Skip to main content

Abstract

Some Aristolochia species have found wide use in traditional Chinese medicine and folk medicine. The Chinese Pharmacopoeia lists the following items:

  • Madouling, Fructus Aristolochiae, is the dry ripe fruit of Aristolochia contorta Bge. or A. debilis Sieb. et Zucc. (Aristolochiaceae) collected in fall when the fruits have become yellow. It is used in the treatment of respiratory diseases as an antitussive and antiasthmatic.

  • Tianxianteng, Herba Aristolochiae, is the dry aerial part of A. contorta or A. debilis harvested in fall and used as a diuretic against edema and as an antirheumatic.

  • Guangfangji, Radix Aristolochiae fangchi, is the dry root of A. fangchi Y. C. Wu ex L. D. Chou et S. M. Hwang collected in fall and winter. It is used as an antirheumatic and diuretic.

  • Guanmutong, Caulis Aristolochiae manshuriensis, is the dry vine of A. manshuriensis Kom. harvested in fall and winter. It is used as a diuretic and antiphlogistic for treatment of edema and rheumatic pain.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ding LS, Lou FC (1983) Chemical constituents of Aristolochia plants. Chin Trad Herb Drugs 14:424–432

    CAS  Google Scholar 

  2. Mix DB, Guinandeau H, Shamma M (1982) The aristolochic acids and aristolactams. J Nat Prod 45:657–666

    Article  CAS  Google Scholar 

  3. Tseng KF, Ku YT (1958) Chemical studies on Aristolochia species. II. Relation between isoaris-tolochic acid and aristolochic acid. Acta Pharm Sin 6:174–177

    CAS  Google Scholar 

  4. Tseng KF, Ku YT (1958) Chemistry of Aristolochia. I. Constituents of Aristolochia debilis. Acta Pharm Sin 6:33–38

    CAS  Google Scholar 

  5. Ku YT, Tseng KF (1957) Structure of debilic acid. Kexue Tongbao 761–762

    Google Scholar 

  6. Zhang XQ, Xu LX (1982) Analysis of active principles in Chinese herbal drugs. IV. Determination of aristolochic acid in Aristolochia debilis Sieb. et Zucc. Chin J Pharm Anal 2:72–75

    CAS  Google Scholar 

  7. Chen ZL, Huang BS, Zhu DY, Yin ML (1981) Studies on the active principles of Aristolochia debilis. II. 7-Hydroxy-aristolochic acid A and 7-methoxy-aristolochic acid A. Acta Chim Sin 39:237–242

    CAS  Google Scholar 

  8. Huang BS, Wu LJ, Yin ML, Chen ZL (1985) Active principles of Aristolochia debilis. III. The isolation and identification of five derivatives of aristolochic acid. Chin Trad Herb Drugs 16:482–484

    CAS  Google Scholar 

  9. Tomita M, Kura S (1957) Ingredients of aristolochiaceous plants. I. Ingredients of Aristolochia kaempferi and A. debilis. Yakugaku Zasshi 77:812–814

    CAS  Google Scholar 

  10. Chang CC, Warig CK, Li CC, Shao IT, Pei YC, Chiang MY, Li T, Hsu TC (1964) Pharmacological studies on magnoflorine, a hypotensive principle from tu qing mu xiang. Acta Pharm Sin 11:42–49

    CAS  Google Scholar 

  11. Tomita M, Fukagawa K (1962) Ingredients of aristolochiaceous plants. V. Ingredients of Aristolochia debilis. Yakugaku Zasshi 82:1673–1675

    PubMed  CAS  Google Scholar 

  12. Rücher G, Mayer R (1985) Bisbenzylisoquinoline alkaloids from roots of Aristolochia debilis. Planta Med 51:183–184

    Article  Google Scholar 

  13. Furukawa S, Soma N (1961) Structure of aristolone, a constituent of Aristolochia debilis. I. Yakugaku Zasshi 81:559–565

    CAS  Google Scholar 

  14. Furukawa S, Soma N (1961) Structure of aristolone, a constituent of Aristolochia debilis. II. Yakugaku Zasshi 81:565–570

    CAS  Google Scholar 

  15. Krepinsky J, Jommi G, Samek Z, Sorm F (1970) Terpenes CCIV. Sesquiterpene constituents of Aristolochia debilis. Structure of debilone. Collect Czech Chem Commun 35:745–748

    CAS  Google Scholar 

  16. Nishida R, Kumazawa Z (1973) 3-Oxoishwarane, a new sesquiterpenic ketone from Aristolochia debilis. Agric Biol Chem 37:341–344

    Article  CAS  Google Scholar 

  17. Rücker G (1968) 1(10)-Aristolenon-(2) and 1,8,9,10-Tetradehydroaristolanone-(2), neue Sesquiterpene-ketone vom Aristolan-Typ. Liebigs Ann Chem 717:221–224

    Article  Google Scholar 

  18. Nakanishi T, Iwasaki K, Nasu M, Miura I, Yoneda K (1982) Aristoloside, an aristolochic acid derivative from stems of Aristolochia manshuriensis. Phytochemistry 21:1759–1762

    CAS  Google Scholar 

  19. Otsuka Pharmaceutical (1983) Aristolochin and its ester. Jpn Kokai Tokkyo JP. 58 152,897 (83 152,897) (CA 100:91346q)

    Google Scholar 

  20. Ding LS, Lou FC, Cao MC, Wang YF, He CG (1986) Chemical constituents of Guanmutong (Mutong Madouling) (Aristolochia manshuriensis). Chin Trad Herb Drugs 17:347–348

    CAS  Google Scholar 

  21. Xu LZ, Sun NJ (1984) Preliminary comparison of chemical constituents between Aristolochia fangchi and A. moupinensis. Bull Chin Mat Med 9:206–207

    CAS  Google Scholar 

  22. Lou FC, Ding LS, Li LL, Wu MY (1986) Chemical constituents of Bei Madouling (Aristolochia contorta). Chin Trad Herb Drugs 17:390–391

    CAS  Google Scholar 

  23. Lou FC, Ding LS, Wu MY, Li LL (1986) Chemical studies on Aristolochia contorta Bunge. II. The structure of aristolochic acid E. Acta Pharm Sin 21:702–705

    CAS  Google Scholar 

  24. Ding LS, Ho MS, Lou FC (1980) Studies on the chemical constituents of Aristolochia mollissima. II. Chin Trad Herb Drugs 11:487

    CAS  Google Scholar 

  25. He LX, Xue HZ, Xu YX, Weng J (1984) Studies on the constituents of Aristolochia mollissima Hance. Acta Bot Sin 26:527–531

    CAS  Google Scholar 

  26. He MS, Fang H, Lin AP (1982) Studies on Aristolochia mollissima. III. Chin Trad Herb Drugs 13:534–535

    CAS  Google Scholar 

  27. Ding LS, Lou FC (1980) Studies on the chemical constituents of Aristolochia mollissima. I. Chin Trad Herb Drugs 11:484–486

    CAS  Google Scholar 

  28. Hua ZQ, Xu XJ, Lou FJ, Ding LS (1983) Molecular and crystal structure of the compound C15H20O2 from Aristolochia mollissima Hance. Jiegou Huaxue 2:197–200

    CAS  Google Scholar 

  29. Lou FC, Ding LS, Wu MY (1984) Studies on chemical constituents of Aristolochia mollissima Hance. IV. Determination of chemical structure of mollislactone. Acta Pharm Sin 18:684–688

    Google Scholar 

  30. Li SY, Yao Q (1981) Isolation and identification of aristolochic acid from Aristolochia kwangsiensis. Chin Pharm Bull 16:16–17

    CAS  Google Scholar 

  31. Li SY, Yao C (1981) Isolation and identification of the chemical constituents in Aristolochia kwangsiensis Chun et How. Chin Trad Herb Drugs 12:25

    CAS  Google Scholar 

  32. Chou FH, Liang PY, Chu SC, Wen C (1981) Chemical constituents in Aristolochia kwangsiensis. Chin Pharm Bull 16:56–57

    CAS  Google Scholar 

  33. Zhou FX, Liang PY, Qu CJ, Wen J (1981) Studies on chemical constituents of Aristolochia kwangsiensis Chun et How ex CF Liang. Acta Pharm Sin 16:638–640

    CAS  Google Scholar 

  34. Zhang XQ, Xu LX (1982) Assay of aristolochic acid in Zhu Sha Lian (Aristolochia tuberosd). Chin Trad Herb Drugs 13:448–451

    CAS  Google Scholar 

  35. Zhu DY, Jiang FX, Xu RS, Qiu YP, Chen XZ, Yu DJ (1981) Studies on the chemical constituents of Zhu Sha Lian (Aristolochia tuberosd). II. Structural elucidation of the lactam and its glycoside. Chin Trad Herb Drugs 12:529–530

    CAS  Google Scholar 

  36. Zhu DY, Wang BD, Huang BS, Xu RS, Qiu YP, Chen XZ (1982) Two new 4,5-dioxoaporphine alkaloids isolated from Aristolochia tuberosa. Heterocycles [Spec Issue] 17:345–347

    Article  CAS  Google Scholar 

  37. Zhu DY, Wang BD, Huang BS, Xu RS, Qiu YP, Chen XZ, Quan DJ (1983) Two new oxoapor-phine alkaloids isolated from Aristolochia tuberosa. I. Structures of tuberosinone and tuberosi-none-N-β-D-glucoside. Acta Chim Sin 41:74–78

    CAS  Google Scholar 

  38. Ding LS, Zeng Q, Lou FC (1981) Active principles of Tong Cheng Hu Geng (roots of Aristolochia tagala). Chin Trad Herb Drugs 12:436–438

    CAS  Google Scholar 

  39. Zhou FX, Wen J, Liang PY, Ma Y (1982) Study on the chemical constituents of San Tong Guan (Aristolochia championii). Chin Trad Herb Drugs 13:3–5

    CAS  Google Scholar 

  40. Zhou FX, Wen J, Liang PY, Ma Y (1981) Studies on chemical constituents of Aristolochia championii. Chin Pharm Bull 17:243

    Google Scholar 

  41. Ho MS, Li XL, Lo JQ, Liu JC (1983) Studies on chemical constituents of Aristolochia heterophylla. Chin Trad Herb Drugs 14:158

    CAS  Google Scholar 

  42. Tian BZ, Zou WQ, Huang S, Tan TQ, Lu LQ (1982) Studies on the chemical constituents of Mu Ping Ma Dou Ling (Aristolochia moupinensis) and Yi Ye Ma Dou Ling (Aristolochia heterophylla) roots. Chin Trad Herb Drugs 13:10–12

    CAS  Google Scholar 

  43. Xu LZ, Sun NJ (1984) Chemical constituents of Aristolochia moupinensis Franch. Acta Pharm Sin 19:48–55

    CAS  Google Scholar 

  44. Xue HZ, Zhang J, He LX (1985) Isolation and identification of the constituents soluble in petrolether from Aristolochia versicolar. J Nanjing Pharm Coll 16:7–9

    CAS  Google Scholar 

  45. Zhang J, He LX (1986) Determination of the structures of versicolactone B and versicolactone C in the root of Aristolochia versicolor S.M. Hwang. Acta Pharm Sin 21:273–278

    CAS  Google Scholar 

  46. Zheng J, Li GP, Chen ZG, Tang YQ, Wei XC, He LX (1986) Crystal and molecular structure of acetyl versicolactone B. Acta Chim Sin 44:551–557

    CAS  Google Scholar 

  47. Zhang CZ, Lao JH, Wang ZW (1986) Studies of chemical components of domesticated and wild Aristolochia cinabaria. Chin J Pharm Anal 6:220–222

    Google Scholar 

  48. Xu FQ, Wu PE (1986) Studies on chemical constituents of Aristolochia austrozechuanica. Chin J Pharm Anal 6:55–56

    CAS  Google Scholar 

  49. Komatsu N, Nawata H, Kimino T, Tsunoda H, Nagumo N, Koike K, Shoji J, Tada A (1973) Biological activity of aristolochic acid. I. Antimicrobial spectrum and effects on bacterial toxins. Showa Igakkai Zasshi 33:769–775 (CA 82:3945m)

    CAS  Google Scholar 

  50. Komatsu N, Nawata H, Kimino T, Shoji J, Tada A (1973) Biological activities of aristolochic acid. II. Effect on experimental tumor, bacterial infection and RES (reticuloendothelial system) function. Showa Igakkai Zasshi 33:776–782 (CA 82:68199v)

    CAS  Google Scholar 

  51. Shunack W, Mutschier E, Rochelmeyer H (1967) Influence of aristolochic acids I and II on the survival rate of mice infected with pneumococci. Arzneimittelforschung 17:1215–1218

    Google Scholar 

  52. Mose JR (1975) The effect of aristolochic acid on the development of methylcholanthrene tumors in mice. Oesterr Z Onkol 2:151–153

    CAS  Google Scholar 

  53. Angeles LT (1975) Sex difference in response to a carcinostatic acid. J Philipp Med Assoc 48:81–95 (CA 78:79647h)

    Google Scholar 

  54. Viel C, Dore JC (1972) New synthetic cytotoxic and antitumor agents from aristolochic acid, a nitrophenanthrene acid with antitumor action, extracted from Aristolochiaceae. Farmaco [Sci] 27:257–312

    CAS  Google Scholar 

  55. Möse JR, Porta J (1974) Aristolochic acid. I. Arzneimittelforschung 24:52–54

    PubMed  Google Scholar 

  56. Möse JR (1974) Aristolochic acid. II. Arzneimittelforschung 24:151–153

    PubMed  Google Scholar 

  57. Wagner H, Porksch A, Vollmar A, Kreutzkamp B, Bauer J (1985) In vitro phagocytosis stimulation by isolated plant materials measured in the phagocytosis-chemoluminescence (CL) model. Planta Med 51:139–144

    Article  Google Scholar 

  58. Siering H, Siering U (1984) Effect of prednisolone and aristolochic acid on the leukocyte adherence inhibition test. Folia Haematol (Leipz) 111:27–31

    CAS  Google Scholar 

  59. Stering H, Przesang R (1984) Effect of glucocorticoids and aristolochic acid on antibody formation in experimental animals. Z Gesamte Inn Med 39:81–84

    CAS  Google Scholar 

  60. Xing BH, Zhao LQ, Lou B, Jin L (1981) Pharmacology of aristolochic acid. Guanxi Yixue 2–4

    Google Scholar 

  61. Xing BH, Chen LL, Zhou LQ, Jin L, Liu F (1982) Experimental study on the carcinogenicity of aristolochic acid. Guangxi Yixue 4:118–121

    CAS  Google Scholar 

  62. Robisch G, Schimmer O, Göggelmann W (1982) Aristolochic acid is a direct mutagen in Salmonella typhimurium. Mutat Res 105:201–204

    Article  PubMed  CAS  Google Scholar 

  63. Schmeiser HH, Pool BL, Wiessler M (1984) Mutagenicity of the two components of commercially available carcinogenic aristolochic acid in Salmonella typhimurium. Cancer Lett 23:97–101

    Article  PubMed  CAS  Google Scholar 

  64. Schmeiser HH, Pool BL, Wiessler M (1986) Identification and mutagenicity of metabolites of aristolochic acid formed by rat liver. Carcinogenesis 7:59–63

    Article  PubMed  CAS  Google Scholar 

  65. Maier P, Schawalder HP, Weibel B, Zbinden G (1985) Aristolochic acid induces 6-thioguanine-resistant mutants in an extrahepatic tissue in rats after oral application. Mutat Res 108:143–148

    Article  Google Scholar 

  66. Mengs U, Lang W, Poch JA (1982) The carcinogenic action of aristolochic acid in rats. Arch Toxicol 51:107–119

    Article  CAS  Google Scholar 

  67. Mengs U (1983) On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid. Arch Toxicol 52:209–220

    Article  PubMed  CAS  Google Scholar 

  68. Wang WH, Zheng JH (1984) Pregnancy terminating effect and toxicity of an active component of Aristolochia mollissima Hance, aristolochic acid A. Acta Pharm Sin 19:405–409

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tang, W., Eisenbrand, G. (1992). Aristolochia spp.. In: Chinese Drugs of Plant Origin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73739-8_21

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73739-8_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73741-1

  • Online ISBN: 978-3-642-73739-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics