Skip to main content

Acanthopanax senticosus (Rupr. et Maxim.) Harms

  • Chapter
Chinese Drugs of Plant Origin

Abstract

Ciwujia, Radix Acanthopanacis senticosi, is the dry root and rootstock of Acanthopanax (Eleutherococcus) senticosus (Rupr. et Maxim.) Harms (Araliaceae), which is collected in spring and fall. It is listed officially in the Chinese Pharmacopoeia and commonly known as “Siberian ginseng”. It belongs to the same plant family as Panax ginseng. In addition, two galenic preparations of A. senticosus are also included in the Chinese Pharmacopoeia:

  • Ciwujia Jingao, Extractum Acanthopanacis senticosi, prepared by extraction of the powdered root of A. senticosus with 75% ethanol and concentration of the extract

  • Ciwujia Pian, Tabellae Acanthopanacis senticosi, prepared from the extract

The roots and rootstock of A. senticosus and its preparations have been used as a tonic in Chinese traditional medicine for a long time.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Shih CL (1981) Study on chemical constituents in Acanthopanax senticosus Harms. Chin Pharm Bull 16:53

    Google Scholar 

  2. Frolova GM, Ovodov YS (1971) Triterpenoid glycosides of Eleutherococcus senticosus leaves. II. Structure of eleutherosides I, K, L and M. Khim Prir Soedin 618–622 (CA 76:59965r)

    Google Scholar 

  3. Yun-Choi HS, Kim SO, Lee JR (1986) Platelet anti-aggregating plant materials. Korean J Pharmacogn 17:161 (CA 105:222802 p)

    CAS  Google Scholar 

  4. Hikino H, Takahashi M, Otake K, Konno C (1986) Isolation and hypoglycemic activity of eleutherans A, B, C, D, E, F, and G, glycans of Eleutherococcus senticosus roots. J Nat Prod 49:293–297

    Article  PubMed  CAS  Google Scholar 

  5. Xu ZB, Tong WJ, Yang G (1984) Assay of active constituents in different parts of manyprickle acanthopanax (Acanthopanax senticosus). Chin Trad Herb Drugs 15:224–226

    CAS  Google Scholar 

  6. Suu WJ, Sha ZI (1986) Determination of syringin in Acanthopanax senticosus by HPLC. Bull Chin Mat Med 11:234–235

    Google Scholar 

  7. Xu ZB, Wang MY (1984) Content variation of some chemical constituents of Ci Wu Jia (Acanthopanax senticosus) during storage. Chin Trad Herb Drugs 15:15–17

    CAS  Google Scholar 

  8. Takasugi N, Moriguchi T, Fuwa TS, Sanada S, Ida Y, Shoji J, Saito H (1985) Effect of Eleutherococcus senticosus and its components on rectal temperature, body and grip tones, motor coordination and exploratory and spontaneous movements in acute stressed mice. Shoyakugaku Zasshi 39:232–237 (CA 104:102464n)

    CAS  Google Scholar 

  9. Nishiyama N, Kamegaya T, Iwai A, Saito H, Sanada S, Ida Y, Shoji J (1985) Effect of Eleutherococcus senticosus and its components on sex- and learning-behaviors and tyrosine hydroxylase activities of adrenal gland and hypothalamic regions in chronic stressed mice. Shoyakugaku Zasshi 39:238–242 (CA 104:102465p)

    CAS  Google Scholar 

  10. Medon PJ, Ferguson PW, Watson CF (1984) Effects of Eleutherococcus senticosus extracts on hexobarbital metabolism in vivo and in vitro. J Ethnopharmacol 10:235–241

    Article  PubMed  CAS  Google Scholar 

  11. Todorov IN, Sizova ST, Mitrokhin YI, German AV, Dardymov IV, Barenboim GM, Shulman ML (1984) Study of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. VII. Effect of the extract and of individual glycosides on protein biosyntheses. Khim Farm Zh 18:920–924

    CAS  Google Scholar 

  12. Todorov IN, Sizova ST, Kosaganova NY, Mitrokhin YI, German AV, Mitrofanova MA (1984) Pharmacokinetics and mechanism of action of glycosides of eleutherococci. Effect of an extract on the metabolism and biosynthesis of protein in several organs and tissues of rats. Khim-Farm Zh 18:529–533

    CAS  Google Scholar 

  13. Barenboim GM, Sterlina AG, Bebyakova NV, Ribokas AA, Fuks BB (1986) Investigation of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. VIII. Investigation of natural killer activation by the Eleutherococcus extract Khim Farm Zh 20:914–917

    CAS  Google Scholar 

  14. Bohn B, Nebe CT, Birr C (1987) Durchflußzytometrische Untersuchungen auf immunmodulatorische Wirkungen von Eleutherococcus senticosus-Extrakt. Arzneim-Forsch 37:1193–1196

    CAS  Google Scholar 

  15. Minkova M, Pantev T, Topalova S, Tenchova V (1982) Peripheral blood changes in Eleutherococcus pretreated mice exposed to acute gamma radiation. Radiobiol Radiother 23:675–678

    CAS  Google Scholar 

  16. Hacker B, Medon PJ (1984) Cytotoxic effects of Eleutherococcus senticosus aqueous extracts in combination with N 6-(Δ 2-isopentenyl)adenosine and 1-β-D-arabinofuranosylcytosine against L 1210 leukemia cells. J Pharm Sci 73:270–272

    Article  PubMed  CAS  Google Scholar 

  17. Xu RS, Feng SC, Fang ZY, Ye CQ, Zhai SK, Shen ML (1983) Polysaccharide components of the roots of Acanthopanax senticosus (Rupr. et Maxim.) Harms. Kexue Tongbao 28:185–187

    CAS  Google Scholar 

  18. Xu RS, Feng SC, Fan ZY, Ye CJ, Zhai SK, Shen ML (1982) Immunopotentiating polysaccharides of Acanthopanax senticosus (Rupr. et Maxim.) Harms. In: Wang Y (ed) Chem Nat Prod, Proc Sino-Am Symp 1980, Sci Press, Beijing, pp 271–274

    Google Scholar 

  19. Zhu CA, Tu GR, Shen ML (1982) Effect of polysaccharide from Acanthopanax senticosus on mouse serum type-specific antibodies. Chin Pharm Bull 17:178

    CAS  Google Scholar 

  20. Yang JC, Xu HZ, Liu JS (1984) Interferon induction by Acanthopanax senticosus polysaccharide and by sodium carboxymethyl starch in S 801 and S 7811 cell culture. Chin J Microbiol Immunol 4:329–330

    Google Scholar 

  21. Fang JN, Proksch A, Wagner H (1985) Immunologically active polysaccharides of Acanthopanax senticosus. Phytochemistry 24:2619–2622

    Article  CAS  Google Scholar 

  22. Song XH, Xu GJ, Jin RL, Xu LS (1983) Studies on the identification of the Chinese drugs Wu Jia Pi. J Nanjing Coll Pharm 15–24

    Google Scholar 

  23. Xiang RD, Xu RS (1983) Studies on chemical constituents of the root bark of Acanthopanax gracilistylus W W. Smith. Acta Bot Sin 25:356–362

    CAS  Google Scholar 

  24. Yang SG, Yan YF, Ye YW (1987) Effects of the total glycoside of Acanthopanax gracilistylus var. pubescens on myocardial infarct size in rabbits with occluded coronary artery. Bull Hunan Med Coll 12:23–27

    CAS  Google Scholar 

  25. Bezdetko GN, German AV, Shevchenko VP, Mitrokhin YI, Myasoedov NF, Dardymov IV, Todorov IN, Barenboim GM (1981) Study of the pharmacokinetics and action mechanism of Eleutherococcus glycosides. I. Incorporation of tritium into eleutherosides B, kinetics of its accumulation and excretion from the body of animal. Khim Farm Zh 15:28–33

    CAS  Google Scholar 

  26. German AV, Bezdetko GN, Mitrokhin YI, Chivkov GN, Shevchenko VP, Barenboim GM, Dardymov IV, Myasoedov NF, Todorov IN (1982) Study of the pharmacokinetics and mechanism of Eleutherococcus glycosides. II. Distribution of eleutheroside in organs and subcellular fraction. Khim Farm Zh 16:26–30

    CAS  Google Scholar 

  27. Bezdetko GN, German AV, Khasina EI, Shevchenko VP, Dardymov IV, Myasoedov NF, Barenboim GM, Todorov IN (1982) Study of the pharmacokinetics and mechanism of action of Eleutherococcus glycosides. V. Metabolism and the kinetics of binding with blood serum components. Khim Farm Zh 16:528–531

    CAS  Google Scholar 

  28. Shao CJ, Kasai R, Xu JD, Tanaka O (1988) Saponins from leaves of Acanthopanax senticosus Harms., Ciwujia: structures of ciwujianosides B, C1, C2, C3, C4, D1, D2, and E. Chem Pharm Bull 36:601–608

    CAS  Google Scholar 

  29. Shao CJ, Kasai R, Xu JD, Tanaka O (1989) Saponins from leaves of Acanthopanax senticosus Harms., Ciwujia: II. Structure of ciwujianoside A1, A2, A3, A4, and D3. Chem Pharm Bull 37:42–45

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 1992 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Tang, W., Eisenbrand, G. (1992). Acanthopanax senticosus (Rupr. et Maxim.) Harms. In: Chinese Drugs of Plant Origin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73739-8_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-73739-8_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73741-1

  • Online ISBN: 978-3-642-73739-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics