Salvia miltiorrhiza Bge.

  • Weici Tang
  • Gerhard Eisenbrand

Abstract

Danshen, Radix Salviae miltiorrhizae, is the dry root and rhizome of Salvia miltiorrhiza Bge. (Lamiaceae), collected in spring and fall. It is officially listed in the Chinese Pharmacopoeia and used for treatment of menstrual disorder, menostasis, menorrhalgia, insomnia, blood circulation diseases, and angina pectoris as well as against inflammation.

Keywords

Morphine Palladium Propranolol Quinone Lactone 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Nakao H, Fukushima T (1934) Chemical composition of S. miltiorrhiza I. Yakugaku Zasshi 54:844–858Google Scholar
  2. 2.
    Von Wessely F, Wang S (1940) Über einen neuartigen natürlichen Chinonfarbstoff aus der Klasse eines Phenanthrofurans. Chem Ber 73:19–24Google Scholar
  3. 3.
    Okumura Y, Kakisawa H, Kato M, Hirata Y (1961) Structure of tanshinone II. Bull Chem Soc Jpn 34:895–897CrossRefGoogle Scholar
  4. 4.
    Takiura K, Koizumi K (1962) Components of the Chinese drug tanshin. IV. The structure of tanshinone IIA. Chem Pharm Bull (Tokyo) 10:112–116Google Scholar
  5. 5.
    Baillie AC, Thomson RH (1968) Naturally occurring quinones. Part XI. The tanshinones. J Chem Soc [C] 48–52Google Scholar
  6. 6.
    Kakisawa H, Hayashi T, Okazaki I, Ohashi M (1968) Isolation and structures of new tanshinones. Tetrahedron Lett 3231–3234Google Scholar
  7. 7.
    Chen MK, Young PT, Ku WH, Chen ZX, Chen HT, Yeh HC (1978) Studies on the active principles of Dan-Shen. I. The structure of sodium tanshinone II A sulfonate and methylene tanshinquinone. Acta Chim Sin 36:199–206Google Scholar
  8. 8.
    Kakisawa H, Hayashi T, Yamazaki T (1969) Structures of isotanshinones. Tetrahedron Lett 301–304Google Scholar
  9. 9.
    Brieskorn CH, Fuchs A, Bredenberg JB, McChesney JD, Wenkert E (1964) The structure of carnosol J Org Chem 29:2293–2298Google Scholar
  10. 10.
    Luo H, Wu BJ, Wu MY, Yong ZG, Niwa M, Hirata Y (1985) Pigments from Salvia miltiorrhiza. Phytochemistry 24:815–817CrossRefGoogle Scholar
  11. 11.
    Feng BS, Li SR (1980) Studies of chemical components of Danshen — discovery of two new isomers. Acta Pharm Sin 15:489–494Google Scholar
  12. 12.
    Luo HW, Hu XJ, Wang N, Ji J (1988) Platelet aggregation inhibitors from Salvia miltiorrhiza Bunge. Acta Pharm Sin 23:830–834Google Scholar
  13. 13.
    Kong DY, Liu XJ (1984) Structure of dihydroisotanshinone I from Dan Shen. Acta Pharm Sin 19:755–759Google Scholar
  14. 14.
    Kong DY, Liu XJ (1983) Studies on the chemical components of “Dan Shen”. Acta Acad Med Primae Shanghai 10:313–315Google Scholar
  15. 15.
    Lee AR, Wu WL, Chang WL, Lin HC, King ML (1987) Isolation and bioactivity of new tanshinones. J Nat Prod 50:157–160PubMedCrossRefGoogle Scholar
  16. 16.
    Fang CN, Chang PL, Hsu TP (1976) The antibacterial components of Dan-shen. Acta Chim Sin 34:197–209Google Scholar
  17. 17.
    Hayashi T, Kakisawa H, Hsu HY, Chen YP (1970) Structure of miltirone, a new diterpenoid quinone. J Chem Soc [D] 299Google Scholar
  18. 18.
    Kakisawa H, Hayashi T, Handa T, Ohashi M, Hsu HY, Chen YP (1971) Structure of salviol, a new phenolic diterpene. J Chem Soc [D] 541–542Google Scholar
  19. 19.
    Onitsuka M, Fujiu M, Shinma N, Maruyama HB (1983) New platelet aggregation inhibitors from Tan-Shen, Salvia miltiorrhiza Bunge root. Chem Pharm Bull (Tokyo) 31:1670–1675Google Scholar
  20. 20.
    Tomita Y, Annaka M, Ikeshiro Y (1989) Biosynthesis of the abietane type diterpene ferruginol in cell cultures of Salvia miltiorrhiza: synthesis of (15S)- and (15R)-(16–2H1)-12-O-methylferrug-inol by enzymic resolution of 12-O-methyl-16-hydroxyferruginol and stereochemistry of 1,2-methyl migration in the formation of the isopropyl group. J Chem Soc Chem Commun 108–110Google Scholar
  21. 21.
    Lin LZ, Wang XM, Huang XL, Huang Y, Yang BJ (1988) A new diterpenoid quinone dehy-dromiltirone. Acta Pharm Sin 23:273–275Google Scholar
  22. 22.
    Ginda H, Kusumi T, Ishitsuka MO, Kakisawa H, Zhao WJ, Chen J, Guo YT (1988) Salviolone, a cytotoxic bisnorditerpene with a benzotropolone chromophore from a Chinese drug Dan-Shen (Salvia miltiorrhiza). Tetrahedron Lett 29:4603–4606CrossRefGoogle Scholar
  23. 23.
    Ikeshiro Y, Mase I, Tomita Y (1989) Abietane type diterpenoids from Salvia miltiorrhiza. Phytochemistry 28:3139–3141CrossRefGoogle Scholar
  24. 24.
    Kusumi T, Ooi T, Hayashi T, Kakisawa H (1985) A diterpenoid phenalenone from Salvia multiorrhiza. Phytochemistry 24:2118–2120CrossRefGoogle Scholar
  25. 25.
    Kong DY, Liu XJ, Teng MK, Rao ZH (1985) The structure of Dan Shen spiroketallactone of Dan Shen (Salvia miltiorrhiza Bunge). Acta Pharm Sin 20:747–751Google Scholar
  26. 26.
    Teng MK, Rao ZH, Kong DY, Liu XJ (1985) Crystal and molecular structure of Danshen spiroketal lactone (crystal IX). Zhong-guo Kexue Jishu Daxue Xuebao 15:92–99Google Scholar
  27. 27.
    Luo HW, Chen SX, Lee JN, Snyder JK (1988) Epi-danshenspiroketal lactone from Salvia miltiorrhiza. Phytochemistry 27:290–292CrossRefGoogle Scholar
  28. 28.
    Luo HW, Wu BJ, Wu MY, Yong ZG, Jin Y (1985) Isolation and structures of danshenxinkun D. Acta Pharm Sin 20:542–544Google Scholar
  29. 29.
    Luo HW, Ji J, Wu MY, Yong ZG, Niwa M, Hirata Y (1986) Tanshinlactone, a novel secoabi-etanoid from Salvia miltiorrhiza. Chem Pharm Bull (Tokyo) 34:3166–3168Google Scholar
  30. 30.
    Kakisawa H, Tateishi M, Kusumi T (1986) Synthesis of tanshinone II and cryptotanshinone. Tetrahedron Lett 3783–3786Google Scholar
  31. 31.
    Kakisawa H, Inouye Y (1968) Total synthesis of tanshinone I, tanshinone II and cryptotanshinone. Chem Commun 1327Google Scholar
  32. 32.
    Chen W, Liu HC (1980) Isolation and identification of catecholaldehyde from danshen (Salvia miltiorrhiza). Chin Trad Herb Drugs 11:442Google Scholar
  33. 33.
    Zhang DC, Wu CL, Liu HC, Pan TC, Yang CH, Chang PT (1980) Studies on the water-soluble active principles in Salvia miltiorrhiza Bunge. II Structure of D-(+)-(3,4-dihydroxyphenyl)lactic acid. Acta Acad Med Primae Shanghai 7:384–385Google Scholar
  34. 34.
    Chen ZX, Gu WH, Huang HZ, Yang XM, Sun CJ, Chen WZ, Dong YL, Ma HL (1981) Studies on the water-soluble phenolic acid constituents of Salvia miltiorrhiza. Chin Pharm Bull 16:24–25Google Scholar
  35. 35.
    Li LN, Tan R, Chen WM (1984) Salvianolic acid A, a new depside from roots of Salvia miltiorrhiza. Planta Med 50:227–228CrossRefGoogle Scholar
  36. 36.
    Ai CB, Li LN (1988) Stereostructure of salvianolic acid B and isolation of salvianolic acid C from Salvia miltiorrhiza. J Nat Prod 51:145–149CrossRefGoogle Scholar
  37. 37.
    Yokozawa T, Chung HY, Oura H, Nonaka G, Nishioka I (1988) Isolation of the active component having the uremic-preventive effect from Salvia miltiorrhiza radix extract. Chem Pharm Bull (Tokyo) 36:316–320Google Scholar
  38. 38.
    Patudin AV, Romanova AS, Sokolov VS, Pribylova GF (1974) Occurrence of phenanthren-quinones in the genus Salvia. Planta Med 26:201–207PubMedCrossRefGoogle Scholar
  39. 39.
    Huang XL, Yang BJ, Huang HZ, Xu Y, Hu ZB (1980) Studies of the active principles of Dan Shen. III. Search for plant resources containing tanshinone IIA. Acta Bot Sin 22:98–100Google Scholar
  40. 40.
    Huang XL, Yang BJ, Hu ZB (1981) Studies on the active principles of Dan-Shen. II. Searching for plant resources containing tanshinone IIA. Acta Bot Sin 23:70–71Google Scholar
  41. 41.
    Huang XL, Yang PC, Hu CP (1980) A brief note on the active principles of Salvia miltiorrhiza Bunge in relation to the sources and seasons. Chin Trad Herb Drugs 11:276Google Scholar
  42. 42.
    Lu HB (1986) Comparison of cryptotanshinone and phenolic components in Danshen from different areas. Bull Chin Mater Med 11:750Google Scholar
  43. 43.
    Xu XL, Xiao ZY (1982) Studies on chemical constituents of Hong Qin Jiu (Salvia przewalskii Maxim.) a Tibetan drug. I. Chin Trad Herb Drugs 13:485–488Google Scholar
  44. 44.
    Xu XM, Xiao ZY (1984) Studies on the chemical constituents of the Tibetan traditional drug Hong Qin Jiao (Salvia przewalskii). II. Chin Trad Herb Drugs 15:1–4Google Scholar
  45. 45.
    Yang BJ, Huang XL, Zhou QR (1984) Structures of four minor diterpene quinones from the root of Salvia przewalskii Maxim, var. mandarinorum (Diels) Stib. Acta Pharm Sin 19:274–281Google Scholar
  46. 46.
    Yang BJ, Hong SH (1985) Stereochemistry of przewaquinone D and przewaquinone E. Acta Chim Sin 43:898–900Google Scholar
  47. 47.
    Yang BJ, Qian MK, Qin GW, Chen ZX (1981) Studies on active principles of Dan-shen (Salvia miltiorrhiza Bunge). V. Isolation and chemical structure of przewaquinone A and przewaquinone B. Acta Pharm Sin 16:837–841Google Scholar
  48. 48.
    Yang BJ, Huang TL, Hu ZB, Chen ZX (1982) Study on chemical constituents of Salvia trijuga Diels. Chin Pharm Bull 17:242Google Scholar
  49. 49.
    Wang XM (1981) Preliminary comparison of the quality between Salvia paramiltiorrhiza f. purpureorubra and Salvia miltiorrhiza Bunge. Chin Pharm Bull 16:8–9Google Scholar
  50. 50.
    Xue QF, Dai SL, Wu YQ, Yuan SY, Zhu LX, Liu CG, Wang ZY (1986) Effect of ligustrazine and Salvia miltiorrhiza on microcirculation in the hamster cheek pouch. Natl Med J China 66:334–337Google Scholar
  51. 51.
    Wang YP, Chen YH, Xu DZ, Jiang WD (1980) Effect of “tanshinone IIA” sodium sulfonate on the hemodynamics and extent of myocardial infarct in coronary occluded dogs. Acta Acad Med Primae Shanghai 7:347–353Google Scholar
  52. 52.
    Jiang WD, Yu YZ, Liu WW, Chen YH, Wang YP, Huang TC (1981) Effects of sodium tanshinone IIA sulfonate and propranolol on coronary collaterals in infarcted dogs. Acta Pharmacol Sin 2:29–33Google Scholar
  53. 53.
    Chen WZ, Dong DL, Wang CG, Ting GS (1979) Pharmacological studies of sodium tanshinone IIA sulfonate. Acta Pharm Sin 14:277–283Google Scholar
  54. 54.
    Gao YG, Song YM, Yang YY, Liu WF, Tang JX (1979) Pharmacology of tanshinone. Acta Pharm Sin 14:75–82Google Scholar
  55. 55.
    Luo HW, Zheng JR, Jiang BL, Xu LF (1982) Relation between the RM value and biological activity of tanshinones. J Nanjing Coll Pharm 42–48Google Scholar
  56. 56.
    Shao HS, Jing XA, Ying LQ, Zhao MM, Gu JE (1981) Distribution and metabolism of 3H-tanshinone IIA sulfonate in rats. Nucl Tech 55–57Google Scholar
  57. 57.
    Luo HW, Sheng LS, Zhang SQ, Xu LF, Wei P (1983) Tanshinones: antimicrobacterial agents — bile excretion and biotransformation in rat liver. Acta Pharm Sin 18:1–6Google Scholar
  58. 58.
    Dong ZT, Jiang WD (1982) Effect of Dan Shen Su on isolated swine coronary artery perfusion preparation. Acta Pharm Sin 17:226–228Google Scholar
  59. 59.
    Cheng YX, Gan SX, Shu SF, Wang QQ, Guo X, Jing FY (1985) Treatment for acute toxipathic hepatitis in rabbits with variously processed danshen. Bull Chin Mater Med 10:161–162Google Scholar
  60. 60.
    Wang ZL (1985) Progress in clinical and experimental studies of Salvia miltiorrhiza in the treatment of chronic hepatitis. Chin J Integrat Trad West Med 5:509–510Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Weici Tang
    • 1
  • Gerhard Eisenbrand
    • 1
  1. 1.Lebensmittelchemie und UmwelttoxikologieUniversität KaiserslauternKaiserslauternGermany

Personalised recommendations