Cancer Therapy pp 143-153 | Cite as

New Developments in Surgical Oncology

  • R. Bittner
  • H. G. Beger
Conference paper

Abstract

Only surgical therapy can influence decisively the course of a solid malignant tumor of the gastrointestinal tract and cure the patient. Today, the results of standard operative procedures have reached an extremely high standard that will hardly be surpassed even in the future. However, only little improvement has been achieved with regard to cure rates, because more than half of the patients admitted for surgery present with an advanced stage of systemic disease, rendering curative surgery impossible.

Keywords

Toxicity Catheter Hepatitis Depression Oncol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bittner R (1985) Das duktale Pankreaskopfkarzinom — Stagnation oder Fortschritt in der chirurgischen Therapie? Klinikarzt 14: 467–477Google Scholar
  2. 2.
    Trede M (1985) The surgical treatment of pancreatic carcinoma. Surgery 97 (1): 8–35Google Scholar
  3. 3.
    Crist DW, Sitzmann JV, Cameron JL (1987) Improved hospital morbidity, mortality, and survival after the Whipple procedure. Ann Surg 206, 3: 358–365PubMedCrossRefGoogle Scholar
  4. 4.
    Peiper HJ, Siewert R (1978) Magenersatz. Chirurg 49: 81–88Google Scholar
  5. 5.
    Bittner R, Schirrow H, Butters M, Roscher R, Krautzberger W, Oettinger W, Beger HG (1985) Total gastrectomy. Arch Surg 120: 1120–1125PubMedGoogle Scholar
  6. 6.
    Herfarth C, Schlag P, Buhl K (1987) Surgical procedures for gastric substitution. World J Surg 11: 689–698PubMedCrossRefGoogle Scholar
  7. 7.
    Siewert JR, Lange J, Böttcher K, Hölscher M, Weiser HF, Gössner W (1987) Magenkarzinom — Bestandsaufnahme aus chirurgischer Sicht. Dtsch Med Wochenschr 112: 622–628PubMedCrossRefGoogle Scholar
  8. 8.
    Bittner R (1987) Gastrectomie de nécessité. Langenbecks Arch Chir 372: 577–582PubMedCrossRefGoogle Scholar
  9. 9.
    Bittner R, Butters M, Roscher R, Schirrow H, Büchler M, Beger HG (1988) Gastrektomie — Gestern und Heute. 105th meeting of the German Association of Surgery, Munich 1988 Scientific Exhibition, 6–9 April 1988Google Scholar
  10. 10.
    Grundmann R, Blettenberg U, Pichlmaier H (1984) Behandlung des koloraktalen Karzinoms in den letzten 35 Jahren — perioperativer Aufwand und postoperatives Ergebnis. Leber Magen Darm 14 (4): 174–180PubMedGoogle Scholar
  11. 11.
    Reifferscheid M, Weishaupt W (1974) Die Chirurgie des Mastdarmkrebses in heutiger Sicht. Chirurg 45: 444–451PubMedGoogle Scholar
  12. 12.
    Gall FP (1986) Chirurgische Therapie des Rektumkarzinoms im mittleren Drittel “Anteriore Resektion”. Leber Magen Darm 5: 325–330Google Scholar
  13. 13.
    Stelzner F (1981) Moderne Radikaloperationen und Ergebnisse — Bedeutung der Kontinenzerhaltung. Krankenhausarzt 54: 288–290Google Scholar
  14. 14.
    Heberer G, Denecke H, Pratschke E, Teichmann R (1982) Anterior and low anterior resection. World J Surg 6: 517–524PubMedCrossRefGoogle Scholar
  15. 15.
    Cady B, Ramsden DA, Stein A, Haggitt RC (1977) Gastric cancer. Am J Surg 133: 423–429PubMedCrossRefGoogle Scholar
  16. 16.
    Buchholtz TW, Welch CE, Malt RA (1978) Clinical correlates of resectability and survival in gastric carcinoma. Ann Surg 188: 711–715PubMedCrossRefGoogle Scholar
  17. 17.
    Diehl JT, Hermann RE, Coopermann AM, Hoerr SO (1983) Gastric carcinoma. A ten-year review. Ann Surg 198: 9–12PubMedCrossRefGoogle Scholar
  18. 18.
    Scott HW, Adkins RB, Sawyers JL (1985) Results of an aggressive surgical approach to gastric carcinoma during a twenty-three-year period. Surgery 97: 55–58PubMedGoogle Scholar
  19. 19.
    Meyer HJ, Jähne J, Pichlmayer R (1987) Magencarcinom: Gastrektomie de principe. Langen-becks Arch Chir 372: 571–576CrossRefGoogle Scholar
  20. 20.
    Fortner JG (1981) Surgical principles for pancreatic cancer: Regional total and subtotal pancreatectomy. Cancer 47: 1712–1718PubMedCrossRefGoogle Scholar
  21. 21.
    Turnbull RB, Kyle K, Watson FR, Spratt J (1967) Cancer of the colon: The influence of the no-touch isolation technique on survival rates. Ann Surg 166: 420–427PubMedCrossRefGoogle Scholar
  22. 22.
    Pezim ME, Nicholls RJ (1984) Survival after high or low ligation of the inferior mesenteric artery during curative surgery for rectal cancer. Ann Surg 200: 729–733PubMedCrossRefGoogle Scholar
  23. 23.
    Pichlmayr R, Meyer HJ (1979) Value of the gastrectomy “de principe”. In: Herfarth C, Schlag P (eds) Gastric cancer. Springer-Verlag Berlin Heidelberg New York, pp 196–204Google Scholar
  24. 24.
    Yoshino K, Haruyama K (1983) Bedeutung der Splenektomie für die Lymphknotenausräumung bei Magenkarzinom. Akt Chir 18: 81–84Google Scholar
  25. 25.
    Koga S, Kaibara N, Kimura O, Nishidoi H, Kishimoto H (1981) Prognostic significance of combined splenectomy or pancreatico-splenectomy in total and proximal gastrectomy for gastric cancer. Am J Surg 142: 546–550PubMedCrossRefGoogle Scholar
  26. 26.
    Maruyama K, Okabayashi K, Kinoshita T (1987) Progress in gastric cancer surgery in Japan and its limits of radicality. World J Surg 11: 418–425PubMedCrossRefGoogle Scholar
  27. 27.
    de Aretxabala X, Konishi K, Yonemura Y, Ueno K, Yagi M, Noguchi M, Miwa K, Miyazaki I (1987) Node dissection in gastric cancer. Br J Surg 74: 770–773PubMedCrossRefGoogle Scholar
  28. 28.
    Wolff BG (1987) Invited commentary. World J Surg 11: 809CrossRefGoogle Scholar
  29. 29.
    Eder M (1984) Die Metastasierung — Fakten und Probleme aus humanpathologischer Sicht. Verh Dtsch Ges Pathol 68: 1–11Google Scholar
  30. 30.
    Kemeny N, Daly J, Reichman B, Geller N, Botet J, Oderman P (1987) Intrahepatic or systemic infusion of fluorodeoxyuridine in patients with liver metastases from colorectal carcinoma. Ann Int Med 107: 459–465PubMedGoogle Scholar
  31. 31.
    Taylor I, Machin D, Mullee M, Trotter G, Cooke T, West C (1985) A randomized controlled trial of adjuvant portal vein cytotoxic perfusion in colorectal cancer. Br J Surg 72: 359–363PubMedCrossRefGoogle Scholar
  32. 32.
    Metzger U, Mermillod B, Aeberhard P, Gloor F, Bissat A, Egeli R, Luffer U, Martinoli S, Mueller W, Schroeder R, Weber W (1987) Intraportal chemotherapy in colorectal carcinoma as an adjuvant modality. World J Surg 11: 452–458PubMedCrossRefGoogle Scholar
  33. 33.
    Abe M, Takahashi M (1981) Intraoperative radiotherapy: The Japanese experience. Int J Radiat Oncol Biol Phys 7: 863–868PubMedCrossRefGoogle Scholar
  34. 34.
    Abe M, Shibamoto Y, Takahashi M, Manabe T, Tobe T, Inamoto T (1987) Intraoperative radiotherapy in carcinoma of the stomach and pancreas. World J Surg 11: 459–464PubMedCrossRefGoogle Scholar
  35. 35.
    Wood CW, Shipley WU, Gunderson LL, Cohen AE, Nardi GL (1982) Intraoperative irradiation for unresectable pancreatic carcinoma. Cancer 49: 1272–1275PubMedCrossRefGoogle Scholar
  36. 36.
    Dosoretz D, Gunderson LL, Hoskins B, Hedberg S, Blitzer PH, Shipley W, Cohen A (1983) Preoperative irradiation for unresectable rectal and rectosigmoid carcinomas. Cancer 52: 814–818PubMedCrossRefGoogle Scholar
  37. 37.
    Gunderson LL, Cohen AM, Dosoretz DD, Shipley W, Hedberg S, Wood W, Rodkey G, Suit H (1983) Residual, unresectable or recurrent colorectal cancer: External beam irradiation and intraoperative electron beam boost resection. Int J Radiat Oncol Biol Phys 9: 1597–1606PubMedGoogle Scholar
  38. 38.
    Koga S, Hamazoe R (1986) Continuous hyperthermic peritoneal perfusion for cancer. In: Gastric cancer surgery (The latest therapy), vol 3. Igaku Kyoiku Shuppan, Tokyo, pp 525–529Google Scholar
  39. 39.
    Balch CM, Levin B (1987) Regional and systemic chemotherapy for colorectal metastases to the liver. World J Surg 11: 521–526PubMedCrossRefGoogle Scholar
  40. 40.
    Ensminger W, Niederhuber J, Dakhil S, Thrall J, Wheeler R (1981) Totally implanted drug delivery system for hepatic arterial chemotherapy. Cancer Treat Rep 65: 393–400PubMedGoogle Scholar
  41. 41.
    Niederhuber JE, Ensminger W, Gyves J, Thrall J, Walker S, Cozzi E (1984) Regional chemo-therapy of colorectal cancer metastatic to the liver. Cancer 53: 1336–1343PubMedCrossRefGoogle Scholar
  42. 42.
    Barone RM, Byfield JE, Goldfarb PB, Frankel S, Ginn S, Greer S (1982) Intra-arterial chemo-therapy using an implantable infusion pump and liver irradiation for the treatment of hepatic metastases. Cancer 50: 850–862PubMedCrossRefGoogle Scholar
  43. 43.
    Cohen AM, Kaufman SD, Wood WC, Greenfield AJ (1983) Regional hepatic chemotherapy using an implantable drug infusion pump. Am J Surg 145: 529–533PubMedCrossRefGoogle Scholar
  44. 44.
    Balch CM, Urist MM, Soong SJ, McGregor MA (1983) A prospective phase II clinical trial of continuous FUDR regional chemotherapy for colorectal metastases to the liver using a totally implantable drug infusion pump. Ann Surg 198: 567-–573Google Scholar
  45. 45.
    Balch CM, Urist MM (1986) Intra-arterial chemotherapy for colorectal liver metastases and hepatomas using a totally implantable drug infusion pump. In: Herfarth C, Schlag P, Hohenberger P (eds) Therapeutic Strategies in primary and metastatic liver cancer. Springer-Verlag Berlin Heidelberg New York Tokyo, pp 234–247 (Recent results in cancer research, vol 100 )Google Scholar
  46. 46.
    Daly JM, Kemeny N, Oderman P, Botet J (1984) Long-term hepatic arterial infusion chemotherapy; Anatomic considerations, operative technique and treatment morbidity. Arch Surg 119: 936–941PubMedGoogle Scholar
  47. 47.
    Shepard KV, Levin B, Karl RC, Faintuch J, DuBrow RA, Hagle M, Cooper RM, Beshorner J, Stablein D (1985) Therapy for metastatic colorectal cancer with hepatic artery infusion chemotherapy using subcutaneous implanted pump. J Clin Oncol 3: 161–169PubMedGoogle Scholar
  48. 48.
    Kemeny N, Reichman B, Oderman P, Daly J, Geller N (1986) Update of randomized study of intrahepatic (H) vs systemic (S) infusion of fluorodeoxyuridine (FUDR) in patients with liver metastases from colorectal carcinoma (CRC). Proc Am Soc Clin Oncol 5: 47Google Scholar
  49. 49.
    Patt YZ, Boddie AW, Charnsangavej C, Ajani JA, Wallace S, Soski M, Claghorn L, Mavligit GM (1986) Hepatic arterial infusion with floxuridine and cisplatin: Overriding importance of antitumor effect versus degree of tumor burden as determinants of survival among patients with colorectal cancer. J Clin Oncol 4: 1356–1364PubMedGoogle Scholar
  50. 50.
    Hottenrott C, Lorenz M (1987) Stellenwert der regionalen Chemotherapie der Leber. Z Gastroenterol 25: 364–373PubMedGoogle Scholar
  51. 51.
    Oldham RK, Smalley RV (1985) Newer methods of cancer treatment: Biologicals and biological response modifiers. In: De Vita Jr VT, Hellman S, Rosenberg SA (eds) Cancer 2nd edn. Lippincott, Philadelphia, pp 2223–2245Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • R. Bittner
    • 1
  • H. G. Beger
    • 1
  1. 1.Department of General SurgeryUniversity of UlmUlmGermany

Personalised recommendations