Cancer Therapy pp 124-131 | Cite as

Possible Mechanism of Interferon Action in Hairy Cell Leukemia

  • F. Porzsolt
  • W. Digel
  • C. Buck
  • A. Raghavachar
  • M. Stefanic
  • W. Schöniger
Conference paper

Abstract

Recently, we described that peripheral blood mononuclear cells (MNC) from patients with hairy cell leukemia (HCL) can be induced in vitro to produce higher levels of interferon-gamma (IFN-γ) but lower levels of IFN-α than in healthy controls [7]. The reduced IFN-α production has been explained by the lack of monocytes in this disease. The increased production of IFN-γ suggests an increased release of cytokines by T cells. This assumption has been confirmed by Ford et al. [2], who described that a conditioned medium of T4-lymphocytes from patients with HCL contains a cytokine that stimulates the growth of activated, normal B cells. Kehrl et al. [5] demonstrated tumor necrosis factor alpha (TNF-α) to be a stimulator of activated normal B cells, and we (Digel et al. 1988) have shown recently that recombinant TNF-α stimulates the growth of purified B cells from patients with B-chronic lymphocytic leukemia (B-CLL). Based on these findings, we hypothesize that TNF is produced in B-cell disorders like HCL and that TNF may stimulate the growth of hairy cells (HC).

Keywords

Leukemia Penicillin Polypeptide Interferon Streptomycin 

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • F. Porzsolt
    • 1
    • 2
  • W. Digel
    • 2
  • C. Buck
    • 2
  • A. Raghavachar
    • 3
  • M. Stefanic
    • 2
  • W. Schöniger
    • 2
  1. 1.Tumor CenterUniversity of UlmUlmGermany
  2. 2.Department of Internal Medicine IIIUniversity of UlmUlmGermany
  3. 3.Department of Transfusion MedicineUniversity of UlmUlmGermany

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