Abstract
Recently, we described that peripheral blood mononuclear cells (MNC) from patients with hairy cell leukemia (HCL) can be induced in vitro to produce higher levels of interferon-gamma (IFN-γ) but lower levels of IFN-α than in healthy controls [7]. The reduced IFN-α production has been explained by the lack of monocytes in this disease. The increased production of IFN-γ suggests an increased release of cytokines by T cells. This assumption has been confirmed by Ford et al. [2], who described that a conditioned medium of T4-lymphocytes from patients with HCL contains a cytokine that stimulates the growth of activated, normal B cells. Kehrl et al. [5] demonstrated tumor necrosis factor alpha (TNF-α) to be a stimulator of activated normal B cells, and we (Digel et al. 1988) have shown recently that recombinant TNF-α stimulates the growth of purified B cells from patients with B-chronic lymphocytic leukemia (B-CLL). Based on these findings, we hypothesize that TNF is produced in B-cell disorders like HCL and that TNF may stimulate the growth of hairy cells (HC).
This work was supported by Grant No. 164/3-1 from the Deutsche Forschungsgemeinschaft.
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© 1989 Springer-Verlag Berlin · Heidelberg
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Porzsolt, F., Digel, W., Buck, C., Raghavachar, A., Stefanic, M., Schöniger, W. (1989). Possible Mechanism of Interferon Action in Hairy Cell Leukemia. In: Beger, H.G., Büchler, M., Reisfeld, R.A., Schulz, G. (eds) Cancer Therapy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73721-3_15
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DOI: https://doi.org/10.1007/978-3-642-73721-3_15
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