Abstract
Records of the facial deformities associated with holoprosencephaly go back to medieval times (Frutiger 1969). Early descriptions of morbid anatomy were published in the 19th century, but identification of the characteristic features is based on the comprehensive treatise of Kundrat (1882). The older literature on cyclopia and arhinencephaly in man and domesticated animals was reviewed by Köhn (1952). Series of cases were studied by Yakovlev (1959), DeMyer et al. (1964), Robain and Gorce (1972), and Jellinger and Groß (1973).
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Friede, R.L. (1989). Dysplasias of the Cerebral Hemispheres. In: Developmental Neuropathology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-73697-1_26
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