VI. Inhibition of reverse transcriptase activity by protoberberine alkaloids and structure-activity relationships. J Pharm Sci 72:538–541

    Article  PubMed  CAS  Google Scholar 

  69. Klimek M, Hnilica L (1959) Influence of deoxyribonucleic acid on ultraviolet and visible light absorption of berberine. Arch Biochem Biophys 81:105–110

    Article  PubMed  CAS  Google Scholar 

  70. Hahn FE, Krey AK (1971) Interactions of alkaloids with DNA. Prog Mol Subcell Biol 2:134–151

    CAS  Google Scholar 

  71. Krey AK, Hahn FE (1969) Berberine: complex with DNA. Science 166:755–757

    Article  PubMed  CAS  Google Scholar 

  72. Davidson MW, Lopp I, Alexander S, Wilson WD (1977) The interaction of plant alkaloids with DNA. Nucleic Acids Res 4:2697–2712

    Article  PubMed  CAS  Google Scholar 

  73. Maiti M, Chaudhuri K (1981) Interaction of berberine chloride with naturally occurring deoxyribonucleic acids. Indian J Biochem Biophys 18:245–250

    PubMed  CAS  Google Scholar 

  74. Smekal E, Kubova N (1984) Alkaloids of protoberberine and benzophenanthridine groups as intercalating drugs with DNA. Stud Biophys 101:121–123 (CA 102:263n)

    CAS  Google Scholar 

  75. Smekal E, Koudelka J, Hung MA (1980) Fluorescence investigation of berberine-nucleic acid complexes. Stud Biophys 81:89–90 (CA 94:204201h)

    CAS  Google Scholar 

  76. Shanbhag SM, Kulkarni HJ, Gaitonde BB (1970) Pharmacological actions of berberine on the central nervous system. Jpn Pharmacol 20:482–487

    Article  CAS  Google Scholar 

  77. Sabir M, Bhide NK (1971) Pharmacological actions of berberine. Indian J Physiol Pharmacol 15:111–132

    PubMed  CAS  Google Scholar 

  78. Yamahara J (1976) Behavioral pharmacology of berberine-type alkaloids. I. Central depressive action of Coptis rhizoma and its constituents. Nippon Yakurigaku Zasshi 72:899–908 (CA 87:193774h)

    Article  PubMed  CAS  Google Scholar 

  79. Vad BG, Raman PH, Desmukh VK (1971) Effect of berberine on serum cholesterol and pentobarbitone sleeping time in rats. Indian J Pharm 33:23–24

    CAS  Google Scholar 

  80. Chen QM, Xie MZ (1986) Hypoglycemic effect of Coptis chinensis extract and berberine. Acta Pharm Sin 21:401–406

    CAS  Google Scholar 

  81. Sabir M, Bhide NK (1971) In vitro antiheparin action of berberine on the dog and human blood. Indian J Physiol Pharmacol 15:97–100

    PubMed  CAS  Google Scholar 

  82. Berlin G, Enerbaeck L (1983) Fluorescent berberine binding as a marker of secretory activity in mast cells. Int Arch Allergy Appl Immunol 71:332–339

    Article  PubMed  CAS  Google Scholar 

  83. Liu GQ, Jiang Y, Pang G, Ibrahim, Zhou LQ (1985) Effect of some isoquinoline alkaloids on monoamines in rat brain. Acta Pharm Sin 20:566–570

    CAS  Google Scholar 

  84. Philogene BJR, Arnason JT, Towers CHN, Abramowski Z, Champagne D, McLachlan D (1984) Berberine: a naturally occurring phototoxic alkaloid. J Chem Ecol 10:115–123

    Article  CAS  Google Scholar 

  85. Bhide MB, Chavan SR, Dutta NK (1969) Absorption, distribution and excretion of berberine. Indian J Med Res 57:2128–2131

    PubMed  CAS  Google Scholar 

  86. Sakurai S, Tezuka M, Tamemasa O (1976) Studies on the absorption, distribution and excretion of 3H-berberine chloride. Oyo Yakuri 11:351–355 (CA 88:145908d)

    CAS  Google Scholar 

  87. Yamahara J, Goto K, Sawada T (1972) Biological studies of Coptis japonica and berberine-type alkaloids. 2. Metabolism and chemotherapeutic effect. Shoyakugaku Zasshi 26:53–57 (CA 78:11673h)

    CAS  Google Scholar 

  88. Mrozikiewicz A, Kowalewski Z, Drost-Karwowska K, Bobkiewicz T, Klimaszewska O (1980) Pharmacokinetics of berberine chloride. Herba Pol 26:123–127 (CA 94:185343w)

    CAS  Google Scholar 

  89. Turova AD, Leskov AI, Bichevina VI (1962) Berberine. Lekarstv Sredstva iz Rast 303–307 (CA 58:2763b)

    Google Scholar 

  90. Hladon B (1975) Toxicity of berberine sulfate. Acta Pol Pharm 32:113–120 (CA 83:91108u)

    PubMed  Google Scholar 

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  1. Lebensmittelchemie und Umwelttoxikologie, Universität Kaiserslautern, Erwin-Schrödinger-Straße, D-6750, Kaiserslautern, Germany

    Professor Dr. Weici Tang & Professor Dr. Gerhard Eisenbrand

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Tang, W., Eisenbrand, G. (1992). Coptis spp.. In: Chinese Drugs of Plant Origin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73739-8_47

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  • DOI: https://doi.org/10.1007/978-3-642-73739-8_47

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