Abstract
The prognosis of colorectal cancer following curative surgery has remained unchanged over the past 40 years. In a patient collective comprising all Dukes stages, the 5-year-survival rates never exceeded 50% [1, 2]. Surgical progress has been restricted to the development of sphincter-saving procedures for rectal cancer at low levels [3–6]. However, an improvement in the prognosis of colorectal cancer patients should not be expected from surgery alone. The value of perioperative radiation therapy is as yet uncertain, and its use is confined to rectal cancer [7]. At present, chemo- and immunotherapy are the essential modalities in trials of adjuvant treatment of colorectal cancer. However, most of the therapy schemes published so far have not led to significantly improved, long-term survival times following either radical or palliative surgery of colorectal cancer [8, 9]. Nonetheless, the sporadic reports of successes with respect to the improvement of survival time [10–12] have encouraged us to investigate the effect of chemotherapy and immunotherapy as adjunctive treatment in a prospective randomized study of patients operated on in one medical center.
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© 1989 Springer-Verlag Berlin · Heidelberg
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Schiessel, R. (1989). Tumor Vaccination in the Treatment of Colorectal Cancer. In: Beger, H.G., Büchler, M., Reisfeld, R.A., Schulz, G. (eds) Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73721-3_16
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DOI: https://doi.org/10.1007/978-3-642-73721-3_16
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