Allium sativum L.

  • Weici Tang
  • Gerhard Eisenbrand


Allium sativum L. (Liliaceae), garlic, is a well known spice and has been used worldwide as a folk medicine for treatment of various infectious diseases; prevention of coronary thrombosis, atherosclerosis, and stroke; and for treatment of hyperlipidemia and vascular disorders. It is included in the appendix of the Chinese Pharmacopoeia.


Allyl Alcohol Garlic Extract Allium Sativum Diallyl Disulfide Diallyl Trisulfide 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    Cavallito CJ, Buck JS, Suter DM (1944) Allium, the antibacterial principle of Allium sativum. II. Determination of the chemical structure. J Am Chem Soc 66:1952–1954CrossRefGoogle Scholar
  2. 2.
    Stoll A, Seebeck E (1948) Über Alliin, die genuine Muttersubstanz des Knoblauchöls. 1. Mitteilung über Allium-Substanzen. Helv Chim Acta 31:189–210PubMedCrossRefGoogle Scholar
  3. 3.
    Freeman GG, Whenham RJ (1975) A survey of volatile components of some Allium species in terms of S-alk(en)yl-L-cysteine sulphoxides present as flavour precursors. J Sci Food Agric 26:1869–1886CrossRefGoogle Scholar
  4. 4.
    Suzuki T, Sugii M, Kakimoto T, Tsuboi N (1961) Isolation of (—)-,S-allyl-L-cysteine from garlic. Chem Pharm Bull 9:251–252Google Scholar
  5. 5.
    Brodnitz MH, Pascale JV, van Derslice L (1971) Flavor components of garlic extract. J Agric Food Chem 19:273–275CrossRefGoogle Scholar
  6. 6.
    Kameoka H, Demizu Y, Iwase Y, Miyazawa M (1978) Structure of cyclic sulfur compounds from Allium genus. Tennen Yuki Kagobutsu Toronkai Koen Yoshihu, 21st, 199–205 (CA 90:69093 h)Google Scholar
  7. 7.
    Apitz-Castro R, Cabrera S, Cruz MR, Ledezma E, Jain MK (1983) Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thromb Res 32:155–169PubMedCrossRefGoogle Scholar
  8. 8.
    Block E, Ahmad S, Catalfamo JL, Jain MK, Apitz-Castro R (1986) Antithrombotic organosulfur compounds from garlic: structural, mechanistic and synthetic studies. J Am Chem Soc 108:7045–7055CrossRefGoogle Scholar
  9. 9.
    Bock H, Mohmand S, Hirabayshi T, Semkow A (1982) Gasphasen-Reaktionen. XXX. Thioacrolein: Das stabilste C3H4S-Isomere und seine PE-spektroskopischer Nachweis in der Gasphase. Chem Ber 115:1339–1348CrossRefGoogle Scholar
  10. 10.
    Vedejs E, Eberlein TH, Varie DL (1982) Dienophilic thioaldehydes. J Am Chem Soc 104:1445–1447CrossRefGoogle Scholar
  11. 11.
    Beslin P (1983) A facile synthesis of two thioacrolein dimers. A new entry to a flavor component in Asparagus. J Heterocycl Chem 20:1753–1754CrossRefGoogle Scholar
  12. 12.
    Suzuki T, Sugii M, Kakimoto T (1961) New γ-glutamyl peptides in garlic. Chem Pharm Bull 9:77–78Google Scholar
  13. 13.
    Iida H, Hashimoto S, Miyazawa M, Kameoka H (1983) Volatile flavor components of nira (Allium tuberosum Rotti.). J Food Sci 48:660–661CrossRefGoogle Scholar
  14. 14.
    Chi MS (1982) Effects of garlic products on lipid metabolism in cholesterol-fed rats. Proc Soc Exp Biol Med 171:174–178PubMedGoogle Scholar
  15. 15.
    Augusti KT (1977) Hypocholesterolemic effect of garlic, Allium sativum Linn. Indian J Exp Biol 15:489–490PubMedGoogle Scholar
  16. 16.
    Jain RC (1977) Effect of garlic on serum lipids, coagulability and fibrinolytic activity of blood. Am J Clin Nutr 30:1380–1381PubMedGoogle Scholar
  17. 17.
    Bhushan S, Sharma SP, Singh SP, Agrawal S, Indrayan A, Seth P (1979) Effect of garlic on normal blood cholesterol level. Indian J Physiol Pharmacol 23:211–214PubMedGoogle Scholar
  18. 18.
    Chaudhuri BN, Mukherjee SK, Mongia SS, Chakravaty SK (1984) Hypolipidemic effect of garlic and thyroid function. Biomed Biochim Acta 43:1041–1043Google Scholar
  19. 19.
    Jain RC (1978) Effect of alcoholic extract of garlic in atherosclerosis. Am J Clin Nutr 31:1982–1983Google Scholar
  20. 20.
    Bordia AK, Joshi HK, Sanadhya YK, Bhu N (1977) Effect of essential oil of garlic on serum fibrinolytic activity in patients with coronary artery disease. Atherosclerosis 28:155–159PubMedCrossRefGoogle Scholar
  21. 21.
    Mohammad SF, Woodward SC (1986) Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from Allium sativum (garlic). Thromb Res 44:793–806PubMedCrossRefGoogle Scholar
  22. 22.
    Boullin DJ (1981) Garlic as a platelet inhibitor. Lancet 1 (8223): 776–777PubMedCrossRefGoogle Scholar
  23. 23.
    Block E, Iyer R, Grisoni S, Saha C, Belman S, Lossing FP (1988) Lipoxygenase inhibitors from the essential oil of garlic. Markovnikov addition of the allyldithio radical to olefins. J Am Chem Soc 110:7813–7827CrossRefGoogle Scholar
  24. 24.
    Makheja AN, Vanderhoek JY, Bryant RW, Bailey JM (1980) Altered arachidonic acid metabolism in platelets inhibition by onion or garlic extracts. Adv Prostaglandin Thromboxane Res 6:309–312PubMedGoogle Scholar
  25. 25.
    Shashikanth KN, Basappa SC, Murthy VS (1985) Allicin concentration in the gut of rats and its influence on the microflora. J Food Sci Technol 22:440–442Google Scholar
  26. 26.
    Barone FE, Tansey MR (1977) Isolation, purification, identification, synthesis and kinetics of activity of the anticandidal component of Allium sativum and a hypothesis for its mode of action. Mycologia 69:793–825PubMedCrossRefGoogle Scholar
  27. 27.
    Yoshida S, Kasuga S, Hayashi N, Ushiroguchi T, Matsuura H, Nakagawa S (1987) Antifungal activity of ajoene derived from garlic. Appl Environ Microbiol 53:615–617PubMedGoogle Scholar
  28. 28.
    Tsai Y, Cole LL, Davis LE, Lockwood SJ, Simmons V, Wild GC (1985) Antiviral properties of garlic: in vitro effects on influenza B, herpes simplex and Coxsackie viruses. Planta Med 51:460–461PubMedCrossRefGoogle Scholar
  29. 29.
    Nakata T (1973) Effect of fresh garlic extract on tumor growth. Nippon Eiseigaku Zasshi 27:538–543 (CA 79:111680x)Google Scholar
  30. 30.
    Cheng HH, Tung TC (1981) Effect of allithiamine on sarcoma-180 tumor growth in mice. Taiwan I Hsueh Hui Isa Chih 80:385–393Google Scholar
  31. 31.
    De Martin R, Knasmueller S, Weniger P (1986) Antimutagen effect of garlic extract in the Ames assay. Oesterreichisches Forschungszentrum, Seibersdorf (Ber) OEFZS-4354 (CA 104:223865c)Google Scholar
  32. 32.
    Nishino H, Iwashima A, Itakura Y, Matsuura H, Fuwa T (1989) Antitumor-promoting activity of garlic extracts. Oncology 46:277–280PubMedCrossRefGoogle Scholar
  33. 33.
    Augusti KT (1975) Studies on the effect of allicin (diallyl disulfide oxide) on alloxan diabetes. Experientia 31:1263–1265PubMedCrossRefGoogle Scholar
  34. 34.
    Mathew PT, Augusti KT (1973) Effect of allicin (diallyl disulfide oxide) on alloxan diabetes. I. Hypoglycemic action and enhancement of serum insulin effect and glycogen synthesis. Indian J Biochem Biophys 10:209–212PubMedGoogle Scholar
  35. 35.
    Wang ZH, Hong XK, Qian WJ, Hu CX, Wang YR (1988) Serum concentration, tissue distribution and bioavailability of allicin in rabbits by GC analysis. Chin Trad Herb Drugs 19:540–541Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1992

Authors and Affiliations

  • Weici Tang
    • 1
  • Gerhard Eisenbrand
    • 1
  1. 1.Lebensmittelchemie und UmwelttoxikologieUniversität KaiserslauternKaiserslauternGermany

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