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Tumor Kinetics in Experimental Mammary Carcinoma

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High-Risk Breast Cancer

Abstract

Cell kinetics describe the dynamic processes involved in growth or regression of tumors in untreated hosts and in hosts perturbed by therapy or other factors. Changes in tumor volume are determined by the cell population kinetics, i.e., the length of the tumor cell cycle and its phases, the growth fraction, the rate of cell loss or cell death, and the volume of noncellular components of the tumor. The observed response of tumors to therapy is determined by all of these factors.

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References

  1. Abdelaal AS, Wheldon FE, Clark BM (1980) Perturbation of the growth kinetics of C3H mouse mammary carcinoma by irradiation of tumor and host and by attempted pre-immunization of host. Br J Cancer 41: 567–576

    Article  PubMed  CAS  Google Scholar 

  2. Agostino D, Clifton EE (1964) Anesthetic effect on pulmonary metastases in rats. Arch Surg 88: 735–739

    PubMed  CAS  Google Scholar 

  3. Alexander P (1961) Mouse lymphoma cells with different radiosensitivities. Nature 192: 572–573

    Article  PubMed  CAS  Google Scholar 

  4. Alexander P, Mikulski ZB (1961) Differences in the response of leukaemia cells in tissue culture to nitrogen mustard and to dimethyl myleran. Biochem Pharmacol 5: 275–282

    Article  PubMed  CAS  Google Scholar 

  5. Barski G, Youn JK (1969) Evolution of cell-mediated immunity in mice bearing an antigenic tumor. Influence of tumor growth and surgical removal. JNCI 43: 111–121

    PubMed  CAS  Google Scholar 

  6. Begg AC (1971) Kinetic and histological changes of a serially transplanted mouse tumour. Cell Tissue Kinet 4: 401–411

    PubMed  CAS  Google Scholar 

  7. Belehradek J, Barski G, Thonier M (1972) Evolution of cell-mediated antitumor immunity in mice bearing a syngeneic chemically induced tumor. Influence of tumor growth, surgical removal and treatment with irradiated tumor cells. Int J Cancer 9: 461–469

    Article  PubMed  Google Scholar 

  8. Boeryd B, Rudenstam C-M (1967) Effect of heparin, plasminogen inhibitor (EACA) and trauma on tumour metastases. Acta Pathol Microbiol Scand 69: 28–34

    Article  CAS  Google Scholar 

  9. Braunschweiger PG (1987) Tumor growth fraction estimation, perturbation, and prognostication. In: Gray JW, Darzynkiewicz Z (eds) Techniques in cell cycle analysis. Humana, Clifton, pp 47–71

    Chapter  Google Scholar 

  10. Braunschweiger PG, Schiffer LM (1978) Therapeutic implications of cell kinetic changes after cyclophosphamide treatment in “spontaneous” and “transplantable” mammary tumors. Cancer Treat Rep 62: 727–736

    CAS  Google Scholar 

  11. Braunschweiger PG, Schiffer LM (1980a) Effect of adriamycin on the cell kinetics of 13762 rat mammary tumors and implications for therapy. Cancer Treat Rep 64: 293–300

    PubMed  CAS  Google Scholar 

  12. Braunschweiger PG, Schiffer LM (1980b) Cell kinetic-directed sequential chemotherapy with cyclophosphamide and adriamycin in T1699 mammary tumors. Cancer Res 40: 737–743

    PubMed  CAS  Google Scholar 

  13. Brauschweiger PG, Schiffer LM (1981) Antiproliferative effects of corticosteroids in C3H/HeJ mammary tumors and implications for sequential combination chemotherapy. Cancer Res 41: 3324–3330

    Google Scholar 

  14. Braunschweiger PG, Schenken LL, Schiffer LM (1979) The cytokinetic basis for the design of efficacious radiotherapy protocols. Int J Radiat Oncol Biol Phys 5: 37–47

    PubMed  CAS  Google Scholar 

  15. Braunschweiger PG, Stragand JJ, Schiffer LM (1978) Effect of methylprednisolone on cell proliferation in C3H/HeJ spontaneous mammary tumors. Cancer Res 38: 4510–4514

    PubMed  CAS  Google Scholar 

  16. Braunschweiger PG, Ting HL, Schiffer LM (1983) Role of corticosteroid hormones in the control of cell proliferation in residual tumor after surgical cytoreduction. Cancer Res 43: 5801–5807

    PubMed  CAS  Google Scholar 

  17. Bresciani F (1965) A comparison of the cell generative cycle in normal, hyperplastic and neoplastic mammary gland of the C3H mouse. In: Symposium on fundamental cancer research. Cellular radiation biology. Williams and Wilkins, Baltimore, pp 547–557

    Google Scholar 

  18. Brown JM (1970) The effect of acute X-irradiation on the cell proliferation kinetics of induced carcinomas and their normal counterpart. Radiation Res 43: 627–653

    Article  PubMed  CAS  Google Scholar 

  19. Brown JM (1977) Effects of radiation and chemotherapeutic agents on the incidence and treatment of blood-borne metastases. In: Stansyl PG, Sato H (eds) Cancer metastases, approaches to the mechanism, prevention and treatment. Gann monograph on cancer research, no 20. University of Tokyo Press, Tokyo, pp 207–225

    Google Scholar 

  20. Burns ER (1969) On the failure of self-inhibition of growth in tumors. Growth 33: 25–45

    PubMed  CAS  Google Scholar 

  21. Chaput B, Relia W, Vetterlein M (1974) Changes in cell mediated immune functions by growing tumor. Eur J Cancer 10: 185–188

    Article  PubMed  CAS  Google Scholar 

  22. Cheshire PJ (1970) The effect of multiple tumours on mammary tumour growth rates in the C3H mouse. Br J Cancer 24: 542–547

    Article  PubMed  CAS  Google Scholar 

  23. Combs JW, Mackey M, Bennington, JL (1971) Regulation of cell proliferation in DMBA-induced rat mammary neoplasms by the estrus cycle. Am J Pathol 62: 61(a)

    Google Scholar 

  24. Crile G, Deodhar SD (1971) Role of preoperative radiation in prolonging concomitant immunity and preventing metastasis in mice. Cancer 27: 629–634

    Article  PubMed  Google Scholar 

  25. de Lacroix WF, Lennartz KJ (1981) Changes in the proliferation characteristics of a solid transplantable tumour of the mouse with time after transplantation. Cell Tissue Kinet 14: 135–142

    Google Scholar 

  26. Denekamp J (1970) The cellular proliferation kinetics of animal tumors. Cancer Res 30: 393–400

    PubMed  CAS  Google Scholar 

  27. Denekamp J, Thomlinson RH (1971) The cell proliferation kinetics of four experimental tumors after X-irradiation. Cancer Res 31: 1279–1284

    PubMed  CAS  Google Scholar 

  28. de Ruiter J, Cramer SJ, Lelieveld P, van Putten LM (1982) Comparison of metastatic disease after local tumour treatment with radiotherapy or surgery in various tumour models. Eur J Cancer 18: 281–289

    Article  Google Scholar 

  29. Dethlefsen LA (1979) Cellular recovery kinetic studies relevant to combined-modality research and therapy. Int J Radiat Oncol Biol Phys 5: 1197–1203

    PubMed  CAS  Google Scholar 

  30. Dethlefsen LA (1980) The growth dynamics of murine mammary tumor cells in situ. In: McGrath C, Brennan MJ, Rich MA (eds) Cell biology of breast cancer. Academic, New York, pp 145–160

    Google Scholar 

  31. Dethlefsen LA, Prewitt JMS, Mendelsohn ML (1968) Analysis of tumor growth curves. JNCI 40: 389–405

    PubMed  CAS  Google Scholar 

  32. Dethlefsen LA, Riley RM, Roti Roti JL (1979) Flow cytometric analysis of adriamycin- perturbed mouse mammary tumors. J Histochem Cytochem 27: 463–469

    Article  PubMed  CAS  Google Scholar 

  33. DeWys WD (1972) Studies correlating the growth rate of a tumor and its metastases and providing evidence for tumor-related systemic growth-retarding factors. Cancer Res 32: 374–379

    PubMed  CAS  Google Scholar 

  34. Dickson JA, Ellis HA (1974) Stimulation of tumour cell dissemination by raised temperature (42°C) in rats with transplanted Yoshida tumours. Nature 248: 354–358

    Article  PubMed  CAS  Google Scholar 

  35. Dickson JA, Ellis HA (1976) The influence of tumor volume and the degree of heating on the response of the solid Yoshida sarcoma to hyperthermia (40–42°). Cancer Res 36: 1188–1195

    PubMed  CAS  Google Scholar 

  36. Dunphy JE (1950) Some observations on the natural behavior of cancer in man. N Engl J Med 242: 167–172

    Article  PubMed  CAS  Google Scholar 

  37. Eccles SA, Alexander P (1975) Immunologically-mediated restraint of latent tumour metastases. Nature 257: 52–53

    Article  PubMed  CAS  Google Scholar 

  38. Fidler IJ, Kripke ML (1980) Tumor cell antigenicity, host immunity, and cancer metastasis. Cancer Immunol Immunother 7: 201–205

    Article  Google Scholar 

  39. Fisher B (1984) The clinical scientific basis of adjuvant chemotherapy in breast cancer. In: Senn H-J (ed) Adjuvant chemotherapy of breast cancer. Springer, Berlin Heidelberg New York Tokyo, pp 8–17 (Recent results in cancer research, vol 96)

    Google Scholar 

  40. Fisher B, Gunduz N (1979) Further observations on the inhibition of tumor growth by Corynebacterium parvum with cyclophosphamide. X. Effect of treatment on tumor cell kinetics in mice. JNCI 62: 1545–1551

    PubMed  CAS  Google Scholar 

  41. Fisher B, Gunduz N, Saffer EA (1983a) Influence of the interval between primary tumor removal and chemotherapy on kinetics and growth of metastases. Cancer Res 43: 1488–1492

    PubMed  CAS  Google Scholar 

  42. Fisher B, Gunduz N, Saffer EA (1983b) Interrelation between tumor cell proliferation and 17-fluoresceinated estrone binding following primary tumor removal, radiation, cyclophosphamide or tamoxifen. Cancer Res 43: 5244–5247

    PubMed  CAS  Google Scholar 

  43. Fisher B, Saffer EA, Deutsch M (1986) Influence of irradiation of a primary tumor on the labeling index and estrogen receptor index in a distant tumor focus. Int J Radiat Oncol Biol Phys 12: 879–885

    Article  PubMed  CAS  Google Scholar 

  44. Fisher B, Saffer EA, Fisher ER (1970) Comparison of concomitant and sinecomitant tumor immunity. Proc Soc Exp Biol Med 135: 68–71

    PubMed  CAS  Google Scholar 

  45. Frindel E, Malaise EP, Alpen E, Tubiana M (1967) Kinetics of cell proliferation of an experimental tumor. Cancer Res 27: 1122–1131

    PubMed  CAS  Google Scholar 

  46. Gershon RK, Carter RL, Kondo K (1968) Immunologic defenses against metastases: impairment by excision of an allotransplanted lymphoma. Science 159: 646–648

    Article  PubMed  CAS  Google Scholar 

  47. Goldie H, Walker M, Kelley L, Gaines J (1956) Free tumor cell growth in the peritoneal cavity (ascites tumor) of mice bearing subcutaneous tumors. Cancer Res 16: 553–558

    PubMed  CAS  Google Scholar 

  48. Goodman GJ (1957) Effects of one tumor upon the growth of another. Proc Am Assoc Cancer Res 2: 207

    Google Scholar 

  49. Gorelik E (1982) Antimetastatic concomitant immunity. In: Liotta LA, Hart IR (eds) Tumor invasion and metastasis. Nijhoff, Boston, pp 113–131

    Chapter  Google Scholar 

  50. Gorelik E, Fogel M, de Baetselier P, Katzav S, Feldman M, Segal S (1982) Immunological diversity of metastatic cells. In: Liotta LA, Hart IR (eds) Tumor invasion and metastasis. Nijhoff, The Hague, pp 133–141

    Chapter  Google Scholar 

  51. Gorelik E, Segal S, Feldman M (1978) Growth of a local tumor exerts a specific inhibitory effect on progression of lung metastases. Int J Cancer 21: 617–625

    Article  PubMed  CAS  Google Scholar 

  52. Gorelik E, Segal S, Feldman M (1980) Control of lung metastasis progression in mice: role of growth kinetics of 3LL Lewis lung carcinoma and immune reactivity. JNCI 65: 1257–1264

    PubMed  CAS  Google Scholar 

  53. Gorelik E, Segal S, Feldman M (1981) On the mechanism of tumor “concomitant immunity”. Int J Cancer 27: 847–856

    Article  PubMed  CAS  Google Scholar 

  54. Greene HSN, Harvey EK (1960) The inhibitory influence of a transplanted hamster lymphoma on metastasis. Cancer Res 20: 1094–1103

    PubMed  CAS  Google Scholar 

  55. Gunduz N, Fisher B, Saffer EA (1979) Effect of surgical removal on the growth and kinetics of residual tumor. Cancer Res 39: 3861–3865

    PubMed  CAS  Google Scholar 

  56. Halleraker B, Hartviet F (1971) Interaction between subcutaneous and intraperitoneal transplants of the Ehrlich carcinoma; the possible role of anti-tumor antibody. J Pathol 105: 95–103

    Article  Google Scholar 

  57. Hartveit F, Halleraker B (1971) Effect of subcutaneous transplants of Ehrlich carcinoma on the survival time of mice with intraperitoneal transplants of the same tumour. J Pathol 105: 85–93

    Article  PubMed  CAS  Google Scholar 

  58. Hermens AF, Barendsen GW (1969) Changes of cell proliferation characteristics in a rat rhabdomyosarcoma before and after X-irradiation. Eur J Cancer 5: 173–189

    Article  PubMed  CAS  Google Scholar 

  59. Howes AE (1969) An estimation of changes in the proportions and absolute number of hypoxic cells after irradiation of transplanted C3H mouse mammary tumours. Br J Radiol 42: 441–447

    Article  PubMed  CAS  Google Scholar 

  60. Huggins C, Grand LC, Brillantes FP (1961) Mammary cancer induced by a single feeding of polynuclear hydrocarbons, and its suppression. Nature 189: 204–207

    Article  PubMed  CAS  Google Scholar 

  61. Janik P (1971) Cell proliferation during the course of immunological rejection of Ehrlich ascites tumour cells. Cell Tissue Kinet 4: 69–74

    PubMed  CAS  Google Scholar 

  62. Janik P, Steel GG (1972) Cell proliferation during immunological perturbation in three transplanted tumours. Br J Cancer 26: 108–114

    Article  PubMed  CAS  Google Scholar 

  63. Jeejeebhoy HF (1974) Stimulation of tumor growth by the immune response. Int J Cancer 13: 665–678

    Article  PubMed  CAS  Google Scholar 

  64. Kaplan HS, Murphy ED (1948) The effect of local roentgen irradiation on the biological behavior of a transplantable mouse carcinoma. I. Increased frequency of pulmonary metastasis. JNCI 9: 407–413

    Google Scholar 

  65. Keller R (1981) Induction of macroscopic metastases via surgery. Invasion Metastasis 1: 136–148

    PubMed  CAS  Google Scholar 

  66. Keller R (1982) Involvement of spontaneous rather than induced antitumor mechanisms in resistance to primary fibrosarcoma implantation and its secondary spread. In: Heberman RD (ed) NK cells and other natural effector cells. Academic, New York, pp 1353–1358

    Google Scholar 

  67. Keller R (1983) Elicitation of macroscopic metastases via surgery: various forms of surgical intervention differ in their induction of metastatic outgrowth. Invasion Metastasis 3: 183–192

    PubMed  CAS  Google Scholar 

  68. Keller R (1985a) Repression of lymphatic metastasis by a second implant of the same tumor. Invasion Metastasis 5: 295–308

    PubMed  CAS  Google Scholar 

  69. Keller R (1985b) Surgical intervention and metastasis. In: Metzger U, Larigiader L, Senn H-J (eds) Perioperative chemotherapy. Springer, Berlin Heidelberg New York Tokyo, pp 11–16 (Recent results in cancer research, vol 98)

    Google Scholar 

  70. Keller R, Hess MW (1982) Divergency between incidence of microscopic and macroscopic metastases. Virchows Arch [17] 398: 33–43

    Google Scholar 

  71. Ketcham AS, Kinsey DL, Wexler H, Mantel N (1961) The development of spontaneous metastases after removal of a “primary” tumor. II. Standardization protocol of 5 animal tumors. Cancer 14: 875–882

    Article  PubMed  CAS  Google Scholar 

  72. Ketcham AS, Wexler H, Mantel N (1959) The effect of removal of a “primary” tumor on the development of spontaneous metastases I. Development of a standardized experimental technique. Cancer Res 19: 940–944

    PubMed  CAS  Google Scholar 

  73. Ketcham AS, Wexler H, Mantel N (1961) Studies on the effects of surgery on transplanted animal tumors and their metastases. JNCI 27: 1311–1321

    PubMed  CAS  Google Scholar 

  74. Ketcham AS, Wexler H, Minton JP (1966) Experimental study of metastases. JAMA 198: 177–184

    Article  Google Scholar 

  75. Laird AK (1964) Dynamics of tumour growth. Br J Cancer 18: 490–502

    Article  Google Scholar 

  76. Laird AK (1965) Dynamics of tumour growth: comparison of growth rates and extrapolation of growth curve to one cell. Br J Cancer 19: 278–291

    Article  PubMed  CAS  Google Scholar 

  77. Lewis MR, Cole WH (1958) Experimental increase of lung metastases after operative trauma (amputation of limb with tumor). Arch Surg 77: 621–626

    CAS  Google Scholar 

  78. McCredie JA, Inch RW, Sutherland RM (1971) Differences in growth and morphology between the spontaneous C3H mammary carcinoma in the mouse and its syngeneic transplants. Cancer 27: 635–642

    Article  PubMed  CAS  Google Scholar 

  79. Mendelsohn ML (1965) The kinetics of tumor cell proliferation. In: Symposium on fundamental cancer research. Cellular radiation biology. Williams and Wilkins, Baltimore, pp 498–513

    Google Scholar 

  80. Mendelsohn ML (1962) Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. III. The growth fraction. JNCI 28: 1015–1029

    PubMed  CAS  Google Scholar 

  81. Mendelsohn ML (1976) Computer analyzed transit times for vertebrate cell cycle and phases. In: Altman PL, Katz DD (eds) Cell biology. Federation of American Society of Experimental Biology, Bethesda, pp 11–13

    Google Scholar 

  82. Mendelsohn ML, Dethlefsen LA (1973) Cell kinetics of breast cancer: the turnover of nonproliferating cells. In: Griem ML, Jensen EV, Ultman JE, Wissler RW (eds) Breast cancer: a challenging problem. Springer, Berlin Heidelberg New York Tokyo, pp 73–86 (Recent results in cancer research, vol 42)

    Google Scholar 

  83. Mendelsohn ML, Dohan FC, Moore HA (1960) Autoradiographic analysis of cell proliferation in spontaneous breast cancer of C3H mouse. I. Typical cell cycle and timing of DNA synthesis. JNCI 25: 477–484

    PubMed  CAS  Google Scholar 

  84. Middle JG, Embleton MJ (1981) Naturally arising tumors of the inbred WAB/Not rat strain. II. Immunogenicity of transplanted tumors. JNCI 67: 637–643

    PubMed  CAS  Google Scholar 

  85. Mikulska ZB, Smith C, Alexander P (1966) Evidence for an immunological reaction of the host directed against its own actively growing tumor. JNCI 36: 29–35

    PubMed  CAS  Google Scholar 

  86. Milas L, Hunter N, Mason K, Withers HR (1974) Immunological resistance to pulmonary metastases in C3Hf/Bu mice bearing syngeneic fibrosarcoma of different sizes. Cancer Res 34: 61–71

    PubMed  CAS  Google Scholar 

  87. Munster AM, Gale GR, Hunt HH (1977) Accelerated tumor growth following experimental burns. J Trauma 17: 373–375

    Article  PubMed  CAS  Google Scholar 

  88. Naito H, Ziegler MM, Tsou KC (1985) Rational selection of adjuvant chemotherapy after cytoreduction surgery for murine neuroblastoma. Cancer Res 45: 3554–3560

    PubMed  CAS  Google Scholar 

  89. North RJ, Kirstein DP (1977) T-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites. J Exp Med 145: 275–292

    Article  PubMed  CAS  Google Scholar 

  90. Ogita S, Tokiwa K, Goto Y, Majima S (1985) Experimental study on the growth and proliferation kinetics of residual tumor after surgery in mouse neuroblastoma. J Pediatr Surg 20: 224–227

    Article  PubMed  CAS  Google Scholar 

  91. Paranjpe MS, Boon CW (1974) Kinetics of the anti-tumor delayed hypersensitivity response in mice with progressively growing tumors: stimulation followed by specific suppression. Int J Cancer 13: 179–186

    Article  PubMed  CAS  Google Scholar 

  92. Prehn RT, Prehn LM (1987) The autoimmune nature of cancer. Cancer Res 47:927–932

    PubMed  CAS  Google Scholar 

  93. Price CHG, Jeffree GM (1973) Metastatic spread of osteosarcoma. Br J Cancer 28: 515–524

    Article  PubMed  CAS  Google Scholar 

  94. Riley V (1975) Mouse mammary tumors: alteration of incidence as apparent function of stress. Science 189: 465–467

    Article  PubMed  CAS  Google Scholar 

  95. Rockwell S, Kallman RF (1972) Growth and cell population kinetics of single and multiple KHT sarcomas. Cell Tissue Kinet 5: 449–457

    PubMed  CAS  Google Scholar 

  96. Romsdahl MM (1963) The experimental influence of operative procedures on distant metastases. Proc Am Assoc Cancer Res 4: 58

    Google Scholar 

  97. Schabel FM Jr, Simpson-Herren L (1984) Tumor growth kinetics and drug treatment of cancer. In: Keummerle HP (ed) Clinical chemotherapy, vol III: antineoplastic chemotherapy. Thieme-Stratton, New York, pp 16–34

    Google Scholar 

  98. Schatten WE (1958a) An experimental study of postoperative tumor metastases. I. Growth of pulmonary metastases following total removal of primary leg tumor. Cancer 11:455–459

    Article  PubMed  CAS  Google Scholar 

  99. Schatten WE, Kramer WM (1958b) An experimental study of postoperative tumor metastases. II. Effects of anesthesia, operation, and cortisone administration on growth of pulmonary metastases. Cancer 11: 460–462

    Article  PubMed  CAS  Google Scholar 

  100. Schiffer LM (1978) The cell kinetics of mammary cancers. In: McGuire WL (ed) Breast cancer: advances in research and treatment, vol 2. Plenum, New York, pp 259–282

    Google Scholar 

  101. Schiffer LM, Braunschweiger PG, Stragand JJ (1978) Tumor cell population kinetics following noncurative treatment. In: Schabel FM Jr (ed) Antiobiotics and chemotherapy, vol 23. Karger, Basel, pp 148–156

    Google Scholar 

  102. Schiffer LM, Markoe AM, Nelson JSR (1973) Evaluation of the PDP index as a monitor of growth fraction during tumor therapy. In: The cell cycle in malignancy and immunotherapy. Proc of thirteenth Annual Hanford Biology Symposium, Technical Information Center, Office of Public Affairs, US Energy Research and Development Administration, pp 459–472

    Google Scholar 

  103. Schiffer LM, Markoe AM, Nelson JSR (1976) Estimation of tumor growth fraction in murine tumors by the primer-available DNA-dependent DNA polymerase assay. Cancer Res 36: 2415–2418

    PubMed  CAS  Google Scholar 

  104. Shapiro J, Jersky J, Katzav S, Feldman M, Segal S (1981) Anesthetic drugs accelerate the progression of postoperative metastases of mouse tumors. J Clin Invest 68: 678–685

    Article  PubMed  CAS  Google Scholar 

  105. Sheldon PW, Fowler JF (1973) The effect of irradiating a transplanted murine lymphosarcoma on the subsequent development of metastases. Br J Cancer 28: 508–514

    Article  PubMed  CAS  Google Scholar 

  106. Sheldon PW, Fowler JF (1976) The effect of low-dose pre-operative x-irradiation of implanted mouse mammary carcinomas on local recurrence and metastasis. Br J Cancer 34: 401–407

    Article  PubMed  CAS  Google Scholar 

  107. Simpson-Herren L (1977) Kinetics and multiple modality therapy. First annual meeting of the Cell Kinetics Society, 11–13 March 1977, Birmingham, AL

    Google Scholar 

  108. Simpson-Herren L (1982) Kinetic perturbations during cancer therapy. Ann NY Acad Sci 397: 88–100

    Article  PubMed  CAS  Google Scholar 

  109. Simpson-Herren L, Griswold DP Jr (1970) Studies of the kinetics of growth and regression of 7,12-dimethylbenz(a)anthracene-induced mammary adenocarcinoma in Sprague-Dawley rats. Cancer Res 30: 813–818

    PubMed  CAS  Google Scholar 

  110. Simpson-Herren L, Griswold DP Jr (1973) Studies of the cell population kinetics of induced and transplanted mammary adenocarcinoma in rats. Cancer Res 33: 2415–2424

    PubMed  CAS  Google Scholar 

  111. Simpson-Herren L, Lloyd HH (1970) Kinetic parameters and growth curves for experimental tumor systems. Cancer Chemother Rep 54: 143–174

    PubMed  CAS  Google Scholar 

  112. Simpson-Herren L, Griswold DP Jr, Corbett TH (1978) Studies of the growth, population kinetics and host lethality of CD8F1 mammary adenocarcinoma. Cancer Treat Rep 62: 519–528

    PubMed  CAS  Google Scholar 

  113. Simpson-Herren L, Sanford AH, Holmquist JP (1976) Effects of surgery on the cell kinetics of residual tumor. Cancer Treat Rep 60: 1749–1760

    PubMed  CAS  Google Scholar 

  114. Skipper HE (1971) Kinetics of mammary tumor cell growth and implications for therapy. Cancer 28: 1479–1499

    Article  PubMed  CAS  Google Scholar 

  115. Sklar LS, Anisman H (1979) Stress and coping factors influence tumor growth. Science 205: 513–515

    Article  PubMed  CAS  Google Scholar 

  116. Steel GG (1977) Growth kinetics of tumors. Clarendon, Oxford

    Google Scholar 

  117. Stragand JJ, Braunschweiger PG, Pollice AA, Schiffer LM (1979) Cell kinetic alterations in murine mammary tumors following fasting and refeeding. Eur J Cancer 15: 281–286

    Article  PubMed  CAS  Google Scholar 

  118. Tannock IF (1970) Population kinetics of carcinoma cells, capillary endothelial cells, and fibroblasts in a transplanted mouse mammary tumor. Cancer Res 30: 2470–2476

    PubMed  CAS  Google Scholar 

  119. Thunold S (1967) Acquired immunity after surgical removal of subcutaneous Ehrlich’s ascites carcinoma. Acta Pathol Microbiol Scand 71: 564–574

    Article  PubMed  CAS  Google Scholar 

  120. Tyzzer EE (1913) F actors in the production and growth of tumor metastases. J Med Res 28: 309–332

    PubMed  CAS  Google Scholar 

  121. van den Brenk HAS, Sharpington C (1971) Effect of local X-irradiation of a primary sarcoma in the rat on dissemination and growth of metastases: dose-response characteristics. Br J Cancer 25: 812–830

    Article  PubMed  Google Scholar 

  122. van Peperzell HA (1972) Effects of single doses of radiation on lung metastases in man and experimental animals. Eur J Cancer 8: 665–675

    Article  Google Scholar 

  123. Visintainer MA, Volpicelli JR, Seligman ME (1982) Tumor rejection in rats after inescapable or escapable shock. Science 216: 437–439

    Article  PubMed  CAS  Google Scholar 

  124. Vollmer TL, Conley FK (1984) Effect of cyclosphosphamide on survival of mice and incidence of metastatic tumor following intravenous and intracardial inoculation of tumor cells. Cancer Res 44: 3902–3906

    PubMed  CAS  Google Scholar 

  125. Walker A, McCallum HM, Wheldon TE, Nias AHW, Abdelaal AS (1978) Promotion of metastasis of C3H mouse mammary carcinoma by local hyperthermia. Br J Cancer 38: 561–563

    Article  PubMed  CAS  Google Scholar 

  126. Watson JV (1976) The perturbed cell proliferation kinetics of the EMT6/M/AC tumour in mice treated with anti-mouse lymphocyte serum. Cell Tissue Kinet 9: 565–571

    PubMed  CAS  Google Scholar 

  127. Whitney RB, Levy JG, Smith AG (1974) Influence of tumor size and surgical resection on cell-mediated immunity in mice. JNCI 53: 111–116

    PubMed  CAS  Google Scholar 

  128. Xu X (1987) The biological foundation of the Gompertz model. Int J Biomed Comput 20: 35–39

    Article  PubMed  CAS  Google Scholar 

  129. Yerushalmi A (1976) Influence on metastatic spread of whole-body or local tumor hyperthermia. Eur J Cancer 12: 455–463

    Article  PubMed  CAS  Google Scholar 

  130. Yuhas JM, Pazmino NH (1974) Inhibition of subcutaneously growing line 1 carcinomas due to metastatic spread. Cancer Res 34: 2005–2010

    PubMed  CAS  Google Scholar 

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  1. Southern Research Institute, 2000 Ninth Avenue South, P.O. Box 55305, 35255-5305, Birmingham, AL, USA

    L. Simpson-Herren

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  1. Medical Oncology, Cancer Control Agency of British Columbia, 600 West 10th Avenue, Vancouver, B.C., V5Z 4E6, Canada

    Joseph Ragaz MD, FRCP

  2. Foundation for Clinical Research Inc., 80 East End Avenue, New York, NY, 10028, USA

    Irving M. Ariel MD

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Simpson-Herren, L. (1989). Tumor Kinetics in Experimental Mammary Carcinoma. In: Ragaz, J., Ariel, I.M. (eds) High-Risk Breast Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73718-3_9

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