Skip to main content
SpringerLink
Log in

Salvia miltiorrhiza Bge.

  • Chapter
Chinese Drugs of Plant Origin

Abstract

Danshen, Radix Salviae miltiorrhizae, is the dry root and rhizome of Salvia miltiorrhiza Bge. (Lamiaceae), collected in spring and fall. It is officially listed in the Chinese Pharmacopoeia and used for treatment of menstrual disorder, menostasis, menorrhalgia, insomnia, blood circulation diseases, and angina pectoris as well as against inflammation.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Nakao H, Fukushima T (1934) Chemical composition of S. miltiorrhiza I. Yakugaku Zasshi 54:844–858

    CAS  Google Scholar 

  2. Von Wessely F, Wang S (1940) Über einen neuartigen natürlichen Chinonfarbstoff aus der Klasse eines Phenanthrofurans. Chem Ber 73:19–24

    Google Scholar 

  3. Okumura Y, Kakisawa H, Kato M, Hirata Y (1961) Structure of tanshinone II. Bull Chem Soc Jpn 34:895–897

    Article  CAS  Google Scholar 

  4. Takiura K, Koizumi K (1962) Components of the Chinese drug tanshin. IV. The structure of tanshinone IIA. Chem Pharm Bull (Tokyo) 10:112–116

    CAS  Google Scholar 

  5. Baillie AC, Thomson RH (1968) Naturally occurring quinones. Part XI. The tanshinones. J Chem Soc [C] 48–52

    Google Scholar 

  6. Kakisawa H, Hayashi T, Okazaki I, Ohashi M (1968) Isolation and structures of new tanshinones. Tetrahedron Lett 3231–3234

    Google Scholar 

  7. Chen MK, Young PT, Ku WH, Chen ZX, Chen HT, Yeh HC (1978) Studies on the active principles of Dan-Shen. I. The structure of sodium tanshinone II A sulfonate and methylene tanshinquinone. Acta Chim Sin 36:199–206

    Google Scholar 

  8. Kakisawa H, Hayashi T, Yamazaki T (1969) Structures of isotanshinones. Tetrahedron Lett 301–304

    Google Scholar 

  9. Brieskorn CH, Fuchs A, Bredenberg JB, McChesney JD, Wenkert E (1964) The structure of carnosol J Org Chem 29:2293–2298

    CAS  Google Scholar 

  10. Luo H, Wu BJ, Wu MY, Yong ZG, Niwa M, Hirata Y (1985) Pigments from Salvia miltiorrhiza. Phytochemistry 24:815–817

    Article  CAS  Google Scholar 

  11. Feng BS, Li SR (1980) Studies of chemical components of Danshen — discovery of two new isomers. Acta Pharm Sin 15:489–494

    CAS  Google Scholar 

  12. Luo HW, Hu XJ, Wang N, Ji J (1988) Platelet aggregation inhibitors from Salvia miltiorrhiza Bunge. Acta Pharm Sin 23:830–834

    CAS  Google Scholar 

  13. Kong DY, Liu XJ (1984) Structure of dihydroisotanshinone I from Dan Shen. Acta Pharm Sin 19:755–759

    CAS  Google Scholar 

  14. Kong DY, Liu XJ (1983) Studies on the chemical components of “Dan Shen”. Acta Acad Med Primae Shanghai 10:313–315

    CAS  Google Scholar 

  15. Lee AR, Wu WL, Chang WL, Lin HC, King ML (1987) Isolation and bioactivity of new tanshinones. J Nat Prod 50:157–160

    Article  PubMed  CAS  Google Scholar 

  16. Fang CN, Chang PL, Hsu TP (1976) The antibacterial components of Dan-shen. Acta Chim Sin 34:197–209

    CAS  Google Scholar 

  17. Hayashi T, Kakisawa H, Hsu HY, Chen YP (1970) Structure of miltirone, a new diterpenoid quinone. J Chem Soc [D] 299

    Google Scholar 

  18. Kakisawa H, Hayashi T, Handa T, Ohashi M, Hsu HY, Chen YP (1971) Structure of salviol, a new phenolic diterpene. J Chem Soc [D] 541–542

    Google Scholar 

  19. Onitsuka M, Fujiu M, Shinma N, Maruyama HB (1983) New platelet aggregation inhibitors from Tan-Shen, Salvia miltiorrhiza Bunge root. Chem Pharm Bull (Tokyo) 31:1670–1675

    CAS  Google Scholar 

  20. Tomita Y, Annaka M, Ikeshiro Y (1989) Biosynthesis of the abietane type diterpene ferruginol in cell cultures of Salvia miltiorrhiza: synthesis of (15S)- and (15R)-(16–2H1)-12-O-methylferrug-inol by enzymic resolution of 12-O-methyl-16-hydroxyferruginol and stereochemistry of 1,2-methyl migration in the formation of the isopropyl group. J Chem Soc Chem Commun 108–110

    Google Scholar 

  21. Lin LZ, Wang XM, Huang XL, Huang Y, Yang BJ (1988) A new diterpenoid quinone dehy-dromiltirone. Acta Pharm Sin 23:273–275

    CAS  Google Scholar 

  22. Ginda H, Kusumi T, Ishitsuka MO, Kakisawa H, Zhao WJ, Chen J, Guo YT (1988) Salviolone, a cytotoxic bisnorditerpene with a benzotropolone chromophore from a Chinese drug Dan-Shen (Salvia miltiorrhiza). Tetrahedron Lett 29:4603–4606

    Article  CAS  Google Scholar 

  23. Ikeshiro Y, Mase I, Tomita Y (1989) Abietane type diterpenoids from Salvia miltiorrhiza. Phytochemistry 28:3139–3141

    Article  CAS  Google Scholar 

  24. Kusumi T, Ooi T, Hayashi T, Kakisawa H (1985) A diterpenoid phenalenone from Salvia multiorrhiza. Phytochemistry 24:2118–2120

    Article  CAS  Google Scholar 

  25. Kong DY, Liu XJ, Teng MK, Rao ZH (1985) The structure of Dan Shen spiroketallactone of Dan Shen (Salvia miltiorrhiza Bunge). Acta Pharm Sin 20:747–751

    CAS  Google Scholar 

  26. Teng MK, Rao ZH, Kong DY, Liu XJ (1985) Crystal and molecular structure of Danshen spiroketal lactone (crystal IX). Zhong-guo Kexue Jishu Daxue Xuebao 15:92–99

    CAS  Google Scholar 

  27. Luo HW, Chen SX, Lee JN, Snyder JK (1988) Epi-danshenspiroketal lactone from Salvia miltiorrhiza. Phytochemistry 27:290–292

    Article  CAS  Google Scholar 

  28. Luo HW, Wu BJ, Wu MY, Yong ZG, Jin Y (1985) Isolation and structures of danshenxinkun D. Acta Pharm Sin 20:542–544

    CAS  Google Scholar 

  29. Luo HW, Ji J, Wu MY, Yong ZG, Niwa M, Hirata Y (1986) Tanshinlactone, a novel secoabi-etanoid from Salvia miltiorrhiza. Chem Pharm Bull (Tokyo) 34:3166–3168

    CAS  Google Scholar 

  30. Kakisawa H, Tateishi M, Kusumi T (1986) Synthesis of tanshinone II and cryptotanshinone. Tetrahedron Lett 3783–3786

    Google Scholar 

  31. Kakisawa H, Inouye Y (1968) Total synthesis of tanshinone I, tanshinone II and cryptotanshinone. Chem Commun 1327

    Google Scholar 

  32. Chen W, Liu HC (1980) Isolation and identification of catecholaldehyde from danshen (Salvia miltiorrhiza). Chin Trad Herb Drugs 11:442

    CAS  Google Scholar 

  33. Zhang DC, Wu CL, Liu HC, Pan TC, Yang CH, Chang PT (1980) Studies on the water-soluble active principles in Salvia miltiorrhiza Bunge. II Structure of D-(+)-(3,4-dihydroxyphenyl)lactic acid. Acta Acad Med Primae Shanghai 7:384–385

    CAS  Google Scholar 

  34. Chen ZX, Gu WH, Huang HZ, Yang XM, Sun CJ, Chen WZ, Dong YL, Ma HL (1981) Studies on the water-soluble phenolic acid constituents of Salvia miltiorrhiza. Chin Pharm Bull 16:24–25

    CAS  Google Scholar 

  35. Li LN, Tan R, Chen WM (1984) Salvianolic acid A, a new depside from roots of Salvia miltiorrhiza. Planta Med 50:227–228

    Article  CAS  Google Scholar 

  36. Ai CB, Li LN (1988) Stereostructure of salvianolic acid B and isolation of salvianolic acid C from Salvia miltiorrhiza. J Nat Prod 51:145–149

    Article  CAS  Google Scholar 

  37. Yokozawa T, Chung HY, Oura H, Nonaka G, Nishioka I (1988) Isolation of the active component having the uremic-preventive effect from Salvia miltiorrhiza radix extract. Chem Pharm Bull (Tokyo) 36:316–320

    CAS  Google Scholar 

  38. Patudin AV, Romanova AS, Sokolov VS, Pribylova GF (1974) Occurrence of phenanthren-quinones in the genus Salvia. Planta Med 26:201–207

    Article  PubMed  CAS  Google Scholar 

  39. Huang XL, Yang BJ, Huang HZ, Xu Y, Hu ZB (1980) Studies of the active principles of Dan Shen. III. Search for plant resources containing tanshinone IIA. Acta Bot Sin 22:98–100

    CAS  Google Scholar 

  40. Huang XL, Yang BJ, Hu ZB (1981) Studies on the active principles of Dan-Shen. II. Searching for plant resources containing tanshinone IIA. Acta Bot Sin 23:70–71

    CAS  Google Scholar 

  41. Huang XL, Yang PC, Hu CP (1980) A brief note on the active principles of Salvia miltiorrhiza Bunge in relation to the sources and seasons. Chin Trad Herb Drugs 11:276

    CAS  Google Scholar 

  42. Lu HB (1986) Comparison of cryptotanshinone and phenolic components in Danshen from different areas. Bull Chin Mater Med 11:750

    CAS  Google Scholar 

  43. Xu XL, Xiao ZY (1982) Studies on chemical constituents of Hong Qin Jiu (Salvia przewalskii Maxim.) a Tibetan drug. I. Chin Trad Herb Drugs 13:485–488

    CAS  Google Scholar 

  44. Xu XM, Xiao ZY (1984) Studies on the chemical constituents of the Tibetan traditional drug Hong Qin Jiao (Salvia przewalskii). II. Chin Trad Herb Drugs 15:1–4

    CAS  Google Scholar 

  45. Yang BJ, Huang XL, Zhou QR (1984) Structures of four minor diterpene quinones from the root of Salvia przewalskii Maxim, var. mandarinorum (Diels) Stib. Acta Pharm Sin 19:274–281

    CAS  Google Scholar 

  46. Yang BJ, Hong SH (1985) Stereochemistry of przewaquinone D and przewaquinone E. Acta Chim Sin 43:898–900

    CAS  Google Scholar 

  47. Yang BJ, Qian MK, Qin GW, Chen ZX (1981) Studies on active principles of Dan-shen (Salvia miltiorrhiza Bunge). V. Isolation and chemical structure of przewaquinone A and przewaquinone B. Acta Pharm Sin 16:837–841

    CAS  Google Scholar 

  48. Yang BJ, Huang TL, Hu ZB, Chen ZX (1982) Study on chemical constituents of Salvia trijuga Diels. Chin Pharm Bull 17:242

    CAS  Google Scholar 

  49. Wang XM (1981) Preliminary comparison of the quality between Salvia paramiltiorrhiza f. purpureorubra and Salvia miltiorrhiza Bunge. Chin Pharm Bull 16:8–9

    CAS  Google Scholar 

  50. Xue QF, Dai SL, Wu YQ, Yuan SY, Zhu LX, Liu CG, Wang ZY (1986) Effect of ligustrazine and Salvia miltiorrhiza on microcirculation in the hamster cheek pouch. Natl Med J China 66:334–337

    CAS  Google Scholar 

  51. Wang YP, Chen YH, Xu DZ, Jiang WD (1980) Effect of “tanshinone IIA” sodium sulfonate on the hemodynamics and extent of myocardial infarct in coronary occluded dogs. Acta Acad Med Primae Shanghai 7:347–353

    CAS  Google Scholar 

  52. Jiang WD, Yu YZ, Liu WW, Chen YH, Wang YP, Huang TC (1981) Effects of sodium tanshinone IIA sulfonate and propranolol on coronary collaterals in infarcted dogs. Acta Pharmacol Sin 2:29–33

    CAS  Google Scholar 

  53. Chen WZ, Dong DL, Wang CG, Ting GS (1979) Pharmacological studies of sodium tanshinone IIA sulfonate. Acta Pharm Sin 14:277–283

    CAS  Google Scholar 

  54. Gao YG, Song YM, Yang YY, Liu WF, Tang JX (1979) Pharmacology of tanshinone. Acta Pharm Sin 14:75–82

    CAS  Google Scholar 

  55. Luo HW, Zheng JR, Jiang BL, Xu LF (1982) Relation between the RM value and biological activity of tanshinones. J Nanjing Coll Pharm 42–48

    Google Scholar 

  56. Shao HS, Jing XA, Ying LQ, Zhao MM, Gu JE (1981) Distribution and metabolism of 3H-tanshinone IIA sulfonate in rats. Nucl Tech 55–57

    Google Scholar 

  57. Luo HW, Sheng LS, Zhang SQ, Xu LF, Wei P (1983) Tanshinones: antimicrobacterial agents — bile excretion and biotransformation in rat liver. Acta Pharm Sin 18:1–6

    CAS  Google Scholar 

  58. Dong ZT, Jiang WD (1982) Effect of Dan Shen Su on isolated swine coronary artery perfusion preparation. Acta Pharm Sin 17:226–228

    CAS  Google Scholar 

  59. Cheng YX, Gan SX, Shu SF, Wang QQ, Guo X, Jing FY (1985) Treatment for acute toxipathic hepatitis in rabbits with variously processed danshen. Bull Chin Mater Med 10:161–162

    Google Scholar 

  60. Wang ZL (1985) Progress in clinical and experimental studies of Salvia miltiorrhiza in the treatment of chronic hepatitis. Chin J Integrat Trad West Med 5:509–510

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Lebensmittelchemie und Umwelttoxikologie, Universität Kaiserslautern, Erwin-Schrödinger-Straße, D-6750, Kaiserslautern, Germany

    Professor Dr. Weici Tang & Professor Dr. Gerhard Eisenbrand

Authors
  1. Professor Dr. Weici Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Professor Dr. Gerhard Eisenbrand
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tang, W., Eisenbrand, G. (1992). Salvia miltiorrhiza Bge.. In: Chinese Drugs of Plant Origin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73739-8_110

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73739-8_110

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73741-1

  • Online ISBN: 978-3-642-73739-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation