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Radioimmunotherapy with Iodine 131-Labelled Antibodies in Ovarian, Colonic and Brain Tumours

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Cancer Therapy

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Abstract

Radiolabeled monoclonal antibodies have been shown to react preferentially to neoplastic cells and offer new approaches for targeted cancer treatment [1]. Monoclonal antibody technology [2] enables an antibody-producing lymphocyte to be fused with a cultured myeloma cell, thus producing a hybridoma that secretes a specific monoclonal antibody. It is now possible to manufacture large quantities of immunoglobulins with unique specificity. Monoclonal antibodies have been raised against tumor-associated antigens found in many types of cancer such as breast, lung, colonic, ovarian and bone cancer, as well as glioma, melanoma etc. Great effort has been directed towards the use of monoclonal antibodies to target potent cytotoxic or biologically active agents. Radiolabeled monoclonal antibodies have been utilised in patients for tumour localisation by external body scintigraphy, and encouraging clinical results have been reported by many workers [3–6]. Other potential uses of monoclonal antibodies include the delivery of chemotherapy [7], toxins [8] or radionuclides [9–13] to specifically destroy tumour cells.

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Authors and Affiliations

  1. Royal Postgraduate Medical School and Imperial Cancer Research Group, Hammersmith Hospital, Du Cane Road, London, W12 OHS, UK

    H. Kalofonos & A. A. Epenetos

Authors
  1. H. Kalofonos
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  2. A. A. Epenetos
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Editor information

Editors and Affiliations

  1. Department of General Surgery, University of Ulm, Steinhövelstraße 9, 7900, Ulm, Germany

    Hans G. Beger FACS (Professor of Surgery) & Markus Büchler (Lecturer in Surgery) (Professor of Surgery) &  (Lecturer in Surgery)

  2. Division of Tumor Cell Biology, Scripps Clinic & Research Foundation, 10666 North Torrey Pines Road, 92037, La Jolla, CA, USA

    Ralph A. Reisfeld

  3. Clinical Research, Behringwerke AG Marburg, P.O. Box 1140, 3550, Marburg, Germany

    Gregor Schulz

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© 1989 Springer-Verlag Berlin · Heidelberg

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Kalofonos, H., Epenetos, A.A. (1989). Radioimmunotherapy with Iodine 131-Labelled Antibodies in Ovarian, Colonic and Brain Tumours. In: Beger, H.G., Büchler, M., Reisfeld, R.A., Schulz, G. (eds) Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73721-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-73721-3_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-73723-7

  • Online ISBN: 978-3-642-73721-3

  • eBook Packages: Springer Book Archive

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