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Cephalotaxus spp.

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Abstract

Cephalotaxus, the only genus of the family Cephalotaxaceae with eight species and few varieties known so far, is mostly native to China. Seven of the eight known Cephalotaxus species growing in China are: C. fortunei Hook. f., C. hainanensis Li, C. wilsoniana Hay., C. mannü Hook, f., C. oliveri Mast., C. lanceolata K.M. Feng, and C. sinensis Li. C. harringtonia occurs in Japan and C. mannii is also found in India [1, 2].

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References

  1. Zhu DY (1987) Recent advances on the active components in Chinese medicines. Abstr Chin Medicines 1:251–286

    Google Scholar 

  2. Alkaloids Group, Laboratory of Plant Chemistry, Institute of Botany, Academia Sinica (1980) Studies on alkaloids of Cephalotaxus sinensis (Rehd. et Will.) Li. Acta Bot Sin 22:156–160

    Google Scholar 

  3. Powell RG, Weisleder D, Smith CR Jr (1972) Antitumor alkaloids from Cephalotaxus harringtonia; structure and activity. J Pharm Sci 61:1227–1230

    PubMed  CAS  Google Scholar 

  4. Well ME, Eddy CR, Williaman JJ, Correll DS, Schuber BG, Gentry HS (1954) Steroidal sapogenins. XII. Survey of plant for steroidal sapogenins and other constituents. J Am Pharm Assoc 43:503–505

    Google Scholar 

  5. Kariyone T, Takahashi M, Nitta A, Tsunehisa Y (1956) The alkaloid of coniferous plants. I. J Pharm Soc Jpn 76:611

    CAS  Google Scholar 

  6. Hsu HY (1957) Alkaloids in leaves of gymnosperms in Taiwan. I. J Taiwan Pharm 9:5–8

    Google Scholar 

  7. Paudler WW, Kerley GI, McKay J (1963) The alkaloids of Cephalotaxus drupacea and Cephalotaxus fortunei. J. Org Chem 28:2194–2197

    CAS  Google Scholar 

  8. Powell RG, Weisleder D, Smith CR Jr, Wolff IA (1969) Structure of cephalotaxine and related alkaloids. Tetrahedron Lett 4081–4084

    Google Scholar 

  9. Abraham DJ, Rosenstein RD, McGandy EL (1969) Single crystal X-ray structures of chemo-therapeutic agents. II. The structure of cephalotaxine methiodide. Tetrahedron Lett 4085–4086

    Google Scholar 

  10. Arora SK, Bates RB, Grady RA, Powell RG (1974) Crystal and molecular structure of cephalotaxine p-bromobenzoate. J Org Chem 39:1269–1271

    PubMed  CAS  Google Scholar 

  11. Arora SK, Bates RB, Grady RA, Germain G, Declercq P, Powell RG (1976) Crystal and molecular structure of cephalotaxine. J Org Chem 41:551–554

    PubMed  CAS  Google Scholar 

  12. Powell RG, Weisleder D, Smith CR Jr, Rohwedder WK (1970) Structures of harringtonine, isoharringtonine and homoharringtonine. Tetrahedron Lett 815–818

    Google Scholar 

  13. Mikolajczak KL, Powell RG, Smith CR Jr (1972) Deoxyharringtonine, a new antitumor alkaloid from Cephalotaxus: structure and synthetic studies. Tetrahedron 28:1995–2001

    CAS  Google Scholar 

  14. Brandange S, Josephson S, Valien S (1974) Absolute configurations of 2-alkylmalic acids. Acta Chem Scand [B]28:153–156

    CAS  Google Scholar 

  15. Brandange S, Josephson S, Valien S, Powell RG (1974) Absolute configuration of 2,3-dihy-droxy-2-isopentyl-butanedioic acid, a component of the alkaloid isoharringtonine. Acta Chem Scand [B]28:1237–1248

    Google Scholar 

  16. Ipaktchi T, Weinreb SM (1973) Relative configuration of the diacid sidechain of isoharringtonine. Tetrahedron Lett 3895–3898

    Google Scholar 

  17. Powell RG (1972) Structures of homoerythrina alkaloids from Cephalotaxus harringtonia. Phytochemistry 11:1467–1472

    CAS  Google Scholar 

  18. Powell RG, Mikolajczak KL (1973) Desmethylcephalotaxinone and its correlation with cephalotaxine. Phytochemistry 12:2987–2991

    CAS  Google Scholar 

  19. Fitzgerald JS, Johns SR, Lamberton JA, Sioumis AA (1969) Alkaloids of Schelhammera pedunculata (Liliaceae). I. Isolation of the alkaloids schelhammerine and schelhammeridine. Aust J Chem 22:2187–2201

    CAS  Google Scholar 

  20. Johns SR, Lamberton JA, Sioumis AA, Suares H (1969) Alkaloids of Schelhammera pedunculata (Liliaceae). II. Reactions of schelhammeridine. Aust J Chem 22:2203–2218

    CAS  Google Scholar 

  21. Johns SR, Lamberton JA, Sioumis AA (1969) Alkaloids of Schelhammera pedunculata (Liliaceae). III. The structures of schelhammericine and alkaloids A, B, E, G, H, J and K. Aust J Chem 22:2219–2231

    CAS  Google Scholar 

  22. Powell RG, Weisleder D, Smith CR Jr, Wolff IA (1969) Structure of cephalotaxine and related alkaloids. Tetrahedron Lett 4081 – 4084

    Google Scholar 

  23. Powell RG, Madrigal RV, Smith CR Jr, Mikolajczak KL (1974) Alkaloids of Cephalotaxus harringtonia var. drupacea. 11-Hydroxycephalotaxine and drupacine. J Org Chem 39:676–680

    PubMed  CAS  Google Scholar 

  24. Asada S (1973) Alkaloids isolated from the Cephalotaxus drupacea. Yakugaku Zasshi 93:916–924

    PubMed  CAS  Google Scholar 

  25. Chinese Academy of Medical Sciences, Chinese People’s Liberation Army 187th Hospital (1976) Studies on the antitumor constituents of Cephalotaxus hainanensis Li. Acta Chim Sin 34:283–293

    Google Scholar 

  26. Xue Z, Xu LZ, Chen DH, Huang L (1981) Studies on minor alkaloids of Cephalotaxus hainanensis Li. Acta Pharm Sin 16:752–756

    CAS  Google Scholar 

  27. Sun NJ, Liang XT (1981) Studies on the structure of a new antitumor constituent, hainanensine. Acta Pharm Sin 16:24–26

    CAS  Google Scholar 

  28. Sun NJ, Liang HT (1980) Structure of a new antitumor constituent, hainanensine. Chin Pharm Bull 15:39–40

    CAS  Google Scholar 

  29. Xue Z, Sun NJ, Chen DH, Xu LZ, Chen WM, Ren LJ, Liang XT, Huang L (1982) The studies of chemical constituents of Cephalotaxus hainanensis Li. In: Wang Y (ed) Chem Nat Prod, Proc Sino-Am Symp 1980. Science Press, Beijing, 195–199

    Google Scholar 

  30. Paudler WW, McKay J (1973) The structures of some of the minor alkaloids of Cephalotaxus fortunei. J Org Chem 38:2110–2112

    PubMed  CAS  Google Scholar 

  31. Ma GE, Lin LT, Chao TY, Fan HC (1977) Studies on the alkaloids of Cephalotaxus. I. Isolation and characterization of anticancer alkaloids and a new alkaloid (+)-acetylcephalo-taxine from Cephalotaxus fortunei. Acta Chim Sin 35:201–208

    CAS  Google Scholar 

  32. Ma GE, Lin LT, Chao TY, Fan HC (1978) Studies on alkaloids of Cephalotaxus. II. Four minor alkaloids from Cephalotaxus fortunei. Hook. f. and the structure of cephalofortuneine. Acta Chim Sin 36:129–136

    CAS  Google Scholar 

  33. Lin W, Chen RT, Xue Z (1985) Studies on the minor alkaloids of Cephalotaxus fortunei Hook. f. Acta Pharm Sin 20:283–287

    CAS  Google Scholar 

  34. Ma GE, Lu CE, ElSohly HN, ElSohly MA, Turner CE (1983) Studies on the alkaloids of Cephalotaxus. IV. Fortuneine, a homoerythrina alkaloid from C. fortunei. Phytochemistry 22:251–253

    CAS  Google Scholar 

  35. Ma GE, Sun GQ, ElSohly MA, Turner CE (1982) Studies on the alkaloids of Cephalotaxus. III. 4-Hydroxycephalotaxine, a new alkaloid from Cephalotaxus fortunei. J Nat Prod 45:585–589

    CAS  Google Scholar 

  36. Ma GE, Lu CE, Fan GJ (1982) Isolation and identification of harringtonine and other alkaloids from seeds of Cephalotaxus fortunei. Chin Pharm Bull 17:205–206

    CAS  Google Scholar 

  37. Ma YQ, Guo MR, Zhu TP, Ma GE, Lu CE, Huang H, Yang YH (1984) Determination of harringtonine and homoharringtonine, antileukemic alkaloids in Cephalotaxus fortunei Hook. f. and C. sinensis (Rehd. et Wils) Li. Acta Bot Sin 26:405–410

    CAS  Google Scholar 

  38. Institute of Botany, Academia Sinica (1980) Studies on alkaloids of Cephalotaxus sinensis (Rehd. et Wils.) Li. Acta Bot Sin 22:156–160

    Google Scholar 

  39. Ren LJ, Xue Z (1981) Studies on the antitumor constituents of Cephalotaxus sinensis. Chin Trad Herb Drugs 12:241–244

    Google Scholar 

  40. Powell RG, Mikolajczak KL, Weisleder D, Smith CR Jr (1972) Alkaloids of Cephalotaxus wilsoniana. Phytochemistry 11:3317–3320

    CAS  Google Scholar 

  41. Furukawa H, Itoigawa M, Haruna M, Jinno Y, Ito K, Lu ST (1976) Alkaloids of Cephalotaxus wilsoniana Hay. Yakugaku Zasshi 96:1373–1377

    PubMed  CAS  Google Scholar 

  42. Zhang FX, Wang ZH, Pan WD, Li YJ, Mai LT, Sun JQ, Ma GE (1978) A study on the antitumor plant Cephalotaxus oliveri Mast. Acta Bot Sin 20:129–134

    CAS  Google Scholar 

  43. Pan WD, Mai LT, Li YJ (1983) Studies on the variation of harringtonine content in Cephalotaxus oliveri with seasons, parts and ages of the tree. Bull Chin Mat Med 8:15–16

    CAS  Google Scholar 

  44. Powell RG, Miller RW, Smith CR Jr (1979) Cephalomannine: a new antitumor alkaloid from Cephalotaxus mannii. J Chem Soc Chem Commun 102–104

    Google Scholar 

  45. Huang L, Xue Z (1984) Cephalotaxus alkaloids. Alkaloids 23:157–226

    CAS  Google Scholar 

  46. Dolby LJ, Nelson SJ, Senkovich D (1972) Study of the synthesis of cephalotaxine. I. J Org Chem 37:3691–3695

    PubMed  CAS  Google Scholar 

  47. Weinstein B, Craig AR (1976) A synthetic approach to the cephalotaxine skeleton. J Org Chem 41:875–878

    CAS  Google Scholar 

  48. Tse I, Snieckus V (1976) Photochemical preparation of dihydropyrrolo[2,1-b] [3] benzazepines. A Cephalotaxus alkaloid synthon. J Chem Soc Chem Commun 505–506

    Google Scholar 

  49. Auerbach J, Weinreb SM (1972) The total synthesis of cephalotaxine. J Am Chem Soc 94:7172–7173

    PubMed  CAS  Google Scholar 

  50. Weinreb SM, Auerbach J (1975) Total synthesis of the Cephalotaxus alkaloids. Cephalotaxine, cephalotaxinone and demethylcephalotaxinone. J Am Chem Soc 97:2503–2506

    CAS  Google Scholar 

  51. Semmelhack MF, Chong BP, Jones LD (1972) Total synthesis of Cephalotaxus alkaloids. J Am Chem Soc 94:8629–8630

    PubMed  CAS  Google Scholar 

  52. Semmelhack MF, Stauffer RD, Rogerson TD (1973) Nucleophilic aromatic substitution via a new nickel-catalyzed process and via the SRN1 reaction. Improved synthesis of cephalotaxinone. Tetrahedron Lett 4519–4522

    Google Scholar 

  53. Semmelhack MF, Chong BP, Stauffer RD, Rogerson TD, Chong A, Jones LD (1975) Total synthesis of the Cephalotaxus alkaloids. A problem in nucleophilic aromatic substitution. J Am Chem Soc 97:2507–2516

    PubMed  CAS  Google Scholar 

  54. Semmelhack MF, Margar TM (1977) Cyclizations of enolates onto aromatic rings via the photo-SRN1 reaction. Preparative and mechanistic aspects. J Org Chem 42:1481–1482

    CAS  Google Scholar 

  55. Mikolajczak KL, Smith CR Jr, Weisleder D, Kelly TR, McKenna JC, Christenson PA (1974) Synthesis of deoxyharringtonine. Tetrahedron Lett 283–286

    Google Scholar 

  56. Huang WK, Li YL, Pan SF (1976) Crystallization of (oxoacyl)cephalotaxine, a key intermediate for deoxyharringtonine synthesis. Kexue Tongbao 21:178

    CAS  Google Scholar 

  57. Huang WK, Li YL, Pan SF (1980) Synthesis of deoxyharringtonine and separation of its stereomers. Sci Sin [Engl] 23:835–846

    CAS  Google Scholar 

  58. Li SW, Dai JY (1975) A study on the deoxyharringtonine and its analogs. Acta Chim Sin 33:75–78

    Google Scholar 

  59. Institute of Pharmacology (1976) Partial synthesis of harringtonine. Kexue Tongbao 21:512

    Google Scholar 

  60. Huang L, Xi YG, Guo JY, Liu DK, Xu SP, Wu KM, Chen JC, Jiang YZ, Cao YS, Guo Z, Li L, Zhang M, Chu F (1979) Partial synthesis of harringtonine. Sci Sin [Engl] 22:1333–1345

    CAS  Google Scholar 

  61. Kelly TR, McNutt RW Jr, Montury M, Tosches NP, Mikolajczak KL, Smith CR Jr, Weisleder D (1979) Preparation of harringtonine from cephalotaxine. J Org Chem 44:63–67

    CAS  Google Scholar 

  62. Zhao ZZ, Xi YG, Zhao HF, Hou JY, Zhang JY, Wang ZH (1980) Partial synthesis of homo-harringtonine from cephalotaxine. Acta Pharm Sin 15:46–49

    Google Scholar 

  63. Wang YK, Li YL, Pan HF, Li CP, Huang WK (1980) Synthesis of antitumor alkaloids. Kexue Tongbao 25:576

    CAS  Google Scholar 

  64. Hiranuma S, Hudlicky T (1982) Synthesis of homoharringtonine and its derivative by partial esterification of cephalotaxine. Tetrahedron Lett 23:3431–3434

    CAS  Google Scholar 

  65. Li YN, Wu KM, Huang L (1982) Synthesis of isoharringtonine and separation of the isomers. Acta Pharm Sin 17:866–867

    CAS  Google Scholar 

  66. Pan XF, Li YL, Li SB, Tian J, Zhang DN, Cui YX, Cheng PG, Wang YK, Huang WK (1982) Synthesis of isoharringtonine. Kexue Tongbao 27:1048

    CAS  Google Scholar 

  67. Chinese Academy of Medical Sciences, Institute of Materia Medica (1978) Separation and identification of harringtonine and epiharringtonine. Kexue Tongbao 23:696–699

    Google Scholar 

  68. Zhang GD, Zhou ZH, Guo YS, Guo JY, Liu DK, Chu FM (1981) Isolation and determination of the two epimers of partially synthesized harringtonine. Anal Chem 291–295

    Google Scholar 

  69. Huang L, Fang QN, Cheng JC, Jiang ZY (1983) Semisynthetic diastereoisomers — separation and identification of harringtonine and epiharringtonine by preparative high-performance liquid chromatography. Anal Chem 158–159

    Google Scholar 

  70. Li YN, Wu KM, Huang L (1984) Synthesis of isoharringtonine and separation of the isomers. Acta Pharm Sin 19:582–589

    CAS  Google Scholar 

  71. Cheng JC, Zhang JH, Zhang QB, Yang J, Huang L (1984) Stereospecific synthesis of deoxyharringtonine and homoharringtonine. Acta Pharm Sin 19:178–183

    CAS  Google Scholar 

  72. Mioskowski C, Solladie G (1980) Synthésis asymétriques de β-hydroxy acids par condensation d’anions énolates d’esters α-sulfïnyle chiraux sur des composés carbonyles. Tetrahedron 36:227–236

    CAS  Google Scholar 

  73. Steffens GL, Buta JG, Gregory LE, Momdava NB, Meudt WJ, Worley JF (1979) New plant growth regulators isolated from higher plants. In: Geissbuehler H (ed) Advances in Pestic Sciences, Vol. 2. Pergamon, Oxford, pp 343–346

    Google Scholar 

  74. Flippen-Anderson JL, Duesler E (1979) Harringtonolide: a complex tropone. Acta Crystallogr [B]35:1253–1254

    Google Scholar 

  75. Sun NJ, Xue Z, Liang XT, Huang L (1979) Studies on the structure of a new antitumor agent — hainanolide. Acta Pharm Sin 14:39–44

    CAS  Google Scholar 

  76. Bao GH, He CH, Xu CF (1983) Crystal structure of hainanolide. Acta Acad Med Sin 5:89–93

    CAS  Google Scholar 

  77. Xue Z, Sun NJ, Liang XT (1982) Studies on the structure of hainanolidol. Acta Pharm Sin 17:236–237

    CAS  Google Scholar 

  78. Sun NJ, Zhao ZF, Chen RT, Lin W, Zhou YZ (1981) Isolation and identification of the antitumor component — hainanolide from Cephalotaxus fortunei. Acta Pharm Sin 16:233–234

    CAS  Google Scholar 

  79. Khan NU, Ilyas M, Rahman W, Okigawa M, Kawano N (1971) Occurrence of biflavones in Cephalotaxus. Phytochemistry 10:2541–2542

    CAS  Google Scholar 

  80. Ishratullah K, Rahman W, Okigawa M, Kawano N (1981) Biflavones from the leaves of Cephalotaxus harringtonia C. Koch (Cephalotaxacaeae). Indian J Chem [B] 20:935–936

    Google Scholar 

  81. Aqil M, Rahman W, Okigawa M, Kawano N (1976) Isolation of C-methylbiflavone from Cephalotaxus and use of lanthanide shift reagent in deciding 6- or 8-C-methylflavone. Chem Ind 567–568

    Google Scholar 

  82. Aqil M, Rahman W, Hasaka N, Okigawa M, Kawano N (1981) A C-methylbiflavone from Cephalotaxus harringtonia K. Koch. J Chem Soc Perkin Trans I 1389–1392

    Google Scholar 

  83. Ma ZW, He GF, Yin WF (1984) Biflavonoids in the leaves of Cephalotaxus fortunei Hook. f. var. alpina native to China. Acta Bot Sin 26:416–418

    CAS  Google Scholar 

  84. Yang WW, Xing YQ, Xu JY, Shi XF (1983) Isolation of chrysoeriol from Cephalotaxus fortunei Hook. f. J Lanzhou Univ [Natl Sci] 19:114

    CAS  Google Scholar 

  85. Yang WW, Xing YQ, Xu JY, Shi XF (1983) Isolation of chrysoeriol from Cephalotaxus fortunei. Chin Trad Herb Drugs 14:164

    CAS  Google Scholar 

  86. Corbett TH, Griswold DP Jr, Roberts BJ, Peckham JC, Schabel FM Jr (1977) Evaluation of single agents and combinations of chemotherapeutic agents in mouse colon carcinoma. Cancer 40:2660–2680

    PubMed  CAS  Google Scholar 

  87. Takeda S, Yajima N, Kitazato K, Unemi N (1982) Antitumor activities of harringtonine and homoharringtonine, Cephalotaxus alkaloids which are active principles from plant by intraperitoneal and oral administration. J Pharmacobiodyn 5:841–847

    PubMed  CAS  Google Scholar 

  88. Baaske DM, Heinstein P (1977) Cytotoxicity and cell cycle specificity of homoharringtonine. Antimicrob Agents Chemother 12:298–300

    PubMed  CAS  Google Scholar 

  89. Jiang TL, Salmon SE, Liu RM (1983) Activity of camptothecin, harringtonine, cantharidin and cucumae in the human tumor stem cell assay. Eur J Cancer Clin Oncol 19:263–270

    PubMed  CAS  Google Scholar 

  90. Jiang TL, Liu RH, Salmon SE (1983) Comparative in vitro antitumor activity of homoharringtonine and harringtonine against clonogenic human tumor cells. Invest New Drugs 1:21–25

    PubMed  CAS  Google Scholar 

  91. Cobb WR, Bogden AE, Reich SD, Griffm TW, Kelton DE, LePage DJ (1983) Activity of two phase I drugs, homoharringtonine and tricyclic nucleotide, against surgical expiants of human tumor in the 6-day subrenal capsule assay. Cancer Treat Rep 67:173–178

    PubMed  CAS  Google Scholar 

  92. Huang MT (1975) Harringtonine, an inhibitor of initiation of protein biosynthesis. Mol Pharmacol 11:511–519

    PubMed  CAS  Google Scholar 

  93. Tscherne JS, Pestka S (1975) Inhibition of protein synthesis in intact HeLa cells. Antimicrob Agents Chemother 8:479–487

    PubMed  CAS  Google Scholar 

  94. Fresno M, Jimenez A, Vazquez D (1977) Inhibition of translation in eukaryotic systems by harringtonine. Eur J Biochem 72:323–330

    PubMed  CAS  Google Scholar 

  95. Si JY, Son KX, Hu WW, Men SS, Han R, Pan ZK, Li ZR (1979) Ultrastructural study on the effect of harringtonine on mouse leukemia L-1210 cells. Acta Biochem Biophys Sin 11:333 – 338

    CAS  Google Scholar 

  96. Wang ZW, Hsu B (1980) Electron microscopic studies of the effect of homoharringtonine on hepatocyte nucleolus and myocardiac cells. Acta Biochim Biophys Sin 12:231–235

    CAS  Google Scholar 

  97. Wu GY, Fang FD, Han R, Sun ZR (1981) Studies on the mechanism of the inhibition of harringtonine on DNA synthesis. I. Effects of harringtonine on DNA template and metabolism. Acta Biochim Biophys Sin 13:509–515

    CAS  Google Scholar 

  98. Wu GY, Fang FD, Zuo J, Han R, Sun ZR (1982) Studies on mechanism of inhibition of harringtonine on DNA and on protein synthesis. Acta Acad Med Sin 4:78–81

    CAS  Google Scholar 

  99. Yang SR, Fang FD, Wu GY (1982) Effects of harringtonine on nucleotide metabolism in tumor cells. Acta Pharm Sin 17:721–727

    CAS  Google Scholar 

  100. Wu GY, Qiou CC (1982) Studies on the mechanism of inhibition of harringtonine on DNA biosynthesis. II. Effect of harringtonine on DNA polymerase. Acta Biochim Biophys Sin 14:553–558

    CAS  Google Scholar 

  101. Qiu CC, Wu GY (1984) Studies on the mechanism of inhibition of harringtonine on DNA synthesis. III. Kinetics of inhibition by harringtonine and comparison with its analogs. Acta Biochim Biophys Sin 16:645–649

    CAS  Google Scholar 

  102. 102/ Pan ZK, Han R, Wang YC (1980) The cytokinetic effects of harringtonine on leukemia L1210 cells. I. Autoradiographic studies. Acta Biochim Biophys Sin 12:13–20

    CAS  Google Scholar 

  103. Xu YT, Du CZ (1981) Effect of harringtonine and its related alkaloids on DNA synthesis in mice bearing leukemias P388, L615 and normal mice. Acta Pharmacol Sin 2:252–256

    CAS  Google Scholar 

  104. Xu YT, Du CZ, Zhang FR, Ji XJ (1981) Effect of harringtonine alkaloids on the protein biosynthesis in mouse leukemias L615 and P388 cells. Acta Pharm Sin 16:661–666

    CAS  Google Scholar 

  105. Li ZR, Sun ZR, Han R (1983) Effects of harringtonine and related alkaloids on the cAMP levels of L615 and P388 leukemic cells. Acta Pharm Sin 18:303–306

    CAS  Google Scholar 

  106. Zhang YJ, Yu H, Luo XY, Zheng YX, Li WJ, Liu XL, Yuan YY (1979) Toxicological studies of harringtonine and homohamngtonine. Acta Pharm Sin 14:135–140

    CAS  Google Scholar 

  107. Lokhandwala MF, Sabouni MH, Jandhyala BS (1985) Cardiovascular actions of an experimental antitumor agent, harringtonine, in anesthetized dogs. Drug Dev Res 5:157–163

    CAS  Google Scholar 

  108. Wu GY, Fang FD, Zuo J, Han R, Sun ZR (1983) Epiharringtonine-induced enhancement of harringtonine inhibition on protein and DNA formation in tumor cells. Acta Acad Med Sin 5:157–160

    CAS  Google Scholar 

  109. Jiang DZ, Xu YH, Li MF, Yuan WD, Wang QR (1985) Lithium protects mouse bone marrow cells against the myelosuppressive effect of harringtonine. Bull Hunan Med Coll 10:307–311

    Google Scholar 

  110. Huang NJ, Chen SM (1986) Induction of induced chromosome aberrations and micronuclei by harringtonine. Acta Pharmacol Sin 7:173–175

    CAS  Google Scholar 

  111. Ji XJ, Liu JS, Liu ZM (1979) Metabolism of harringtonine. Acta Pharm Sin 14:234–240

    CAS  Google Scholar 

  112. Chinese Academy of Medical Sciences (1979) Chemical, pharmacological and clinical studies on the antitumor active principle of Cephalotaxus hainanensis Li. Chin J Oncol 1:176–182

    Google Scholar 

  113. Ji XJ, Liu Y, Lin H, Liu ZM (1982) Metabolism of homohamngtonine in rats and mice. Acta Pharm Sin 17:881–888

    CAS  Google Scholar 

  114. Harringtonine Cooperative Group (1975) Preliminary clinical evaluation of cephalotaxine ester in the treatment of acute leukemia. Natl Med J China 55:712

    Google Scholar 

  115. Zhang ZY (1981) Clinical analysis of the therapeutic effect of semisynthetic harringtonine in treating 55 cases of nonlymphocytic leukemia. Chin J Intern Med 20:667

    CAS  Google Scholar 

  116. Chang CN (1985) Antileukemia Chinese herbs and the effective ingredients. In: Chang HM, Yeung HW, Tso WW, Koo A (eds) Advances in Chinese Medical Material Research. World Scientific, Singapore, pp 369–375

    Google Scholar 

  117. Mikolajczak KL, Smith CR Jr, Powell RG (1974) Partial synthesis of harringtonine analogs. J Pharm Sci 63:1280–1283

    PubMed  CAS  Google Scholar 

  118. Mikolajczak KL, Powell RG, Smith CR Jr (1975) Preparation and antitumor activity of a rearranged ester of cephalotaxine. J Med Chem 18:63–66

    PubMed  CAS  Google Scholar 

  119. Mikolajczak KL, Smith CR Jr, Weisleder D (1977) Synthesis of cephalotaxine esters and correlation of their structures with antitumor activity. J Med Chem 20:328–332

    PubMed  CAS  Google Scholar 

  120. Li SW, Sun HL, Lu SJ, Zhang SY, Lu FL, Dai JY, Xu YB (1981) Synthesis of cephalotaxine esters and their antitumor activity. Acta Pharm Sin 16:821–827

    CAS  Google Scholar 

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Tang, W., Eisenbrand, G. (1992). Cephalotaxus spp.. In: Chinese Drugs of Plant Origin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73739-8_38

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  • DOI: https://doi.org/10.1007/978-3-642-73739-8_38

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