Balloon-Expandable Intraarterial Stents: Effect of Antithrombotic Medication on Thrombus Formation

  • J. C. Palmaz
  • O. Garcia
  • D. T. Kopp
  • F. O. Tio
  • V. Ciaravino
  • R. A. Schatz
  • C. Rees
  • R. Alvarado
  • J. L. Lancaster
  • R. D. Borchert


Growing interest in the research of percutaneous intravascular metallic stents is evidenced by the rapidly increasing number of investigations on the subject [1–6]. Sigwart et al. [7] first demonstrated successful clinical use of intracoronary stents. However, recent reports indicate thrombosis of the stent after placement in 39% of the series by Puel et al. [8] and 11% in the series by Sigwart et al. [9]. This underscores the fact that thrombogenicity may be one of the most challenging problems for the safe use of intravascular stents.


Stent Placement Activity Ratio Stent Diameter Antithrombotic Medication Intracoronary Stents 
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  1. 1.
    Dotter CT (1969) Transluminal placed coilspring endarterial tube grafts. Invest Radiol 4: 329–332PubMedCrossRefGoogle Scholar
  2. 2.
    Maass D, Zollikofer ChL, Largiader F, Senning A (1984) Radiological follow-up of transluminal inserted vascular endoprostheses: an experimental study using expanding spirals. Radiology 152: 659–663PubMedGoogle Scholar
  3. 3.
    Dotter CT, Buschmann RW, McKinney MK, Rosch J (1983) Transluminal expandable nitinol coil stent grafting: preliminary report. Radiology 147: 259–260PubMedGoogle Scholar
  4. 4.
    Cragg A, Lund G, Rysavy J, Castaneda F, Castaneda-Zuniga W, Amplatz K (1983) Nonsurgical placement of arterial endoprosteses: a new technique using nitinol wire. Radiology 147: 261–263PubMedGoogle Scholar
  5. 5.
    Palmaz JC, Sibbitt RR, Reuter SR, Tio FO, Rice WJ (1985) Expandable intraluminal graft: a preliminary study. Radiology 156: 73–77PubMedGoogle Scholar
  6. 6.
    Wright KC, Wallace S, Charsangavej C, Carrasco HC, Gianturco C (1985) Percutaneous endovascular stents: an experimental evaluation. Radiology 156: 69–72PubMedGoogle Scholar
  7. 7.
    Sigwart V, Puel J, Mirkovitch V, Joffre F, Kappenberger L (1987) Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty. N Engl J Med 316: 701–706PubMedCrossRefGoogle Scholar
  8. 8.
    Puel J, Rousseau H, Joffre F, Hatem S, Fauvel JM, Bounhoure JP (1987) Intravascular stents to prevent restenosis after transluminal coronary angioplasty (Abstr). Circulation 76 [Suppl IV–27]Google Scholar
  9. 9.
    Sigwart V, Imbert C, Essinger A, Fisher A, Sadeghi H, Kappenberger L (1987) One year of percutaneous coronary stenting (PTCS) (Abstr) Circulation 76 [Suppl IV–26]Google Scholar
  10. 10.
    Wright CB, Hobson II RW, Hiratzka LF, Lynch TG (1983) Vascular grafting. Clinical applications and techniques. John Wright, PSG Inc., BostonGoogle Scholar
  11. 11.
    Strandness DE, Sumner DS (1985) Hemodynamics for surgeons. Grune and Stratton, New YorkGoogle Scholar
  12. 12.
    Schatz RA, Palmaz JC, Tio FO, Garcia F, Garcia O, Reuter SR (1987) Balloon-expandable intracoronary stents in the adult dog. Circulation 76: 450–457PubMedCrossRefGoogle Scholar
  13. 13.
    Palmaz JC, Kopp DT, Hayashi H, Schatz RA, Hunter G, Tio FO, Garcia O, Alvarado R, Rees C, Thomas SC (1987) Normal and stenotic renal arteries: experimental balloon-ex¬pandable intraluminal stenting. Radiology 164: 705–708PubMedGoogle Scholar
  14. 14.
    Thakur MC, Welch MJ, Joist JH, Coleman RE (1976) Indium-Ill labeled platelets: studies on preparation and evaluation of in vitro and in vivo functions. Throm Res 9: 345–357CrossRefGoogle Scholar
  15. 15.
    Sostman HD, Zoghbi SS, Carbo P, Lord PF (1987) Coumadin and ulIn-labeled platelet uptake on experimental thrombi in dogs. Invest Radiol 22: 316–322Google Scholar
  16. 16.
    DePalma VA, Baier RE, Ford JW, Gocc VC, Furuse A (1972) Investigation of three-surface properties of several metals and their relation to blood compatibility. J Biomed Mater Res Symposium 3: 37–75CrossRefGoogle Scholar
  17. 17.
    Sawyer PN, Page JW (1953) Bio-electric phenomena as an etiologic factor in intravascular thrombosis. Am J Physiol 175: 103–107PubMedGoogle Scholar
  18. 18.
    Schultz JS; Lindenauer SM, Penner JA, Barenberg S (1980) Determinants of thrombus formation on surfaces. Trans Am Soc Artif Intern Organs 26: 279–283PubMedGoogle Scholar
  19. 19.
    Brown CH, Lemuth RF, Heliums JD, Leverett LB, Alfrey CP (1975) Response of human platelets to shear stress. Trans Am Soc Artif Intern Organs 21: 35–39PubMedGoogle Scholar
  20. 20.
    Mansfield PB, Wechezak AR, DiBenedetto G, Sauvage LR (1978) Antithrombogenic func¬tions of the endothelium in vascular grafts. In: Sawyer PN, Kaplitt MJ (eds) Appleton-Century Crofts, New YorkGoogle Scholar
  21. 21.
    Harker LA, Slichter SJ (1970) Studies of platelet and fibrinogen kinetics in patients with prosthetic heart valves. N Engl J Med 283: 1302–1305PubMedCrossRefGoogle Scholar
  22. 22.
    O–Gara PT, Guerrero JL, Feldman B, Fallon JT, Block PC (1984) Effect of dextran and aspirin on platelet adherence after transluminal angioplasty of normal canine arteries. Am J Cardiol 53: 1695–1698PubMedCrossRefGoogle Scholar
  23. 23.
    Schoenfeld NA, Eldrup-Jorgenson J, Connolly R, Callow AD, Valeri CR, Ramberg K, Mackey WC, L’Donnell TF (1987) The effect of low molecular weight dextran on platelet deposition onto prosthetic materials. J Vase Surg 5: 76–82Google Scholar
  24. 24.
    Kakkar WW (1981) Prevention of venous thromboembolism. Clinics Hematol 10: 543–582Google Scholar
  25. 25.
    Bernstein EF, Emmings FG, Mackey GC, Castaneda A, Varco RL (1962) Effect of low molecular weight dextran on red blood cell change during extracorporeal circulation. Trans Am Soc Artif Int Organs 8: 23–29Google Scholar
  26. 26.
    Winfrey EW, Foster JH (1962) Prevention of arterial thrombosis with a negatively charged wire suture. Surg Forum 13: 229–231PubMedGoogle Scholar
  27. 27.
    Palmaz JC, Tio FO, Schatz RA, Alvarado R, Rees C, Garcia O (1988) Early endothelisation of balloon-expandable stents: experimental observations. Interventional Radiology 3: 1–6Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • J. C. Palmaz
  • O. Garcia
  • D. T. Kopp
  • F. O. Tio
  • V. Ciaravino
  • R. A. Schatz
  • C. Rees
  • R. Alvarado
  • J. L. Lancaster
  • R. D. Borchert

There are no affiliations available

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