Asarum spp.

  • Weici Tang
  • Gerhard Eisenbrand


Xixin, Herba Asari, is the dry whole plant of Asarum heterotropoides Fr. var. mand-shuricum (Maxim.) Kitag., A. sieboldii Miq. var. seoulense Nakai, or A. sieboldii Miq. (Aristolochiaceae) collected in summer or fall when the fruits are ripe. It is listed officially in the Chinese Pharmacopoeia and used as an analgesic and antitussive agent for treatment of influenza, headache, rheumatic pain, and asthma.


Acid Ethyl Ester Urinary Metabolite Chinese Pharmacopoeia Bornyl Acetate Aspergillus Versicolor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Tian Z, Dong SN, Wang BY, Lou ZC (1981) Identification of the constituents of volatile oil from Chinese Asarum species. II. Volatile oil from huaxixin, Asarum sieboldii. J Beijing Med Coll 13:282–284Google Scholar
  2. 2.
    Shen ZX (1982) GC/MS analysis of the essential oil of Asarum sieboldii Miq. Chin J Pharm Anal 2:335–338Google Scholar
  3. 3.
    Pan JG, Xu ZL, Wang GH, Yang CS, Zhang JJ (1984) GC/MS analysis of volatile oils from Chinese Asarum species. II. Asarum sieboldii forma seoulense, A. forbesii, A. inflaium, A. magnificum var. dinghugense and A. caudigerum var. cardiophyllum. Bull Chin Mat Med 9:175–177Google Scholar
  4. 4.
    Yang CS, Zhang JJ, Pan QG, Xu ZL, Zhu QC, Wang GF (1986) Gas chromatography-mass spectroscopic analysis of volatile oils from Chinese Asarum species. IV. Bull Chin Mat Med 11:423–427Google Scholar
  5. 5.
    Shen ZX (1981) Constituents of the essential oil of Asarum himalaicum. Chin Pharm Bull 16:695Google Scholar
  6. 6.
    Xu ZL, Pan JG, Zhu QC, Wang GH, Yang CS, Zhang JJ (1986) GC-MS of the volatile oils of Asarum species (III). Bull Chin Mat Med 11:46–49Google Scholar
  7. 7.
    Yang GM, Zhou TD (1986) Botanical resources and utilization of Asarum — the volatile oil contents and components of Xiang Xixin. Hunan Zhongyi Zazhi 40–42Google Scholar
  8. 8.
    Shen ZZ, Liu L, Zhou TJ, Li QN, Wang HX (1981) Comparative effects of Asarum heterotropoides, higenamine and isoprenaline on function of left ventricle in dogs. Acta Pharm Sin 16:721–727Google Scholar
  9. 9.
    Liu L, Li YE, Chen CC, Chou TC, Wang HH (1981) Comparative study of Asarum heterotropoides, higenamine and isoprenaline on the hemodynamics in anesthetized dogs. Chin Pharm Bull 16:50Google Scholar
  10. 10.
    Ling SS, Fang Q, Zhang J, Sun WL (1986) Experimental studies on the antihyperlipemic effect of Asarum forbesii Maxim. Chin Trad Herb Drugs 17:21–23Google Scholar
  11. 11.
    Ohmoto T, Sung YI (1982) Antimycotic substances in the crude drugs. II. Shoyakugaku Zasshi 36:307–314Google Scholar
  12. 12.
    International Agency for the Research on Cancer (1976) IARC Monogr Eval Carcinog Risk Chem Man 10:231–244Google Scholar
  13. 13.
    Innes JRM, Ulland BM, Valerio MG, Petrucelli L, Fishbein L, Hart ER, Pallota AJ, Bates RR, Falk HL, Garg JJ, Klein M, Mitchell I, Peters J (1969) Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. JNCI 42:1101–1114PubMedGoogle Scholar
  14. 14.
    Long EL, Nelson AA, Fitzhugh OG, Hansen WH (1963) Liver tumors produced in rats by feeding safrole. Arch Pathol 75:595–604Google Scholar
  15. 15.
    Epstein SS, Fujii K, Andrea J, Mantel N (1970) Carcinogenicity testing of selected food additives by parenteral administration to infant Swiss mice. Toxicol Appl Pharmacol 16:321PubMedCrossRefGoogle Scholar
  16. 16.
    Borchert P, Wislocki PG, Miller JA, Miller EC (1973) The metabolism of the naturally occurring hepatocarcinogen safrole to 1’-hydroxysafrole and the electrophilic reactivity of 1’-ace-toxysafrole. Cancer Res 33:575–589PubMedGoogle Scholar
  17. 17.
    Borchert P, Miller JA, Miller EC, Shires TK (1973) 1′-Hydroxysafrole, a proximate carcinogenic metabolite of safrole in the rat and mouse. Cancer Res 33:590–600PubMedGoogle Scholar
  18. 18.
    Wislocki PG, Borchert P, Miller JA, Miller EC (1976) The metabolic activation of the carcinogen 1′-hydroxysafrole in vivo and in vitro and the electrophilic reactivities of possible ultimate carcinogens. Cancer Res 36:1686–1695PubMedGoogle Scholar
  19. 19.
    Phillips DH, Miller JA, Miller EC, Adams B (1981) The N 2-atom of guanine and the N 6-atom of adenine residues as sites for covalent binding of metabolically activated 1′-hydroxysafrole to mouse-liver DNA in vivo. Cancer Res 41:2664–2671PubMedGoogle Scholar
  20. 20.
    Oswald EO, Fishbein L, Corbett BJ, Walker MP (1971) Identification of tertiary aminoethylene-dioxypropion-phenones as urinary metabolites of safrole in the rat and guinea pig. Biochim Biophys Acta 230:237–247PubMedCrossRefGoogle Scholar
  21. 21.
    Stillwell WG, Carman MJ, Bell L, Homing MG (1974) The metabolism of safrole and 2′,3′-epoxysafrole in the rat and guinea pig. Drug Metab Dispos 12:489–498Google Scholar
  22. 22.
    Kamienski FX, Casida JE (1970) Importance of demethylenation in the metabolism in vivo and in vitro of methylenedioxyphenyl synergists and related compounds in mammals. Biochem Pharmacol 19:91–112PubMedCrossRefGoogle Scholar
  23. 23.
    Jenner PM, Hagen EC, Taylor JM, Cook EL, Fitzhugh OG (1964) Food flavourings and compounds of related structure. I. Acute oral toxicity. Food Cosmet Toxicol 2:327–343CrossRefGoogle Scholar
  24. 24.
    Miller JA, Miller EC, Phillips DH (1982) The metabolic activation and carcinogenicity of alkenylbenzenes that occur naturally in many spices. In: Stich HF (ed) Carcinogens and Mutagens in the Environment, vol 1. CRC, Boca Raton, pp 83–95Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Weici Tang
    • 1
  • Gerhard Eisenbrand
    • 1
  1. 1.Lebensmittelchemie und UmwelttoxikologieUniversität KaiserslauternKaiserslauternGermany

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