Advertisement

Anisodus tanguticus (Max.) Pasch

  • Weici Tang
  • Gerhard Eisenbrand

Abstract

Anisodus tanguticus (Max.) Pasch. (Scopolia tangutica Maxim.) (Solanaceae) is a medicinal plant growing in the Qinghai province of China and used in folk medicine as a spasmolytic and antiasthmatic agent.

Keywords

Hemorrhagic Shock Tropane Alkaloid Endotoxin Shock Acta Acad Superior Mesenteric Artery Occlusion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Chinese Academy of Medical Science (1976) Chemical studies on anisodamine. Acta Chim Sin 34:39–44Google Scholar
  2. 2.
    Hsieh CH, Wang L, Liu YL, Shang TM, Hsieh FC, Ke TL (1975) Structure of anisodine. Kexue Tongbao 20:52–53Google Scholar
  3. 3.
    He LY (1982) TLC separation and densitometric determination of tropine alkaloids. Chin Trad Herb Drugs 13:13–16Google Scholar
  4. 4.
    Yang JS, Chen YW, Feng HC (1981) Studies on trace amounts of alkaloids in Anisodus tanguticus Pascher. Chin Trad Herb Drugs 12:4–7Google Scholar
  5. 5.
    Liu YL, Xie FZ (1979) Study on the alkaloids of Physochlaina physaloides G. Don. Acta Pharm Sin 14:497–501Google Scholar
  6. 6.
    Xie JX, Yang JH, Zhao YX, Zhang CZ (1983) Absolute configuration of (—)-anisodine (a new ganglion blocking agent) and (—)-anisodinic acid. Sci Sin [B] [Engl] 26:931–935Google Scholar
  7. 7.
    Wang ZB, Wu XQ (1979) Variation of the contents of two alkaloids in Anisodus tanguticus. Acta Bot Sin 21:85–87Google Scholar
  8. 8.
    Xie JX, Liu CX, Jia XX, Zhou J (1975) Total synthesis of anisodamine. Kexue Tongbao 20:197–198Google Scholar
  9. 9.
    Xie JX, Zhou J, Jia XX, Liu CX, Xu HQ, Fang AS, Wang JZ, Xia BY (1980) Studies on the total synthesis of anisodamine. Acta Pharm Sin 15:403–409Google Scholar
  10. 10.
    Su JY, Wu LL, Tang CS (1983) Experimental study in rabbits of the antishock effect of anisodamine (654–2), and its mechanism of action. Resuscitation 10:173–184PubMedCrossRefGoogle Scholar
  11. 11.
    Peking Medical College (1977) A comparison of the effectiveness of anisodamine and nor­adrenaline on hemorrhagic shock in rabbits. Chin Med J [Engl] 3:63–68Google Scholar
  12. 12.
    Peking Medical College (1978) A comparison of the effectiveness of anisodamine and norepinephrine on hemorrhagic shock in rabbits. Cardiology 63:160–167CrossRefGoogle Scholar
  13. 13.
    Su JY, Hock CE, Lefer AM (1984) Beneficial effect of anisodamine in hemorrhagic shock. Naunyn-Schmiedebergs Arch Pharmacol 325:360–365PubMedCrossRefGoogle Scholar
  14. 14.
    Su JY (1984) Mechanism of the antishock effect of anisodamine. Ziran Zazhi 7:638–639Google Scholar
  15. 15.
    Zhu Y, Su YJ (1985) Protective effect of anisodamine on hepatic lysosomes in hemorrhage-shocked rats. J Beijing Med Coll 17:161–164Google Scholar
  16. 16.
    Hock CE, Su JY, Lefer AM (1983) Salutary effects of anisodamine in murine traumatic shock. Circ Shock 11:211–216PubMedGoogle Scholar
  17. 17.
    Tang CS, Wu LL, Su JY (1981) Mechanism of antishock function of anisodamine. Protective effect on intestinal shock. Kexue Tongbao 26:1402–1404Google Scholar
  18. 18.
    Wu LL, Su JY (1982) Comparison of antishock effect of 654–2 (anisodamine) to dopamine and aramine. Natl Med J China 62:678–680Google Scholar
  19. 19.
    Sun RY, Guo HY, Zhou CF, Yan YZ (1982) Effect of anisodamine on pulmonary circulation and function of dogs in shock. Natl Med J China 62:458–460Google Scholar
  20. 20.
    Guo HY, Sun RY (1982) Effects of intravenously injected anisodamine (654) on hemodynamics in normal anesthetized and endotoxin-shocked dogs. Kexue Tongbao 27:320Google Scholar
  21. 21.
    Guo HY, Sun RY (1983) Effects of intravenous administration of anisodamine (654–2) on hemodynamics of nonshocked and endotoxin-shocked dogs. Kexue Tongbao [Foreign Lang] 28:142Google Scholar
  22. 22.
    Wang PP, Shi LB (1985) Effect of anisodamine on renal sympathetic nerve discharge during endotoxin shock in anesthetized rabbits. Acta Acad Med Primae Shanghai 12:309–311Google Scholar
  23. 23.
    Xu SH, Chen L, Su MC, Chen HC (1984) Significance of 5-HT in endotoxic shock and possible effect of anisodamine on 5-HT. Acta Acad Med Sin 6:142–144Google Scholar
  24. 24.
    Xiao DM, Wang ZG, Chen HC (1983) Variation in plasma levels of cAMP and cGMP in dogs with endotoxin shock and effects of anisodamine on these variations. Acta Acad Med Sin 5:202–204Google Scholar
  25. 25.
    Ye SJ (1984) Change of plasma levels of cyclic nucleotides (cAMP, cGMP) in septic shock. Kexue Tongbao [Foreign Lang] 29:1135–1136Google Scholar
  26. 26.
    Xiao DM, Wang ZG, Chen HC (1983) Changes in plasma levels of prostaglandin E and F2α in E. coli endotoxin-shocked dogs and children with epidemic meningococcal meningitis. Acta Acad Med Sin 5:186–189Google Scholar
  27. 27.
    Xiao DM, Wang XL, Chen HC (1985) Changes of plasma 6-keto-prostaglandin F1α levels during canine endotoxin shock. Acta Acad Med Sin 7:50–52Google Scholar
  28. 28.
    Xiao DM, Chen HC (1985) Changes in the plasma levels of PGE, PGF2 and 6-keto-PGF1 in canine endotoxic shock. Chin Med J [Engl] 98:501–506Google Scholar
  29. 29.
    Shi JC, Miao ZH, Yang MG, Yu ZJ, Zhang SL, Yang XY (1986) Negative effects of anisodamine on cardiovascular function in anesthetized dogs. Tianjin Med J 14:135–138Google Scholar
  30. 30.
    Han QD, Hao HQ, Wang X (1985) Effects of anisodamine on the hemodynamics of rats with experimental myocardial infarction. Xian Yixueyuan Xuebao 6:12–15Google Scholar
  31. 31.
    Shi JC, Miao ZH, Zhang SL, Zhou XY, Yu ZL (1984) The protective effect of anisodamine (654–2) on the acute ischemic myocardium in anesthetized dogs. Tianjin Med J 12:551–553Google Scholar
  32. 32.
    Han QD, Xi YP (1985) Effects of anisodamine on the ultrastructural changes of ischemic myocardium. J Beijing Med Coll 17:101–103Google Scholar
  33. 33.
    Yao T, Xiao YF, Sun XY, Tong HH, Yuan M, Xu ZY, Dai ZY (1984) Effects of anisodamine on cardiovascular activities in endotoxin-shocked dogs. Chin Med J [Engl] 97:871–876Google Scholar
  34. 34.
    Xiu RJ, DeLano FA, Zweifach BW (1985) Influence of anisodamine on microhemodynamics in skeletal muscle preparations. In: Chang HM (ed) Adv Chin Med Mater Res Int Symp 1984. World Science, Singapore, pp 545–552Google Scholar
  35. 35.
    Lu SF, Yu JL, Li YT, Zhao WJ, Zheng SX, Zou DB, Liu SJ, Yu SM, Sheng ZL (1986) Mechanism of anisodamine in treatment of aplastic anemia. Chin J Intern Med 25:10–12Google Scholar
  36. 36.
    Culver PL, Dodak P, Staub NC (1985) Effect of anisodamine on pulmonary microcirculation during experimental lung injury. Natl Med J China 65:389–392Google Scholar
  37. 37.
    Wang SM, Huang F, Fu YZ, Zhang ZL, Dong RJ, Hu CQ (1983) Differential scanning thermoanalysis of effects of tropane alkaloids on fluidity of phospholipid liposomes. Kexue Tongbao 28:60–62Google Scholar
  38. 38.
    Huang F, Wang SM, Hu CC (1983) The disordering effect of hyoscyamine drugs on phospholipid membranes. Biochim Biophys Acta 736:220–225CrossRefGoogle Scholar
  39. 39.
    Wang SM, Huang F, Fu YZ, Zhang ZL, Dong RJ, Hu CQ (1983) The effect of hyoscyamine drugs on the fluidity of phospholipid model membranes assessed by a differential scanning calorimetric method. Kexue Tongbao [Foreign Lang] 28:693–696Google Scholar
  40. 40.
    Wang SM, Huang F, Fu YZ, Zhang ZL, Dong RJ, Hu CQ (1984) The interaction of anisodamine with phospholipid membranes. Kexue Tongbao [Foreign Lang] 29:529–532Google Scholar
  41. 41.
    Sun YT, Wang SM (1986) Raman spectroscopic study on the interaction of anisodamine and phospholipid membrane. Kexue Tongbao [Foreign Lang] 31:413–418Google Scholar
  42. 42.
    Huang F, Chen JW, Chao BC, Wang ZF (1984) ESR studies of the effect of anisodamine on the fluidity of dipalmitoylphosphatidic acid liposomes. Bopuxue Zazhi 1:481–485Google Scholar
  43. 43.
    Huang F, Chen JW, Fu YG, Wu YW, Wang ZF, Zhang ZY (1985) ESR and fluorescence polarization studies of the effect of anisodamine on the fluidity of phospholipid liposomes. Kexue Tongbao [Foreign Lang] 30:539–543Google Scholar
  44. 44.
    Peng JZ, Jin LR, Chen XY, Chen ZX (1983) Central effects of anisodamine, atropine, anisodine and scopolamine after intraventricular injection. Acta Pharmacol Sin 4:81–87Google Scholar
  45. 45.
    Peng JZ, Chen ZX, Chen XY (1982) Effects of anisodine of EEG and behavior of conscious cats. Acta Pharmacol Sin 3:78–81Google Scholar
  46. 46.
    Bian CF, Duan SM (1981) Experimental observation of the pharmacological effect of anisodine on central nervous system. Acta Pharm Sin 16:801–805Google Scholar
  47. 471.
    Niu XY, Ren ZH (1981) Effect of anisodine on synthesis and release of acetylcholine by rat cerebral cortex in vitro. Acta Pharm Sin 16:545–547Google Scholar
  48. 48.
    Huang JH, Chen ZX, Chen XY (1983) Effects of anisodine alone and in combination with chlorpromazine on spontaneous acetylcholine release from sensory-motor cortex of cats. Acta Pharmacol Sin 4:1–4Google Scholar
  49. 49.
    Han YF, Chen XY (1983) Effects of anisodine and other cholinergic drugs on learning and memory in spatial discrimination by mice. Acta Pharmacol Sin 4:220–225Google Scholar
  50. 50.
    Han YF, Chen XY (1984) Effects of anisodine and other cholinergic drugs on the conditioned response of the hippocampal θ-rhythm in rabbits. Acta Pharmacol Sin 5:166–170Google Scholar
  51. 51.
    Institute of Materia Medica, Chinese Academy of Medical Sciences (1973) Pharmacologic effects of anisodamine. Natl Med J China 269–273Google Scholar
  52. 52.
    Department of Pharmacology, Chinese Academy of Medical Sciences (1975) Pharmacological effects of anisodamine. Natl Med J China, 133–138Google Scholar
  53. 53.
    Chen XY, Wang ZQ, Yan YZ (1982) Studies on reactivity of bronchial smooth muscle. I. Effects of Yiqi Huoxue (YH) and anisodamine on bronchial smooth muscle. Acta Acad Med Sin 4:57–59Google Scholar
  54. 54.
    Yu SR, Ma JW (1982) Expectorant effect of anisodamine (654). Acta Acad Med Sin 4:258–260Google Scholar
  55. 55.
    Yu XY, Luo ZY, You JL, Luo H (1985) Effect of anisodamine (compound 654–2) on the cells from bronchoalveolar lavage in experimental respiratory distress syndrome. Bull Hunan Med Coll 10:13–18Google Scholar
  56. 56.
    Chen XY, Yan YZ, Xi PX, Zhang H (1985) Protective effect of anisodamine (654–2) on oleic acid induced lung injury. Acta Acad Med Sin 7:97–101Google Scholar
  57. 57.
    Wu LS, Yang GD, Jiang ML, Dong C (1984) Effects of henbane drugs on the phagocytosis of colloidal gold-198 by liver and spleen in mice. Acta Pharmacol Sin 5:140–142Google Scholar
  58. 58.
    Institute of Materia Medica, Chinese Academy of Medical Sciences (1973) Absorption, distri­bution and excretion of anisodamine. Natl Med J China 274–278Google Scholar
  59. 59.
    Yue TL, Wang GF, Song ZY (1979) Metabolism of 3H-scopolamine and 3H-anisodamine. Acta Pharm Sin 14:208–217Google Scholar
  60. 60.
    Xie JX, Yang JH, Zhang CZ (1981) Synthesis of quaternary ammonium salts and N-oxides of anisodamine and anisodine. Acta Pharm Sin 16:762–766Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Weici Tang
    • 1
  • Gerhard Eisenbrand
    • 1
  1. 1.Lebensmittelchemie und UmwelttoxikologieUniversität KaiserslauternKaiserslauternGermany

Personalised recommendations